Potent inhibition of tumour cell proliferation and immunoregulatory function by mitochondria-targeted atovaquone.

abstract：:Recent studies including the SPRINT trial have shown beneficial effects of intensive systolic blood pressure reduction over the standard approach. The awareness of the J-curve for diastolic blood pressure (DBP) causes some uncertainty regarding the net clinical effects of blood pressure reduction. The current analysis...

journal_title：Scientific reports

authors： Sobieraj P,Lewandowski J,Siński M,Gaciong Z

更新日期：2019-09-10 00:00:00

abstract：:The non-enzymatic browning, namely Maillard reaction is commonly invoked to account for abiotic chemical transformations of organic matter. Here we report a new reaction pathway via the Maillard reaction to systematically synthesize a series of nitrogen-doped carbon dots (C-dots) with superhigh quantum yield (QY) and ...

journal_title：Scientific reports

authors： Wei W,Xu C,Wu L,Wang J,Ren J,Qu X

更新日期：2014-01-06 00:00:00

abstract：:Absolute numbers of lymphocytes are decreased in uninfected infants born to HIV-1-infected women (HIV-1-exposed). Although the exact mechanism is unknown, fetal exposure to maternal HIV-1-infection could prime the immune system and affect T cell trafficking. We compared the expression of chemokine receptors on cord bl...

journal_title：Scientific reports

authors： Bunders MJ,van Hamme JL,Jansen MH,Boer K,Kootstra NA,Kuijpers TW

更新日期：2014-10-24 00:00:00

abstract：:Natural Bacillus isolates generate limited amounts of surfactin (<10% of their biomass), which functions as an antibiotic or signalling molecule in inter-/intra-specific interactions. However, overproduction of surfactin in Bacillus amyloliquefaciens MT45 was observed at a titre of 2.93 g/l, which is equivalent to hal...

journal_title：Scientific reports

authors： Zhi Y,Wu Q,Xu Y

更新日期：2017-01-23 00:00:00

abstract：:A marine isolate, Nesiotobacter exalbescens COD22, isolated from deep sea sediment (2100 m depth) was capable of degrading aromatic hydrocarbons. The Nesiotobacter sp. grew well in the presence of toluene at 0.1 MPa and 10 MPa at a rate of 0.24 h-1 and 0.12 h-1, respectively, in custom designed high pressure reactors....

journal_title：Scientific reports

authors： Ganesh Kumar A,Mathew NC,Sujitha K,Kirubagaran R,Dharani G

更新日期：2019-12-10 00:00:00

abstract：:We presented the unusual result of photobleaching (PB) in Ge-deficient Ge16.8Se83.2 thin films with continuous irradiation with 560 nm laser for 12000 s, which is contradicted with the previous reports that the PB only occurs in GexSe100-x films with x > 30. Observation of the dynamics variations of the photo-induced ...

journal_title：Scientific reports

authors： Zhang S,Chen Y,Wang R,Shen X,Dai S

更新日期：2017-11-06 00:00:00

abstract：:The present study aimed to develop a plate-screening method, based on the specific color development of complexes formed between chlorogenic acid, a valuable plant-derived compound, and aluminum (III), to detect chlorogenic acid-producing microbial strains. Modified media with 0.75 mM aluminum chloride were developed ...

journal_title：Scientific reports

authors： Wang X,Qin L,Zhou J,Li Y,Fan X

更新日期：2018-10-03 00:00:00

abstract：:The parasitic salmon louse, and its resistance to chemical delousing agents, represents one of the largest challenges to the salmon aquaculture industry. We genotyped lice sampled from wild salmon and sea trout throughout Norway with the recently identified Phe362Tyr mutation that conveys resistance to organophosphate...

journal_title：Scientific reports

authors： Fjørtoft HB,Besnier F,Stene A,Nilsen F,Bjørn PA,Tveten AK,Finstad B,Aspehaug V,Glover KA

更新日期：2017-10-27 00:00:00

abstract：:Head and neck squamous cell carcinoma (HNSCC) development is a multistage process includes the normal, dysplasia and squamous cell carcinoma (SCC) stages. Recently, increasing evidence has suggested that the tumor microenvironment (TME) is an integral part of malignant transformation. Exploring certain key node genes ...

journal_title：Scientific reports

authors： Wu T,Hong Y,Jia L,Wu J,Xia J,Wang J,Hu Q,Cheng B

更新日期：2016-02-01 00:00:00

abstract：:The protection of tropical forests is one of the most urgent issues in conservation biology because of the rapid deforestation that has occurred over the last 50 years. Even in protected forests, the anthropogenic effects from newly expanding villages such as harvesting of medicinal plants, pasturing cattle and forest...

journal_title：Scientific reports

authors： Popradit A,Srisatit T,Kiratiprayoon S,Yoshimura J,Ishida A,Shiyomi M,Murayama T,Chantaranothai P,Outtaranakorn S,Phromma I

更新日期：2015-10-05 00:00:00

abstract：:This longitudinal population-based study analyses the frequency of diabetic ketoacidosis (DKA) at type 1 diabetes diagnosis in Italian children under 15 years of age, during 2004-2013. DKA was defined as absent (pH ≥ 7.30), mild/moderate (7.1 ≤ pH < 7.30) and severe (pH < 7.1). Two multiple logistic regression models ...

journal_title：Scientific reports

authors： Cherubini V,Skrami E,Ferrito L,Zucchini S,Scaramuzza A,Bonfanti R,Buono P,Cardella F,Cauvin V,Chiari G,D Annunzio G,Frongia AP,Iafusco D,Patera IP,Toni S,Tumini S,Rabbone I,Lombardo F,Carle F,Gesuita R,Diabetes St

更新日期：2016-12-19 00:00:00

abstract：:Mesenchymal stem cells (MSCs) aid the regeneration of tissues damaged by treatment with cisplatin. However, the effects of this cytotoxic drug on the stem cells have been largely unknown. Here we demonstrate that human bone marrow-derived MSCs are relatively resistant to cisplatin treatment and show resistance levels ...

journal_title：Scientific reports

authors： Nicolay NH,Lopez Perez R,Rühle A,Trinh T,Sisombath S,Weber KJ,Ho AD,Debus J,Saffrich R,Huber PE

更新日期：2016-01-25 00:00:00

abstract：:Dengue virus (DENV) is currently the most prevalent mosquito-borne viral pathogen. DENVs naturally exist as highly heterogeneous populations. Even though the descriptions on DENV diversity are plentiful, only a few studies have narrated the dynamics of intra-epidemic virus diversity at a fine scale. Such accounts are ...

journal_title：Scientific reports

authors： Hapuarachchi HC,Koo C,Kek R,Xu H,Lai YL,Liu L,Kok SY,Shi Y,Chuen RL,Lee KS,Maurer-Stroh S,Ng LC

更新日期：2016-03-04 00:00:00

abstract：:Neuronal activity-dependent synaptic plasticity, a basis for learning and memory, is tightly correlated with the pattern of increase in intracellular Ca(2+) concentration ([Ca(2+)](i)). Here, using combined application of electrophysiological experiments and systems biological simulation, we show that such a correlati...

journal_title：Scientific reports

authors： Kawaguchi SY,Nagasaki N,Hirano T

更新日期：2011-01-01 00:00:00

abstract：:The magnetization process is a very important probe to study magnetic materials, particularly in search of spin-liquid states in quantum spin systems. Regrettably, however, progress of the theoretical analysis has been unsatisfactory, mostly because it is hard to obtain sufficient numerical data to support the theory....

journal_title：Scientific reports

authors： Nakamura T

更新日期：2020-08-26 00:00:00

abstract：:Pandanus odorifer (Forssk) Kuntze grows naturally along the coastal regions and withstands salt-sprays as well as strong winds. A combination of omics approaches and enzyme activity studies was employed to comprehend the mechanistic basis of high salinity tolerance in P. odorifer. The young seedlings of P. odorifer we...

journal_title：Scientific reports

authors： Rashmi D,Barvkar VT,Nadaf A,Mundhe S,Kadoo NY

更新日期：2019-01-30 00:00:00

abstract：:Murraya koenigii (MK) leaf being a rich source of bioactive secondary metabolites has received inordinate attention in drug development research. Formation of secondary plant metabolite(s) in medicinal plants depends on several factors and in this study the cause of variation in bioavailability and content of a vital ...

journal_title：Scientific reports

authors： Kandimalla R,Das M,Barge SR,Sarma PP,Koiri DJ,Devi A,Karki AK,Kumar A,Devi R,Pal BC,Talukdar NC,Samanta SK

更新日期：2020-11-18 00:00:00

abstract：:The new π-extended redox-active ligand with both TTF and triazole units, 6-(4,5-bis(propylthio)-1,3-dithiol-2-ylidene)-1H-[1,3]dithiolo[4',5':4,5]benzo [1,2-d] [1-3]triazole, has been successfully prepared. Based on the versatile ligand and Cu(tta)2 precursors (tta(-) = 4,4,4-trifluoro-1-(thiophen-2-yl)butane-1,3-dion...

journal_title：Scientific reports

authors： Cui L,Geng YF,Leong CF,Ma Q,D'Alessandro DM,Deng K,Zeng QD,Zuo JL

更新日期：2016-05-06 00:00:00

abstract：:Scrophularia striata, commonly known as figwort, is one of the most important medicinal plants that mainly grows in cold regions of the Zagros Mountains (West of Iran). Although the chemical composition of this plant species has not yet been explored, people living in Ilam province (W Iran) have used it for many years...

journal_title：Scientific reports

authors： Zargoosh Z,Ghavam M,Bacchetta G,Tavili A

更新日期：2019-11-05 00:00:00

abstract：:In this study, 111 Cryptosporidium parvum IId isolates from several species of animals in China, Sweden, and Egypt were subtyped by multilocus sequence typing (MLST). One to eleven subtypes were detected at each of the 12 microsatellite, minisatellite, and single nucleotide polymorphism (SNP) loci, forming 25 MLST sub...

journal_title：Scientific reports

authors： Wang R,Zhang L,Axén C,Bjorkman C,Jian F,Amer S,Liu A,Feng Y,Li G,Lv C,Zhao Z,Qi M,Dong H,Wang H,Sun Y,Ning C,Xiao L

更新日期：2014-02-27 00:00:00

abstract：:Delay embedding-a method for reconstructing dynamical systems by delay coordinates-is widely used to forecast nonlinear time series as a model-free approach. When multivariate time series are observed, several existing frameworks can be applied to yield a single forecast combining multiple forecasts derived from vario...

journal_title：Scientific reports

authors： Okuno S,Aihara K,Hirata Y

更新日期：2020-01-20 00:00:00

abstract：:Different anti-PD-1 and anti-PD-L1 antibodies bind different epitopes. However, whether the results from the SP142 and 22C3 immunochemistry (IHC) assays can be interchanged to determine patient eligibility for immunotherapy remains largely unknown. Histologic sections from 135 tumor samples were probed with both 22C3 ...

journal_title：Scientific reports

authors： Xu H,Lin G,Huang C,Zhu W,Miao Q,Fan X,Wu B,Zheng X,Lin X,Jiang K,Hu D,Li C

更新日期：2017-12-05 00:00:00

abstract：:Propionibacterium freudenreichii, a dairy starter, can reach a population of almost 109 propionibacteria per gram in Swiss-type cheese at the time of consumption. Also consumed as a probiotic, it displays strain-dependent anti-inflammatory properties mediated by surface proteins that induce IL-10 in leukocytes. We sel...

journal_title：Scientific reports

authors： Deutsch SM,Mariadassou M,Nicolas P,Parayre S,Le Guellec R,Chuat V,Peton V,Le Maréchal C,Burati J,Loux V,Briard-Bion V,Jardin J,Plé C,Foligné B,Jan G,Falentin H

更新日期：2017-04-13 00:00:00

abstract：:HUWE1 is a HECT domain containing ubiquitin ligase implicated in neurogenesis, spermatogenesis and cancer development. The purpose of the current study is to investigate the role of HUWE1 in early embryo development. Here we demonstrate that Huwe1 is expressed in both nucleus and cytoplasm of preimplantation mouse emb...

journal_title：Scientific reports

authors： Chen LJ,Xu WM,Yang M,Wang K,Chen Y,Huang XJ,Ma QH

更新日期：2016-11-30 00:00:00

abstract：:Conduction Electron Paramagnetic Resonance Imaging (CEPRI) is presented as a sensitive technique for mapping metallic lithium species. The method is demonstrated using different samples that are either thick or thin compared to the microwave skin depth. As a thin sample, microstructured metallic lithium deposits in a ...

journal_title：Scientific reports

authors： Niemöller A,Jakes P,Eichel RA,Granwehr J

更新日期：2018-09-25 00:00:00

abstract：:Treatment of azo dye effluents has received increasing concerns over the years due to their potential harms to natural environment and human health. The present study described the degrading ability of the as-synthesized crystalline Al-Cu alloys for removal of high-concentration Acid Scarlet 3R in alkaline aqueous sol...

journal_title：Scientific reports

authors： Zhang L,Gao X,Zhang Z,Zhang M,Cheng Y,Su J

更新日期：2016-08-18 00:00:00

abstract：:Colloidal particles immersed in a dynamic speckle pattern experience an optical force that fluctuates both in space and time. The resulting dynamics presents many interesting analogies with a broad class of non-equilibrium systems like: active colloids, self propelled microorganisms, transport in dynamical intracellul...

journal_title：Scientific reports

authors： Bianchi S,Pruner R,Vizsnyiczai G,Maggi C,Di Leonardo R

更新日期：2016-06-09 00:00:00

abstract：:The effects of dairy products on human health have been studied for years. However, the relationship between dairy products as well as calcium intake and the risk of lung cancer is still inconclusive. A total of 32 studies regarding this association were identified from the PubMed and Web of Science databases through ...

journal_title：Scientific reports

authors： Yang Y,Wang X,Yao Q,Qin L,Xu C

更新日期：2016-02-15 00:00:00

abstract：:Lung cancer (LC) is the leading cause of cancer-related deaths. Downregulation of CDK1, 4 and 6, key regulators of cell cycle progression, correlates with decreased LC cell proliferation. Enforced expression of miRNAs (miRs) is a promising approach to regulate genes. Here, we study the combinatorial treatment of miR-1...

journal_title：Scientific reports

authors： Hossian AKMN,Sajib MS,Tullar PE,Mikelis CM,Mattheolabakis G

更新日期：2018-07-12 00:00:00

abstract：:Ursolic acid (UA) has proved to have broad-spectrum anti-tumor effects, but its poor water solubility and incompetent targeting property largely limit its clinical application and efficiency. Here, we synthesized a nanoparticle-based drug carrier composed of chitosan, UA and folate (FA-CS-UA-NPs) and demonstrated that...

journal_title：Scientific reports

authors： Jin H,Pi J,Yang F,Jiang J,Wang X,Bai H,Shao M,Huang L,Zhu H,Yang P,Li L,Li T,Cai J,Chen ZW

更新日期：2016-07-29 00:00:00