Abstract：
:Detecting neuroplastic changes during locomotor neurorehabilitation is crucial for independent primal motor behaviours. However, long-term locomotor training-related neuroplasticity remains unexplored. We compared the effects of end-effector robot-assisted gait training (E-RAGT) and bodyweight-supported treadmill training (BWST) on cortical activation in individuals with hemiparetic stroke. Twenty-three men and five women aged 53.2 ± 11.2 years were recruited and randomly assigned to participate in E-RAGT (n = 14) or BWST (n = 14) for 30 min/day, 5 days/week, for 4 weeks. Cortical activity, lower limb motor function, and gait speed were evaluated before and after training. Activation of the primary sensorimotor cortex, supplementary motor area, and premotor cortex in the affected hemisphere significantly increased only in the E-RAGT group, although there were no significant between-group differences. Clinical outcomes, including the Fugl-Meyer assessment (FMA), timed up and go test, and 10-m walk test scores, improved after training in both groups, with significantly better FMA scores in the E-RAGT group than in the BWST group. These findings suggest that E-RAGT effectively improves neuroplastic outcomes in hemiparetic stroke, although its superiority over conventional training remains unclear. This may have clinical implications and provides insight for clinicians interested in locomotor neurorehabilitation after hemiparetic stroke.Trial Registration: ClinicalTrials.gov Identifier NCT04054739 (12/08/2019).
journal_name
Sci Repjournal_title
Scientific reportsauthors
Kim H,Park G,Shin JH,You JHdoi
10.1038/s41598-020-69367-3subject
Has Abstractpub_date
2020-07-27 00:00:00pages
12461issue
1issn
2045-2322pii
10.1038/s41598-020-69367-3journal_volume
10pub_type
杂志文章,随机对照试验abstract：:Phaseonium is a three-level Λ quantum system, in which a coherent microwave and an optical control (pump) beams can be used to actively modulate the dielectric response. Here we propose a new metamaterial structure comprising of a periodic array of triangular phaseonium metamolecules arranged as a trefoil. We present ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep21083
更新日期：2016-02-16 00:00:00
abstract：:Cancer is widely recognized as a genetic disease in which somatic mutations are sequentially accumulated to drive tumor progression. Although genomic landscape studies are informative for individual cancer types, a comprehensive comparative study of tumorigenic mutations across cancer types based on integrative data s...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep12566
更新日期：2015-07-27 00:00:00
abstract：:Drug-resistant tuberculosis (TB) is a serious global problem, and pathogen factors involved in the transmission of isoniazid (INH)-resistant TB have not been fully investigated. We performed whole genome sequencing of 332 clinical Mycobacterium tuberculosis (Mtb) isolates collected from patients newly diagnosed with s...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-51812-7
更新日期：2019-10-25 00:00:00
abstract：:The proteolytic system of Lactobacillus plays an essential role in bacterial growth, contributes to the flavor development of fermented products, and can release bioactive health-beneficial peptides during milk fermentation. In this work, a genomic analysis of all genes involved in the proteolytic system of L. delbrue...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-09124-1
更新日期：2017-08-17 00:00:00
abstract：:Western wheatgrass (Pascopyrum smithii Rydb.) is an important cool-season forage and turfgrass. However, due to seed dormancy and poor seedling vigor, it is difficult to develop high seed yield production systems, and assessing these components in response to seed yield. Based on multifactor orthogonally designed fiel...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-54586-0
更新日期：2019-11-29 00:00:00
abstract：:cAMP is one of the most important second messengers in biological processes. Cellular dynamics of cAMP have been investigated using a series of fluorescent indicators; however, their sensitivity was sub-optimal for detecting cAMP dynamics at a low concentration range, due to a low ligand affinity and/or poor dynamic r...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-20251-1
更新日期：2018-01-30 00:00:00
abstract：:High frequency repetitive transcranial magnetic stimulation (HF-rTMS) over the left dorsolateral prefrontal cortex (L-DLPFC) is a widely applied treatment protocol for chronic smoking and major depressive disorder. However, no previous study has measured the effects of rTMS on both nicotine consumption and anxiety/dep...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-80927-5
更新日期：2021-01-15 00:00:00
abstract：:Streptococcus mutans is known to be a major causative agent of dental caries, and strains expressing the cell surface collagen-binding Cnm protein contribute to the development of several systemic diseases. A relationship between tonsillar immunity and glomerulonephritis has been recognized in IgA nephropathy (IgAN), ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-56679-2
更新日期：2019-12-27 00:00:00
abstract：:An empirical approach was taken to screen a novel synthetic compound library designed to be active against Gram-positive bacteria. We obtained five compounds that were active against spores from the model organism Bacillus subtilis and the food-borne pathogen Bacillus cereus during our population based experiments. Us...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-27529-4
更新日期：2018-06-14 00:00:00
abstract：:Previous studies demonstrated distinct neural correlates underpinning impaired self-regulation (dysregulation) between individuals with autism spectrum disorder (ASD) and typically developing controls (TDC). However, the impacts of dysregulation on white matter (WM) microstructural property in ASD and TDC remain uncle...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-70836-y
更新日期：2020-08-14 00:00:00
abstract：:Mutations in the TGFβR2 gene have been associated with a life threatening risk of aortic dissection but no arrhythmic death has been previously reported. Two young females carrying a TGFβR2 mutation, initially diagnosed as Marfan syndrome or Loeys Dietz syndrome, presented sudden death with autopsy ruling out dissecti...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-31298-5
更新日期：2018-08-29 00:00:00
abstract：:Test anxiety is a condition in which people experience extreme distress and anxiety before and in test situations. It affects up to 40 percent of all students. Conventional treatment includes both medication and psychotherapy, but studies also demonstrated that placebos affect anxiety symptoms. Although in the traditi...
journal_title：Scientific reports
pub_type： 杂志文章,随机对照试验
doi：10.1038/s41598-019-49466-6
更新日期：2019-09-16 00:00:00
abstract：:We present detailed investigations on single crystals of quaternary EuRhAl4Si2 and EuIrAl4Si2. The two compounds order antiferromagnetically at TN1 = 11.7 and 14.7 K, respectively, each undergoing two magnetic transitions. The magnetic properties in the ordered state present a large anisotropy despite Eu(2+)being an S...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep12021
更新日期：2015-07-09 00:00:00
abstract：:Photonic qubits lie at the heart of quantum information technology, often encoding information in their polarization state. So far, only low-frequency optical and infrared photons have been employed as flying qubits, as the resources that are at present easiest to control. With their essentially different way of inter...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep25136
更新日期：2016-04-27 00:00:00
abstract：:A number of Bruton's tyrosine kinase (BTK) inhibitors are currently in development, yet it has been difficult to visualize BTK expression and pharmacological inhibition in vivo in real time. We synthesized a fluorescent, irreversible BTK binder based on the drug Ibrutinib and characterized its behavior in cells and in...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep04782
更新日期：2014-04-24 00:00:00
abstract：:Corals build their skeletons using extracellular calcifying fluid located in the tissue-skeleton interface. However, the mechanism by which corals control the transport of calcium and other ions from seawater and the mechanism of constant alkalization of calcifying fluid are largely unknown. To address these questions...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep40324
更新日期：2017-01-18 00:00:00
abstract：:Natural history collections are often plagued by missing or inaccurate metadata for collection items, particularly for specimens that are difficult to verify or rare. Avian eggshell in particular can be challenging to identify due to extensive morphological ambiguity among taxa. Species identifications can be improved...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-79852-4
更新日期：2021-01-15 00:00:00
abstract：:A discrete optical system can broaden the spatial distribution of the input light through optical coupling in array waveguides, just like diffraction in continuous media. Here, we theoretically demonstrate several kinds of control methods of optical field propagation in a discrete optical system, which is composed of ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-05414-w
更新日期：2017-07-12 00:00:00
abstract：:The electrowetting lenses has attracted researchers in many fields, such as biology, beam shaping, and drug delivery. Previous research on electrowetting lens has focused on neither expanding the dynamic focal length range nor reducing the wavefront aberration. However, the properties with large numerical aperture and...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-73260-4
更新日期：2020-10-01 00:00:00
abstract：:There is growing evidence that hydrogen sulfide (H2S) is involved in many physiological processes in plants, but the role of H2S in dark-induced leaf senescence remains unknown. In this work, we found that H2S not only inhibited chlorophyll degradation but also caused the accumulation of photoreactive pheide a in deta...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-02872-0
更新日期：2017-06-01 00:00:00
abstract：:Uric acid (UA) has been proposed as an important risk factor for cardiovascular and renal morbidity. We conducted an interventional trial to assess effects of altered salt intake on plasma and urine UA levels and the relationship between UA levels and salt sensitivity in humans. Ninety subjects (18-65 years old) were ...
journal_title：Scientific reports
pub_type： 临床试验,杂志文章
doi：10.1038/s41598-018-20048-2
更新日期：2018-01-23 00:00:00
abstract：:The precision and efficiency of the registration of megavolt-level electronic portal imaging devices (EPID) images with the naked eye in the orthogonal window are reduced. This study aims to develop a new registration algorithm with enhanced accuracy and efficiency. Ten setup errors with different translation and rota...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-67331-9
更新日期：2020-06-24 00:00:00
abstract：:The neuropeptide oxytocin has been shown to affect social interaction. Meanwhile, the underlying mechanism remains highly debated. Using an interpersonal finger-tapping paradigm, we investigated whether oxytocin affects the ability to synchronise with and adapt to the behaviour of others. Dyads received either oxytoci...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep38416
更新日期：2016-12-08 00:00:00
abstract：:Trypanosomes are masters of adaptation to different host environments during their complex life cycle. Large-scale proteomic approaches provide information on changes at the cellular level, and in a systematic way. However, detailed work on single components is necessary to understand the adaptation mechanisms on a mo...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep35826
更新日期：2016-10-25 00:00:00
abstract：:Resistance to 157 different herbicides and 88% of known sites of action has been observed, with many weeds resistant to two or more modes. Coupled with tighter environmental regulation, this demonstrates the need to identify new modes of action and novel herbicides. The plant sphingolipid biosynthetic enzyme, inositol...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-44544-1
更新日期：2019-05-30 00:00:00
abstract：:Genome-wide experiments to map the DNA-binding locations of transcription-associated factors (TFs) have shown that the number of genes bound by a TF far exceeds the number of possible direct target genes. Distinguishing functional from non-functional binding is therefore a major challenge in the study of transcription...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep20649
更新日期：2016-02-09 00:00:00
abstract：:Current studies addressing the influence of interleukin-33 or its receptor (IL-33R/ST2) on development of atopic dermatitis-like inflammation in mice have reported conflicting results. We compared the response in single- and double-deficient IL-33-/-/ST2-/- C57BL/6J BomTac mice in the well-established calcipotriol-ind...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-63410-z
更新日期：2020-04-15 00:00:00
abstract：:Balancing the amounts of enzymes is one of the important factors to achieve optimum performance of a designed metabolic pathway. However, the random mutagenesis approach is impractical since it requires searching an unnecessarily large number of variants and often results in searching a narrow range of expression leve...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep04515
更新日期：2014-03-31 00:00:00
abstract：:Plasmacytoid dendritic cells (pDCs) are specialized in the production of interferons (IFNs) in response to viral infections. The Flaviviridae family comprises enveloped RNA viruses such as Hepatitis C virus (HCV) and Dengue virus (DENV). Cell-free flaviviridae virions poorly stimulate pDCs to produce IFN. By contrast,...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-29235-7
更新日期：2018-07-18 00:00:00
abstract：:Microglia are the resident phagocytic cells with various functions in the central nervous system, and the morphologies of microglia imply the different stages and functions. In optical nerve transection (ONT) model in the retina, the retrograde degeneration of retinal ganglion cells (RGCs) induces microglial activatio...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep10788
更新日期：2015-06-02 00:00:00
