Inhibition of insulin resistance by PGE1 via autophagy-dependent FGF21 pathway in diabetic nephropathy.

abstract：:High quality factor (High-Q) and transmission optical devices are required for various applications in the fields of physics and engineering. Critical for these applications is the realization of a structure with high-Q, complete transmission and small volume. A robust high-Q filter with complete transmission by conju...

journal_title：Scientific reports

authors： Lin YC,Chou SH,Hsueh WJ

更新日期：2020-04-27 00:00:00

abstract：:The FDA-approved prophylactic antimalarial drug atovaquone (ATO) recently was repurposed as an antitumor drug. Studies show that ATO exerts a profound antiproliferative effect in several cancer cells, including breast, ovarian, and glioma. Analogous to the mechanism of action proposed in parasites, ATO inhibits mitoch...

journal_title：Scientific reports

authors： Cheng G,Hardy M,Topchyan P,Zander R,Volberding P,Cui W,Kalyanaraman B

更新日期：2020-10-21 00:00:00

abstract：:Efficient inactivation of Escherichia coli (E. coli) under visible (532 nm) pulsed light irradiation was achieved by fusion of a visible light-absorbing dye with E. coli. Inactivation experiments showed that 3-log inactivation of E. coli was obtained within 20 min under a 50 kJ/cm2 dose. This treatment time and dose m...

journal_title：Scientific reports

authors： Kohmura Y,Igami N,Tatsuno I,Hasegawa T,Matsumoto T

更新日期：2020-10-20 00:00:00

abstract：:With the increasing amount of research work in surface studies, a more effective method of producing patterned microstructures is highly desired due to the geometric limitations and complex fabricating process of current techniques. This paper presents an efficient and cost-effective method to generate customizable mi...

journal_title：Scientific reports

authors： He R,Wang S,Andrews G,Shi W,Liu Y

更新日期：2016-02-23 00:00:00

abstract：:Amyloid-β (Aβ) deposition is known to starts decades before the onset of clinical symptoms of Alzheimer's disease (AD), however, the detailed pathophysiological processes underlying this preclinical period are not well understood. This study aimed to investigate functional network alterations in cognitively intact eld...

journal_title：Scientific reports

authors： Nakamura A,Cuesta P,Kato T,Arahata Y,Iwata K,Yamagishi M,Kuratsubo I,Kato K,Bundo M,Diers K,Fernández A,Maestú F,Ito K

更新日期：2017-07-26 00:00:00

abstract：:Accurately establishing the state of large-scale quantum systems is an important tool in quantum information science; however, the large number of unknown parameters hinders the rapid characterisation of such states, and reconstruction procedures can become prohibitively time-consuming. Compressive sensing, a procedur...

journal_title：Scientific reports

authors： Tonolini F,Chan S,Agnew M,Lindsay A,Leach J

更新日期：2014-10-13 00:00:00

abstract：:Physiological regulation of blood flow in bone marrow is important to maintain oxygen and glucose supplies but also the physiological hypoxic state of the hematopoietic stem cell (HSC) niche. However, regulatory mechanisms underlying microcirculation in the bone marrow (BM) niche remain unclear. Here, we identify vess...

journal_title：Scientific reports

authors： Morikawa T,Tamaki S,Fujita S,Suematsu M,Takubo K

更新日期：2020-04-14 00:00:00

abstract：:A major translational challenge in the fields of therapeutic angiogenesis and regenerative medicine is the need to create functional microvasculature. The purpose of this study was to assess whether a potentially autologous endothelial cell (EC) source derived from human induced pluripotent stem cells (iPSC-ECs) can f...

journal_title：Scientific reports

authors： Bezenah JR,Kong YP,Putnam AJ

更新日期：2018-02-08 00:00:00

abstract：:Listeria monocytogenes is an intracellular pathogen that causes listeriosis. Due to its intracellular niche, L. monocytogenes has evolved to limit immune recognition and response to infection. Antibodies that are slightly induced by listerial infection are completely unable to protect re-infection of L. monocytogenes....

journal_title：Scientific reports

authors： Asano K,Sashinami H,Osanai A,Hirose S,Ono HK,Narita K,Hu DL,Nakane A

更新日期：2016-12-22 00:00:00

abstract：:Genome editing via CRISPR/Cas9 has become an efficient and reliable way to make precise, targeted changes to the genome of living cells. CXCR4 is a co-receptor for the human immunodeficiency virus type 1 (HIV-1) infection and has been considered as an important therapeutic target for AIDS. CXCR4 mediates viral entry i...

journal_title：Scientific reports

authors： Hou P,Chen S,Wang S,Yu X,Chen Y,Jiang M,Zhuang K,Ho W,Hou W,Huang J,Guo D

更新日期：2015-10-20 00:00:00

abstract：:Keloid is the abnormal wound healing puzzled by the aggressive growth and high recurrence rate due to its unrevealed key pathogenic mechanism. MicroRNAs contribute to a series of biological processes including epithelial-mesenchymal transition (EMT) and cells stemness involved in fibrotic disease. Here, using microRNA...

journal_title：Scientific reports

authors： Yan L,Cao R,Liu Y,Wang L,Pan B,Lv X,Jiao H,Zhuang Q,Sun X,Xiao R

更新日期：2016-09-06 00:00:00

abstract：:Circular RNA (circRNA) is a newly discovered non-coding RNA, which play significant roles in the function and transcriptional regulation of microRNA. To date, in Chinese cabbage, the functional characteristic of circRNAs in response to calcium deficiency-induced tip-burn have not been reported. In this study, 730 circ...

journal_title：Scientific reports

authors： Wang W,Wang J,Wei Q,Li B,Zhong X,Hu T,Hu H,Bao C

更新日期：2019-10-10 00:00:00

abstract：:In the last forty years therapy outcomes for depression have remained the same with approximately 50% of patients responding to treatments. Advances are urgently required. We hypothesised that a recent treatment, metacognitive therapy (MCT), might be more effective, by targeting mental control processes that directly ...

journal_title：Scientific reports

authors： Callesen P,Reeves D,Heal C,Wells A

更新日期：2020-05-12 00:00:00

abstract：:Cytochrome P450 (CYP) 3A accounts for nearly 30% of the total CYP enzymes in the human liver and participates in the metabolism of over 50% of clinical drugs. Moreover, CYP3A plays an important role in chemical metabolism, toxicity, and carcinogenicity. New animal models are needed to investigate CYP3A functions, espe...

journal_title：Scientific reports

authors： Lu J,Shao Y,Qin X,Liu D,Chen A,Li D,Liu M,Wang X

更新日期：2017-02-20 00:00:00

abstract：:PAP80-2a, purified from Pholiota adiposa mycelia, is a polysaccharide exhibiting prominent antitumor effects. However, the yield of PAP80-2a was low and its structure has not been characterized, impeding the exploration of its structure-function relationship, thus influencing the development of oral drugs for antitumo...

journal_title：Scientific reports

authors： Zou Y,Du F,Hu Q,Wang H

更新日期：2019-02-11 00:00:00

abstract：:The contribution of paternal obesity to pregnancy outcomes has been little described. Our aims were to determine whether the effect of an antenatal maternal dietary and lifestyle intervention among women who are overweight or obese on newborn adiposity, was modified by paternal obesity. We conducted a secondary analys...

journal_title：Scientific reports

authors： Dodd JM,Du Plessis LE,Deussen AR,Grivell RM,Yelland LN,Louise J,Mcphee AJ,Robinson JS,Owens JA

更新日期：2017-05-08 00:00:00

abstract：:The physical mechanism of the anthropogenic triggering of large earthquakes on active faults is studied on the basis of experimental phenomenology, i.e., that earthquakes occur on active tectonic faults, that crustal stress values are those measured in situ and, on active faults, comply to the values of the stress dro...

journal_title：Scientific reports

authors： Mulargia F,Bizzarri A

更新日期：2014-08-26 00:00:00

abstract：:Endogenous K. pneumoniae endophthalmitis (EKE) has a higher incidence among East Asians, and the most common infectious source of EKE is pyogenic liver abscess (PLA). We investigate the risk factors for poor visual outcomes in patients with PLA-related EKE. The retrospective medical records of 104 patients (120 eyes) ...

journal_title：Scientific reports

authors： Chen YH,Li YH,Lin YJ,Chen YP,Wang NK,Chao AN,Liu L,Wu WC,Lai CC,Chen TL,Chen KJ

更新日期：2019-01-31 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Scientific reports

authors： Selfslagh A,Shokur S,Campos DSF,Donati ARC,Almeida S,Yamauti SY,Coelho DB,Bouri M,Nicolelis MAL

更新日期：2019-12-04 00:00:00

abstract：:The Csf1r locus encodes the receptor for macrophage colony-stimulating factor, which controls the proliferation, differentiation and survival of macrophages. The 300 bp Fms intronic regulatory element (FIRE), within the second intron of Csf1r, is necessary and sufficient to direct macrophage-specific transcription. We...

journal_title：Scientific reports

authors： Hume DA,Wollscheid-Lengeling E,Rojo R,Pridans C

更新日期：2017-12-07 00:00:00

abstract：:Parasites comprise a huge part of the biodiversity on earth. However, on a local scale, not much is known about their diversity and community structure. Here, we assess the diversity of larval trematode communities in an interconnected freshwater system of the River Ruhr in Germany and analyse how the parasites are sp...

journal_title：Scientific reports

authors： Selbach C,Soldánová M,Feld CK,Kostadinova A,Sures B

更新日期：2020-02-14 00:00:00

abstract：:Adult stem cells are considered promising candidates for cellular therapies due to their capacity to differentiate and self-renew. Differentiation leads to changes in the metabolism, structure, and gene expression patterns of cells. Hedgehog is one of the pathways that is involved in the enhancement of osteogenesis an...

journal_title：Scientific reports

authors： Shigunov P,Balvedi LT,Santos MDM,Herai RH,de Aguiar AM,Dallagiovanna B

更新日期：2018-05-30 00:00:00

abstract：:An experimental method for fabrication of a nanocomposite metamaterial based on a self-assembly of titanium dioxide microtubes with encapsulated gold nanoparticles (NPs) is proposed. The formation of microtubes is induced by laser irradiation in the presence of an external magnetic field. It is shown that the variatio...

journal_title：Scientific reports

authors： Kutrovskaya S,Kucherik A,Osipov A,Samyshkin V,Istratov A,Kavokin AV

更新日期：2019-05-07 00:00:00

abstract：:We aimed to characterize the type 2 diabetes mellitus (T2DM) epidemic and the role of key risk factors in Jordan between 1990-2050, and to forecast the T2DM-related costs. A recently-developed population-level T2DM mathematical model was adapted and applied to Jordan. The model was fitted to six population-based surve...

journal_title：Scientific reports

authors： Awad SF,Huangfu P,Dargham SR,Ajlouni K,Batieha A,Khader YS,Critchley JA,Abu-Raddad LJ

更新日期：2020-12-03 00:00:00

abstract：:Up to now, a very few catalysts have been developed approaching the heterogeneous catalytic degradation of Eosin Y and Chromotrope 2R dyes (Acid Red 29). The present study provides a complete perspective of recyclable nanocomposite Au(Salen)@CC for catalytic degradation of hazardous water pollutant dyes viz., Eosin Y ...

journal_title：Scientific reports

authors： Mayani VJ,Mayani SV,Kim SW

更新日期：2017-08-03 00:00:00

abstract：:Selective pressure from pathogens is considered a key selective force driving the evolution of components of the immune system. Since single components of the immune system may interact with many pathogens, and single pathogens may be recognized by multiple components of the immune system, gaining a better understandi...

journal_title：Scientific reports

authors： Kloch A,Wenzel MA,Laetsch DR,Michalski O,Bajer A,Behnke JM,Welc-Falęciak R,Piertney SB

更新日期：2018-05-30 00:00:00

abstract：:An accurate prediction of the outcome of a given drug treatment requires quantitative values for all parameters and concentrations involved as well as a detailed characterization of the network of interactions where the target molecule is embedded. Here, we present a high-throughput in silico screening of all potentia...

journal_title：Scientific reports

authors： Doldán-Martelli V,Míguez DG

更新日期：2018-08-21 00:00:00

abstract：:Two objects can be distinguished if they have different measurable properties. Thus, distinguishability depends on the Physics of the objects. In considering graphs, we revisit the Ising model as a framework to define physically meaningful spectral invariants. In this context, we introduce a family of refinements of t...

journal_title：Scientific reports

authors： Vinci W,Markström K,Boixo S,Roy A,Spedalieri FM,Warburton PA,Severini S

更新日期：2014-07-16 00:00:00

abstract：:Primary biliary cholangitis (PBC) is an autoimmune liver disease characterized by the destruction of interlobular biliary ductules, which progressively leads to cholestasis, hepatic fibrosis, cirrhosis, and eventually liver failure. Several mouse models have been used to clarify the pathogenesis of PBC and are general...

journal_title：Scientific reports

authors： Ma WT,Liu QZ,Yang JB,Yang YQ,Zhao ZB,Ma HD,Gershwin ME,Lian ZX

更新日期：2017-11-10 00:00:00

abstract：:Magnetron sputtering techniques were used to prepare molecularly smooth titanium thin films possessing an average roughness between 0.18 nm and 0.52 nm over 5 μm × 5 μm AFM scanning areas. Films with an average roughness of 0.52 nm or lower were found to restrict the extent of P. aeruginosa cell attachment, with less ...

journal_title：Scientific reports

authors： Ivanova EP,Truong VK,Webb HK,Baulin VA,Wang JY,Mohammodi N,Wang F,Fluke C,Crawford RJ

更新日期：2011-01-01 00:00:00