Abstract:
:β1 integrin regulates the response of both normal and cancer cells to their local environment. Although mis-localised in prostate cancer, the role β1 integrin plays in prostate development and carcinogenesis remains unknown. To assess the role of β1 integrin in vivo, we conditionally deleted β1 integrin from prostate epithelium and subsequently crossed these mice to the TRAMP prostate carcinogenesis model. Deletion of β1 integrin following castration and subsequent androgen supplementation resulted in an expansion of the p63-positive basal cell population and decreased differentiation. Consistent with these findings, deletion of β1 integrin in TRAMP mice decreased animal survival, decreased retention of normal prostate morphology, increased the percentage of tissue with poorly differentiated carcinoma, and increased cell proliferation. This study demonstrates that β1 integrin regulates several aspects of normal prostate development and in contrast to its role in several other tissues, its loss is associated with increased rates of prostate tumour progression.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Moran-Jones K,Ledger A,Naylor MJdoi
10.1038/srep00526subject
Has Abstractpub_date
2012-01-01 00:00:00pages
526issn
2045-2322journal_volume
2pub_type
杂志文章abstract::The expanding distribution of African swine fever (ASF) is threatening the pig industry worldwide. Most outbreaks occur in backyard and small-scale herds, where poor farmers often attempt to limit the disease's economic consequences by the emergency sale of their pigs. The risk of African swine fever virus (ASFV) rele...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep17074
更新日期:2015-11-27 00:00:00
abstract::We propose an approach for characterizing structural heterogeneity of lung cancer nodules using Computed Tomography Texture Analysis (CTTA). Measures of heterogeneity were used to test the hypothesis that heterogeneity can be used as predictor of nodule malignancy and patient survival. To do this, we use the National ...
journal_title:Scientific reports
pub_type: 杂志文章,随机对照试验
doi:10.1038/s41598-019-38831-0
更新日期:2019-03-14 00:00:00
abstract::The association of fasting glucose with the risk of death according to sex and age remains unclear, and insufficient information is available on sex- and age-specific glucose concentrations within ethnic groups. This study analyzed a sample of 12,455,361 Korean adults who participated in health examinations during 200...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-08498-6
更新日期:2017-08-15 00:00:00
abstract::Networks science plays an enormous role in many aspects of modern society from distributing electrical power across nations to spreading information and social networking amongst global populations. While modern networks constantly change in size, few studies have sought methods for the difficult task of optimising th...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep25627
更新日期:2016-05-11 00:00:00
abstract::Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive, and fatal lung disease. This disease is characterized by an excessive accumulation of extracellular matrix deposition that modify normal lung physiology. Up to date, there are not efficient therapeutic tools to fight IPF. Glucagon-like peptide-1 receptor (...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-74912-1
更新日期:2020-10-22 00:00:00
abstract::Image enhancement techniques are able to improve the contrast and visual quality of magnetic resonance (MR) images. However, conventional methods cannot make up some deficiencies encountered by respective brain tumor MR imaging modes. In this paper, we propose an adaptive intuitionistic fuzzy sets-based scheme, called...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep35760
更新日期:2016-10-27 00:00:00
abstract::Parental age is increasing rapidly in many countries. Analysis of this potentially important influence on offspring well-being is hampered by strong secular trends and socioeconomic patterning and by a shortage of follow-up data for adult offspring. We used Swedish national data on up to 3,653,938 offspring to conside...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep45278
更新日期:2017-03-27 00:00:00
abstract::All-trans-retinoic acid (atRA), the active metabolite of vitamin A, is a critical signaling molecule during embryonic and fetal development and is necessary for maternal health. Fetal exposure to endogenous atRA is tightly regulated during gestation in a tissue specific manner and maternal exposure to exogenous retino...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-40995-8
更新日期:2019-03-15 00:00:00
abstract::Prognostic biomarkers for the pancreatic neuroendocrine tumors are needed. Proteomic study on insulinoma has been rarely reported. We identified the differential expression of proteins between insulinoma and their paired tissues by proteomic analysis, and evaluated the prognostic significance of specific proteins in p...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-02051-1
更新日期:2017-05-19 00:00:00
abstract::Asthma phenotypes based on age-of-onset may be differently influenced by the interaction between variation in toll-like receptor (TLR)/CD14 genes and environmental microbes. We examined the associations between single-nucleotide polymorphisms (SNP) in the TLR/CD14 genes and asthma, and their interaction with proxies o...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep43681
更新日期:2017-03-06 00:00:00
abstract::Current saliva testing methods rely on cutting edge yet expensive techniques for the detection and analysis of genetic material, proteins and biomarkers for clinical use. However, these techniques are limited in scope and often cannot be used with complex food materials. We propose an efficient ex-vivo tool for evalua...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-31625-w
更新日期:2018-09-06 00:00:00
abstract::We demonstrate an ultrahigh-sensitivity gas pressure sensor based on the Fabry-Perot interferometer employing a fiber-tip diaphragm-sealed cavity. The cavity is comprised of a silica capillary and ultrathin silica diaphragm with a thickness of 170 nm, with represents the thinnest silica diaphragm fabricated thus far b...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-00931-0
更新日期:2017-04-11 00:00:00
abstract::Malaria in India, while decreasing, remains a serious public health problem, and the contribution of submicroscopic and asymptomatic infections to its persistence is poorly understood. We conducted community surveys and clinic studies at three sites in India differing in their eco-epidemiologies: Chennai (Tamil Nadu),...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-53386-w
更新日期:2019-11-19 00:00:00
abstract::Hydrocarbons fuel our economy. Furthermore, intermediate goods and consumer products are often hydrocarbon-based. Beside all the progress they made possible, hydrogen-containing substances can have severe detrimental effects on materials exposed to them. Hydrogen-assisted failure of iron alloys has been recognised mor...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-60370-2
更新日期:2020-02-27 00:00:00
abstract::We report command electro-optical switching on photolithographically-patterned graphene into a high-density electrode pattern for a high-transmission in-plane-switching (IPS) liquid crystal device. A highly-effective liquid crystal photoalignment method is used to maximize the field-driven optical contrast of a protot...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-11903-9
更新日期:2017-09-18 00:00:00
abstract::Development of new antimicrobial agents is required against the causative agent for listeriosis, Listeria monocytogenes, as the number of drug resistant strains continues to increase. A promising target is the β-ketoacyl-acyl carrier protein synthase FabF, which participates in the catalysis of fatty acid synthesis an...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep39277
更新日期:2017-01-03 00:00:00
abstract::Understanding the human cytotoxic T lymphocyte (CTL) biology is crucial to develop novel strategies aiming at maximizing their lytic capacity against cancer cells. Here we introduce an agent-based model, calibrated on population-scale experimental data that allows quantifying human CTL per capita killing. Our model hi...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-48711-2
更新日期:2019-08-23 00:00:00
abstract::Electron-hole exchange interaction in semiconductor quantum dots (QDs) splits the band-edge exciton manifold into optically active ("bright") and passive ("dark") states, leading to a complicated exciton fine structure. In the present work, we resolve by atomistic million-atom many-body pseudopotential calculations th...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-09812-y
更新日期:2017-08-24 00:00:00
abstract::Multifocal multiphoton microscopy (MMM) achieves fast imaging by simultaneously scanning multiple foci across different regions of specimen. The use of imaging detectors in MMM, such as CCD or CMOS, results in degradation of image signal-to-noise-ratio (SNR) due to the scattering of emitted photons. SNR can be partly ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep05153
更新日期:2014-06-05 00:00:00
abstract::We describe the realization and characterization of a compact, autonomous fiber laser system that produces the optical frequencies required for laser cooling, trapping, manipulation, and detection of 87Rb atoms - a typical atomic species for emerging quantum technologies. This device, a customized laser system from th...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-59971-8
更新日期:2020-02-24 00:00:00
abstract::Microbial life below the seafloor has changed over geological time, but these changes are often not obvious, as they are not recorded in the sediment. Sulphur (S) isotope values in pyrite extracted from a Plio- to Holocene sequence of the Peru Margin (Ocean Drilling Program, ODP, Site 1229) show a down-core pattern th...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-36943-7
更新日期:2019-01-24 00:00:00
abstract::Nanospheres of lead (Pb) have recently been identified in zircon (ZrSiO4) with the potential to compromise the veracity of U-Pb age determinations. The key assumption that the determined age is robust against the effects of Pb mobility, as long as Pb is not lost from the zircon during subsequent geological events, is ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-49882-8
更新日期:2019-09-23 00:00:00
abstract::Duchenne muscular dystrophy (DMD) is a common and severe X-linked myopathy, characterized by muscle degeneration due to altered or absent dystrophin. DMD has no effective cure, and the underlying molecular mechanisms remain incompletely understood. The aim of this study is to investigate the metabolic changes in DMD u...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-021-81090-1
更新日期:2021-01-21 00:00:00
abstract::We here describe the dc magnetic field over the human head produced by healthy hair follicles when the scalp is lightly pressed. This phenomenon was briefly reported decades earlier, where a double-planar SQUID (Superconducting Quantum Interference Devices) gradiometer at a single location was used. We here perform a ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-52110-y
更新日期:2019-10-30 00:00:00
abstract::Root-knot nematodes (RKNs) are obligate biotrophic parasites that invade plant roots and engage in prolonged and intimate relationships with their hosts. Nematode secretions, some of which have immunosuppressing activity, play essential roles in successful parasitism; however, their mechanisms of action remain largely...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep19443
更新日期:2016-01-22 00:00:00
abstract::The salmon louse is an ectoparasitic copepod of salmonids in the marine environment, and represents a global challenge to salmon aquaculture. A major issue is the reliance of the industry on a limited number of chemicals to delouse salmonids on farms, and the high levels of resistance that lice have developed to all o...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-12384-6
更新日期:2017-09-27 00:00:00
abstract::Tyrosine kinase activity of the asymmetric EGFR homodimer is negatively regulated via ERK-mediated phosphorylation of Thr-669 in the juxtamembrane domain. In the present study, we investigated in human breast cancer cells whether a similar mechanism plays a role in the feedback regulation of the ErbB2/ErbB3 heterodime...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep31502
更新日期:2016-08-17 00:00:00
abstract::Alveolar β2-receptor blockade worsens lung diffusion in heart failure (HF). This effect could be mitigated by stimulating alveolar β2-receptors. We investigated the safety and the effects of indacaterol on lung diffusion, lung mechanics, sleep respiratory behavior, cardiac rhythm, welfare, and exercise performance in ...
journal_title:Scientific reports
pub_type: 杂志文章,随机对照试验
doi:10.1038/s41598-020-62644-1
更新日期:2020-04-28 00:00:00
abstract::Preterm infants are susceptible to inflammation-induced white matter injury but the exposures that lead to this are uncertain. Histologic chorioamnionitis (HCA) reflects intrauterine inflammation, can trigger a fetal inflammatory response, and is closely associated with premature birth. In a cohort of 90 preterm infan...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep37932
更新日期:2016-12-01 00:00:00
abstract::Highly porous tri-metallic AgxAuyPdz networks with a sub-monolayer bimetallic Au-Pd nanoparticle coating were synthesized via a designed galvanic replacement reaction of Ag nanosponges suspended in mixed solutions of HAuCl4 and K2PdCl4. The resulting networks' ligaments have a rough surface with bimetallic nanoparticl...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep37092
更新日期:2016-11-15 00:00:00