Abstract:
:Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive, and fatal lung disease. This disease is characterized by an excessive accumulation of extracellular matrix deposition that modify normal lung physiology. Up to date, there are not efficient therapeutic tools to fight IPF. Glucagon-like peptide-1 receptor (GLP-1R) activation plays an essential role in lung functions in normal and in pathological conditions. The aim of the present study was to study the possible beneficial effects of the administration of the GLP-1R agonist, liraglutide, in the pathogenesis of the fibrotic process in an animal model of pulmonary fibrosis induced by bleomycin. We observed that liraglutide decreased mRNA expression of collagen, hydroxyproline and key enzymes for the synthesis of collagen. In addition, GLP-1R activation restored the ACE2 mRNA levels modulating the activities of the RAS components, increased the production of surfactant proteins (SFTPa1, SFTPb, SFTPc) and promoted an improvement in pulmonary and cardiac functionality, including a partial restoration of lung alveolar structure. Liraglutide effects are shown at both the pro-inflammatory and fibrosis phases of the experimental disease. For these reasons, GLP-1 might be regarded as a promising drug for treating pulmonary fibrosis.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Fandiño J,Toba L,González-Matías LC,Diz-Chaves Y,Mallo Fdoi
10.1038/s41598-020-74912-1subject
Has Abstractpub_date
2020-10-22 00:00:00pages
18091issue
1issn
2045-2322pii
10.1038/s41598-020-74912-1journal_volume
10pub_type
杂志文章abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title:Scientific reports
pub_type: 已发布勘误
doi:10.1038/s41598-020-59766-x
更新日期:2020-02-11 00:00:00
abstract::Glioblastoma multiforme (GBM), an extremely invasive and high-grade (grade IV) glioma, is the most common and aggressive form of brain cancer. It has a poor prognosis, with a median overall survival of only 11 months in the general GBM population and 14.6 to 21 months in clinical trial participants with standard GBM t...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-33641-2
更新日期:2018-10-18 00:00:00
abstract::We compared the prognostic value of nutritional or volumetric parameters measured by body composition in hospitalized patients on maintenance hemodialysis. We conducted a cohort study to assess the association of different parameters of body composition with all-cause mortality in inpatients admitted to our nephrology...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-67019-0
更新日期:2020-06-23 00:00:00
abstract::Early cow-calf separation prevents much of cows' natural maternal behaviour. Early separation is thought to prevent the development of a cow-calf bond. To assess this bond, we measured motivation of dairy cows to reunite with their calf. To vary the degree of bonding, some cows were allowed continued contact with thei...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-70927-w
更新日期:2020-08-28 00:00:00
abstract::In glaucoma, retinal ganglion cells degenerate progressively, leading to visual field loss and blindness. Presently, the only treatment strategy for glaucoma is lowering the intraocular pressure. However, there are cases in which patients develop progressive visual field loss even though their intraocular pressures ar...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-78731-2
更新日期:2020-12-10 00:00:00
abstract::The protective effect of estrogens against chronic glomerular diseases is admitted but remains debated during acute kidney injury (AKI). Using a model of resuscitated hemorrhagic shock in C57/Bl6 female mice, this study evaluated at 1 and 21 days the renal effect of (1) endogenous estrogen, using ovariectomized mice w...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-73974-5
更新日期:2020-10-14 00:00:00
abstract::TLR4 location, and bacterial species-derived lipopolysaccharides, play a significant role in the downstream activation of transcription factors, accessory molecules, and products. Here, this is demonstrated through the use of classically-activated and alternatively-activated macrophages. We show that, when polarized, ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-79145-w
更新日期:2021-01-14 00:00:00
abstract::CIC-DUX4 sarcoma (CDS) is a group of rare, mesenchymal, small round cell tumours that harbour the unique CIC-DUX4 translocation, which causes aberrant gene expression. CDS exhibits an aggressive course and poor clinical outcome, thus novel therapeutic approaches are needed for CDS treatment. Although patient-derived c...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-04967-0
更新日期:2017-07-05 00:00:00
abstract::Fatty infiltration in muscle is often observed in patients with sizable rotator cuff tear (RCT) and is thought to be an irreversible event that significantly compromises muscle plasticity and contraction strength. These changes in the mechanical properties of the affected muscle render surgical repair of RCT highly fo...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep41552
更新日期:2017-01-31 00:00:00
abstract::To investigate the safety and efficiency of using robotic staplers for intracorporeal gastroduodenostomy in reduced-port robotic gastrectomy for gastric adenocarcinoma. We retrospectively reviewed patients who underwent totally robotic and laparoscopic gastrectomy with intracorporeal gastroduodenostomy. Gastroduodenos...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-71807-z
更新日期:2020-09-07 00:00:00
abstract::This study compared effects of five hypoxia-inducible factor (HIF) prolyl hydroxylases (PHD) inhibitors on PC12 cells and primary rat neurons following oxygen-glucose deprivation (OGD). At 100 µM, the PHD inhibitors did not cause cytotoxicity and apoptosis. MTT activity was only significantly reduced by FG4592 or Baye...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-58482-w
更新日期:2020-01-31 00:00:00
abstract::The magnetic skyrmion is a nanoscale topological object characterized by the winding of magnetic moments, appearing in magnetic materials with broken inversion symmetry. Because of its low current threshold for driving the skyrmion motion, they have been intensely studied toward novel storage applications by using ele...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-54833-4
更新日期:2019-12-05 00:00:00
abstract::Mastery over the structure of nanoparticles might be an effective way to enhance their performance for a given application. Herein we demonstrate the design of cage-bell nanostructures to enhance the methanol tolerance of platinum (Pt) nanoparticles while remaining their catalytic activity for oxygen reduction reactio...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep16219
更新日期:2015-11-18 00:00:00
abstract::The present study aimed to determine the effect of thyroid hormone dysfunction on brown adipose tissue activity and white adipose tissue browning in mice. Twenty randomized female C57BL/6NTac mice per treatment group housed at room temperature were rendered hypothyroid or hyperthyroid. In-vivo small animal 18F-FDG PET...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep38124
更新日期:2016-12-12 00:00:00
abstract::The conservation of plant and animal genetic heritage is not a purpose in itself, but it represents the sine qua non condition for practicing a sustainable agriculture and to ensure nutrition and food security on long-term. Our research focused on identifying the areas with the richest genetic diversity of vegetables ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-75413-x
更新日期:2020-10-28 00:00:00
abstract::The release of radon in active fault zones is a sustained radioactive pollution source of the atmospheric environment. The species, concentration and flux of radon emitted in soil gas in active fault zones in the Capital of China were investigated by in-situ field measurements. Two main species of radon discharging fr...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-35262-1
更新日期:2018-11-13 00:00:00
abstract::We have proposed a scheme and presented the first experimental demonstration of acoustic illusion, by using anisotropic metamaterials to manipulate the acoustic field near boundaries of arbitrary curved geometry. Numerical simulations and experimental results show that in the presence of an illusion cloak, any object ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep01427
更新日期:2013-01-01 00:00:00
abstract::Afforestation is an important approach to mitigate global warming. Its complex interactions with the climate system, however, makes it controversial. Afforestation is expected to be effective in the tropics where biogeochemical and biogeophysical effects act in concert; however, its potential in the large semi-arid re...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-19265-6
更新日期:2018-01-17 00:00:00
abstract::Free-living animals must make dietary choices in terms of chemical and physical properties, depending on their digestive physiology and availability of food resources. Here we comprehensively evaluated the dietary choices of proboscis monkeys (Nasalis larvatus) consuming young leaves. We analysed the data for leaf tou...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep42774
更新日期:2017-02-17 00:00:00
abstract::Fundamental life history processes of mycorrhizal fungi with inconspicuous fruiting bodies can be difficult to elucidate. In this study we investigated the species identities and life history of the orchid mycorrhizal Tulasnella fungi, which associate with the south eastern Australia orchid genus Chiloglottis. Tulasne...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-05855-3
更新日期:2017-07-17 00:00:00
abstract::Tench (Tinca tinca L.) is one of the most valued species of the Cyprinidae. This species is commercially important and has been intensively domesticated in recent years. To avoid excessive production losses, the health of farm fish must be maintained. Characterization of the tench gut microbiome can help achieve this ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-61351-1
更新日期:2020-03-10 00:00:00
abstract::We present theoretical results on the high-temperature phase stability and phonon spectra of paramagnetic bcc iron which explicitly take into account many-body effects. Several peculiarities, including a pronounced softening of the [110] transverse (T1) mode and a dynamical instability of the bcc lattice in harmonic a...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep05585
更新日期:2014-07-07 00:00:00
abstract::Nano-suspensions (NS) exhibit unusual thermophysical behaviors once interparticle aggregations and the shear flows are imposed, which occur ubiquitously in applications but remain poorly understood, because existing theories have not paid these attentions but focused mainly on stationary NS. Here we report the critica...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep39446
更新日期:2016-12-20 00:00:00
abstract::We provide an explicit model for a spin-1/2 quasi-particle, based on the superposition of plasmon excitations in a quantum plasmas with intrinsic orbital angular momentum. Such quasi-particle solutions can show remarkable similarities with single electrons moving in vacuum: they have spin-1/2, a finite rest mass, and ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-26196-9
更新日期:2018-05-18 00:00:00
abstract::To study quantitatively replicative senescence as a tumor suppressor mechanism, we investigate the distribution of a growing clonal cell population restricted by Hayflick's limit. We find that in the biologically relevant range of parameters, if the imbalance between cell division and death is moderate or low (high de...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep17660
更新日期:2015-12-09 00:00:00
abstract::The objective of our study is to highlight the therapeutic effect and mechanism of action by which purified Flaxseed hydrolysate (PFH) which is a lignan rich fraction exerts its anticancer activity on a human breast cancer cell line (T47D) and in mice bearing tumor. HPLC analysis of PFH of six flaxseed cultivars had s...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-18944-0
更新日期:2018-01-11 00:00:00
abstract::A range of chemistries were explored for the efficient covalent conjugation of DNA to poly(N-isopropylacrylamide) (poly(NIPAM)) in organic solvents. Amide coupling and thiol-ene Michael addition were found to be ineffective for the synthesis of the desired products. However, the inverse electron-demand Diels-Alder (DA...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep39192
更新日期:2016-12-16 00:00:00
abstract::Some 1,3-diarylureas and 1-((1,4-trans)-4-aryloxycyclohexyl)-3-arylureas (cHAUs) activate heme-regulated kinase causing protein synthesis inhibition via phosphorylation of the eukaryotic translation initiation factor 2 (eIF2) in mammalian cancer cells. To evaluate if these agents have potential to inhibit trypanosome ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-23259-9
更新日期:2018-03-20 00:00:00
abstract::The therapeutic potential of targeting CD4+Foxp3+ regulatory T cells (Tregs) remains controversial under the condition of neuroinflammation. This study aims to explore the neuroprotective role of Tregs in optic nerve ischemia (ONI) and evaluate the therapeutic strategy of Tregs transfer with a focus on targeting the m...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep37805
更新日期:2016-11-25 00:00:00
abstract::The role of Toll-like receptor-2 (TLR2) in radio-resistance remained largely unknown. TLR2 knockout (TLR2(-/-)) mice received radiation of 6.5 Gy, and then were studied. We found that radiation resulted in more severe mortality and morbidity rates in TLR2(-/-) mice. The cause of death in TLR2(-/-) mice may be severe a...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep13004
更新日期:2015-08-13 00:00:00