Vasculogenic dynamics in 3D engineered tissue constructs.

abstract：:β1 integrin regulates the response of both normal and cancer cells to their local environment. Although mis-localised in prostate cancer, the role β1 integrin plays in prostate development and carcinogenesis remains unknown. To assess the role of β1 integrin in vivo, we conditionally deleted β1 integrin from prostate ...

journal_title：Scientific reports

authors： Moran-Jones K,Ledger A,Naylor MJ

更新日期：2012-01-01 00:00:00

abstract：:Next generation sequencing panels have been developed for hereditary cancer, although there is some debate about their cost-effectiveness compared to exome sequencing. The performance of two panels is compared to exome sequencing. Twenty-four patients were selected: ten with identified mutations (control set) and four...

journal_title：Scientific reports

authors： Feliubadaló L,Tonda R,Gausachs M,Trotta JR,Castellanos E,López-Doriga A,Teulé À,Tornero E,Del Valle J,Gel B,Gut M,Pineda M,González S,Menéndez M,Navarro M,Capellá G,Gut I,Serra E,Brunet J,Beltran S,Lázaro C

更新日期：2017-01-04 00:00:00

abstract：:We report an observation of rapid (exceeding 2,000 K/s) heating of polydimethylsiloxane (PDMS), one of the most popular microchannel materials, under cyclic loadings at high (~MHz) frequencies. A microheater was developed based on the finding. The heating mechanism utilized vibration damping in PDMS induced by sound w...

journal_title：Scientific reports

authors： Ha BH,Lee KS,Destgeer G,Park J,Choung JS,Jung JH,Shin JH,Sung HJ

更新日期：2015-07-03 00:00:00

abstract：:A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper. ...

journal_title：Scientific reports

authors： Rombaut D,Chiu HS,Decaesteker B,Everaert C,Yigit N,Peltier A,Janoueix-Lerosey I,Bartenhagen C,Fischer M,Roberts S,D'Haene N,De Preter K,Speleman F,Denecker G,Sumazin P,Vandesompele J,Lefever S,Mestdagh P

更新日期：2019-07-17 00:00:00

abstract：:The development of new anode materials having high electrochemical performances and interesting reaction mechanisms is highly required to satisfy the need for long-lasting mobile electronic devices and electric vehicles. Here, we report a layer crystalline structured SnP3 and its unique electrochemical behaviors with ...

journal_title：Scientific reports

authors： Park JW,Park CM

更新日期：2016-10-24 00:00:00

abstract：:Staphylococcus lugdunensis is a commensal bacterium in humans and other animals that can cause serious infections. The aim of this research was to estimate the frequency of S. lugdunensis in pet cats and to characterize the S. lugdunensis isolates obtained. The prevalence of S. lugdunensis was 0.77% (4/523) in healthy...

journal_title：Scientific reports

authors： Bierowiec K

更新日期：2020-09-22 00:00:00

abstract：:A correction to this article has been published and is linked from the HTML version of this paper. The error has been fixed in the paper. ...

journal_title：Scientific reports

authors： Yang CH,Chuang LY,Lin YD

更新日期：2017-11-23 00:00:00

abstract：:Loss of olfactomedin 4 (OLFM4) gene expression is associated with the progression of human prostate cancer, but its role and the molecular mechanisms involved in this process have not been completely understood. In this study, we found that Olfm4-knockout mice developed prostatic intraepithelial neoplasia and prostati...

journal_title：Scientific reports

authors： Li H,Liu W,Chen W,Zhu J,Deng CX,Rodgers GP

更新日期：2015-11-19 00:00:00

abstract：:Climate change-induced extinctions are estimated to eliminate one in six known species by the end of the century. One major factor that will contribute to these extinctions is extreme climatic events. Here, we show the ecological impacts of recent record warm air temperatures and simultaneous peak drought conditions i...

journal_title：Scientific reports

authors： Bucciarelli GM,Clark MA,Delaney KS,Riley SPD,Shaffer HB,Fisher RN,Honeycutt RL,Kats LB

更新日期：2020-02-25 00:00:00

abstract：:Whether an infectious disease threat to wildlife arises from pathogen introduction or the increased incidence of an already-present agent informs mitigation policy and actions. The prior absence of a pathogen can be difficult to establish, particularly in free-living wildlife. Subsequent to the epidemic emergence of t...

journal_title：Scientific reports

authors： Cunningham AA,Smith F,McKinley TJ,Perkins MW,Fitzpatrick LD,Wright ON,Lawson B

更新日期：2019-03-12 00:00:00

abstract：:A novel polyphenolic natural product, galewone, with undescribed carbon skeleton, was isolated as a racemate from the culture of Daldinia eschscholzii IFB-TL01, a fungus obtained from the mantis (Tenodera aridifolia) gut. The galewone structure was elucidated by a combination of MS and NMR spectra, and substantiated b...

journal_title：Scientific reports

authors： Zhang AH,Jiang N,Wang XQ,Tan RX

更新日期：2019-10-04 00:00:00

abstract：:Glycans are biologically important structures synthesised by glycosyltransferase (GT) enzymes. Disruptive genetic null variants in GT genes can lead to serious illness but benign phenotypes are also seen, including antigenic differences on the red blood cell (RBC) surface, giving rise to blood groups. To characterise ...

journal_title：Scientific reports

authors： Jöud M,Möller M,Olsson ML

更新日期：2018-04-16 00:00:00

abstract：:No study to date has prospectively evaluated the association between pre-diagnostic cruciferous vegetables intake and lung cancer survival among women. This analysis included 547 incident lung cancer cases identified from the Shanghai Women's Health Study (SWHS) during the follow-up period of 1997-2011. Dietary intake...

journal_title：Scientific reports

authors： Wu QJ,Yang G,Zheng W,Li HL,Gao J,Wang J,Gao YT,Shu XO,Xiang YB

更新日期：2015-05-19 00:00:00

abstract：:The synthesis of artificial cell is a route for searching the origin of protocell. Here, we create a novel cell model of graphene capsules with selective ion channels, indicating that graphene might be an embryo of protocell membrane. Firstly, we found that the highly oxidized graphene and phospholipid-graphene oxide ...

journal_title：Scientific reports

authors： Li Z,Wang C,Tian L,Bai J,Yao H,Zhao Y,Zhang X,Cao S,Qi W,Wang S,Shi K,Xu Y,Mingliang Z,Liu B,Qiu H,Liu J,Wu W,Wang X,Wenzhen A

更新日期：2015-05-19 00:00:00

abstract：:The queens of eusocial bees, ants and wasps mate only during a very short period early in life and males therefore produce ejaculates consisting of large numbers of high quality sperm. Such extreme selection for high fecundity resulted in males investing minimally into their somatic survival, including their immune sy...

journal_title：Scientific reports

authors： Peng Y,Baer-Imhoof B,Millar AH,Baer B

更新日期：2015-06-30 00:00:00

abstract：:One fundamental question in prey luring systems is to understand how visual signals are interpreted by the receiver. Predators lure prey by falsely imitating the signal of a model, or may exploit sensory preferences of the receivers, which search for rewarding signals. Crab spiders reflect ultraviolet (UV) light, ambu...

journal_title：Scientific reports

authors： Vieira C,Ramires EN,Vasconcellos-Neto J,Poppi RJ,Romero GQ

更新日期：2017-08-23 00:00:00

abstract：:Fundamental cell signaling mechanisms that regulate dynamic remodeling of the extracellular matrix (ECM) in mechanically loaded tissues are not yet clearly understood. Trabecular meshwork (TM) tissue in the eye is under constant mechanical stress and continuous remodeling of ECM is crucial to maintain normal aqueous h...

journal_title：Scientific reports

authors： Tellios N,Belrose JC,Tokarewicz AC,Hutnik C,Liu H,Leask A,Motolko M,Iijima M,Parapuram SK

更新日期：2017-04-11 00:00:00

abstract：:We report evidence of the transition from n- to p-type conduction of InN with increasing Mg dopant concentration by using photoconductivity (PC) measurement at room temperature. This transition is depicted as a conversion from negative to positive PC under above-bandgap optical excitation. The n- to p-type transition ...

journal_title：Scientific reports

authors： Guo L,Wang XQ,Zheng XT,Yang XL,Xu FJ,Tang N,Lu LW,Ge WK,Shen B,Dmowski LH,Suski T

更新日期：2014-03-13 00:00:00

abstract：:The centromeric nucleosome is a key epigenetic determinant of centromere identity and function. Consequently, deciphering how CENP-A containing nucleosomes contribute structurally to centromere function is a fundamental question in chromosome biology. Here, we performed microsecond timescale all-atom molecular dynamic...

journal_title：Scientific reports

authors： Winogradoff D,Zhao H,Dalal Y,Papoian GA

更新日期：2015-11-25 00:00:00

abstract：:Recent research shows that continuous overgrazing not only causes grassland biodiversity to decline, but also causes light fungal disease. Achnatherum inebrians is susceptible to fungal diseases and increases in prevalence during over grazing due its toxicity to livestock. This study aimed to examine the effects of A....

journal_title：Scientific reports

authors： Yao X,Fan Y,Chai Q,Johnson RD,Nan Z,Li C

更新日期：2016-09-16 00:00:00

abstract：:In preclinical stages of drug development, anticipating potential adverse drug effects such as toxicity is an important issue for both saving resources and preventing public health risks. Current in vitro cytotoxicity tests are restricted by their predictive potential and their ability to provide mechanistic informati...

journal_title：Scientific reports

authors： García-Cañaveras JC,Castell JV,Donato MT,Lahoz A

更新日期：2016-06-06 00:00:00

abstract：:Pharmacological activities of some natural products diminish and even disappear after purification. In this study, we explored the mechanisms underlying the decrease of acute oral toxicity of Coptidis Rhizoma extract after purification. The water solubility, in vitro absorption, and plasma exposure of berberine (the m...

journal_title：Scientific reports

authors： Ma BL,Yin C,Zhang BK,Dai Y,Jia YQ,Yang Y,Li Q,Shi R,Wang TM,Wu JS,Li YY,Lin G,Ma YM

更新日期：2016-01-29 00:00:00

abstract：:Common estimates of external training intensity for resistance exercise do not incorporate inter-set recovery duration, and might not reflect the overall demands of training. This study aimed to assess novel metrics of exercise density (ED) during resistance exercise, and how these related to a physiological marker of...

journal_title：Scientific reports

authors： Marston KJ,Peiffer JJ,Newton MJ,Scott BR

更新日期：2017-07-17 00:00:00

abstract：:Despite growing acknowledgement of the role of oxidized fatty acids (oxFA) as cellular signaling molecules and in the pathogenesis of disease, developing methods to measure these species in biological samples has proven challenging. Here we describe a novel method utilizing HPLC-ESI-MS/MS to identify and quantify mult...

journal_title：Scientific reports

authors： Ahern KW,Serbulea V,Wingrove CL,Palas ZT,Leitinger N,Harris TE

更新日期：2019-08-01 00:00:00

abstract：:Mammalian sperm are unable to fertilize the egg immediately after ejaculation. To gain fertilization competence, they need to undergo a series of modifications inside the female reproductive tract, known as capacitation. Capacitation involves several molecular events such as phosphorylation cascades, hyperpolarization...

journal_title：Scientific reports

authors： Ritagliati C,Luque GM,Stival C,Baro Graf C,Buffone MG,Krapf D

更新日期：2018-09-06 00:00:00

abstract：:To assess the effectiveness of losartan 50 mg on post dialysis euvolemic hypertensive patients against standard antihypertensive pharmacotherapy. A multicentre, prospective, randomized, single-blind trial was conducted to assess the effect of losartan 50 mg every other day (EOD), once a morning (OM) among post-dialysi...

journal_title：Scientific reports

authors： Aftab RA,Khan AH,Adnan AS,Sulaiman SAS,Khan TM

更新日期：2016-12-06 00:00:00

abstract：:Glucagon is a pancreatic hormone and increases the blood glucose levels. It may be incorporated in a dual hormone artificial pancreas, a device to automatically and continuously control blood glucose levels of individuals with diabetes. Artificial pancreas systems have been developed for use in the subcutaneous tissue...

journal_title：Scientific reports

authors： Åm MK,Dirnena-Fusini I,Fougner AL,Carlsen SM,Christiansen SC

更新日期：2020-08-13 00:00:00

abstract：:In biological tissues, radiation causes the formation of reactive oxygen species (ROS), some of which lead to sequential oxidation of certain protein cysteine residues. Resultant cysteinyl radicals are subject to post-translational modification through S-glutathionylation. The present clinical trial was designed to de...

journal_title：Scientific reports

authors： Zhang L,Zhang J,Ye Z,Manevich Y,Townsend DM,Marshall DT,Tew KD

更新日期：2019-09-24 00:00:00

abstract：:Erythropoietin (EPO) has been identified as being crucial for obesity modulation; however, its erythropoietic activity may limit its clinical application. EPO-derived Helix B-surface peptide (pHBSP) is nonerythrogenic but has been reported to retain other functions of EPO. The current study aimed to evaluate the effec...

journal_title：Scientific reports

authors： Liu Y,Luo B,Shi R,Wang J,Liu Z,Liu W,Wang S,Zhang Z

更新日期：2015-10-13 00:00:00

abstract：:A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has not been fixed in the paper. ...

journal_title：Scientific reports

authors： Safra L,Ioannou C,Amsellem F,Delorme R,Chevallier C

更新日期：2018-12-21 00:00:00