Abstract：
:To assess the effectiveness of losartan 50 mg on post dialysis euvolemic hypertensive patients against standard antihypertensive pharmacotherapy. A multicentre, prospective, randomized, single-blind trial was conducted to assess the effect of losartan 50 mg every other day (EOD), once a morning (OM) among post-dialysis euvolemic hypertensive patients. Covariate-adaptive randomization was used to allocate participants to a standard or treatment arm, and they were followed up for eight weeks. Pre-, intra- and post-dialysis session blood pressure (BP) measurements were recorded along with any adverse events. A total of 88 patients were randomized into standard (n = 44) and treatment arms (n = 44) and were followed for a period of 8 weeks. In the standard group, the mean post-dialysis blood pressure dropped by 0.3 mmHg by the end of the 8th week. However the treatment arm reported a drop of 2.4 mmHg of BP drop during the 8-week trial period. Analysis suggests that there was a significant difference in blood pressure readings at the end of 8 weeks among patients treated with losartan (P < 0.001). However, no such statistical association was observed in the standard arm (P 0.75). A slow, steady significant decline in post-dialysis BP was observed among euvolemic hypertensive patients that were treated with losartan 50 mg.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Aftab RA,Khan AH,Adnan AS,Sulaiman SAS,Khan TMdoi
10.1038/srep36592subject
Has Abstractpub_date
2016-12-06 00:00:00pages
36592issn
2045-2322pii
srep36592journal_volume
6pub_type
杂志文章,多中心研究,随机对照试验abstract：:Gene targeting in embryonic stem cells (ESCs) has become the principal technology for generating knockout models. Although numerous studies have predicted that the disruption of p53 leads to increased developmental anomalies and malignancies, most p53 knockout mice develop normally. Therefore, the role of p53 in anima...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep00945
更新日期：2012-01-01 00:00:00
abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title：Scientific reports
pub_type： 已发布勘误
doi：10.1038/s41598-020-62013-y
更新日期：2020-03-17 00:00:00
abstract：:We sought to investigate the prevalence, functional characteristics, and clinical significance of right ventricular (RV) involvement in patients with hypertrophic cardiomyopathy (HCM). A total of 256 patients with HCM who underwent both cardiac magnetic resonance (CMR) imaging and transthoracic echocardiography within...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-78945-4
更新日期：2020-12-14 00:00:00
abstract：:The present work is aimed at studying the dynamic behaviour of the tryptopnanase (tna) operon, which encodes the proteins necessary to uptake and metabolise tryptophan to use it as a carbon source in the absence of glucose. To this end, we designed a micro-bioreactor capable of driving a bacterial culture to a station...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-41856-0
更新日期：2019-04-01 00:00:00
abstract：:Challenges in social communication and interaction are core features of autism spectrum disorder (ASD) for which social skills group training (SSGT) is a commonly used intervention. SSGT has shown modest and heterogeneous effects. One of the major genetic risk factors in ASD is rare copy number variation (CNV). Howeve...
journal_title：Scientific reports
pub_type： 杂志文章,多中心研究
doi：10.1038/s41598-019-46396-1
更新日期：2019-07-08 00:00:00
abstract：:Silicon, the workhorse of semiconductor industry, is being exploited for various functional applications in numerous fields of nanotechnology. In this paper, we report the fabrication of depth controllable amorphous silicon (a-Si) layers under 80 keV Ar+ ion sputtering at off-normal ion incidences of 30°, 40° and 50° ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-68873-8
更新日期：2020-07-17 00:00:00
abstract：:Energy storage devices that provide high specific power without compromising on specific energy are highly desirable for many electric-powered applications. Here, we demonstrate that polymer organic radical gel materials support fast bulk-redox charge storage, commensurate to surface double layer ion exchange at carbo...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep22194
更新日期：2016-02-26 00:00:00
abstract：:Increasing the thermostability of proteins is often crucial for their successful use as analytic, synthetic or therapeutic tools. Most rational thermostabilization strategies were developed on small two-state proteins and, unsurprisingly, they tend to fail when applied to the much more abundant, larger, non-fully coop...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep09129
更新日期：2015-03-16 00:00:00
abstract：:Various nanostructures found in biological organisms are often complex and they exhibit unique optical functions. This study surprisingly found that typical random lasing occurs in cancerous human tissues embedded with the nanotextured organic dye 4-(dicyanomethylene)-2-tert-butyl-6-(1,1,7,7- tetramethyljulolidyl-9-en...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-08625-3
更新日期：2017-08-21 00:00:00
abstract：:Physiological regulation of blood flow in bone marrow is important to maintain oxygen and glucose supplies but also the physiological hypoxic state of the hematopoietic stem cell (HSC) niche. However, regulatory mechanisms underlying microcirculation in the bone marrow (BM) niche remain unclear. Here, we identify vess...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-63533-3
更新日期：2020-04-14 00:00:00
abstract：:Cell motility requires the precise coordination of cell polarization, lamellipodia formation, adhesion, and force generation. LKB1 is a multi-functional serine/threonine kinase that associates with actin at the cellular leading edge of motile cells and suppresses FAK. We sought to understand how LKB1 coordinates these...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep40929
更新日期：2017-01-19 00:00:00
abstract：:The identification of the earliest dogs is challenging because of the absence and/or mosaic pattern of morphological diagnostic features in the initial phases of the domestication process. Furthermore, the natural occurrence of some of these characters in Late Pleistocene wolf populations and the time it took from the...
journal_title：Scientific reports
pub_type： 历史文章,杂志文章
doi：10.1038/s41598-020-69940-w
更新日期：2020-08-07 00:00:00
abstract：:Optimized mesoporous photocatalyst endowed with high specific surface area and large pore size was synthesized by sol-gel method. These large pore mesoporous materials (33.39 nm) were conducive to the movement of larger molecules or groups in pore path and for effective use of active sites. The high specific surface a...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep29902
更新日期：2016-07-19 00:00:00
abstract：:Human pluripotent stem cells (hPSCs) offer tremendous promise in tissue engineering and cell-based therapies due to their unique combination of two properties: pluripotency and unlimited proliferative capacity. However, directed differentiation of hPSCs to clinically relevant cell lineages is needed to achieve the goa...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-01684-6
更新日期：2017-05-08 00:00:00
abstract：:Large consortia efforts and genome-wide association studies (GWASs) have linked a number of genetic variants within the 6p21 chromosomal region to non-Hodgkin lymphoma (NHL). Complementing these efforts, we genotyped previously reported SNPs in the human leukocyte antigen (HLA) class I (rs6457327) and class II (rs9271...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep41400
更新日期：2017-01-31 00:00:00
abstract：:The importance of metallurgy for social and economic development is indisputable. Although copper (Cu) was essential for the wealth of pre- and post-colonial societies in the Andes, the onset of extensive Cu metallurgy in South America is still debated. Comprehensive archaeological findings point to first sophisticate...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep41855
更新日期：2017-01-31 00:00:00
abstract：:Myostatin (Mstn) is a conserved negative regulator of skeletal muscle mass in mammals. However, whether precise disruption of Mstn in livestock can be achieved and safely used to improve meat productivity has not been proven. We applied CRISPR/Cas9 system to generate Mstn knock-out (KO) rabbits and goats and then anal...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep29855
更新日期：2016-07-15 00:00:00
abstract：:In the present work, we demonstrated the biosynthesis of silver nanoparticles (AgNPs) by highly stable, economic and eco-friendly method using leaf extract of Terminalia arjuna (T. arjuna) and employing as a catalyst for the degradation of methyl orange (MO), methylene blue (MB), congo red (CR) and 4- nitrophenol (4-N...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-66851-8
更新日期：2020-06-15 00:00:00
abstract：:We investigated retinal structure and function in eyes with optic nerve hypoplasia (ONH). Twenty-nine eyes of 18 patients with ONH and 21 eyes of 21 control patients were analyzed. Spectral-domain optical coherence tomography (SD-OCT), full-field electroretinography (FF-ERG), and focal macular ERG (FM-ERG) were perfor...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep42480
更新日期：2017-02-16 00:00:00
abstract：:Aluminium nitride (AlN) is a promising semiconductor material for use as a substrate in high-power, high-frequency electronic and deep-ultraviolet optoelectronic devices. We study the feasibility of a novel AlN fabrication technique by using the Al/GaN substitution reaction method. The substitution method we propose h...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-69992-y
更新日期：2020-08-03 00:00:00
abstract：:Epilepsy is a widespread neurological disease characterized by abnormal neuronal activity resulting in recurrent seizures. There is mounting evidence that a circadian system disruption, involving clock genes and their downstream transcriptional regulators, is associated with epilepsy. In this study, we characterized t...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-60638-7
更新日期：2020-02-28 00:00:00
abstract：:The present study shows chronic adjustments in the myotendinous junction (MTJ) in response to different ladder-based resistance training (LRT) protocols. Thirty adult male Wistar rats were divided into groups: sedentary (S), calisthenics (LRT without additional load [C]), and resistance-trained (LRT with extra weight ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-70971-6
更新日期：2020-08-24 00:00:00
abstract：:Knowledge of the ecology of N2-fixing (diazotrophic) plankton is mainly limited to oligotrophic (sub)tropical oceans. However, diazotrophs are widely distributed and active throughout the global ocean. Likewise, relatively little is known about the temporal dynamics of diazotrophs in productive areas. Between February...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-39586-4
更新日期：2019-03-06 00:00:00
abstract：:Bacterial outer membrane lipopolysaccharide (LPS) potently stimulates the mammalian innate immune system, and can lead to sepsis, the primary cause of death from infections. LPS is sensed by Toll-like receptor 4 (TLR4) in complex with its lipid-binding coreceptor MD-2, but subtle structural variations in LPS can profo...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep17997
更新日期：2015-12-09 00:00:00
abstract：:Upconversion nanoparticles (UCNPs) are utilized extensively for biomedical imaging, sensing, and therapeutic applications, yet the molecular weight of UCNPs has not previously been reported. Herein, we present a theory based upon the crystal structure of UCNPs to estimate the molecular weight of UCNPs: enabling insigh...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-19415-w
更新日期：2018-01-18 00:00:00
abstract：:Cytological and molecular studies have revealed that inversion chromosomal polymorphism is widespread across taxa and that inversions are among the most common structural changes fixed between species. Two major mechanisms have been proposed for the origin of inversions considering that breaks occur at either repetiti...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-53582-8
更新日期：2019-11-18 00:00:00
abstract：:The microRNA (miR)-183/96/182 cluster plays important roles in the development and functions of sensory organs, including the inner ear. Point-mutations in the seed sequence of miR-96 result in non-syndromic hearing loss in both mice and humans. However, the lack of a functionally null mutant has hampered the evaluati...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-36894-z
更新日期：2018-12-21 00:00:00
abstract：:The malaria vaccine BK-SE36 is a recombinant protein (SE36) based on the Honduras 1 serine repeat antigen-5 of Plasmodium falciparum, adsorbed to aluminium hydroxide gel. The phase Ib trial in Uganda demonstrated the safety and immunogenicity of BK-SE36. Ancillary analysis in the follow-up study of 6-20 year-old volun...
journal_title：Scientific reports
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1038/srep34363
更新日期：2016-10-05 00:00:00
abstract：:Which factors are related to false negative results of the interferon-γ release assay (IGRA) is unclear. This systematic review described the risk factors associated with false negative IGRA results. Two authors independently identified studies designed to evaluate risk factors for false negative IGRA results from Pub...
journal_title：Scientific reports
pub_type： 杂志文章,meta分析
doi：10.1038/s41598-020-58459-9
更新日期：2020-01-31 00:00:00
abstract：:Loss of miR-200c is correlated to advanced cancer-subtypes due to increased EMT and decreased treatment efficacy by chemotherapeutics. As miRNAs regulate a multitude of targets, the analysis of differentially expressed proteins upon a genomic knock-out (KO) is of interest. In this study, we generated a TALENs KO of mi...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-25240-y
更新日期：2018-05-02 00:00:00
