p53 functional states are associated with distinct aldehyde dehydrogenase transcriptomic signatures.

abstract：:Helicobacter pylori (H. pylori) is one of the most important factors that affect the development of gastric cancer, and its mechanism remains un-elucidated. Our present study found that, miR-30a is crucial for regulating the growth and migration of H. pylori infected gastric cancer in vitro by targeting COX-2 and BCL9...

journal_title：Scientific reports

authors： Liu X,Ji Q,Zhang C,Liu X,Liu Y,Liu N,Sui H,Zhou L,Wang S,Li Q

更新日期：2017-08-02 00:00:00

abstract：:Rapid vertebrate diversity evaluation is invaluable for monitoring changing ecosystems worldwide. Wild blow flies naturally recover DNA and chemical signatures from animal carcasses and feces. We demonstrate the power of blow flies as biodiversity monitors through sampling of flies in three environments with varying h...

journal_title：Scientific reports

authors： Owings CG,Banerjee A,Asher TMD,Gilhooly WP 3rd,Tuceryan A,Huffine M,Skaggs CL,Adebowale IM,Manicke NE,Picard CJ

更新日期：2019-07-22 00:00:00

abstract：:People mimic each other's actions and postures during everyday interactions. It is widely believed this mimicry acts as a social glue, leading to increased rapport. We present two studies using virtual reality to rigorously test this hypothesis. In Study 1, 50 participants interacted with two avatars who either mimick...

journal_title：Scientific reports

authors： Hale J,Hamilton AF

更新日期：2016-10-14 00:00:00

abstract：:This paper reports the fabrication and operation of a transmission-type polarization rotator for visible light with a wavelength of 450 nm using indirect-transition-type semiconductor crystalline SiC in which Al atoms were implanted as a p-type dopant. A novel dressed-photon-phonon (DPP)-assisted annealing method was ...

journal_title：Scientific reports

authors： Kadowaki T,Kawazoe T,Ohtsu M

更新日期：2020-07-31 00:00:00

abstract：:Our recent studies, using (SWRxNZB)F1 (SNF1) mice, showed a potential contribution of the gut microbiota and pro-inflammatory immune responses of the gut mucosa to systemic autoimmunity in lupus. Here, using this mouse model, we determined the abundance and the nAg reactivity of IgA antibody produced in the intestine ...

journal_title：Scientific reports

authors： Sun W,Gudi RR,Johnson BM,Vasu C

更新日期：2020-08-31 00:00:00

abstract：:Cephalotaxus oliveri is an endangered tertiary relict conifer endemic to China. The species survives in a wide range from west to east with heterogeneous climatic conditions. Precipitation and temperature are main restrictive factors for distribution of C. oliveri. In order to comprehend the mechanism of adaptive evol...

journal_title：Scientific reports

authors： Wang T,Wang Z,Xia F,Su Y

更新日期：2016-04-26 00:00:00

abstract：:Voltage-gated ether à go-go (EAG) K(+) channels are expressed in various types of cancer cells and also in the central nervous system. Aberrant overactivation of human EAG1 (hEAG1) channels is associated with cancer and neuronal disorders such as Zimmermann-Laband and Temple-Baraitser syndromes. Although hEAG1 channel...

journal_title：Scientific reports

authors： Han B,He K,Cai C,Tang Y,Yang L,Heinemann SH,Hoshi T,Hou S

更新日期：2016-03-23 00:00:00

abstract：:Multisensory integration provides continuous and stable perception from separate sensory inputs. Here, we investigated the functional role of temporal binding between the visual and the tactile senses. To this end we used the paradigm of compression that induces shifts in time when probe stimuli are degraded, e.g., by...

journal_title：Scientific reports

authors： Zimmermann E,Derichs C,Fink GR

更新日期：2016-05-16 00:00:00

abstract：:Hirsutella sinensis mycelium (HSM), the anamorph of Cordyceps sinensis, is a traditional Chinese medicine that has been shown to possess various pharmacological properties. We previously reported that this fungus suppresses interleukin-1β and IL-18 secretion by inhibiting both canonical and non-canonical inflammasomes...

journal_title：Scientific reports

authors： Huang TT,Lai HC,Ko YF,Ojcius DM,Lan YW,Martel J,Young JD,Chong KY

更新日期：2015-10-26 00:00:00

abstract：:Autoantibodies against ion channels are the cause of numerous neurologic autoimmune disorders. Frequently, such pathogenic autoantibodies have a restricted epitope-specificity. In such cases, competing antibody formats devoid of pathogenic effector functions (blocker antibodies) have the potential to treat disease by ...

journal_title：Scientific reports

authors： Losen M,Labrijn AF,van Kranen-Mastenbroek VH,Janmaat ML,Haanstra KG,Beurskens FJ,Vink T,Jonker M,'t Hart BA,Mané-Damas M,Molenaar PC,Martinez-Martinez P,van der Esch E,Schuurman J,de Baets MH,Parren PWHI

更新日期：2017-04-20 00:00:00

abstract：:Thus far, underwater and underground positioning techniques have been limited to those using classical waves (sound waves, electromagnetic waves or their combination). However, the positioning accuracy is strongly affected by the conditions of media they propagate (temperature, salinity, density, elastic constants, op...

journal_title：Scientific reports

authors： Tanaka HKM

更新日期：2020-11-03 00:00:00

abstract：:Metabotropic glutamate receptor subtype 1 (mGluR1) is a crucial pharmacological target for several central nervous system disorders. In this study, we aimed to monitor in vivo regional changes of mGluR1 related to neuroinflammation in the brains of rats after pilocarpine-induced status epilepticus (PISE) using longitu...

journal_title：Scientific reports

authors： Yamasaki T,Fujinaga M,Mori W,Zhang Y,Wakizaka H,Nengaki N,Xie L,Hatori A,Zhang MR

更新日期：2017-11-02 00:00:00

abstract：:This study was intended to determine the efficacy of nivolumab, we evaluated treatment response with respect to PD-1/PD-L1 SNPs among patients with NSCLC. A total of 50 patients with NSCLC were treated with nivolumab and were also evaluated for PD-1/PD-L1 single nucleotide polymorphisms (SNPs) from plasma DNA. We inve...

journal_title：Scientific reports

authors： Nomizo T,Ozasa H,Tsuji T,Funazo T,Yasuda Y,Yoshida H,Yagi Y,Sakamori Y,Nagai H,Hirai T,Kim YH

更新日期：2017-03-23 00:00:00

abstract：:Photoswitchable fluorescent proteins with controllable light-dark states and spectral shifts in emission in response to light have led to breakthroughs in the study of cell biology. Nevertheless, conventional photoswitching is not applicable for weakly fluorescent proteins and requires UV light with low depth penetrat...

journal_title：Scientific reports

authors： Harrington WN,Haji MR,Galanzha EI,Nedosekin DA,Nima ZA,Watanabe F,Ghosh A,Biris AS,Zharov VP

更新日期：2016-11-08 00:00:00

abstract：:The architecture of the genome influences the functions of DNA from bacteria to eukaryotes. Intrinsically disordered regions (IDR) of eukaryotic histones have pivotal roles in various processes of gene expression. IDR is rare in bacteria, but interestingly, mycobacteria produce a unique histone-like protein, MDP1 that...

journal_title：Scientific reports

authors： Savitskaya A,Nishiyama A,Yamaguchi T,Tateishi Y,Ozeki Y,Nameta M,Kon T,Kaboso SA,Ohara N,Peryanova OV,Matsumoto S

更新日期：2018-05-29 00:00:00

abstract：:A new energy dispersive X-ray absorption spectroscopy (EDXAS) method is presented for simultaneous wide-field imaging and transmission X-ray absorption spectroscopy (XAS) to enable rapid imaging and speciation of elements. Based on spectral K-Edge Subtraction imaging (sKES), a bent Laue imaging system diffracting in t...

journal_title：Scientific reports

authors： Qi P,Samadi N,Martinson M,Ponomarenko O,Bassey B,Gomez A,George GN,Pickering IJ,Chapman LD

更新日期：2019-11-27 00:00:00

abstract：:Carbon coated TiO2 (TiO2@C) is fabricated by a convenient and green one-pot solvothermal method, in which ethylene glycol serve as both the reaction medium and carbon source without the addition of any other carbon additives. During the solvothermal process, ethylene glycol polymerize and coordinate with Ti4+ to form ...

journal_title：Scientific reports

authors： Tao H,Zhou M,Wang K,Cheng S,Jiang K

更新日期：2017-03-03 00:00:00

abstract：:A collection of ancient Roman orichalcum coins, i.e., a copper-zinc alloy, minted under the reigns from Caesar to Domitianus, have been characterised using scanning electron microscopy (SEM-EDS) and electron microprobe analysis (EMPA). We studied, for the first time, coins emitted by Romans after the reforms of August...

journal_title：Scientific reports

authors： Di Fazio M,Felici AC,Catalli F,De Vito C

更新日期：2019-09-03 00:00:00

abstract：:Familial history of hypertension is associated with autonomic dysfunction and increase in blood pressure (BP). However, an active lifestyle has been found to improve a number of health outcomes and reduce all-cause mortality. The aim of the present study was to investigate the effects of an active lifestyle on hemodyn...

journal_title：Scientific reports

authors： Santa-Rosa FA,Shimojo GL,Dias DS,Viana A,Lanza FC,Irigoyen MC,De Angelis K

更新日期：2020-07-24 00:00:00

abstract：:Mechanical interlocking is widely applied in industry and general lives of human beings. In this work, we realized the control of locking or sliding states of cotton fibers on the metal surfaces with slightly different textures through traditional machining. Three types of sliding states, i.e., locking, one-way slidin...

journal_title：Scientific reports

authors： Zhang Y,Tian Y,Meng Y

更新日期：2016-05-09 00:00:00

abstract：:The positioning of electrodes in electrical impedance myography (EIM) is critical for accurately assessing disease progression and effectiveness of treatment. In human and animal trials for neuromuscular disorders, inconsistent electrode positioning adds errors to the muscle impedance. Despite its importance, how the ...

journal_title：Scientific reports

authors： Sanchez B,Pacheck A,Rutkove SB

更新日期：2016-09-02 00:00:00

abstract：:Perturbations in lipid metabolic pathways to meet the bioenergetic and biosynthetic requirements is a principal characteristic of cancer cells. Sphingolipids (SPLs) are the largest class of bioactive lipids associated to various aspects of tumorigenesis and have been extensively studied in cancer cell lines and experi...

journal_title：Scientific reports

authors： Bhadwal P,Dahiya D,Shinde D,Vaiphei K,Math RGH,Randhawa V,Agnihotri N

更新日期：2020-03-13 00:00:00

abstract：:Circadian clocks keep time via ~ 24 h transcriptional feedback loops. In Drosophila, CLOCK-CYCLE (CLK-CYC) activators and PERIOD-TIMELESS (PER-TIM) repressors are feedback loop components whose transcriptional status varies over a circadian cycle. Although changes in the state of activators and repressors has been cha...

journal_title：Scientific reports

authors： Mahesh G,Rivas GBS,Caster C,Ost EB,Amunugama R,Jones R,Allen DL,Hardin PE

更新日期：2020-10-21 00:00:00

abstract：:Odontogenic infection of Porphyromonas gingivalis (P.g.), a major periodontal pathogen, exacerbates pathological progression of non-alcoholic steatohepatitis (NASH). In this study, we aimed to clarify the detailed mechanism in which P.g. induced hepatic stellate cells (HSCs; key effector cells in liver fibrosis) activ...

journal_title：Scientific reports

authors： Nagasaki A,Sakamoto S,Chea C,Ishida E,Furusho H,Fujii M,Takata T,Miyauchi M

更新日期：2020-03-05 00:00:00

abstract：:Mineral dust aerosols are responsible for some of the largest sources of uncertainties in our current understanding of climate change. Here we show that a severe drought is having a significant impact in one of largest sources of mineral dust aerosols of the U.S., the Owens Lake area in California's southwest. Measure...

journal_title：Scientific reports

authors： Borlina CS,Rennó NO

更新日期：2017-05-11 00:00:00

abstract：:Evidence indicates that astronauts experience significant bone loss in space. We previously showed that simulated microgravity (μXg) using the NASA developed rotary cell culture system (RCCS) enhanced bone resorbing osteoclast (OCL) differentiation. However, the mechanism by which μXg increases OCL formation is unclea...

journal_title：Scientific reports

authors： Sambandam Y,Baird KL,Stroebel M,Kowal E,Balasubramanian S,Reddy SV

更新日期：2016-05-04 00:00:00

abstract：:Whether 2nd-line-chemotherapy (2LCTX) + best-supportive-care (BSC) benefits patients with advanced biliary tract cancer (aBTC) more than BSC alone is unclear. We therefore conducted a propensity-score-based comparative effectiveness analysis of overall survival (OS) outcomes in 80 patients with metastatic, recurrent, ...

journal_title：Scientific reports

authors： Moik F,Riedl JM,Winder T,Terbuch A,Rossmann CH,Szkandera J,Bauernhofer T,Kasparek AK,Schaberl-Moser R,Reicher A,Prinz F,Pichler M,Stöger H,Stotz M,Gerger A,Posch F

更新日期：2019-04-03 00:00:00

abstract：:Lung adenosquamous cell carcinomas (ASCs) is a rare variant of NSCLC with a poorer prognosis and fewer treatment option than the more common variants. PD-L1 expression is reported to be the predictor of clinical response in trials of NSCLC. In our study, PD-L1 expression was evaluated via immunohistochemistry using a ...

journal_title：Scientific reports

authors： Shi X,Wu S,Sun J,Liu Y,Zeng X,Liang Z

更新日期：2017-04-07 00:00:00

abstract：:The northern microrefugia that existed during the Last Glacial Maximum (LGM) are a key factor in the demographic history of species. Pinus koraiensis has a unique distribution in northeast Asia. The Changbai Mountains and the Korean peninsula (CM/KP) are usually considered to be the LGM refugia for P. koraiensis. Howe...

journal_title：Scientific reports

authors： Bao L,Kudureti A,Bai W,Chen R,Wang T,Wang H,Ge J

更新日期：2015-12-22 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Scientific reports

authors： Yoshida S,Miyagawa S,Toyofuku T,Fukushima S,Kawamura T,Kawamura A,Kashiyama N,Nakamura Y,Toda K,Sawa Y

更新日期：2020-06-17 00:00:00