Abstract：
:Intracellular pathogens belonging to the genus Leishmania have developed effective strategies that enable them to survive within host immune cells. Immunostimulatory compounds that counteract such immunological escape mechanisms represent promising treatment options for diseases. Here, we demonstrate that a lipopeptidephosphoglycan (LPPG) isolated from the membrane of a protozoan parasite, Entamoeba histolytica (Eh), shows considerable immunostimulatory effects targeted against Leishmania (L.) major, a representative species responsible for cutaneous leishmaniasis (CL). Treatment led to a marked reduction in the number of intracellular Leishmania parasites in vitro, and ameliorated CL in a mouse model. We next designed and synthesized analogs of the phosphatidylinositol anchors harbored by EhLPPG; two of these analogs reproduced the anti-leishmanial activity of the native compound by inducing production of pro-inflammatory cytokines. The use of such compounds, either alone or as a supportive option, might improve the currently unsatisfactory treatment of CL and other diseases caused by pathogen-manipulated immune responses.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Choy SL,Bernin H,Aiba T,Bifeld E,Lender SC,Mühlenpfordt M,Noll J,Eick J,Marggraff C,Niss H,Roldán NG,Tanaka S,Kitamura M,Fukase K,Clos J,Tannich E,Fujimoto Y,Lotter Hdoi
10.1038/s41598-017-09894-8subject
Has Abstractpub_date
2017-08-25 00:00:00pages
9472issue
1issn
2045-2322pii
10.1038/s41598-017-09894-8journal_volume
7pub_type
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