Abstract:
:Incidence of glioma is approximately 50% higher in males. Previous analyses have examined exposures related to sex hormones in women as potential protective factors for these tumors, with inconsistent results. Previous glioma genome-wide association studies (GWAS) have not stratified by sex. Potential sex-specific genetic effects were assessed in autosomal SNPs and sex chromosome variants for all glioma, GBM and non-GBM patients using data from four previous glioma GWAS. Datasets were analyzed using sex-stratified logistic regression models and combined using meta-analysis. There were 4,831 male cases, 5,216 male controls, 3,206 female cases and 5,470 female controls. A significant association was detected at rs11979158 (7p11.2) in males only. Association at rs55705857 (8q24.21) was stronger in females than in males. A large region on 3p21.31 was identified with significant association in females only. The identified differences in effect of risk variants do not fully explain the observed incidence difference in glioma by sex.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Ostrom QT,Kinnersley B,Wrensch MR,Eckel-Passow JE,Armstrong G,Rice T,Chen Y,Wiencke JK,McCoy LS,Hansen HM,Amos CI,Bernstein JL,Claus EB,Il'yasova D,Johansen C,Lachance DH,Lai RK,Merrell RT,Olson SH,Sadetzki S,Schidoi
10.1038/s41598-018-24580-zsubject
Has Abstractpub_date
2018-05-09 00:00:00pages
7352issue
1issn
2045-2322pii
10.1038/s41598-018-24580-zjournal_volume
8pub_type
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