当前位置： SCI文献检索 > Scientific Reports期刊下所有文献 > Overlapping motifs on the herpes viral proteins ICP27 and ORF57 mediate interactions with the mRNA export adaptors ALYREF and UIF.

Overlapping motifs on the herpes viral proteins ICP27 and ORF57 mediate interactions with the mRNA export adaptors ALYREF and UIF.

Abstract：

:The TREX complex mediates the passage of bulk cellular mRNA export to the nuclear export factor TAP/NXF1 via the export adaptors ALYREF or UIF, which appear to act in a redundant manner. TREX complex recruitment to nascent RNA is coupled with 5' capping, splicing and polyadenylation. Therefore to facilitate expression from their intronless genes, herpes viruses have evolved a mechanism to circumvent these cellular controls. Central to this process is a protein from the conserved ICP27 family, which binds viral transcripts and cellular TREX complex components including ALYREF. Here we have identified a novel interaction between HSV-1 ICP27 and an N-terminal domain of UIF in vivo, and used NMR spectroscopy to locate the UIF binding site within an intrinsically disordered region of ICP27. We also characterized the interaction sites of the ICP27 homolog ORF57 from KSHV with UIF and ALYREF using NMR, revealing previously unidentified binding motifs. In both ORF57 and ICP27 the interaction sites for ALYREF and UIF partially overlap, suggestive of mutually exclusive binding. The data provide a map of the binding sites responsible for promoting herpes virus mRNA export, enabling future studies to accurately probe these interactions and reveal the functional consequences for UIF and ALYREF redundancy.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Tunnicliffe RB,Tian X,Storer J,Sandri-Goldin RM,Golovanov AP

doi

10.1038/s41598-018-33379-x

subject

Has Abstract

pub_date

2018-10-09 00:00:00

pages

15005

issue

1

issn

2045-2322

pii

10.1038/s41598-018-33379-x

journal_volume

8

pub_type

杂志文章

相关文献

Scientific Reports文献大全
  • Coherent perfect absorption in one-sided reflectionless media.

    abstract：:In optical experiments one-sided reflectionless (ORL) and coherent perfect absorption (CPA) are unusual scattering properties yet fascinating for their fundamental aspects and for their practical interest. Although these two concepts have so far remained separated from each other, we prove that the two phenomena are i...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep35356

    authors： Wu JH,Artoni M,La Rocca GC

    更新日期：2016-10-19 00:00:00

  • Better brain connectivity is associated with higher total fat mass and lower visceral adipose tissue in military pilots.

    abstract：:A lack of exercise leads to being overweight or obese affecting regional brain structure and functional connectivity associated with impaired cognitive function and dementia. In recent decades, several studies of healthy individuals suggest that adiposity may also produce negative independent effects on the brain. We ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-57345-3

    authors： Cárdenas D,Madinabeitia I,Vera J,de Teresa C,Alarcón F,Jiménez R,Catena A

    更新日期：2020-01-17 00:00:00

  • Complex rice systems to improve rice yield and yield stability in the face of variable weather conditions.

    abstract：:Extreme weather events and pest outbreaks decrease rice yields and increase their variability, presenting challenges for the agricultural agenda to increase rice productivity and yield stability in Asia. The integration of azolla, fish and ducks has been shown to create robust systems that maintain high yields under h...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-32915-z

    authors： Khumairoh U,Lantinga EA,Schulte RPO,Suprayogo D,Groot JCJ

    更新日期：2018-10-03 00:00:00

  • Link between plasminogen activator inhibitor-1 and cardiovascular risk in chronic hepatitis C after viral clearance.

    abstract：:The pathophysiological implications of plasminogen activator inhibitor-1 (PAI-1) in HCV infection remain obscure. This prospective study evaluated 669 HCV patients, of whom 536 had completed a course of anti-HCV therapy and had pre-, peri- and post-therapy measurements of various profiles, including PAI-1 levels. Mult...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep42503

    authors： Chang ML,Lin YS,Pao LH,Huang HC,Chiu CT

    更新日期：2017-02-13 00:00:00

  • An extraterrestrial trigger for the Early Cretaceous massive volcanism? Evidence from the paleo-Tethys Ocean.

    abstract：:The Early Cretaceous Greater Ontong Java Event in the Pacific Ocean may have covered ca. 1% of the Earth's surface with volcanism. It has puzzled scientists trying to explain its origin by several mechanisms possible on Earth, leading others to propose an extraterrestrial trigger to explain this event. A large oceanic...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep00268

    authors： Tejada ML,Ravizza G,Suzuki K,Paquay FS

    更新日期：2012-01-01 00:00:00

  • VirusMapper: open-source nanoscale mapping of viral architecture through super-resolution microscopy.

    abstract：:The nanoscale molecular assembly of mammalian viruses during their infectious life cycle remains poorly understood. Their small dimensions, generally bellow the 300nm diffraction limit of light microscopes, has limited most imaging studies to electron microscopy. The recent development of super-resolution (SR) light m...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep29132

    authors： Gray RD,Beerli C,Pereira PM,Scherer KM,Samolej J,Bleck CK,Mercer J,Henriques R

    更新日期：2016-07-04 00:00:00

  • Comparative metabonomics of Wenxin Keli and Verapamil reveals differential roles of gluconeogenesis and fatty acid β-oxidation in myocardial injury protection.

    abstract：:Metabonomics/metabolomics is a rapid technology for comprehensive profiling of small molecule metabolites in cells, tissues, or whole organisms, the application of which has led to understanding pathophysiologic mechanisms of cardiometabolic diseases, defining predictive biomarkers for those diseases, and also assessi...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-09547-w

    authors： Jiang M,Wang Q,Chen J,Wang Y,Fan G,Zhu Y

    更新日期：2017-08-18 00:00:00

  • Loss of A20 in BM-MSCs regulates the Th17/Treg balance in Rheumatoid Arthritis.

    abstract：:Mesenchymal stem cells (MSCs) are multi-potent cells that are self-renewable and possess the potential to differentiate into multiple lineages. Several studies demonstrated that MSCs could regulate a Th17/Treg balance and could be a potential therapeutic target for Rheumatoid Arthritis (RA). A20 is highly expressed in...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-18693-0

    authors： Feng Z,Zhai Y,Zheng Z,Yang L,Luo X,Dong X,Han Q,Jin J,Chen ZN,Zhu P

    更新日期：2018-01-11 00:00:00

  • Biodegradation of 2-hydroxyl-1,4 naphthoquinone (lawsone) by Pseudomonas taiwanensis LH-3 isolated from activated sludge.

    abstract：:2-hydroxy-1,4 naphthoquinone (lawsone) is widely used and induces environmental pollutions during its production and application. In the present study, a lawsone-degrading bacterium strain, LH-3 was successfully isolated from the activated sludge. Based on the 16S rRNA gene analysis, the strain LH-3 phylogenetically b...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-06338-1

    authors： Yang L,Cai T,Ding D,Cai T,Jiang C,Li H,Yang Q,Chen L

    更新日期：2017-07-28 00:00:00

  • InGaN Light-Emitting Diodes with an Embedded Nanoporous GaN Distributed Bragg Reflectors.

    abstract：:InGaN light emitting diodes (LED) structure with an embedded 1/4λ-stack nanoporous-GaN/undoped-GaN distributed Bragg reflectors (DBR) structure have been demonstrated. Si-heavily doped GaN epitaxial layers (n(+)-GaN) in the 12-period n(+)-GaN/u-GaN stack structure are transformed into low refractive index nanoporous G...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep29138

    authors： Shiu GY,Chen KT,Fan FH,Huang KP,Hsu WJ,Dai JJ,Lai CF,Lin CF

    更新日期：2016-07-01 00:00:00

  • Auranofin, at clinically achievable dose, protects mice and prevents recurrence from Clostridioides difficile infection.

    abstract：:Clostridioides difficile is the leading cause of nosocomial infections and a worldwide urgent public health threat. Without doubt, there is an urgent need for new effective anticlostridial agents due to the increasing incidence and severity of C. difficile infection (CDI). The aim of the present study is to investigat...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-64882-9

    authors： Abutaleb NS,Seleem MN

    更新日期：2020-05-07 00:00:00

  • Human GPR42 is a transcribed multisite variant that exhibits copy number polymorphism and is functional when heterologously expressed.

    abstract：:FFAR3 (GPR41) is a G-protein coupled receptor for which short-chain fatty acids serve as endogenous ligands. The receptor is found on gut enteroendocrine L-cells, pancreatic β-cells, and sympathetic neurons, and is implicated in obesity, diabetes, allergic airway disease, and altered immune function. In primates, FFAR...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep12880

    authors： Puhl HL 3rd,Won YJ,Lu VB,Ikeda SR

    更新日期：2015-08-11 00:00:00

  • Microaneurysms cause refractory macular edema in branch retinal vein occlusion.

    abstract：:Intravitreal anti-vascular endothelial growth factor (VEGF) agents can treat macular edema (ME) in branch retinal vein occlusion (BRVO). However, refractory ME, the mechanism of which is not well elucidated, occurs frequently. Sixty-six eyes with ME secondary to BRVO were enrolled in this retrospective observational c...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep29445

    authors： Tomiyasu T,Hirano Y,Yoshida M,Suzuki N,Nishiyama T,Uemura A,Yasukawa T,Ogura Y

    更新日期：2016-07-08 00:00:00

  • New Genome-Wide Algorithm Identifies Novel In-Vivo Expressed Mycobacterium Tuberculosis Antigens Inducing Human T-Cell Responses with Classical and Unconventional Cytokine Profiles.

    abstract：:New strategies are needed to develop better tools to control TB, including identification of novel antigens for vaccination. Such Mtb antigens must be expressed during Mtb infection in the major target organ, the lung, and must be capable of eliciting human immune responses. Using genome-wide transcriptomics of Mtb in...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep37793

    authors： Coppola M,van Meijgaarden KE,Franken KL,Commandeur S,Dolganov G,Kramnik I,Schoolnik GK,Comas I,Lund O,Prins C,van den Eeden SJ,Korsvold GE,Oftung F,Geluk A,Ottenhoff TH

    更新日期：2016-11-28 00:00:00

  • Recent loss of closed forests is associated with Ebola virus disease outbreaks.

    abstract：:Ebola virus disease (EVD) is a contagious, severe and often lethal form of hemorrhagic fever in humans. The association of EVD outbreaks with forest clearance has been suggested previously but many aspects remained uncharacterized. We used remote sensing techniques to investigate the association between deforestation ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-14727-9

    authors： Olivero J,Fa JE,Real R,Márquez AL,Farfán MA,Vargas JM,Gaveau D,Salim MA,Park D,Suter J,King S,Leendertz SA,Sheil D,Nasi R

    更新日期：2017-10-30 00:00:00

  • Shared somatosensory and motor functions in musicians.

    abstract：:Skilled individuals are characterized by fine-tuned perceptual and motor functions. Here, we tested the idea that the sensory and motor functions of highly-trained individuals are coupled. We assessed the relationships among multifaceted somatosensory and motor functions of expert pianists. The results demonstrated a ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep37632

    authors： Hosoda M,Furuya S

    更新日期：2016-11-25 00:00:00

  • Transition metal sulfides grown on graphene fibers for wearable asymmetric supercapacitors with high volumetric capacitance and high energy density.

    abstract：:Fiber shaped supercapacitors are promising candidates for wearable electronics because they are flexible and light-weight. However, a critical challenge of the widespread application of these energy storage devices is their low cell voltages and low energy densities, resulting in limited run-time of the electronics. H...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep26890

    authors： Cai W,Lai T,Lai J,Xie H,Ouyang L,Ye J,Yu C

    更新日期：2016-06-01 00:00:00

  • Insights about multi-targeting and synergistic neuromodulators in Ayurvedic herbs against epilepsy: integrated computational studies on drug-target and protein-protein interaction networks.

    abstract：:Epilepsy, that comprises a wide spectrum of neuronal disorders and accounts for about one percent of global disease burden affecting people of all age groups, is recognised as apasmara in the traditional medicinal system of Indian antiquity commonly known as Ayurveda. Towards exploring the molecular level complex regu...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-46715-6

    authors： Choudhary N,Singh V

    更新日期：2019-07-22 00:00:00

  • The lag-phase during diauxic growth is a trade-off between fast adaptation and high growth rate.

    abstract：:Bi-phasic or diauxic growth is often observed when microbes are grown in a chemically defined medium containing two sugars (for example glucose and lactose). Typically, the two growth stages are separated by an often lengthy phase of arrested growth, the so-called lag-phase. Diauxic growth is usually interpreted as an...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep25191

    authors： Chu D,Barnes DJ

    更新日期：2016-04-29 00:00:00

  • In Silico Models of DNA Damage and Repair in Proton Treatment Planning: A Proof of Concept.

    abstract：:There is strong in vitro cell survival evidence that the relative biological effectiveness (RBE) of protons is variable, with dependence on factors such as linear energy transfer (LET) and dose. This is coupled with the growing in vivo evidence, from post-treatment image change analysis, of a variable RBE. Despite thi...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-56258-5

    authors： Smith EAK,Henthorn NT,Warmenhoven JW,Ingram SP,Aitkenhead AH,Richardson JC,Sitch P,Chadwick AL,Underwood TSA,Merchant MJ,Burnet NG,Kirkby NF,Kirkby KJ,Mackay RI

    更新日期：2019-12-27 00:00:00

  • Down regulation of p-coumarate 3-hydroxylase in petunia uniquely alters the profile of emitted floral volatiles.

    abstract：:Petunia × hybrida cv 'Mitchell Diploid' floral volatile benzenoid/phenylpropanoid (FVBP) biosynthesis ultimately produces floral volatiles derived sequentially from phenylalanine, cinnamic acid, and p-coumaric acid. In an attempt to better understand biochemical steps after p-coumaric acid production, we cloned and ch...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-45183-2

    authors： Kim JY,Swanson RT,Alvarez MI,Johnson TS,Cho KH,Clark DG,Colquhoun TA

    更新日期：2019-06-20 00:00:00

  • Characteristics of Atrial Fibrillation Patients Suffering Esophageal Injury Caused by Ablation for Atrial Fibrillation.

    abstract：:The close proximity of esophagus to the left atrial posterior wall predisposes esophagus to thermal injury during catheter ablation for atrial fibrillation (AF). In this retrospective study, we aimed to investigate risk factors of esophageal injury (EI) caused by catheter ablation for AF. Patients who underwent first-...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-59539-6

    authors： Zhang P,Zhang YY,Ye Q,Jiang RH,Liu Q,Ye Y,Wu JG,Sheng X,Fu GS,Cha YM,Jiang CY

    更新日期：2020-02-17 00:00:00

  • A plasmonic refractive index sensor with an ultrabroad dynamic sensing range.

    abstract：:Refractive index sensors based on surface plasmon resonance (SPR) promise to deliver high sensitivities. However, these sensitivities depend on the derivative of the monitored SPR parameters near resonance, so this dependency leads to a relatively narrow detection range for refractive index changes. Herein, we introdu...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-41353-4

    authors： Cheng YC,Chang YJ,Chuang YC,Huang BZ,Chen CC

    更新日期：2019-03-26 00:00:00

  • Enhancement of Environmental Hazard Degradation in the Presence of Lignin: a Proteomics Study.

    abstract：:Proteomics studies of fungal systems have progressed dramatically based on the availability of more fungal genome sequences in recent years. Different proteomics strategies have been applied toward characterization of fungal proteome and revealed important gene functions and proteome dynamics. Presented here is the ap...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-10132-4

    authors： Sun S,Xie S,Cheng Y,Yu H,Zhao H,Li M,Li X,Zhang X,Yuan JS,Dai SY

    更新日期：2017-09-12 00:00:00

  • Systems approach to characterize the metabolism of liver cancer stem cells expressing CD133.

    abstract：:Liver cancer stem cells (LCSCs) have attracted attention because they cause therapeutic resistance in hepatocellular carcinoma (HCC). Understanding the metabolism of LCSCs can be a key to developing therapeutic strategy, but metabolic characteristics have not yet been studied. Here, we systematically analyzed and comp...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep45557

    authors： Hur W,Ryu JY,Kim HU,Hong SW,Lee EB,Lee SY,Yoon SK

    更新日期：2017-04-03 00:00:00

  • Abscisic and Jasmonic Acids Contribute to Soybean Tolerance to the Soybean Aphid (Aphis glycines Matsumura).

    abstract：:Plant resistance can provide effective, economical, and sustainable pest control. Tolerance to the soybean aphid has been identified and confirmed in the soybean KS4202. Although its resistance mechanisms are not fully understood, evidence suggests that enhanced detoxification of reactive oxygen species (ROS) is an ac...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-33477-w

    authors： Chapman KM,Marchi-Werle L,Hunt TE,Heng-Moss TM,Louis J

    更新日期：2018-10-11 00:00:00

  • Active and passive sexual roles that arise in Drosophila male-male courtship are modulated by dopamine levels in PPL2ab neurons.

    abstract：:The neurology of male sexuality has been poorly studied owing to difficulties in studying brain circuitry in humans. Dopamine (DA) is essential for both physiological and behavioural responses, including the regulation of sexuality. Previous studies have revealed that alterations in DA synthesis in dopaminergic neuron...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep44595

    authors： Chen SL,Chen YH,Wang CC,Yu YW,Tsai YC,Hsu HW,Wu CL,Wang PY,Chen LC,Lan TH,Fu TF

    更新日期：2017-03-15 00:00:00

  • Early change in circulating tumor DNA as a potential predictor of response to chemotherapy in patients with metastatic colorectal cancer.

    abstract：:The impact of ctDNA changes after chemotherapy on the clinical outcomes of patients with metastatic colorectal cancer (mCRC) remains unclear. The present study evaluated the clinical implications of the early change in ctDNA levels as a predictor of objective response and clinical outcome in mCRC patients who received...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-53711-3

    authors： Osumi H,Shinozaki E,Yamaguchi K,Zembutsu H

    更新日期：2019-11-22 00:00:00

  • Applications of chitosan (CHI)-reduced graphene oxide (rGO)-polyaniline (PAni) conducting composite electrode for energy generation in glucose biofuel cell.

    abstract：:A glassy carbon electrode (GC) immobilized with chitosan (CHI)@reduced graphene (rGO)-polyaniline (PAni)/ferritin (Frt)/glucose oxidase (GOx) bioelectrode was prepared. The prepared electrode was characterized by using cyclic voltammetry (CV), linear sweep voltammetry (LSV) and electrochemical impedance spectroscopy (...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-67253-6

    authors： Haque SU,Nasar A,Inamuddin,Rahman MM

    更新日期：2020-06-26 00:00:00

  • Repellency Assessment of Nepeta cataria Essential Oils and Isolated Nepetalactones on Aedes aegypti.

    abstract：:There is an increased need for improved and affordable insect repellents to reduce transmission of rapidly spreading diseases with high mortality rates. Natural products are often used when DEET cannot be afforded or accessed and when consumers choose not to use a synthetic repellent. The essential oils from two newly...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-36814-1

    authors： Reichert W,Ejercito J,Guda T,Dong X,Wu Q,Ray A,Simon JE

    更新日期：2019-02-06 00:00:00