Abstract：
:Cephalotaxus oliveri is an endangered tertiary relict conifer endemic to China. The species survives in a wide range from west to east with heterogeneous climatic conditions. Precipitation and temperature are main restrictive factors for distribution of C. oliveri. In order to comprehend the mechanism of adaptive evolution to climate variation, we employed ISSR markers to detect adaptive evolution loci, to identify the association between variation in temperature and precipitation and adaptive loci, and to investigate the genetic structure for 22 C. oliveri natural populations. In total, 14 outlier loci were identified, of which five were associated with temperature and precipitation. Among outlier loci, linkage disequilibrium (LD) was high (42.86%), which also provided strong evidence for selection. In addition, C. oliveri possessed high genetic variation (93.31%) and population differentiation, which may provide raw material to evolution and accelerate local adaptation, respectively. Ecological niche modeling showed that global warming will cause a shift for populations of C. oliveri from south to north with a shrinkage of southern areas. Our results contribute to understand the potential response of conifers to climatic changes, and provide new insights for conifer resource management and conservation strategies.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Wang T,Wang Z,Xia F,Su Ydoi
10.1038/srep25031subject
Has Abstractpub_date
2016-04-26 00:00:00pages
25031issn
2045-2322pii
srep25031journal_volume
6pub_type
杂志文章abstract：:The peptidyl nucleoside blasticidin S (BS) isolated from Streptomyces griseochromogenes was the first non-mercurial fungicide used on a large scale to prevent rice blast. In the biosynthesis of BS, leucylblasticidin S (LBS) was suggested as the penultimate metabolite with 20-fold less inhibitory activity than the fina...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep17641
更新日期：2015-12-01 00:00:00
abstract：:This study compared effects of five hypoxia-inducible factor (HIF) prolyl hydroxylases (PHD) inhibitors on PC12 cells and primary rat neurons following oxygen-glucose deprivation (OGD). At 100 µM, the PHD inhibitors did not cause cytotoxicity and apoptosis. MTT activity was only significantly reduced by FG4592 or Baye...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-58482-w
更新日期：2020-01-31 00:00:00
abstract：:Aryl nitriles are versatile compounds that can be synthesized via transition-metal-mediated cyanation of aryl halides. Most of the supported-heterogeneous catalysts are noble-metals based and there are very limited numbers of efficient non-noble metal based catalysts demonstrated for the cyanation of aryl halides. Her...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-57483-z
更新日期：2020-01-20 00:00:00
abstract：:Electronic textiles have garnered significant attention as smart technology for next-generation wearable electronic devices. The existing power sources lack compatibility with wearable devices due to their limited flexibility, high cost, and environment unfriendliness. In this work, we demonstrate bamboo fabric as a s...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-70182-z
更新日期：2020-08-06 00:00:00
abstract：:A fundamental question in biology is how cell populations evolve into different subtypes based on homogeneous processes at the single cell level. Here we show that population bimodality can emerge even when biological processes are homogenous at the cell level and the environment is kept constant. Our model is based o...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-45882-w
更新日期：2019-06-28 00:00:00
abstract：:Orexins are originally characterized as orexigenic hypothalamic neuropeptides in mammals. Subsequent studies found orexin to be expressed and perform pleiotropic functions in multiple tissues in mammals. In avian (non-mammalian) species, however, orexin seemed to not affect feeding behavior and its physiological roles...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-76329-2
更新日期：2020-11-05 00:00:00
abstract：:A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has not been fixed in the paper. ...
journal_title：Scientific reports
pub_type： 已发布勘误
doi：10.1038/s41598-018-22649-3
更新日期：2018-03-12 00:00:00
abstract：:Influenza virus remains an emerging virus and causes pandemics with high levels of fatality. After screening different plant extracts with potential anti-influenza activity, a water extract of Taxodium distichum stems (TDSWex) showed excellent activity against influenza viruses. The EC50 of TDSWex was 0.051 ± 0.024 mg...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep36015
更新日期：2016-10-31 00:00:00
abstract：:Facio-Scapulo Humeral dystrophy (FSHD) is the third most common myopathy, affecting 1 amongst 10,000 individuals (FSHD1, OMIM #158900). This autosomal dominant pathology is associated in 95% of cases with genetic and epigenetic alterations in the subtelomeric region at the extremity of the long arm of chromosome 4 (q ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-46861-x
更新日期：2019-07-17 00:00:00
abstract：:The use of impedance-based label free cell analysis is increasingly popular and has many different applications. Here, we report that a real-time cell analyzer (RTCA) can be used to study the stimulation of Natural Killer (NK) cells. Engagement of NK cells via plate-bound antibodies directed against different activati...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-23368-5
更新日期：2018-03-21 00:00:00
abstract：:Contrast-induced nephropathy (CIN) has become the third-leading cause of hospital-acquired acute renal injury. Although alprostadil has been proposed as an effective preventative measure, this conclusion remains inconsistent. Thus, we performed a meta-analysis of the published studies on this topic to evaluate the pre...
journal_title：Scientific reports
pub_type： 杂志文章,meta分析
doi：10.1038/s41598-017-01160-1
更新日期：2017-04-21 00:00:00
abstract：:Clouds play a major role in the climate system, but large uncertainties remain about their decadal variations. Here we report a widespread decrease in cloud cover since the 1970 s over the Mediterranean region, in particular during the 1970 s-1980 s, especially in the central and eastern areas and during springtime. C...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep41475
更新日期：2017-02-02 00:00:00
abstract：:Given that observational associations may be inaccurate, we used offspring blood pressure (BP) to provide alternative estimates of the associations between own BP and mortality. Observational associations between BP and mortality, estimated as hazard ratios (HRs) from Cox regression, were compared to HRs obtained usin...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep12399
更新日期：2015-07-22 00:00:00
abstract：:Platelet-driven reduction in blood clot volume (clot contraction or retraction) has been implicated to play a role in hemostasis and thrombosis. Although these processes are often linked with inflammation, the role of inflammatory cells in contraction of blood clots and thrombi has not been investigated. The aim of th...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-05601-9
更新日期：2017-07-11 00:00:00
abstract：:Interference of two combined white light beams produces Newton colors if one of the beams is retarded relative to the other by from 400 nm to 2000 nm. In this case the corresponding interfering spectral components are added as two scalars at the beam combination. If the retardance is below 400 nm the two-beam interfer...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep17340
更新日期：2015-11-27 00:00:00
abstract：:Functional reactivation of p53 pathway, although arduous, can potentially provide a broad-based strategy for cancer therapy owing to frequent p53 inactivation in human cancer. Using a phosphoprotein-screening array, we found that Benzyl Isothiocynate, (BITC) increases p53 phosphorylation in breast cancer cells and rev...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep40070
更新日期：2017-01-10 00:00:00
abstract：:Animals are capable of using visual cues to find the correct route during navigation. These visual cues, which contain spatial information on the direction towards the goal point, are perceived either allocentrically or egocentrically. In this study, we examined how navigating with these two types of visual cues affec...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-42852-0
更新日期：2019-04-23 00:00:00
abstract：:With countless biological details emerging from cancer experiments, there is a growing need for minimal mathematical models which simultaneously advance our understanding of single tumors and metastasis, provide patient-personalized predictions, whilst avoiding excessive hard-to-measure input parameters which complica...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep00031
更新日期：2011-01-01 00:00:00
abstract：:The most important goals of brain network analyses are to (a) detect pivotal regions and connections that contribute to disproportionate communication flow, (b) integrate global information, and (c) increase the brain network efficiency. Most centrality measures assume that information propagates in networks with the ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-42322-7
更新日期：2019-04-11 00:00:00
abstract：:Tomato spotted wilt virus is a wide-spread plant disease in the world. It can threaten thousands of plants with a persistent and propagative manner. Early disease detection is expected to be able to control the disease spread, to facilitate management practice, and further to guarantee accompanying economic benefits. ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-40066-y
更新日期：2019-03-13 00:00:00
abstract：:Filamentous fungi grow exclusively at their tips, where many growth-related fungal processes, such as enzyme secretion and invasion into host cells, take place. Hyphal tips are also a site of active metabolism. Understanding metabolic dynamics within the tip region is therefore important for biotechnology and medicine...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-80270-9
更新日期：2021-01-14 00:00:00
abstract：:We developed a new technique to observe macroautophagy in the brain in vivo, and examined whether fasting induced macroautophagy in neurons and how the induction was different between Alzheimer's disease (AD) model and control mice. Lentivirus for EGFP-LC3 injected into the brain successfully visualized autophagosome ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep12115
更新日期：2015-07-14 00:00:00
abstract：:In adipose tissue, agonists of the β3-adrenergic receptor (ADRB3) regulate lipolysis, lipid oxidation, and thermogenesis. The deficiency in the thermogenesis induced by neuroblast differentiation-associated protein AHNAK in white adipose tissue (WAT) of mice fed a high-fat diet suggests that AHNAK may stimulate energy...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep23426
更新日期：2016-03-18 00:00:00
abstract：:Pearl millet hybrids biofortified with iron (Fe) and zinc (Zn) promise to be part of a long-term strategy to combat micronutrient malnutrition in the arid and semi-arid tropical (SAT) regions of the world. Biofortification through molecular breeding is the way forward to achieving a rapid trait-based breeding strategy...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-76230-y
更新日期：2020-11-10 00:00:00
abstract：:Studies in mice suggest that early life represents a critical time window, where antibiotics may exert profound and lasting effects on the gut microbiota and metabolism. We aimed to test the hypothesis that prenatal antibiotic exposure is associated with increased risk of childhood overweight in a population-based coh...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-48065-9
更新日期：2019-08-08 00:00:00
abstract：:Pleiotrophin (PTN) is a cytokine that is upregulated in different neuroinflammatory disorders. Using mice with transgenic PTN overexpression in the brain (Ptn-Tg), we have found a positive correlation between iNos and Tnfα mRNA and Ptn mRNA levels in the prefrontal cortex (PFC) of LPS-treated mice. PTN is an inhibitor...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-76415-5
更新日期：2020-11-20 00:00:00
abstract：:PCR-mediated chromosome splitting (PCS) was developed in the yeast Saccharomyces cerevisiae. It is based on homologous recombination and enables division of a chromosome at any point to form two derived and functional chromosomes. However, because of low homologous recombination activity, PCS is limited to a single si...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep30278
更新日期：2016-08-17 00:00:00
abstract：:Infection of bone is a severe complication due to the variety of bacteria causing it, their resistance against classical antibiotics, the formation of a biofilm and the difficulty to eradicate it. Antimicrobial peptides (AMPs) are naturally occurring peptides and promising candidates for treatment of joint infections....
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-01698-0
更新日期：2017-05-04 00:00:00
abstract：:FFAR3 (GPR41) is a G-protein coupled receptor for which short-chain fatty acids serve as endogenous ligands. The receptor is found on gut enteroendocrine L-cells, pancreatic β-cells, and sympathetic neurons, and is implicated in obesity, diabetes, allergic airway disease, and altered immune function. In primates, FFAR...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep12880
更新日期：2015-08-11 00:00:00
abstract：:Although hepatitis B virus (HBV) infection is the leading cause of liver fibrosis (LF), the mechanisms underlying liver fibrotic progression remain unclear. Here, we investigated the gene expression profiles of HBV-related LF patients. Whole genome expression arrays were used to detect gene expression in liver biopsy ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep43446
更新日期：2017-03-06 00:00:00
