当前位置： SCI文献检索 > Scientific Reports期刊下所有文献 > Deletion of metal transporter Zip14 (Slc39a14) produces skeletal muscle wasting, endotoxemia, Mef2c activation and induction of miR-675 and Hspb7.

Deletion of metal transporter Zip14 (Slc39a14) produces skeletal muscle wasting, endotoxemia, Mef2c activation and induction of miR-675 and Hspb7.

Abstract：

:Skeletal muscle represents the largest pool of body zinc, however, little is known about muscle zinc homeostasis or muscle-specific zinc functions. Zip14 (Slc39a14) was the most highly expressed zinc transporter in skeletal muscle of mice in response to LPS-induced inflammation. We compared metabolic parameters of skeletal muscle from global Zip14 knockout (KO) and wild-type mice (WT). At basal steady state Zip14 KO mice exhibited a phenotype that included muscle wasting and metabolic endotoxemia. Microarray and qPCR analysis of gastrocnemius muscle RNA revealed that ablation of Zip14 produced increased muscle p-Mef2c, Hspb7 and miR-675-5p expression and increased p38 activation. ChIP assays showed enhanced binding of NF-[Formula: see text] to the Mef2c promoter. In contrast, LPS-induced systemic inflammation enhanced Zip14-dependent zinc uptake by muscle, increased expression of Atrogin1 and MuRF1 and markedly reduced MyoD. These signatures of muscle atrophy and cachexia were not influenced by Zip14 ablation, however. LPS-induced miR-675-3p and -5p expression was Zip14-dependent. Collectively, these results with an integrative model are consistent with a Zip14 function in skeletal muscle at steady state that supports myogenesis through suppression of metabolic endotoxemia and that Zip14 ablation coincides with sustained activity of phosphorylated components of signaling pathways including p-Mef2c, which causes Hspb7-dependent muscle wasting.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Kim J,Aydemir TB,Jimenez-Rondan FR,Ruggiero CH,Kim MH,Cousins RJ

doi

10.1038/s41598-020-61059-2

subject

Has Abstract

pub_date

2020-03-04 00:00:00

pages

4050

issue

1

issn

2045-2322

pii

10.1038/s41598-020-61059-2

journal_volume

10

pub_type

杂志文章

相关文献

Scientific Reports文献大全
  • IRGM1 enhances B16 melanoma cell metastasis through PI3K-Rac1 mediated epithelial mesenchymal transition.

    abstract：:Melanoma is one of the most aggressive skin cancers and is well known for its high metastatic rate. Studies have shown that epithelial mesenchymal transition (EMT) is essential for melanoma cell metastasis. However, the molecular mechanisms underlying EMT are still not fully understood. We have shown that IRGM1, a mem...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep12357

    authors： Tian L,Li L,Xing W,Li R,Pei C,Dong X,Fu Y,Gu C,Guo X,Jia Y,Wang G,Wang J,Li B,Ren H,Xu H

    更新日期：2015-07-23 00:00:00

  • Identification of strong candidate genes for backfat and intramuscular fatty acid composition in three crosses based on the Iberian pig.

    abstract：:Meat quality has an important genetic component and can be modified by the fatty acid (FA) composition and the amount of fat contained in adipose tissue and muscle. The present study aimed to find genomic regions associated with the FA composition in backfat and muscle (longissimus dorsi) in 439 pigs with three differ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-70894-2

    authors： Crespo-Piazuelo D,Criado-Mesas L,Revilla M,Castelló A,Noguera JL,Fernández AI,Ballester M,Folch JM

    更新日期：2020-08-18 00:00:00

  • Computational delineation and quantitative heterogeneity analysis of lung tumor on 18F-FDG PET for radiation dose-escalation.

    abstract：:Quantitative measurement and analysis of tumor metabolic activities could provide a more optimal solution to personalized accurate dose painting. We collected PET images of 58 lung cancer patients, in which the tumor exhibits heterogeneous FDG uptake. We design an automated delineation and quantitative heterogeneity m...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-28818-8

    authors： Wang X,Cui H,Gong G,Fu Z,Zhou J,Gu J,Yin Y,Feng D

    更新日期：2018-07-13 00:00:00

  • Extract of Vernonia condensata, Inhibits Tumor Progression and Improves Survival of Tumor-allograft Bearing Mouse.

    abstract：:Medicinal plants are considered as one of the ideal sources for cancer therapy due to their bioactive contents and low toxicity to humans. Vernonia genus is one of the common medicinal plants, which has wide spread usage in food and medicine. However, there are limited studies to explore its anticancer properties. In ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep23255

    authors： Thomas E,Gopalakrishnan V,Somasagara RR,Choudhary B,Raghavan SC

    更新日期：2016-03-24 00:00:00

  • The face inversion effect in non-human primates revisited - an investigation in chimpanzees (Pan troglodytes).

    abstract：:Faces presented upside-down are harder to recognize than presented right-side up, an effect known as the face inversion effect. With inversion the perceptual processing of the spatial relationship among facial parts is disrupted. Previous literature indicates a face inversion effect in chimpanzees toward familiar and ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep02504

    authors： Dahl CD,Rasch MJ,Tomonaga M,Adachi I

    更新日期：2013-01-01 00:00:00

  • Compact flexible multi-pass rotary delay line using spinning micro-machined mirrors.

    abstract：:We propose a new method to extend the path length tunability of rotary delay-lines. This method was shown to achieve a duty cycle of >80% and repetition rates of over 40 kHz. The new method relies on a new multi-segmented micro-machined mirror and serial injection of a single reflection onto separate segments of this ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-09576-5

    authors： Fleddermann R,Lee WM,Huang K,Campbell GT,Lam PK,Chow JH

    更新日期：2017-08-24 00:00:00

  • Predicting adult neuroscience intensive care unit admission from emergency department triage using a retrospective, tabular-free text machine learning approach.

    abstract：:Early admission to the neurosciences intensive care unit (NSICU) is associated with improved patient outcomes. Natural language processing offers new possibilities for mining free text in electronic health record data. We sought to develop a machine learning model using both tabular and free text data to identify pati...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-021-80985-3

    authors： Klang E,Kummer BR,Dangayach NS,Zhong A,Kia MA,Timsina P,Cossentino I,Costa AB,Levin MA,Oermann EK

    更新日期：2021-01-14 00:00:00

  • Endothelial dysfunction correlates with decompression bubbles in rats.

    abstract：:Previous studies have documented that decompression led to endothelial dysfunction with controversial results. This study aimed to clarify the relationship between endothelial dysfunction, bubble formation and decompression rate. Rats were subjected to simulated air dives with one of four decompression rates: one slow...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep33390

    authors： Zhang K,Wang D,Jiang Z,Ning X,Buzzacott P,Xu W

    更新日期：2016-09-12 00:00:00

  • In vitro metabolic zonation through oxygen gradient on a chip.

    abstract：:Among the multiple metabolic signals involved in the establishment of the hepatic zonation, oxygen could play a key role. Indeed, depending on hepatocyte position in the hepatic lobule, gene expression and metabolism are differently affected by the oxygen gradient present across the lobule. The aim of this study is to...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-49412-6

    authors： Tonon F,Giobbe GG,Zambon A,Luni C,Gagliano O,Floreani A,Grassi G,Elvassore N

    更新日期：2019-09-19 00:00:00

  • Downregulation of miR-335-5P in Amyotrophic Lateral Sclerosis Can Contribute to Neuronal Mitochondrial Dysfunction and Apoptosis.

    abstract：:Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease for which the pathophysiological mechanisms of motor neuron loss are not precisely clarified. Environmental and epigenetic mechanisms such as microRNAs (miRNAs) could have a role in disease progression. We studied the expression pattern of miRNAs in AL...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-61246-1

    authors： De Luna N,Turon-Sans J,Cortes-Vicente E,Carrasco-Rozas A,Illán-Gala I,Dols-Icardo O,Clarimón J,Lleó A,Gallardo E,Illa I,Rojas-García R

    更新日期：2020-03-09 00:00:00

  • Blockade of integrin α3 attenuates human pancreatic cancer via inhibition of EGFR signalling.

    abstract：:The prognosis of pancreatic cancer remains dismal despite continuous and considerable efforts. Integrins (ITGs) are highly expressed in various malignant cancers. However, very few studies investigated the role of integrin α3 (ITGα3) in malignant cancers. Here, we determined the functional role of ITGα3 in pancreatic ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-39628-x

    authors： Lee J,Lee J,Choi C,Kim JH

    更新日期：2019-02-26 00:00:00

  • mRNA Transfection-Induced Activation of Primary Human Monocytes and Macrophages: Dependence on Carrier System and Nucleotide Modification.

    abstract：:Monocytes and macrophages are key players in maintaining immune homeostasis. Identifying strategies to manipulate their functions via gene delivery is thus of great interest for immunological research and biomedical applications. We set out to establish conditions for mRNA transfection in hard-to-transfect primary hum...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-60506-4

    authors： Moradian H,Roch T,Lendlein A,Gossen M

    更新日期：2020-03-06 00:00:00

  • The high-affinity metal Transporters NRAMP1 and IRT1 Team up to Take up Iron under Sufficient Metal Provision.

    abstract：:Iron (Fe) and manganese (Mn) are essential metals which, when scarce in the growth medium, are respectively taken up by the root high affinity transporters IRT1 and NRAMP1 in Arabidopsis thaliana. The molecular bases for low affinity transport however remained unknown. Since IRT1 and NRAMP1 have a broad range of subst...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep37222

    authors： Castaings L,Caquot A,Loubet S,Curie C

    更新日期：2016-11-16 00:00:00

  • Site-selective local fluorination of graphene induced by focused ion beam irradiation.

    abstract：:The functionalization of graphene remains an important challenge for numerous applications expected by this fascinating material. To keep advantageous properties of graphene after modification or functionalization of its structure, local approaches are a promising road. A novel technique is reported here that allows p...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep19719

    authors： Li H,Daukiya L,Haldar S,Lindblad A,Sanyal B,Eriksson O,Aubel D,Hajjar-Garreau S,Simon L,Leifer K

    更新日期：2016-01-29 00:00:00

  • Performance of Deep Learning Architectures and Transfer Learning for Detecting Glaucomatous Optic Neuropathy in Fundus Photographs.

    abstract：:The ability of deep learning architectures to identify glaucomatous optic neuropathy (GON) in fundus photographs was evaluated. A large database of fundus photographs (n = 14,822) from a racially and ethnically diverse group of individuals (over 33% of African descent) was evaluated by expert reviewers and classified ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-35044-9

    authors： Christopher M,Belghith A,Bowd C,Proudfoot JA,Goldbaum MH,Weinreb RN,Girkin CA,Liebmann JM,Zangwill LM

    更新日期：2018-11-12 00:00:00

  • Role of RPTPβ/ζ in neuroinflammation and microglia-neuron communication.

    abstract：:Pleiotrophin (PTN) is a cytokine that is upregulated in different neuroinflammatory disorders. Using mice with transgenic PTN overexpression in the brain (Ptn-Tg), we have found a positive correlation between iNos and Tnfα mRNA and Ptn mRNA levels in the prefrontal cortex (PFC) of LPS-treated mice. PTN is an inhibitor...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-76415-5

    authors： Fernández-Calle R,Galán-Llario M,Gramage E,Zapatería B,Vicente-Rodríguez M,Zapico JM,de Pascual-Teresa B,Ramos A,Ramos-Álvarez MP,Uribarri M,Ferrer-Alcón M,Herradón G

    更新日期：2020-11-20 00:00:00

  • Long-term memory guides resource allocation in working memory.

    abstract：:Working memory capacity is incredibly limited and thus it is important to use this resource wisely. Prior knowledge in long-term memory can aid in efficient encoding of information by allowing for the prioritization of novel stimuli over familiar ones. Here we used a full-report procedure in a visual working memory pa...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-79108-1

    authors： Bruning AL,Lewis-Peacock JA

    更新日期：2020-12-17 00:00:00

  • Establishment of an experimental ferret ocular hypertension model for the analysis of central visual pathway damage.

    abstract：:Glaucoma optic neuropathy (GON) is a condition where pathogenic intraocular pressure (IOP) results in axonal damage following retinal ganglion cell (RGC) death, and further results in secondary damage of the lateral geniculate nucleus (LGN). Therapeutic targets for glaucoma thus focus on both the LGN and RGC. However,...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep06501

    authors： Fujishiro T,Kawasaki H,Aihara M,Saeki T,Ymagishi R,Atarashi T,Mayama C,Araie M

    更新日期：2014-10-13 00:00:00

  • Strategies and limitations in app usage and human mobility.

    abstract：:Cognition has been found to constrain several aspects of human behaviour, such as the number of friends and the number of favourite places a person keeps stable over time. This limitation has been empirically defined in the physical and social spaces. But do people exhibit similar constraints in the digital space? We ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-47493-x

    authors： De Nadai M,Cardoso A,Lima A,Lepri B,Oliver N

    更新日期：2019-07-29 00:00:00

  • Experimental evidence for the preservation of U-Pb isotope ratios in mantle-recycled crustal zircon grains.

    abstract：:Zircon of crustal origin found in mantle-derived rocks is of great interest because of the information it may provide about crust recycling and mantle dynamics. Consideration of this requires understanding of how mantle temperatures, notably higher than zircon crystallization temperatures, affected the recycled zircon...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-30934-4

    authors： Bea F,Montero P,Palma JFM

    更新日期：2018-08-27 00:00:00

  • High-harmonic generation and parametric amplification in the soft X-rays from extended electron trajectories.

    abstract：:We report, for the first time, the generation of high-order harmonics in a spectral range between 200 eV and 1 keV with an unusual spectral property: only every 4(th) (4i + 1, i∈ℵ) harmonic line appears, whereas the usual high-harmonic spectra consist of every odd (2i + 1) harmonic. We attribute this unique property t...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep04234

    authors： Seres J,Seres E,Landgraf B,Ecker B,Aurand B,Kuehl T,Spielmann C

    更新日期：2014-02-28 00:00:00

  • Genome wide association study identifies novel potential candidate genes for bovine milk cholesterol content.

    abstract：:This study aimed to identify single nucleotide polymorphisms (SNPs) associated with milk cholesterol (CHL) content via a genome wide association study (GWAS). Milk CHL content was determined by gas chromatography and expressed as mg of CHL in 100 g of fat (CHL_fat) or in 100 mg of milk (CHL_milk). GWAS was performed w...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-31427-0

    authors： Do DN,Schenkel FS,Miglior F,Zhao X,Ibeagha-Awemu EM

    更新日期：2018-09-05 00:00:00

  • Wild chimpanzees (Pan troglodytes troglodytes) exploit tortoises (Kinixys erosa) via percussive technology.

    abstract：:Chimpanzees (Pan troglodytes), one of humankinds' closest living relatives, are known to hunt and consume the meat of various animal taxa. Although some researchers have presented indirect evidence that chimpanzees may also prey on tortoises, until now, direct observations of this behaviour did not exist. Here, we pro...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-43301-8

    authors： Pika S,Klein H,Bunel S,Baas P,Théleste E,Deschner T

    更新日期：2019-05-23 00:00:00

  • Innovative methods for random field establishment and statistical parameter inversion exemplified with 6082-T6 aluminum alloy.

    abstract：:This paper aims to eliminate the disharmony between simulation and experiment, and takes the mechanical properties of 6082-T6 Al alloy as an example. In order to obtain the equivalent distribution of material properties after considering the randomicity of materials, a new inversion method combining with stochastic fi...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-54046-9

    authors： Zheng K,Yang K,Shi J,Yuan J,Zhou G

    更新日期：2019-11-28 00:00:00

  • Lsh/HELLS regulates self-renewal/proliferation of neural stem/progenitor cells.

    abstract：:Epigenetic mechanisms are known to exert control over gene expression and determine cell fate. Genetic mutations in epigenetic regulators are responsible for several neurologic disorders. Mutations of the chromatin remodeling protein Lsh/HELLS can cause the human Immunodeficiency, Centromere instability and Facial ano...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-00804-6

    authors： Han Y,Ren J,Lee E,Xu X,Yu W,Muegge K

    更新日期：2017-04-25 00:00:00

  • A direct comparison of interphase FISH versus low-coverage single cell sequencing to detect aneuploidy reveals respective strengths and weaknesses.

    abstract：:Aneuploidy has been reported to occur at remarkably high levels in normal somatic tissues using Fluorescence In Situ Hybridization (FISH). Recently, these reports were contradicted by single-cell low-coverage whole genome sequencing (scL-WGS) analyses, which showed aneuploidy frequencies at least an order of magnitude...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-46606-w

    authors： Andriani GA,Maggi E,Piqué D,Zimmerman SE,Lee M,Quispe-Tintaya W,Maslov A,Campisi J,Vijg J,Mar JC,Montagna C

    更新日期：2019-07-19 00:00:00

  • Optimized Isolation of Extracellular Vesicles From Various Organic Sources Using Aqueous Two-Phase System.

    abstract：:From biomarkers to drug carriers, Extracellular Vesicles (EVs) are being used successfully in numerous applications. However, while the subject has been steadily rising in popularity, current methods of isolating EVs are lagging behind, incapable of isolating EVs at a high enough quantity or quality while also requiri...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-55477-0

    authors： Kırbaş OK,Bozkurt BT,Asutay AB,Mat B,Ozdemir B,Öztürkoğlu D,Ölmez H,İşlek Z,Şahin F,Taşlı PN

    更新日期：2019-12-16 00:00:00

  • Moonlight controls lunar-phase-dependency and regular oscillation of clock gene expressions in a lunar-synchronized spawner fish, Goldlined spinefoot.

    abstract：:Goldlined spinefoot, Siganus guttatus, inhabits tropical and subtropical waters and synchronizes its spawning around the first quarter moon likely using an hourglass-like lunar timer. In previous studies, we have found that clock genes (Cryptochrome3 and Period1) could play the role of state variable in the diencephal...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-24538-1

    authors： Takeuchi Y,Kabutomori R,Yamauchi C,Miyagi H,Takemura A,Okano K,Okano T

    更新日期：2018-04-18 00:00:00

  • Effect of dietary advanced glycation end products on inflammation and cardiovascular risks in healthy overweight adults: a randomised crossover trial.

    abstract：:Diets high in advanced glycation end products (AGEs) are thought to be detrimental to cardiovascular health. However, there remains uncertainty about the beneficial effect of a low AGE diet on cardiovascular risk factors and inflammatory markers in overweight individuals. We thus performed a randomised, double blind, ...

    journal_title：Scientific reports

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1038/s41598-017-04214-6

    authors： Baye E,de Courten MP,Walker K,Ranasinha S,Earnest A,Forbes JM,de Courten B

    更新日期：2017-06-23 00:00:00

  • Pyridoxamine improves survival and limits cardiac dysfunction after MI.

    abstract：:Advanced glycation end products (AGEs) play a key role in the progression of heart failure. Whether treatments limiting AGEs formation would prevent adverse left ventricular remodeling after myocardial infarction (MI) remain unknown. We investigated whether pyridoxamine (PM) could limit adverse cardiac outcome in MI. ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-16255-y

    authors： Deluyker D,Ferferieva V,Driesen RB,Verboven M,Lambrichts I,Bito V

    更新日期：2017-11-22 00:00:00