当前位置： SCI文献检索 > Scientific Reports期刊下所有文献 > TERT Promoter Mutations Are Predictive of Aggressive Clinical Behavior in Patients with Spitzoid Melanocytic Neoplasms.

TERT Promoter Mutations Are Predictive of Aggressive Clinical Behavior in Patients with Spitzoid Melanocytic Neoplasms.

Abstract：

:Spitzoid neoplasms constitute a morphologically distinct category of melanocytic tumors, encompassing Spitz nevus (benign), atypical Spitz tumor (intermediate malignant potential), and spitzoid melanoma (fully malignant). Currently, no reliable histopathological criteria or molecular marker is known to distinguish borderline from overtly malignant neoplasms. Because TERT promoter (TERT-p) mutations are common in inherently aggressive cutaneous conventional melanoma, we sought to evaluate their prognostic significance in spitzoid neoplasms. We analyzed tumors labeled as atypical Spitz tumor or spitzoid melanoma from 56 patients with available follow-up data for the association of TERT-p mutations, biallelic CDKN2A deletion, biallelic PTEN deletion, kinase fusions, BRAF/NRAS mutations, nodal status, and histopathological parameters with risk of hematogenous metastasis. Four patients died of disseminated disease and 52 patients were alive and disease free without extranodal metastasis (median follow-up, 32.5 months). We found TERT-p mutations in samples from the 4 patients who developed hematogenous metastasis but in none of tumors from patients who had favorable outcomes. Presence of TERT-p mutations was the most significant predictor of haematogenous dissemination (P < 0.0001) among variables analyzed. We conclude that TERT-p mutations identify a clinically high-risk subset of patients with spitzoid tumors. Application of TERT-p mutational assays for risk stratification in the clinic requires large-scale validation.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Lee S,Barnhill RL,Dummer R,Dalton J,Wu J,Pappo A,Bahrami A

doi

10.1038/srep11200

subject

Has Abstract

pub_date

2015-06-10 00:00:00

pages

11200

issn

2045-2322

pii

srep11200

journal_volume

5

pub_type

杂志文章

相关文献

Scientific Reports文献大全
  • Differential cohesin loading marks paired and unpaired regions of platypus sex chromosomes at prophase I.

    abstract：:Cohesins are vital for chromosome organisation during meiosis and mitosis. In addition to the important function in sister chromatid cohesion, these complexes play key roles in meiotic recombination, DSB repair, homologous chromosome pairing and segregation. Egg-laying mammals (monotremes) feature an unusually complex...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-04560-5

    authors： Casey AE,Daish TJ,Barbero JL,Grützner F

    更新日期：2017-06-26 00:00:00

  • Analysis of the genetic association between IL27 variants and coronary artery disease in a Chinese Han population.

    abstract：:Interleukin-27 (IL-27) is an important cytokine in inflammatory diseases, including coronary artery disease (CAD). To explore the precise role of IL-27 in CAD, we investigated the genetic association between IL27 and CAD in the GeneID Chinese Han population. A two-stage case control association analysis was performed ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep25782

    authors： Fan Q,Nie S,Li S,Liao Y,Zhang H,Zha L,Wang F,Tang T,Xia N,Xu C,Wang P,Xie T,Xie J,Lu Q,Li Q,Qian J,Li B,Wu G,Wu Y,Yang Y,Wang QK,Tu X,Cheng X

    更新日期：2016-05-12 00:00:00

  • STAT3 signaling stimulates miR-21 expression in bovine cumulus cells during in vitro oocyte maturation.

    abstract：:MicroRNAs are potent regulators of gene expression that have been widely implicated in reproduction and embryo development. Recent studies have demonstrated that miR-21, a microRNA extensively studied in the context of disease, is important in multiple facets of reproductive biology including folliculogenesis, ovulati...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-29874-w

    authors： Tscherner A,Brown AC,Stalker L,Kao J,Dufort I,Sirard MA,LaMarre J

    更新日期：2018-08-01 00:00:00

  • Intrinsic and extrinsic noise of gene expression in lineage trees.

    abstract：:Cell-to-cell heterogeneity is driven by stochasticity in intracellular reactions and the population dynamics. While these sources are usually studied separately, we develop an agent-based framework that accounts for both factors while tracking every single cell of a growing population. Apart from the common intrinsic ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-35927-x

    authors： Thomas P

    更新日期：2019-01-24 00:00:00

  • Structure-Property-Function Relationship in Humic Substances to Explain the Biological Activity in Plants.

    abstract：:Knowledge of the structure-property-function relationship of humic substances (HSs) is key for understanding their role in soil. Despite progress, studies on this topic are still under discussion. We analyzed 37 humic fractions with respect to their isotopic composition, structural characteristics, and properties resp...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep20798

    authors： García AC,de Souza LG,Pereira MG,Castro RN,García-Mina JM,Zonta E,Lisboa FJ,Berbara RL

    更新日期：2016-02-10 00:00:00

  • Lath formation mechanisms and twinning as lath martensite substructures in an ultra low-carbon iron alloy.

    abstract：:Lath martensite is the dominant microstructural feature in quenched low-carbon Fe-C alloys. Its formation mechanism is not clear, despite extensive research. The microstructure of an Fe-0.05 C (wt.%) alloy water-quenched at various austenitizing temperatures has been investigated using transmission electron microscopy...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-32679-6

    authors： Ping DH,Guo SQ,Imura M,Liu X,Ohmura T,Ohnuma M,Lu X,Abe T,Onodera H

    更新日期：2018-09-24 00:00:00

  • The contrasting roles of creep and stress relaxation in the time-dependent deformation during in-situ cooling of a nickel-base single crystal superalloy.

    abstract：:Time dependent plastic deformation in a single crystal nickel-base superalloy during cooling from casting relevant temperatures has been studied using a combination of in-situ neutron diffraction, transmission electron microscopy and modelling. Visco-plastic deformation during cooling was found to be dependent on the ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-10091-w

    authors： Panwisawas C,D'Souza N,Collins DM,Bhowmik A

    更新日期：2017-09-11 00:00:00

  • Solution-Based Synthesis of Few-Layer WS2 Large Area Continuous Films for Electronic Applications.

    abstract：:Unlike MoS2 ultra-thin films, where solution-based single source precursor synthesis for electronic applications has been widely studied, growing uniform and large area few-layer WS2 films using this approach has been more challenging. Here, we report a method for growth of few-layer WS2 that results in continuous and...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-58694-0

    authors： Abbas OA,Zeimpekis I,Wang H,Lewis AH,Sessions NP,Ebert M,Aspiotis N,Huang CC,Hewak D,Mailis S,Sazio P

    更新日期：2020-02-03 00:00:00

  • Role of water in cyclooxygenase catalysis and design of anti-inflammatory agents targeting two sites of the enzyme.

    abstract：:While designing the anti-inflammatory agents targeting cyclooxygenase-2 (COX-2), we first identified a water loop around the heme playing critical role in the enzyme catalysis. The results of molecular dynamic studies supported by the strong hydrogen-bonding equilibria of the participating atoms, radical stabilization...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-67655-6

    authors： Kaur M,Kaur B,Kaur J,Kaur A,Bhatti R,Singh P

    更新日期：2020-07-01 00:00:00

  • Protease induced plasticity: matrix metalloproteinase-1 promotes neurostructural changes through activation of protease activated receptor 1.

    abstract：:Matrix metalloproteinases (MMPs) are a family of secreted endopeptidases expressed by neurons and glia. Regulated MMP activity contributes to physiological synaptic plasticity, while dysregulated activity can stimulate injury. Disentangling the role individual MMPs play in synaptic plasticity is difficult due to overl...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep35497

    authors： Allen M,Ghosh S,Ahern GP,Villapol S,Maguire-Zeiss KA,Conant K

    更新日期：2016-10-20 00:00:00

  • Experimental quantification of pollen with DNA metabarcoding using ITS1 and trnL.

    abstract：:Although the use of metabarcoding to identify taxa in DNA mixtures is widely approved, its reliability in quantifying taxon abundance is still the subject of debate. In this study we investigated the relationships between the amount of pollen grains in mock solutions and the abundance of high-throughput sequence reads...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-61198-6

    authors： Baksay S,Pornon A,Burrus M,Mariette J,Andalo C,Escaravage N

    更新日期：2020-03-06 00:00:00

  • Systems approach to characterize the metabolism of liver cancer stem cells expressing CD133.

    abstract：:Liver cancer stem cells (LCSCs) have attracted attention because they cause therapeutic resistance in hepatocellular carcinoma (HCC). Understanding the metabolism of LCSCs can be a key to developing therapeutic strategy, but metabolic characteristics have not yet been studied. Here, we systematically analyzed and comp...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep45557

    authors： Hur W,Ryu JY,Kim HU,Hong SW,Lee EB,Lee SY,Yoon SK

    更新日期：2017-04-03 00:00:00

  • Low Temperature Vacuum Synthesis of Triangular CoO Nanocrystal/Graphene Nanosheets Composites with Enhanced Lithium Storage Capacity.

    abstract：:CoO nanocrystal/graphene nanosheets (GNS) composites, consisting of a triangular CoO nanocrystal of 2~20 nm on the surface of GNS, are synthesized by a mild synthetic method. First, cobalt acetate tetrahydrate is recrystallized in the alcohol solution at a low temperature. Then, graphene oxide mixed with cobalt-precur...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep10017

    authors： Guan Q,Cheng J,Li X,Wang B,Huang L,Nie F,Ni W

    更新日期：2015-05-11 00:00:00

  • Reconstruction of the South Atlantic Subtropical Dipole index for the past 12,000 years from surface temperature proxy.

    abstract：:Climate indices based on sea surface temperature (SST) can synthesize information related to physical processes that describe change and variability in continental precipitation from floods to droughts. The South Atlantic Subtropical Dipole index (SASD) is based on the distribution of SST in the South Atlantic and fit...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep05291

    authors： Wainer I,Prado LF,Khodri M,Otto-Bliesner B

    更新日期：2014-06-13 00:00:00

  • Performance of Azure-winged magpies in Aesop's fable paradigm.

    abstract：:In this study, the improved Aesop's fable paradigm-a series of experiments originally used to test whether some animals understand the causality associated with water replacement-was used to explore the cognitive ability of Azure-winged magpies (Cyanopica cyanus). Experimental results on causal cue tasks showed that t...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-80452-5

    authors： Zhang Y,Yu C,Chen L,Li Z

    更新日期：2021-01-12 00:00:00

  • Healthy lifestyle behaviors and control of hypertension among adult hypertensive patients.

    abstract：:The aim of the present study was to evaluate the healthy lifestyle behaviors in hypertensive patients (aware, n = 1364 and not aware, n = 1213) based on 2011 national survey of risk factors of non-communicable disease (SuRFNCD) of Iran. Lifestyle score was calculated based on lifestyle behaviors, including smoking sta...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-26823-5

    authors： Akbarpour S,Khalili D,Zeraati H,Mansournia MA,Ramezankhani A,Fotouhi A

    更新日期：2018-05-31 00:00:00

  • RNAi-based bioinsecticide for Aedes mosquito control.

    abstract：:Zika virus infection and dengue and chikungunya fevers are emerging viral diseases that have become public health threats. Their aetiologic agents are transmitted by the bite of genus Aedes mosquitoes. Without effective therapies or vaccines, vector control is the main strategy for preventing the spread of these disea...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-39666-5

    authors： Lopez SBG,Guimarães-Ribeiro V,Rodriguez JVG,Dorand FAPS,Salles TS,Sá-Guimarães TE,Alvarenga ESL,Melo ACA,Almeida RV,Moreira MF

    更新日期：2019-03-11 00:00:00

  • Identification of temozolomide resistance factors in glioblastoma via integrative miRNA/mRNA regulatory network analysis.

    abstract：:Drug resistance is a major issue in the treatment of glioblastoma. Almost all glioblastomas are intrinsically resistant to chemotherapeutic temozolomide (TMZ) or develop resistance during treatment. The interaction networks of microRNAs (miRNAs) and mRNAs likely regulate most biological processes and can be employed t...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep05260

    authors： Hiddingh L,Raktoe RS,Jeuken J,Hulleman E,Noske DP,Kaspers GJ,Vandertop WP,Wesseling P,Wurdinger T

    更新日期：2014-06-11 00:00:00

  • Plastic flow anisotropy drives shear fracture.

    abstract：:Fracture of initially crack-free bodies often occurs due to plastic instabilities known as shear bands. Previous computer simulations advanced a myriad of mechanisms to rationalize shear banding. However, they were restricted to planar geometries. We investigate the relevance of anisotropic plasticity by picking an ax...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-38437-y

    authors： Benzerga AA,Thomas N,Herrington JS

    更新日期：2019-02-05 00:00:00

  • FliS/flagellin/FliW heterotrimer couples type III secretion and flagellin homeostasis.

    abstract：:Flagellin is amongst the most abundant proteins in flagellated bacterial species and constitutes the major building block of the flagellar filament. The proteins FliW and FliS serve in the post-transcriptional control of flagellin and guide the protein to the flagellar type III secretion system (fT3SS), respectively. ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-29884-8

    authors： Altegoer F,Mukherjee S,Steinchen W,Bedrunka P,Linne U,Kearns DB,Bange G

    更新日期：2018-08-01 00:00:00

  • Characterization of porcine milk oligosaccharides over lactation between primiparous and multiparous female pigs.

    abstract：:Milk oligosaccharides (MOs) are complex carbohydrates with multifunctional health benefits for the neonate. Poor reproductive performance in primiparous gilts limits their productivity. Changes in the structure and abundance of porcine MO (PMOs) through lactation with parity remains unknown and may explain superior ne...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-23025-x

    authors： Wei J,Wang ZA,Wang B,Jahan M,Wang Z,Wynn PC,Du Y

    更新日期：2018-03-16 00:00:00

  • Interaction between hexon and L4-100K determines virus rescue and growth of hexon-chimeric recombinant Ad5 vectors.

    abstract：:The immunogenicity of recombinant adenovirus serotype 5 (rAd5) vectors has been shown to be suppressed by neutralizing antibodies (NAbs) directed primarily against hexon hypervariable regions (HVRs). Preexisting immunity can be circumvented by replacing HVRs of rAd5 hexon with those derived from alternate adenovirus s...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep22464

    authors： Yan J,Dong J,Wu J,Zhu R,Wang Z,Wang B,Wang L,Wang Z,Zhang H,Wu H,Yu B,Kong W,Yu X

    更新日期：2016-03-03 00:00:00

  • Defect spectroscopy on the dielectric material aluminum oxide.

    abstract：:A method for defect characterization is presented that allows to measure the activation energy, capture cross-section, and defect density in dielectric materials. This is exemplarily performed on aluminum oxide thin films deposited on hydrogen-terminated diamond. During the measurement, samples were illuminated using ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-69240-3

    authors： Oing D,Geller M,Stahl L,Kerski J,Lorke A,Wöhrl N

    更新日期：2020-07-27 00:00:00

  • Dimerisation induced formation of the active site and the identification of three metal sites in EAL-phosphodiesterases.

    abstract：:The bacterial second messenger cyclic di-3',5'-guanosine monophosphate (c-di-GMP) is a key regulator of bacterial motility and virulence. As high levels of c-di-GMP are associated with the biofilm lifestyle, c-di-GMP hydrolysing phosphodiesterases (PDEs) have been identified as key targets to aid development of novel ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep42166

    authors： Bellini D,Horrell S,Hutchin A,Phippen CW,Strange RW,Cai Y,Wagner A,Webb JS,Tews I,Walsh MA

    更新日期：2017-02-10 00:00:00

  • Hic-5 is required for activation of pancreatic stellate cells and development of pancreatic fibrosis in chronic pancreatitis.

    abstract：:Accumulated evidence suggests that activated pancreatic stellate cells (PSCs) serve as the main source of the extracellular matrix proteins accumulated under the pathological conditions leading to pancreatic fibrosis in chronic pancreatitis (CP). However, little is known about the mechanisms of PSC activation. PSCs ha...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-76095-1

    authors： Gao L,Lei XF,Miyauchi A,Noguchi M,Omoto T,Haraguchi S,Miyazaki T,Miyazaki A,Kim-Kaneyama JR

    更新日期：2020-11-05 00:00:00

  • Low factor XIII levels after intravenous thrombolysis predict short-term mortality in ischemic stroke patients.

    abstract：:In this observational study we investigated whether levels of factor XIII (FXIII) and its major polymorphisms affect the outcome of thrombolysis by recombinant tissue plasminogen activator (rtPA) in acute ischemic stroke (AIS) patients. Study cohort included 132 consecutive AIS patients undergoing i.v. thrombolysis wi...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-26025-z

    authors： Székely EG,Czuriga-Kovács KR,Bereczky Z,Katona É,Mezei ZA,Nagy A,Tóth NK,Berényi E,Muszbek L,Csiba L,Bagoly Z

    更新日期：2018-05-16 00:00:00

  • Adaptive Control of Ion Yield in Femtosecond Laser Post-ionization for Secondary Ion Mass Spectrometry.

    abstract：:Secondary ion mass spectrometry is an excellent technique of analytical chemistry, where primary ions sputter a solid sample generating the secondary ions which are determined. Although the ion yield is inherently low, it can be enhanced by using a post-ionization of sputtered neutral species. Our novel approach integ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-06562-9

    authors： Lorenc D,Jerigova M,Stupavska M,Velic D

    更新日期：2017-07-20 00:00:00

  • A Comparative Analysis of Sonic Defences in Bombycoidea Caterpillars.

    abstract：:Caterpillars have long been used as models for studying animal defence. Their impressive armour, including flamboyant warning colours, poisonous spines, irritating sprays, and mimicry of plant parts, snakes and bird droppings, has been extensively documented. But research has mainly focused on visual and chemical disp...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep31469

    authors： Bura VL,Kawahara AY,Yack JE

    更新日期：2016-08-11 00:00:00

  • Hydroxyoleoside-type seco-iridoids from Symplocos cochinchinensis and their insulin mimetic activity.

    abstract：:As part of an ongoing study of new insulin mimetic agents from medicinal plants, the 70% EtOH extract of Symplocos cochinchinensis was found to have a stimulatory effect on glucose uptake in 3T3-L1 adipocyte cells. The intensive targeted isolation of this active extract resulted in ten new hydroxyoleoside-type compoun...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-38013-4

    authors： Lee BW,Ha TKQ,Pham HTT,Hoang QH,Tran VO,Oh WK

    更新日期：2019-02-19 00:00:00

  • Author Correction: Radiative recombination of confined electrons at the MgZnO/ZnO heterojunction interface.

    abstract：:A correction to this article has been published and is linked from the HTML version of this paper. The error has been fixed in the paper. ...

    journal_title：Scientific reports

    pub_type： 已发布勘误

    doi：10.1038/s41598-017-14857-0

    authors： Choi S,Rogers DJ,Sandana EV,Bove P,Teherani FH,Nenstiel C,Hoffmann A,McClintock R,Razeghi M,Look D,Gentle A,Phillips MR,Ton-That C

    更新日期：2017-11-16 00:00:00