Early change in circulating tumor DNA as a potential predictor of response to chemotherapy in patients with metastatic colorectal cancer.

abstract：:α-synuclein plays a key role in the pathogenesis of Parkinson's disease (PD); its deposits are found as amyloid fibrils in Lewy bodies and Lewy neurites, the histopathological hallmarks of PD. Amyloid fibrillation is a progressive polymerization path starting from peptide/protein misfolding and proceeding through the ...

journal_title：Scientific reports

authors： Palazzi L,Bruzzone E,Bisello G,Leri M,Stefani M,Bucciantini M,Polverino de Laureto P

更新日期：2018-05-29 00:00:00

abstract：:Transcriptome diversity in adult neurons is partly mediated by RNA binding proteins (RBPs), including the RBFOX factors. RBFOX3/NeuN, a neuronal maturity marker, is strangely depleted in suprachiasmatic nucleus (SCN) neurons, and may be compensated by a change in Rbfox2 expression. In this study, we found no superfici...

journal_title：Scientific reports

authors： Partridge LMM,Carter DA

更新日期：2017-08-30 00:00:00

abstract：:Spitzoid neoplasms constitute a morphologically distinct category of melanocytic tumors, encompassing Spitz nevus (benign), atypical Spitz tumor (intermediate malignant potential), and spitzoid melanoma (fully malignant). Currently, no reliable histopathological criteria or molecular marker is known to distinguish bor...

journal_title：Scientific reports

authors： Lee S,Barnhill RL,Dummer R,Dalton J,Wu J,Pappo A,Bahrami A

更新日期：2015-06-10 00:00:00

abstract：:Temporal-difference (TD) learning models afford the neuroscientist a theory-driven roadmap in the quest for the neural mechanisms of reinforcement learning. The application of these models to understanding the role of phasic midbrain dopaminergic responses in reward prediction learning constitutes one of the greatest ...

journal_title：Scientific reports

authors： Mahmud A,Petrov P,Esber GR,Iordanova MD

更新日期：2019-04-12 00:00:00

abstract：:PC4, a well-known general transcription cofactor, has multiple functions in transcription and DNA repair. Residue W89, is engaged in stacking interactions with DNA in PC4, but substituted by tyrosine in some PC4 orthologous proteins. In order to understand the consequences and reveal the molecular details of this subs...

journal_title：Scientific reports

authors： Huang J,Zhao Y,Liu H,Huang D,Cheng X,Zhao W,Taylor IA,Liu J,Peng YL

更新日期：2015-03-05 00:00:00

abstract：:Graphene has been identified as an emerging horizon for a nanoscale photonic platform because the Fermi level of intrinsic graphene can be engineered to support surface plasmons (SPs). The current solid back electrical gating and chemical doping methods cannot facilitate the demonstration of graphene SPs at the near-i...

journal_title：Scientific reports

authors： Zhang Q,Li X,Hossain MM,Xue Y,Zhang J,Song J,Liu J,Turner MD,Fan S,Bao Q,Gu M

更新日期：2014-10-09 00:00:00

abstract：:Carbon fiber-synthetic foam core sandwich composites are widely used for many structural applications due to their superior mechanical performance and low weight. Unfortunately these structures typically have very poor acoustic performance. There is increasingly growing demand in mitigating this noise issue in sandwic...

journal_title：Scientific reports

authors： Sargianis J,Kim HI,Suhr J

更新日期：2012-01-01 00:00:00

abstract：:Caterpillars of the silk moth genus Hyalophora (Lepidoptera; Saturniidae) construct multilayered cocoons that function as overwintering housing during the pupal to adult developmental period. While all cocoons share the primary function of protecting the developing moth, cocoons spun by different Hyalophora silk moth ...

journal_title：Scientific reports

authors： Guerra PA,Lawson LP,Gatto LJ,Albright ME,Smith SJ

更新日期：2020-03-27 00:00:00

abstract：:This systematic review and meta-analysis was designed to investigate whether maternal psychological stress and recent life events are associated with an increased risk of miscarriage. A literature search was conducted to identify studies reporting miscarriage in women with and without history of exposure to psychologi...

journal_title：Scientific reports

authors： Qu F,Wu Y,Zhu YH,Barry J,Ding T,Baio G,Muscat R,Todd BK,Wang FF,Hardiman PJ

更新日期：2017-05-11 00:00:00

abstract：:CRISPR/Cas9-mediated genome editing is a next-generation strategy for genetic modifications. Typically, sgRNA is constitutively expressed relying on RNA polymerase III promoters. Polymerase II promoters initiate transcription in a flexible manner, but sgRNAs generated by RNA polymerase II promoter lost their nuclease ...

journal_title：Scientific reports

authors： Xie C,Chen YL,Wang DF,Wang YL,Zhang TP,Li H,Liang F,Zhao Y,Zhang GY

更新日期：2017-07-19 00:00:00

abstract：:The transglutaminase (TG) family comprises eight isozymes that form the isopeptide bonds between glutamine and lysine residues and contribute to the fibrotic diseases via crosslinking-mediated stabilization of ECM and the activation of TGF-β in several tissues. However, despite a growing body of evidence implicating T...

journal_title：Scientific reports

authors： Tatsukawa H,Tani Y,Otsu R,Nakagawa H,Hitomi K

更新日期：2017-03-22 00:00:00

abstract：:Transcriptome analysis by RNA-seq technology allows novel insights into gene expression and regulatory networks in health and disease. To better understand the molecular basis of renal fibrosis, we performed RNA-seq analysis in the Unilateral Ureteric Obstruction (UUO) mouse model. We analysed sham operated, 2- and 8-...

journal_title：Scientific reports

authors： Arvaniti E,Moulos P,Vakrakou A,Chatziantoniou C,Chadjichristos C,Kavvadas P,Charonis A,Politis PK

更新日期：2016-05-18 00:00:00

abstract：:The ejection of internal organs, i.e., evisceration, is a well-known phenomenon in sea-cucumbers. We report the ability of a member of the Chordate phyla, the tropical ascidian Polycarpa mytiligera, to eviscerate and regenerate its gut within 12 days, and to rebuild its branchial sac within 19 days. Evisceration occur...

journal_title：Scientific reports

authors： Shenkar N,Gordon T

更新日期：2015-04-16 00:00:00

abstract：:Faithful DNA replication is a prerequisite for cell proliferation. Several cytological studies have shown that chromosome structures alter in the S-phase of the cell cycle. However, the molecular mechanisms behind the alteration of chromosome structures associated with DNA replication have not been elucidated. Here, w...

journal_title：Scientific reports

authors： Ruan K,Yamamoto TG,Asakawa H,Chikashige Y,Kimura H,Masukata H,Haraguchi T,Hiraoka Y

更新日期：2015-07-30 00:00:00

abstract：:The purpose of this study was to compare the performance of arrival-time-insensitive (ATI) and arrival-time-sensitive (ATS) computed tomography perfusion (CTP) algorithms in Philips IntelliSpace Portal (v9, ISP) and to investigate optimal thresholds for ATI regarding the prediction of final infarct volume (FIV). Retro...

journal_title：Scientific reports

authors： Pennig L,Thiele F,Goertz L,Laukamp KR,Perkuhn M,Kabbasch C,Schlamann M,Fink GR,Borggrefe J

更新日期：2020-06-09 00:00:00

abstract：:Werner syndrome (WS) is the canonical adult human progeroid ('premature aging') syndrome. Patients with this autosomal recessive Mendelian disorder display constitutional genomic instability and an elevated risk of important age-associated diseases including cancer. Remarkably few analyses of WS patient tissue and tum...

journal_title：Scientific reports

authors： Tokita M,Kennedy SR,Risques RA,Chun SG,Pritchard C,Oshima J,Liu Y,Bryant-Greenwood PK,Welcsh P,Monnat RJ

更新日期：2016-08-25 00:00:00

abstract：:Although recent studies focused on traditional Chinese medicine (TCM) for the treatment of refractory schizophrenia have reported that it may be beneficial, there is still lack of convincing evidence and critical meta-analytic work regarding its effectiveness as an adjunctive therapy. Therefore, we performed a meta-an...

journal_title：Scientific reports

authors： Wei YY,Lin WF,Zhang TH,Tang YX,Wang JJ,Zhong MF

更新日期：2018-04-18 00:00:00

abstract：:Accumulating evidences suggest that p53 is a key coordinator of cellular events triggered by oxidative stress often associated with the impairment in thiamine metabolism and its functions. However, there are limited data regarding the pursuant feedback between p53 transactivation and thiamine homeostasis. Impairment i...

journal_title：Scientific reports

authors： Chornyy S,Parkhomenko Y,Chorna N

更新日期：2017-09-06 00:00:00

abstract：:Autistic spectrum disorder (ASD) is a neurodevelopmental disorder characterized by impairment in social communication and restricted/repetitive behavior patterns or interests. Antagonists targeting histamine H3 receptor (H3R) are considered potential therapeutic agents for the therapeutic management of different brain...

journal_title：Scientific reports

authors： Eissa N,Jayaprakash P,Azimullah S,Ojha SK,Al-Houqani M,Jalal FY,Łażewska D,Kieć-Kononowicz K,Sadek B

更新日期：2018-08-30 00:00:00

abstract：:Measurement-based quantum computing is one of the most promising quantum computing models. Although various universal resource states have been proposed so far, it was open whether only two Pauli bases are enough for both of universal measurement-based quantum computing and its verification. In this paper, we construc...

journal_title：Scientific reports

authors： Takeuchi Y,Morimae T,Hayashi M

更新日期：2019-09-19 00:00:00

abstract：:Apterous (Ap), the best studied LIM-homeodomain transcription factor in Drosophila, cooperates with the cofactor Chip (Chi) to regulate transcription of specific target genes. Although Ap regulates various developmental processes, its function in the adult brain remains unclear. Here, we report that Ap and Chi in the ...

journal_title：Scientific reports

authors： Shimada N,Inami S,Sato S,Kitamoto T,Sakai T

更新日期：2016-11-17 00:00:00

abstract：:Covalent functionalisation of graphene is a continuously progressing field of research. The optical properties of such derivatives attract particular attention. In virtually all optical responses, however, an enhancement in peak intensity with increase of sp3 carbon content, and a vanishing of the peak position shift ...

journal_title：Scientific reports

authors： Vecera P,Eigler S,Koleśnik-Gray M,Krstić V,Vierck A,Maultzsch J,Schäfer RA,Hauke F,Hirsch A

更新日期：2017-03-27 00:00:00

abstract：:Helicobacter pylori (H. pylori) is one of the most important factors that affect the development of gastric cancer, and its mechanism remains un-elucidated. Our present study found that, miR-30a is crucial for regulating the growth and migration of H. pylori infected gastric cancer in vitro by targeting COX-2 and BCL9...

journal_title：Scientific reports

authors： Liu X,Ji Q,Zhang C,Liu X,Liu Y,Liu N,Sui H,Zhou L,Wang S,Li Q

更新日期：2017-08-02 00:00:00

abstract：:The global problem of unowned domestic cats, driven by their phenomenal reproductive success, carries significant economic, animal welfare and biodiversity costs. Desexing owned cats prior to puberty prevents unwanted litters that contribute to unowned cat populations. The prevalence and predictors of desexing, and th...

journal_title：Scientific reports

authors： Mazeau L,Wylie C,Boland L,Beatty JA

更新日期：2021-01-18 00:00:00

abstract：:The stress distribution around endosseous implants is an important determinant of the surgical success. However, no method developed so far to determine the implant stability is sensitive to the loading conditions of the bone-implant interface (BII). The objective of this study is to investigate whether a quantitative...

journal_title：Scientific reports

authors： Hériveaux Y,Nguyen VH,Geiger D,Haïat G

更新日期：2019-10-02 00:00:00

abstract：:The aim was to investigate the ability of self-assembling Peptide P11-4 Matrix (SAPM) to remineralize artificial initial caries lesions compared to the use of fluoride varnish. Volunteers were recruited for this randomised, cross-over in situ trial. Bovine specimens, half including orthodontic brackets, were recessed ...

journal_title：Scientific reports

authors： Jablonski-Momeni A,Korbmacher-Steiner H,Heinzel-Gutenbrunner M,Jablonski B,Jaquet W,Bottenberg P

更新日期：2019-01-22 00:00:00

abstract：:Autosomal dominant tubulointerstitial kidney disease (ADTKD) is an inherited disorder that causes progressive kidney damage and renal failure. Mutations in the UMOD gene, encoding uromodulin, lead to ADTKD-UMOD related. Uromodulin is a GPI-anchored protein exclusively produced by epithelial cells of the thick ascendin...

journal_title：Scientific reports

authors： Trudu M,Schaeffer C,Riba M,Ikehata M,Brambilla P,Messa P,Martinelli-Boneschi F,Rastaldi MP,Rampoldi L

更新日期：2017-08-07 00:00:00

abstract：:A central challenge in designing and administering effective anticoagulants is achieving the proper therapeutic window and dosage for each patient. The Hill coefficient, nH, which measures the steepness of a dose-response relationship, may be a useful gauge of this therapeutic window. We sought to measure the Hill coe...

journal_title：Scientific reports

authors： Chang JB,Quinnies KM,Realubit R,Karan C,Rand JH,Tatonetti NP

更新日期：2016-07-21 00:00:00

abstract：:Pseudooxynicotine amine oxidase (Pnao) is essential to the pyrrolidine pathway of nicotine degradation of Pseudomonas putida strain S16, which is significant for the detoxification of nicotine, through removing the CH3NH2 group. However, little is known about biochemical mechanism of this enzyme. Here, we characterize...

journal_title：Scientific reports

authors： Hu H,Wang W,Tang H,Xu P

更新日期：2015-12-04 00:00:00

abstract：:The accumulation of mannosyl-glycerate (MG), the salinity stress response osmolyte of Thermococcales, was investigated as a function of hydrostatic pressure in Thermococcus barophilus strain MP, a hyperthermophilic, piezophilic archaeon isolated from the Snake Pit site (MAR), which grows optimally at 40 MPa. Strain MP...

journal_title：Scientific reports

authors： Cario A,Jebbar M,Thiel A,Kervarec N,Oger PM

更新日期：2016-07-05 00:00:00