Sex-specific glioma genome-wide association study identifies new risk locus at 3p21.31 in females, and finds sex-differences in risk at 8q24.21.

Abstract:

:Incidence of glioma is approximately 50% higher in males. Previous analyses have examined exposures related to sex hormones in women as potential protective factors for these tumors, with inconsistent results. Previous glioma genome-wide association studies (GWAS) have not stratified by sex. Potential sex-specific genetic effects were assessed in autosomal SNPs and sex chromosome variants for all glioma, GBM and non-GBM patients using data from four previous glioma GWAS. Datasets were analyzed using sex-stratified logistic regression models and combined using meta-analysis. There were 4,831 male cases, 5,216 male controls, 3,206 female cases and 5,470 female controls. A significant association was detected at rs11979158 (7p11.2) in males only. Association at rs55705857 (8q24.21) was stronger in females than in males. A large region on 3p21.31 was identified with significant association in females only. The identified differences in effect of risk variants do not fully explain the observed incidence difference in glioma by sex.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Ostrom QT,Kinnersley B,Wrensch MR,Eckel-Passow JE,Armstrong G,Rice T,Chen Y,Wiencke JK,McCoy LS,Hansen HM,Amos CI,Bernstein JL,Claus EB,Il'yasova D,Johansen C,Lachance DH,Lai RK,Merrell RT,Olson SH,Sadetzki S,Schi

doi

10.1038/s41598-018-24580-z

subject

Has Abstract

pub_date

2018-05-09 00:00:00

pages

7352

issue

1

issn

2045-2322

pii

10.1038/s41598-018-24580-z

journal_volume

8

pub_type

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