Myotendinous junction adaptations to ladder-based resistance training: identification of a new telocyte niche.

Abstract:

:The present study shows chronic adjustments in the myotendinous junction (MTJ) in response to different ladder-based resistance training (LRT) protocols. Thirty adult male Wistar rats were divided into groups: sedentary (S), calisthenics (LRT without additional load [C]), and resistance-trained (LRT with extra weight [R]). We demonstrated longer lengths of sarcoplasmatic invaginations in the trained groups; however, evaginations were seen mainly in group R. We showed a greater thickness of sarcoplasmatic invaginations in groups C and R, in addition to greater evaginations in R. We also observed thinner basal lamina in trained groups. The support collagen layer (SCL) adjacent to the MTJ and the diameters of the transverse fibrils were larger in R. We also discovered a niche of telocytes in the MTJ with electron micrographs of the plantar muscle and with immunostaining with CD34+ in the gastrocnemius muscle near the blood vessels and pericytes. We concluded that the continuous adjustments in the MTJ ultrastructure were the result of tissue plasticity induced by LRT, which is causally related to muscle hypertrophy and, consequently, to the remodeling of the contact interface. Also, we reveal the existence of a collagen layer adjacent to MTJ and discover a new micro anatomic location of telocytes.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Pimentel Neto J,Rocha LC,Barbosa GK,Jacob CDS,Krause Neto W,Watanabe IS,Ciena AP

doi

10.1038/s41598-020-70971-6

subject

Has Abstract

pub_date

2020-08-24 00:00:00

pages

14124

issue

1

issn

2045-2322

pii

10.1038/s41598-020-70971-6

journal_volume

10

pub_type

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