Evaluation of subconjunctival liposomal steroids for the treatment of experimental uveitis.

abstract：:Positions of leaves along a stem usually adhere to a genetically determined, species-specific pattern known as a leaf phyllotaxis. We investigated whether the arrangement of lateral secondary veins along primary midveins adhered to a species-specific pattern that resembled an alternate or opposite phyllotaxis. We anal...

journal_title：Scientific reports

authors： Koyama K,Masuda T

更新日期：2018-11-06 00:00:00

abstract：:Somatic copy number alterations (SCNAs) affecting oncogenic drivers have a firmly established role in promoting cancer. However, no agreed-upon standard exists for calling locus-specific amplifications and deletions in each patient sample. Here, we report the correlative analysis of copy number amplitude and length wi...

journal_title：Scientific reports

authors： Roszik J,Wu CJ,Siroy AE,Lazar AJ,Davies MA,Woodman SE,Kwong LN

更新日期：2016-01-20 00:00:00

abstract：:The patient-derived tumor xenograft (PDTX) model has become the most realistic model for preclinical studies. PDTX models of gastric cancer using surgical tissues are reported occasionally; however, the PDTX models using gastroscopic biopsies, which are best for evaluating new drugs, are unreported. In our study, a to...

journal_title：Scientific reports

authors： Zhu Y,Tian T,Li Z,Tang Z,Wang L,Wu J,Li Y,Dong B,Li Y,Li N,Zou J,Gao J,Shen L

更新日期：2015-02-25 00:00:00

abstract：:Cues previously paired with rewarding stimuli induce a time-dependent increase in the motivational craving state (incubation of craving). Whether there is an increase in craving for high-fat (HF) food over time, which may contribute to overeating and obesity, has not been determined. We hypothesized that cues paired w...

journal_title：Scientific reports

authors： Darling RA,Dingess PM,Schlidt KC,Smith EM,Brown TE

更新日期：2016-08-03 00:00:00

abstract：:SLC10A7 represents an orphan member of the Solute Carrier Family SLC10. Recently, mutations in the human SLC10A7 gene were associated with skeletal dysplasia, amelogenesis imperfecta, and decreased bone mineral density. However, the exact molecular function of SLC10A7 and the mechanisms underlying these pathologies ar...

journal_title：Scientific reports

authors： Karakus E,Wannowius M,Müller SF,Leiting S,Leidolf R,Noppes S,Oswald S,Diener M,Geyer J

更新日期：2020-04-29 00:00:00

abstract：:Neuromodulation is an increasingly accepted treatment for neurological and psychiatric disorders but is limited by its invasiveness or its inability to target deep brain structures using noninvasive techniques. We propose a new concept called Multimodal Synchronization Therapy (mSync) for achieving targeted activation...

journal_title：Scientific reports

authors： Markovitz CD,Smith BT,Gloeckner CD,Lim HH

更新日期：2015-03-25 00:00:00

abstract：:Filamentous fungi naturally grow on solid surfaces, yet most genetic and biochemical analyses are still performed in liquid cultures. Here, we report a multiplexing platform using high-throughput photometric continuous reading that allows parallel quantification of hyphal growth and reporter gene expression directly o...

journal_title：Scientific reports

authors： Cánovas D,Studt L,Marcos AT,Strauss J

更新日期：2017-06-27 00:00:00

abstract：:Microwave absorbers have important applications in various areas including stealth, camouflage, and antenna. Here, we have designed an ultra-broadband light absorber by integrating two different-sized tapered hyperbolic metamaterial (HMM) waveguides, each of which has wide but different absorption bands due to broadba...

journal_title：Scientific reports

authors： Yin X,Long C,Li J,Zhu H,Chen L,Guan J,Li X

更新日期：2015-10-19 00:00:00

abstract：:The amphibian chytrid fungus Batrachochytrium dendrobatidis is an emerging infectious pathogen present on every continent except Antarctica. It causes the disease chytridiomycosis in a subset of species but does not always result in disease or death for every host. Ambient temperature influences both amphibian metabol...

journal_title：Scientific reports

authors： Campbell L,Bower DS,Clulow S,Stockwell M,Clulow J,Mahony M

更新日期：2019-01-14 00:00:00

abstract：:Optical coherence tomography (OCT) is a valuable ancillary test in the diagnosis and management of chorioretinal disease. The evaluation of choroid thickness using OCT has become the focus of clinical applications. We report a linear artifact that acts as a confounding factor in choroidal thickness measurements by enh...

journal_title：Scientific reports

authors： Zuo C,Mi L,Yang S,Guo X,Xiao H,Liu X

更新日期：2017-08-16 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Scientific reports

authors： Brill R,Brill E,Uller W,Teusch V,Gufler H,Hammer S,Fellner C,Evert K,Goldann C,Helm M,Rosendahl J,Wohlgemuth WA

更新日期：2020-02-07 00:00:00

abstract：:Glaucoma optic neuropathy (GON) is a condition where pathogenic intraocular pressure (IOP) results in axonal damage following retinal ganglion cell (RGC) death, and further results in secondary damage of the lateral geniculate nucleus (LGN). Therapeutic targets for glaucoma thus focus on both the LGN and RGC. However,...

journal_title：Scientific reports

authors： Fujishiro T,Kawasaki H,Aihara M,Saeki T,Ymagishi R,Atarashi T,Mayama C,Araie M

更新日期：2014-10-13 00:00:00

abstract：:This study measured the effects of vitamin D (VD) supplementation on the underlying molecular pathways involved in renal and testicular damage induced by lead (Pb) toxicity. Thirty two adult male Wistar rats were divided equally into four groups that were treated individually or simultaneously, except the negative con...

journal_title：Scientific reports

authors： BaSalamah MA,Abdelghany AH,El-Boshy M,Ahmad J,Idris S,Refaat B

更新日期：2018-03-19 00:00:00

abstract：:Hot days in summer (involving a few hours at particularly high temperatures) are expected to become more common under climate change. How such events at different life stages affect survival and reproduction remains unclear in most organisms. Here, we investigated how an exposure to 40 °C at different life stages in t...

journal_title：Scientific reports

authors： Zhang W,Chang XQ,Hoffmann A,Zhang S,Ma CS

更新日期：2015-05-22 00:00:00

abstract：:Analysis of coordinated Greater Scaup (Aythya marila) count data from the last 30 years showed a 38.1% decrease in wintering numbers in North-West Europe, from 309,000 during 1988-1991 to c.192,300 individuals during 2015-2018. Annual trends in wintering numbers differed throughout the range. Numbers decreased in the ...

journal_title：Scientific reports

authors： Marchowski D,Ławicki Ł,Fox AD,Nielsen RD,Petersen IK,Hornman M,Nilsson L,Haas F,Wahl J,Kieckbusch J,Nehls HW,Calbrade N,Hearn R,Meissner W,Fitzgerald N,Luigujoe L,Zenatello M,Gaudard C,Koschinski S

更新日期：2020-11-20 00:00:00

abstract：:Adipose tissue dysfunction is considered an important contributor to systemic insulin resistance and Type 2 diabetes (T2D). Recently, a novel family of endogenous lipids, palmitic acid hydroxy stearic acids (PAHSAs), was discovered. These have anti-diabetic and anti-inflammatory effects in mice and are reduced in seru...

journal_title：Scientific reports

authors： Hammarstedt A,Syed I,Vijayakumar A,Eliasson B,Gogg S,Kahn BB,Smith U

更新日期：2018-10-25 00:00:00

abstract：:Cognitive impairment is one of the most common problem saffecting older adults. In this study, we investigated whether Tai Chi Chuan and Baduanjin practice can modulate mental control functionand the resting state functional connectivity (rsFC) of the cognitive control network in older adults. Participants in the two ...

journal_title：Scientific reports

authors： Tao J,Chen X,Egorova N,Liu J,Xue X,Wang Q,Zheng G,Li M,Hong W,Sun S,Chen L,Kong J

更新日期：2017-02-07 00:00:00

abstract：:The sensitivity and accuracy of the Risk/Injury/Failure/Loss/End-stage (RIFLE) versus acute kidney injury Network (AKIN) criteria for acute kidney injury (AKI) in critically ill patients remains uncertain. Therefore, we performed a systematic review and meta-analysis to investigate the incidence and prognostic value o...

journal_title：Scientific reports

authors： Xiong J,Tang X,Hu Z,Nie L,Wang Y,Zhao J

更新日期：2015-12-07 00:00:00

abstract：:Herein, triphenyltin (TPT) biodegradation efficiency and its transformation pathway have been elucidated. To better understand the molecular mechanism of TPT degradation, the interactions between amino acids, primary structures, and quaternary conformations of effector proteins and TPT were studied. The results verifi...

journal_title：Scientific reports

authors： Wang L,Ye J,Ou H,Qin H,Long Y,Ke J

更新日期：2017-06-23 00:00:00

abstract：:Width-controlled M-type hexagonal SrFe12O19 nanoribbons were synthesized for the first time via polyvinylpyrrolidone (PVP) sol assisted electrospinning followed by heat treatment in air, and their chemical composition, microstructure and magnetic performance were investigated. Results demonstrated that as-obtained SrF...

journal_title：Scientific reports

authors： Jing P,Du J,Wang J,Wei J,Pan L,Li J,Liu Q

更新日期：2015-10-14 00:00:00

abstract：:Cisplatin is a highly effective anti-cancer chemotherapeutic agent; however, its clinical use is severely limited by serious side effects, of which nephrotoxicity is the most important. In this study, we investigated whether Qiong-Yu-Gao (QYG), a popular traditional Chinese medicinal formula described 840 years ago, e...

journal_title：Scientific reports

authors： Teng ZY,Cheng XL,Cai XT,Yang Y,Sun XY,Xu JD,Lu WG,Chen J,Hu CP,Zhou Q,Wang XN,Li SL,Cao P

更新日期：2015-10-29 00:00:00

abstract：:Cardiopulmonary resuscitation (CPR) training and its quality are critical in improving the survival rate of cardiac arrest. This randomized controlled study investigated the efficacy of a newly developed CPR training program for the public in a Taiwanese setting. A total of 832 adults were randomized to either a tradi...

journal_title：Scientific reports

authors： Chien CY,Fang SY,Tsai LH,Tsai SL,Chen CB,Seak CJ,Weng YM,Lin CC,Chien WC,Huang CH,Lin CY,Chaou CH,Liu PH,Tseng HJ,Chen JC,Peng SY,Cheng TH,Hsu KH,Ng CJ

更新日期：2020-06-22 00:00:00

abstract：:Attention and saccadic eye movements are critical components of visual perception. Recent studies proposed the hypothesis of a tight coupling between saccadic adaptation (SA) and attention: SA increases the processing speed of unpredictable stimuli, while increased attentional load boosts SA. Moreover, their cortical ...

journal_title：Scientific reports

authors： Nicolas J,Bidet-Caulet A,Pélisson D

更新日期：2020-08-10 00:00:00

abstract：:GPR88 is an orphan G-protein-coupled receptor with predominant expression in reward-related areas in the brain. While the lack of GPR88 has been demonstrated to induce behavioral deficits, the potential function of the receptor in the control of food intake and energy balance remains unexplored. In this work, the role...

journal_title：Scientific reports

authors： Lau J,Farzi A,Enriquez RF,Shi YC,Herzog H

更新日期：2017-08-30 00:00:00

abstract：:On an SiO2-patterned c-plane sapphire substrate, GaN domains were grown with their polarity controlled in accordance with the pattern. While N-polar GaN was grown on hexagonally arranged circular openings, Ga-polar GaN was laterally overgrown on mask regions due to polarity inversion occurring at the boundary of the c...

journal_title：Scientific reports

authors： Jang D,Jue M,Kim D,Kim HS,Lee H,Kim C

更新日期：2018-03-07 00:00:00

abstract：:Insulin resistance is a critical process in the initiation and progression of diabetic nephropathy (DN). Alprostadil (Prostaglandin E1, PGE1) had protective effects on renal function. However, it is unknown whether PGE1 inhibited insulin resistance in renal tubule epithelial cells via autophagy, which plays a protecti...

journal_title：Scientific reports

authors： Wei W,An XR,Jin SJ,Li XX,Xu M

更新日期：2018-01-08 00:00:00

abstract：:An abrupt onset of the new tongue-shaped deformation of magnetic surface in magnetized plasmas, which was conjectured in since the 1960s but has not been observed, is experimentally identified just before an abrupt onset of a large-scale collapse event. Two novel properties of the event are identified. First, the tran...

journal_title：Scientific reports

authors： Ida K,Kobayashi T,Itoh K,Yoshinuma M,Tokuzawa T,Akiyama T,Moon C,Tsuchiya H,Inagaki S,Itoh SI

更新日期：2016-10-31 00:00:00

abstract：:During locomotion, the human ankle-foot system dynamically alters its gearing, or leverage of the ankle joint on the ground. Shifting ankle-foot gearing regulates speed of plantarflexor (i.e., calf muscle) contraction, which influences economy of force production. Here, we tested the hypothesis that manipulating ankle...

journal_title：Scientific reports

authors： Ray SF,Takahashi KZ

更新日期：2020-05-29 00:00:00

abstract：:Retinitis pigmentosa (RP) is an inherited photoreceptor-degenerative disease, and neuronal degeneration in RP is exacerbated by glial activation. Cassia seed (Jue-ming-zi) is a traditional herbal medicine commonly used to treat ocular diseases in Asia. In this report, we investigated the retina-protective effect of ch...

journal_title：Scientific reports

authors： Lin FL,Lin CH,Ho JD,Yen JL,Chang HM,Chiou GC,Cheng YW,Hsiao G

更新日期：2017-01-23 00:00:00

abstract：:The dissolution of ferrihydrite induced by low molar mass (LMM) organics is an important process that provides bioavailable iron for organisms. Here, ATR-FTIR analysis was combined with characterization of ferrihydrite nanoparticles and kinetic modeling to investigate the roles of different oxalate surface complex spe...

journal_title：Scientific reports

authors： Li F,Koopal L,Tan W

更新日期：2018-02-01 00:00:00