Abstract：
:Functional brain connectivity is altered during the pathological processes of Alzheimer's disease (AD), but the specific evolutional rules are insufficiently understood. Resting-state functional magnetic resonance imaging indicates that the functional brain networks of individuals with AD tend to be disrupted in hub-like nodes, shifting from a small world architecture to a random profile. Here, we proposed a novel evolution model based on computational experiments to simulate the transition of functional brain networks from normal to AD. Specifically, we simulated the rearrangement of edges in a pathological process by a high probability of disconnecting edges between hub-like nodes, and by generating edges between random pair of nodes. Subsequently, four topological properties and a nodal distribution were used to evaluate our model. Compared with random evolution as a null model, our model captured well the topological alteration of functional brain networks during the pathological process. Moreover, we implemented two kinds of network attack to imitate the damage incurred by the brain in AD. Topological changes were better explained by 'hub attacks' than by 'random attacks', indicating the fragility of hubs in individuals with AD. This model clarifies the disruption of functional brain networks in AD, providing a new perspective on topological alterations.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Li W,Wang M,Zhu W,Qin Y,Huang Y,Chen Xdoi
10.1038/srep34156subject
Has Abstractpub_date
2016-09-28 00:00:00pages
34156issn
2045-2322pii
srep34156journal_volume
6pub_type
杂志文章abstract：:The mechanism by which enzymes arose from both abiotic and biological worlds remains an unsolved natural mystery. We postulate that an enzyme can emerge from any sequence of any functional polymer under permissive evolutionary conditions. To support this premise, we have arbitrarily chosen a 50-nucleotide DNA fragment...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep11405
更新日期：2015-06-19 00:00:00
abstract：:Lung adenocarcinoma (LUAD) is characterized by high infiltration and rapid growth. The function of the stem cell population is to control and maintain cell regeneration. Therefore, it is necessary to study the prognostic value of stem cell-related genes in LUAD. Signature genes were screened out from 166 stem cell-rel...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-80453-4
更新日期：2021-01-18 00:00:00
abstract：:M2BP (also called 90K) is an interferon-stimulated gene product that is upregulated in HIV-1 infection. A recent study revealed that M2BP reduces the infectivity of HIV-1 by inhibiting the processing of the viral envelope protein. Here we report that in addition to reducing viral infectivity, M2BP inhibits HIV-1 virio...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep32736
更新日期：2016-09-08 00:00:00
abstract：:Hypothalamic growth hormone-releasing hormone (GHRH) neurons orchestrate body growth/maturation and have been implicated in feeding responses and ageing. However, the electrical patterns that dictate GHRH neuron functions have remained elusive. Since the inhibitory neuropeptide somatostatin (SST) is considered to be a...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep24394
更新日期：2016-04-13 00:00:00
abstract：:The G-protein bile acid receptor 1 (GPBAR1) has emerged in the last decade as prominent target for the treatment of metabolic and inflammatory diseases including type 2 diabetes, obesity, and non-alcoholic steatohepatitis. To date numerous bile acid derivatives have been identified as GPBAR1 agonists, however their cl...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-38840-z
更新日期：2019-02-21 00:00:00
abstract：:Present study aimed to estimate the incidence of recurrent SARS-CoV-2 RNA positivity after recovery from COVID-19 and to determine the factors associated with recurrent positivity. We searched the PubMed, MedRxiv, BioRxiv, the Cochrane Library, ClinicalTrials.gov, and the World Health Organization International Clinic...
journal_title：Scientific reports
pub_type： 杂志文章,meta分析
doi：10.1038/s41598-020-77739-y
更新日期：2020-11-26 00:00:00
abstract：:We present experimental demonstrations of two-photon interference involving temporally separated photons within two types of interferometers: a Mach-Zehnder interferometer and a polarization-based Michelson interferometer. The two-photon states are probabilistically prepared in a symmetrically superposed state within ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep34805
更新日期：2016-10-06 00:00:00
abstract：:The long-standing challenge for forming Al-based BMGs and their matrix composites with a critical size larger than 1 mm have not been answered over the past three decades. In this paper, we reported formation of a series of BMG matrix composites which contain a high Al content up to 55 at.%. These composites can be ca...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep03353
更新日期：2013-11-27 00:00:00
abstract：:Here we show that electrical tuning of the sensitivity of chemitransistor sensors, namely field-effect-transistors (FETs) exploiting nano/mesostructured sensing materials, can be used to effectively address two chief problems of state-of-the-art gas sensors, specifically fabrication reliability and degradation by agin...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep01161
更新日期：2013-01-01 00:00:00
abstract：:Soil physical properties and soil organic carbon (SOC) are considered as important factors of soil quality. Arable land, grassland, and forest land coexist in the saline-alkali reclamation area of the Yellow River Delta (YRD), China. Such different land uses strongly influence the services of ecosystem to induce soil ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-77303-8
更新日期：2020-11-23 00:00:00
abstract：:The enzyme browning reaction results in grey speckles on tobacco leaves, which impairs the value and industrial usability of tobacco leaves. To demonstrate the influences of different browning degrees (BDs) of tobacco leaves on the usability of different cultivars and positions and identified structure of brown (grey)...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-54360-2
更新日期：2019-11-28 00:00:00
abstract：:Implantable 3D engineered vascular tissue constructs can be formed by co-culturing endothelial and fibroblast cells on macroporous scaffolds. Here we show that these constructs can be used for studying the dynamics of neovascular formation in-vitro by a combination of live confocal imaging and an array of image proces...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep17840
更新日期：2015-12-09 00:00:00
abstract：:Glaucoma optic neuropathy (GON) is a condition where pathogenic intraocular pressure (IOP) results in axonal damage following retinal ganglion cell (RGC) death, and further results in secondary damage of the lateral geniculate nucleus (LGN). Therapeutic targets for glaucoma thus focus on both the LGN and RGC. However,...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep06501
更新日期：2014-10-13 00:00:00
abstract：:The newly discovered Candidatus 'Methanoperedens nitroreducens' (M. nitroreducens), mediating nitrate-dependent anaerobic oxidation of methane, is an important microorganism in linking carbon and nitrogen cycles. In order to explore the diversity of M. nitroreducens-like archaea in various environmental niches with ad...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-24974-z
更新日期：2018-05-16 00:00:00
abstract：:Ample evidence indicates that obesity causes dysfunctions in the lung. Previous studies also show that cholinergic anti-inflammatory pathways play crucial roles in obesity-induced chronic inflammation via α7 nicotinic acetylcholine receptor (α7nAChR) signaling. However, it remains unclear whether and how obesity affec...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-75414-w
更新日期：2020-10-27 00:00:00
abstract：:We show how adaptive protocols of quantum and private communication through bosonic Gaussian channels can be simplifed into much easier block versions that involve resource states with finite energy. This is achieved by combining an adaptive-to-block reduction technique devised earlier, based on teleportation stretchi...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-33332-y
更新日期：2018-10-15 00:00:00
abstract：:Theranostics is the emerging field of medicine that uniquely combines diagnostic techniques and active agents to diagnose and treat medical conditions simultaneously or sequentially. Finding a theranostic agent capable to cure the affected cells and being safe for the healthy ones is the key for successful treatment. ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-79238-6
更新日期：2020-12-17 00:00:00
abstract：:Tractography atlas-based analysis (TABS) is a new diffusion tensor image (DTI) statistical analysis method for detecting and understanding voxel-wise white matter properties along a fiber tract. An important requisite for accurate and sensitive TABS is the availability of a deformation field that is able to register D...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-12965-5
更新日期：2017-10-04 00:00:00
abstract：:Circulating microRNAs (c-miRNAs) in human plasma have been described as a potential marker of exercise. The present study investigated the effects of three acute resistance training (RT) protocols on the time-course changes of the c-miRNAs profiles in young males. The subjects (n = 45) were randomly divided into three...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-02294-y
更新日期：2017-05-19 00:00:00
abstract：:Isolation of low abundance proteins or rare cells from complex mixtures, such as blood, is required for many diagnostic, therapeutic and research applications. Current affinity-based protein or cell separation methods use binary 'bind-elute' separations and are inefficient when applied to the isolation of multiple low...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep23589
更新日期：2016-03-30 00:00:00
abstract：:COX-2 inhibition may be of benefit in the treatment of tuberculosis (TB) through a number of pathways including efflux pump inhibition (increasing intracellular TB drug levels) and diverse effects on inflammation and the immune response. We investigated celecoxib (a COX-2 inhibitor) alone and with standard anti-tuberc...
journal_title：Scientific reports
pub_type： 杂志文章,随机对照试验
doi：10.1038/s41598-018-31590-4
更新日期：2018-09-10 00:00:00
abstract：:Anterior-posterior body axis in all bilaterians is determined by the Hox gene clusters that are activated in a spatio-temporal order. This expression pattern of Hox genes is established and maintained by regulatory mechanisms that involve higher order chromatin structure and Polycomb group (PcG) and trithorax group (t...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep03011
更新日期：2013-10-22 00:00:00
abstract：:Trimethylamine-N-Oxide (TMAO) is a microbiome-related metabolite that is cleared by the kidney and linked to renal function. We explored the relationship between TMAO and all-cause mortality, and determined whether this association was modified by renal function. A prospective study was performed among PREVEND partici...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-13739-9
更新日期：2017-10-23 00:00:00
abstract：:Psoriasis is a chronic, relapsing inflammatory skin disease. The pathogenesis of psoriasis is complex and has not been fully understood. C10orf99 was a recently identified human antimicrobial peptide whose mRNA expression is elevated in psoriatic human skin samples. In this study, we investigated the functional roles ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-26996-z
更新日期：2018-06-05 00:00:00
abstract：:An important step in oxide photochemistry, the loading of electrons into shallow trap states, was studied using infrared (IR) spectroscopy on both, rutile TiO2 powders and single-crystal, r-TiO2(110) oriented samples. After UV-irradiation or n-doping by exposure to H-atoms broad IR absorption lines are observed for th...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep03808
更新日期：2014-01-22 00:00:00
abstract：:Increased evidence suggests that dysregulation of cholesterol metabolism may be a key event contributing to progression of multiple sclerosis (MS). Using an experimental autoimmune encephalomyelitis (EAE) model of MS we revealed specific changes in the mRNA and protein expression of key molecules involved in the maint...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-02638-8
更新日期：2017-06-02 00:00:00
abstract：:Non-infectious anterior uveitis (AU) is a potentially sight threatening inflammatory condition. The current gold standard for treatment is topical steroids, but low ocular bioavailability and compliance issues with the intensive dosing regimen limit the efficacy of this treatment. Liposomes as a drug delivery system m...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-24545-2
更新日期：2018-04-26 00:00:00
abstract：:A variety of animals use Earth's magnetic field as a reference for their orientation behaviour. Although distinctive magnetoreception mechanisms have been postulated for many migrating or homing animals, the molecular mechanisms are still undefined. In this study, we found that zebrafish, a model organism suitable for...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep00727
更新日期：2012-01-01 00:00:00
abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title：Scientific reports
pub_type： 已发布勘误
doi：10.1038/s41598-020-57959-y
更新日期：2020-02-05 00:00:00
abstract：:Mouse embryonic stem cells (ESCs) and epiblast stem cells (EpiSCs) represent naive and primed pluripotency states, respectively, and are maintained in vitro by specific signalling pathways. Furthermore, ESCs cultured in serum-free medium with two kinase inhibitors (2i-ESCs) are thought to be the ground naïve pluripote...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-23822-4
更新日期：2018-04-10 00:00:00
