Sex-specific glioma genome-wide association study identifies new risk locus at 3p21.31 in females, and finds sex-differences in risk at 8q24.21.

abstract：:A series of La1-xCexCoO3 perovskite nanoparticles with rhombohedral phases was synthesized via sol-gel chemical process. X-ray diffraction (XRD), Transmission Electron Microscopy (TEM), Electron Diffraction Spectroscopy (EDS), Thermogravimetric Analysis (TGA), UV-Vis spectroscopy, Fourier Transform Infrared spectra (F...

journal_title：Scientific reports

authors： Ansari AA,Adil SF,Alam M,Ahmad N,Assal ME,Labis JP,Alwarthan A

更新日期：2020-09-14 00:00:00

abstract：:Developmental neurotoxic compounds impair the developing human nervous system at lower doses than those affecting adults. Standardized test methods for assessing developmental neurotoxicity (DNT) require the use of high numbers of laboratory animals. Here, we use a novel assay that is based on the development of an in...

journal_title：Scientific reports

authors： Bode K,Nolte L,Kamin H,Desens M,Ulmann A,Bergmann GA,Betker P,Reitmeier J,Ripken T,Stern M,Meyer H,Bicker G

更新日期：2020-02-14 00:00:00

abstract：:It is challenging to create artificial catalysts that approach enzymes with regard to catalytic efficiency and selectivity. The enantioselective catalysis ranks the privileged characteristic of enzymatic transformations. Here, we report two pyridine-linked bis(β-cyclodextrin) (bisCD) copper(II) complexes that enantios...

journal_title：Scientific reports

authors： Xue SS,Zhao M,Ke ZF,Cheng BC,Su H,Cao Q,Cao ZK,Wang J,Ji LN,Mao ZW

更新日期：2016-02-26 00:00:00

abstract：:Our aim was to evaluate intervention components of an alcohol reduction app: Drink Less. Excessive drinkers (AUDIT>=8) were recruited to test enhanced versus minimal (reduced functionality) versions of five app modules in a 25 factorial trial. Modules were: Self-monitoring and Feedback, Action Planning, Identity Chang...

journal_title：Scientific reports

authors： Crane D,Garnett C,Michie S,West R,Brown J

更新日期：2018-03-12 00:00:00

abstract：:Common genetic risk variants for colorectal cancer (CRC) have been identified at approximately 40 loci by genome-wide association studies (GWAS). We investigated the association of these risk variants by age at onset of CRC using case-only and case-control analysis. A total of 1,962 CRC cases and 2,668 controls from t...

journal_title：Scientific reports

authors： Song N,Shin A,Park JW,Kim J,Oh JH

更新日期：2017-01-13 00:00:00

abstract：:Protein aggregation is a common biological phenomenon, observed in different physiological and pathological conditions. Decreased protein solubility and a tendency to aggregate is also observed during physiological aging but the causes are currently unknown. Herein we performed a biophysical separation of aging-relate...

journal_title：Scientific reports

authors： Tanase M,Urbanska AM,Zolla V,Clement CC,Huang L,Morozova K,Follo C,Goldberg M,Roda B,Reschiglian P,Santambrogio L

更新日期：2016-01-18 00:00:00

abstract：:Power semiconductor devices require low on-resistivity and high breakdown voltages simultaneously. Vertical-type metal-oxide-semiconductor field-effect transistors (MOSFETs) meet these requirements, but have been incompleteness in diamond. Here we show vertical-type p-channel diamond MOSFETs with trench structures and...

journal_title：Scientific reports

authors： Oi N,Inaba M,Okubo S,Tsuyuzaki I,Kageura T,Onoda S,Hiraiwa A,Kawarada H

更新日期：2018-07-13 00:00:00

abstract：:In 2010, a new rabbit hemorrhagic disease virus (RHDV) variant, designated RHDV2, was identified for the first time in Italy. Studies have shown that RHDV2 differs from RHDV1 (traditional RHDV) in terms of its antigenic profile and genetic characteristics. The VP60 protein of RHDV is a structural protein that plays im...

journal_title：Scientific reports

authors： Kong D,Liu J,Jiang Q,Yu Z,Hu X,Guo D,Huang Q,Jiao M,Qu L

更新日期：2016-02-16 00:00:00

abstract：:There is lack of consensus regarding the prognostic significance of primary tumor location of upper tract urothelial carcinoma(UTUC). We performed a meta-analysis to evaluate the impact of primary tumor location on prognosis in patients with UTUC who had undergone radical nephroureterectomy(RNU). We included eligible ...

journal_title：Scientific reports

authors： Wu Y,Dong Q,Liu L,Han P,Wei Q

更新日期：2014-09-15 00:00:00

abstract：:In optical experiments one-sided reflectionless (ORL) and coherent perfect absorption (CPA) are unusual scattering properties yet fascinating for their fundamental aspects and for their practical interest. Although these two concepts have so far remained separated from each other, we prove that the two phenomena are i...

journal_title：Scientific reports

authors： Wu JH,Artoni M,La Rocca GC

更新日期：2016-10-19 00:00:00

abstract：:Dysregulation of specific microRNAs or Wnt/β-catenin signaling pathway is critically implicated in the pathogenesis of various renal diseases. However, the relationship between microRNAs and Wnt/β-catenin signaling in diabetes-induced glomerular sclerosis remains unknown. Here, we found that decreased miR-29a expressi...

journal_title：Scientific reports

authors： Hsu YC,Chang PJ,Ho C,Huang YT,Shih YH,Wang CJ,Lin CL

更新日期：2016-07-27 00:00:00

abstract：:Boulders are ubiquitously found on the surfaces of small rocky bodies in the inner solar system and their spatial and size distributions give insight into the geological evolution and collisional history of the parent bodies. Using images acquired by the Chang'e-2 spacecraft, more than 200 boulders have been identifie...

journal_title：Scientific reports

authors： Jiang Y,Ji J,Huang J,Marchi S,Li Y,Ip WH

更新日期：2015-11-02 00:00:00

abstract：:Immunosuppression is critical for tumor growth and metastasis as well as obstacle to effective immunotherapy. Here, we demonstrate that host deficiency in caveolin-2, a member of caveolin protein family, increases M1-polarized tumor-associated macrophage (TAM) and CD8 T cell infiltration into subcutaneously implanted ...

journal_title：Scientific reports

authors： Liu Y,Qi X,Li G,Sowa G

更新日期：2019-12-12 00:00:00

abstract：:Human papillomavirus (HPV) is the most common sexually transmitted infection in the world and the main cause of cervical cancer. Nowadays, the virus-like particles (VLPs) based on L1 proteins have been considered as the best candidate for vaccine development against HPV infections. Two commercial HPV (Gardasil and Cer...

journal_title：Scientific reports

authors： Namvar A,Bolhassani A,Javadi G,Noormohammadi Z

更新日期：2019-10-23 00:00:00

abstract：:This was a nine-year retrospective cohort study to investigate obstetric and perinatal outcomes in a cohort of adolescent girls with twin pregnancies from a major Australian tertiary centre in Brisbane, Australia. The adolescent cohort was aged <19 years and the control group was aged 20-24 years. The total study coho...

journal_title：Scientific reports

authors： Robson D,Daniels S,Flatley C,Kumar S

更新日期：2018-12-24 00:00:00

abstract：:Fertilisation datasets collected from field experiments (n = 21) in tea-producing areas from 2016 to 2018 were used to build a quantitative evaluation of the fertility of tropical soils (QUEFTS) model to estimate nutrient uptake of tea plants, and to investigate relationships between tea yield and nutrient accumulatio...

journal_title：Scientific reports

authors： Tang S,Liu Y,Zheng N,Li Y,Ma Q,Xiao H,Zhou X,Xu X,Jiang T,He P,Wu L

更新日期：2020-02-04 00:00:00

abstract：:Intracellular pathogens belonging to the genus Leishmania have developed effective strategies that enable them to survive within host immune cells. Immunostimulatory compounds that counteract such immunological escape mechanisms represent promising treatment options for diseases. Here, we demonstrate that a lipopeptid...

journal_title：Scientific reports

authors： Choy SL,Bernin H,Aiba T,Bifeld E,Lender SC,Mühlenpfordt M,Noll J,Eick J,Marggraff C,Niss H,Roldán NG,Tanaka S,Kitamura M,Fukase K,Clos J,Tannich E,Fujimoto Y,Lotter H

更新日期：2017-08-25 00:00:00

abstract：:Carbon-based nanomaterials such as single-walled carbon nanotubes and reduced graphene oxide are currently being evaluated for biomedical applications including in vivo drug delivery and tumor imaging. Several reports have studied the toxicity of carbon nanomaterials, but their effects on human male reproduction have ...

journal_title：Scientific reports

authors： Asghar W,Shafiee H,Velasco V,Sah VR,Guo S,El Assal R,Inci F,Rajagopalan A,Jahangir M,Anchan RM,Mutter GL,Ozkan M,Ozkan CS,Demirci U

更新日期：2016-08-19 00:00:00

abstract：:Both genetic and environmental factors are suggested to influence overweight and obesity risks. Although individual loci and genes have been frequently shown to be associated with body mass index (BMI), the overall interaction of these genes and their role in BMI remains underexplored. Data were collected in 90 health...

journal_title：Scientific reports

authors： Joseph PV,Jaime-Lara RB,Wang Y,Xiang L,Henderson WA

更新日期：2019-05-15 00:00:00

abstract：:Albuminuria is widely used to indicate early phases of diabetic nephropathy although it is limited by the fact that structural damage might precede albumin excretion. This necessitates identifying better biomarkers that diagnose or predict diabetic nephropathy. This is a cross-sectional hospital based study recruiting...

journal_title：Scientific reports

authors： Al-Rubeaan K,Siddiqui K,Al-Ghonaim MA,Youssef AM,Al-Sharqawi AH,AlNaqeb D

更新日期：2017-06-02 00:00:00

abstract：:Clinical observations suggest neuronal control of bone remodeling. Sensory nerve fibers innervating bone, bone marrow and periosteum signal via neurotransmitters including substance P (SP). In previous studies we observed impaired biomechanical and structural bone parameters in tachykinin (Tac) 1-deficient mice lackin...

journal_title：Scientific reports

authors： Niedermair T,Schirner S,Seebröker R,Straub RH,Grässel S

更新日期：2018-06-15 00:00:00

abstract：:Functional brain connectivity is altered during the pathological processes of Alzheimer's disease (AD), but the specific evolutional rules are insufficiently understood. Resting-state functional magnetic resonance imaging indicates that the functional brain networks of individuals with AD tend to be disrupted in hub-l...

journal_title：Scientific reports

authors： Li W,Wang M,Zhu W,Qin Y,Huang Y,Chen X

更新日期：2016-09-28 00:00:00

abstract：:Nanoporous structures have proven as an effective way for enhanced electrochromic performance by providing a large surface area can get fast ion/electron transfer path, leading to larger optical modulation and fast response time. Herein, for the first time, application of vacuum cathodic arc plasma (CAP) deposition te...

journal_title：Scientific reports

authors： Chen PW,Chang CT,Ko TF,Hsu SC,Li KD,Wu JY

更新日期：2020-05-21 00:00:00

abstract：:Protein kinase C-δ (PKC-δ), a member of the lipid-regulated serine/threonine PKC family, has been implicated in a wide range of important cellular processes, such as cell growth, differentiation, and apoptosis. Lampreys belong to the most primitive class of vertebrates, and there is little information on PKC-δ in thes...

journal_title：Scientific reports

authors： Xu Y,Zhu S,Zhao H,Li Q

更新日期：2017-09-22 00:00:00

abstract：:Phase modulators are one of the key components of many applications in electromagnetic and opto-electric wave propagations. Phase-shifters play an integral role in communications, imaging and in coherent material excitations. In order to realize the terahertz (THz) electromagnetic spectrum as a fully-functional bandwi...

journal_title：Scientific reports

authors： Dutta M,Betal S,Peralta XG,Bhalla AS,Guo R

更新日期：2016-11-30 00:00:00

abstract：:Umami taste perception indicates the presence of amino acids, which are essential nutrients. Although the physiology of umami perception has been described in mammals, how insects detect amino acids remains unknown except in Drosophila melanogaster. We functionally characterized a gustatory receptor responding to L-am...

journal_title：Scientific reports

authors： Lim S,Jung J,Yunusbaev U,Ilyasov R,Kwon HW

更新日期：2019-08-12 00:00:00

abstract：:Early life overfeeding is associated with cognitive decline and anxiety-like behaviors in later life. It is not clear whether there are individual differences in the effects of early life overfeeding and what the underlying mechanistic pathways are. We investigated the long-lasting effects of small litter size, an exp...

journal_title：Scientific reports

authors： Salari AA,Samadi H,Homberg JR,Kosari-Nasab M

更新日期：2018-07-26 00:00:00

abstract：:Cancer chemotherapies have improved prognosis in cancer patients, resulting in a large and rapidly increasing number of cancer survivors. "Onco-cardiology" or "cardio-oncology" is a new discipline for addressing the unanticipated cardiac side effects of newly developed cancer drugs. Lapatinib, a tyrosine kinase inhibi...

journal_title：Scientific reports

authors： Ando K,Wada T,Cao X

更新日期：2020-01-20 00:00:00

abstract：:Enterovirus 71 (EV71) is a major pathogen of hand, foot, and mouth disease (HFMD). To date, no antiviral drug has been approved to treat EV71 infection. Due to the essential role that EV71 3 C protease (3Cpro) plays in the viral life cycle, it is generally considered as a highly appealing target for antiviral drug dev...

journal_title：Scientific reports

authors： Zhang Y,Ke X,Zheng C,Liu Y,Xie L,Zheng Z,Wang H

更新日期：2017-09-04 00:00:00

abstract：:The Mont-Blanc massif, being iconic with its large glaciers and peaks of over 4,000 m, will experience a sharp increase in summer temperatures during the twenty-first century. By 2100, the impact of climate change on the cryosphere and hydrosphere in the Alps is expected to lead to a decrease in annual river discharge...

journal_title：Scientific reports

authors： Laurent L,Buoncristiani JF,Pohl B,Zekollari H,Farinotti D,Huss M,Mugnier JL,Pergaud J

更新日期：2020-06-26 00:00:00