Abstract:
:Clinically isolated syndrome (CIS) is the earliest clinical episode in multiple sclerosis (MS). Low environmental exposure to UV radiation is implicated in risk of developing MS, and therefore, narrowband UVB phototherapy might delay progression to MS in people with CIS. Twenty individuals with CIS were recruited, and half were randomised to receive 24 sessions of narrowband UVB phototherapy over a period of 8 weeks. Here, the effects of narrowband UVB phototherapy on the frequencies of circulating immune cells and immunoglobulin levels after phototherapy are reported. Peripheral blood samples for all participants were collected at baseline, and 1, 2, 3, 6 and 12 months after enrolment. An extensive panel of leukocyte populations, including subsets of T cells, B cells, monocytes, dendritic cells, and natural killer cells were examined in phototherapy-treated and control participants, and immunoglobulin levels measured in serum. There were significant short-term increases in the frequency of naïve B cells, intermediate monocytes, and fraction III FoxP3+ T regulatory cells, and decreases in switched memory B cells and classical monocytes in phototherapy-treated individuals. Since B cells are increasingly targeted by MS therapies, the effects of narrowband UVB phototherapy in people with MS should be investigated further.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Trend S,Jones AP,Cha L,Cooper MN,Geldenhuys S,Fabis-Pedrini MJ,Carroll WM,Cole JM,Booth DR,Lucas RM,French MA,Byrne SN,Kermode AG,Hart PHdoi
10.1038/s41598-019-44488-6subject
Has Abstractpub_date
2019-05-28 00:00:00pages
7980issue
1issn
2045-2322pii
10.1038/s41598-019-44488-6journal_volume
9pub_type
杂志文章abstract::Temporal fluctuation of neural activity in the brain has an important function in optimal information processing. Spontaneous activity is a source of such fluctuation. The distribution of excitatory postsynaptic potentials (EPSPs) between cortical pyramidal neurons can follow a log-normal distribution. Recent studies ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-49286-8
更新日期:2019-09-04 00:00:00
abstract::Local and global changes associated with anthropogenic activities are impacting marine and terrestrial ecosystems. Macroalgae, especially habitat-forming species like kelp, play critical roles in temperate coastal ecosystems. However, their abundance and distribution patterns have been negatively affected by warming i...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-60104-4
更新日期:2020-02-21 00:00:00
abstract::Colorectal cancer (CRC) is one of the most prevalent cancers worldwide and Alpha B-crystallin (CRYAB) protein has been identified as a prognostic biomarker for CRC. We evaluated CRYAB C-802G (rs14133)polymorphism in association with CRC risk and survival in Chinese population. We genotyped for CRYAB C-802G (rs14133), ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-29589-y
更新日期:2018-08-06 00:00:00
abstract::Delay embedding-a method for reconstructing dynamical systems by delay coordinates-is widely used to forecast nonlinear time series as a model-free approach. When multivariate time series are observed, several existing frameworks can be applied to yield a single forecast combining multiple forecasts derived from vario...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-57255-4
更新日期:2020-01-20 00:00:00
abstract::Quantum cryptography is set to become a key technology for future secure communications. However, to get maximum benefit in communication networks, transmission links will need to be shared among several quantum keys for several independent users. Such links will enable switching in quantum network nodes of the quantu...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-12309-3
更新日期:2017-09-29 00:00:00
abstract::The graphdiyne (GD), a carbon allotrope with a 2D structure comprising benzene rings and carbon-carbon triple bonds, can be synthesized through cross-coupling on the surface of copper foil. The key problem is in understanding the dependence of layers number and properties, however, the controlled growth of the layers ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep07756
更新日期:2015-01-13 00:00:00
abstract::Neurovascular unit (NVU) is a basic unit in the brain, including neurons, glial cells, blood vessels and extracellular matrix. This concept implies the importance of a three-dimensional (3D) culture model including these cell types for investigating brain functions. However, little is known about the construction of a...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-17411-0
更新日期:2017-12-11 00:00:00
abstract::Ecosystem carbon carrying capacity (CCC) is determined by prevailing climate and natural disturbance regimes, conditions that are projected to change significantly. The interaction of changing climate and its effects on disturbance regimes is expected to affect forest regeneration and growth, which may diminish forest...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-02686-0
更新日期:2017-05-25 00:00:00
abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title:Scientific reports
pub_type: 已发布勘误
doi:10.1038/s41598-020-62742-0
更新日期:2020-04-10 00:00:00
abstract::Flexible thermoelectric generators (TEGs) can provide uninterrupted, green energy from body-heat, overcoming bulky battery configurations that limit the wearable-technologies market today. High-throughput production of flexible TEGs is currently dominated by printing techniques, limiting material choices and performan...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-41000-y
更新日期:2019-03-13 00:00:00
abstract::Absolute numbers of lymphocytes are decreased in uninfected infants born to HIV-1-infected women (HIV-1-exposed). Although the exact mechanism is unknown, fetal exposure to maternal HIV-1-infection could prime the immune system and affect T cell trafficking. We compared the expression of chemokine receptors on cord bl...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep06690
更新日期:2014-10-24 00:00:00
abstract::The possibility of changing the intracranial vasculature computed tomography (CT) attenuation under the influence of variable factors is a long-held unestablished belief. The purpose of this study is to evaluate factors affecting dural sinus density in non-contrast computed tomography of the brain. Patients presented ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-48545-y
更新日期:2019-08-19 00:00:00
abstract::IgLONs are members of the immunoglobulin superfamily of cell adhesion proteins implicated in the process of neuronal outgrowth, cell adhesion and subdomain target recognition. IgLONs form homophilic and heterophilic complexes on the cell surface that repress or promote growth depending on the neuronal population, the ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-08315-0
更新日期:2017-08-11 00:00:00
abstract::Because of their exceptional local-field enhancement and ultrasmall mode volume, plasmonic components can integrate photonics and electronics at nanoscale, and active control of plasmons is the key. However, all-optical modulation of plasmonic response with nanometer mode volume and unity modulation depth is still lac...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep24293
更新日期:2016-04-11 00:00:00
abstract::Solar thermoelectric generators (STEGs), which are used for various applications, (particularly small size electronic devices), have optical concentration systems for high energy conversion efficiency. In this study, a refraction-assisted STEG (R-STEG) is designed based on phase-change materials. As the phase-change m...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep27913
更新日期:2016-06-10 00:00:00
abstract::Thermal perception is essential for the survival and daily activities of people. Thus, it is desirable to realize thermal feedback stimulation for improving the sense of realism in virtual reality (VR) for users. For thermal stimulus, conventional systems utilize liquid circulation with bulky external sources or therm...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-68362-y
更新日期:2020-07-09 00:00:00
abstract::Ge-monopnictides (GeAs) plays critical role in high-tech industry, especially in the field of advanced optical devices and infrared. As a secondary material, coal fly ash could be further recycled to retrieve germanium and prepare GeAs material with high added values. Hence, the aim of this paper is to propose a one-p...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-03398-1
更新日期:2017-06-16 00:00:00
abstract::Ruminococcus albus 8 is a specialist plant cell wall degrading ruminal bacterium capable of utilizing hemicellulose and cellulose. Cellulose degradation requires a suite of enzymes including endoglucanases, exoglucanases, and β-glucosidases. The enzymes employed by R. albus 8 in degrading cellulose are yet to be compl...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep29979
更新日期:2016-07-21 00:00:00
abstract::Ocean acidification and global warming have been shown to significantly affect the physiological performances of marine calcifiers; however, the underlying mechanisms remain poorly understood. In this study, the transcriptome and biomineralization responses of Pinctada fucata to elevated CO2 (pH 7.8 and pH 7.5) and te...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep18943
更新日期:2016-01-06 00:00:00
abstract::Spitzoid neoplasms constitute a morphologically distinct category of melanocytic tumors, encompassing Spitz nevus (benign), atypical Spitz tumor (intermediate malignant potential), and spitzoid melanoma (fully malignant). Currently, no reliable histopathological criteria or molecular marker is known to distinguish bor...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep11200
更新日期:2015-06-10 00:00:00
abstract::The present work demonstrates the synthesis, characterization and biological activities of different concentrations of tin doped indium oxide nanoparticles (Sn doped In2O3 NPs), i.e., (Sn/In = 5%, 10% and 15%). We have synthesized different size (38.11 nm, 18.46 nm and 10.21 nm) of Sn doped In2O3 NPs. by using an ultr...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-60295-w
更新日期:2020-02-24 00:00:00
abstract::Large classes of electronic, photonic, and acoustic crystals and quasi-crystals have been predicted to support topological wave-modes. Some of these modes are stabilized by certain symmetries but others occur as pure wave phenomena, hence they can be observed in many other media that support wave propagation. Surface ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-21462-2
更新日期:2018-02-20 00:00:00
abstract::Nitric oxide (NO), a vascular signaling molecule, is primarily produced by endothelial NO synthase. Recently, a functional endothelial NO synthase (eNOS) was described in red blood cells (RBC). The RBC-eNOS contributes to the intravascular NO pool and regulates physiological functions. However the regulatory mechanism...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep26935
更新日期:2016-06-27 00:00:00
abstract::We have applied a combined computational procedure based on inverse and direct docking in order to identify putative protein targets of a panel of mycotoxins and xenobiotic compounds that can contaminate food and that are known to have several detrimental effects on human health. This procedure allowed us to identify ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-15148-4
更新日期:2017-11-09 00:00:00
abstract::Nanothermometry methods with intracellular sensitivities have the potential to make important contributions to fundamental cell biology and medical fields, as temperature is a relevant physical parameter for molecular reactions to occur inside the cells and changes of local temperature are well identified therapeutic ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-44023-7
更新日期:2019-05-17 00:00:00
abstract::Quasi two-dimensional metasurfaces composed of subwavelength nanoresonator arrays can dramatically alter the properties of light in an ultra-thin planar geometry, enabling new optical functions such as anomalous reflection and refraction, polarization filtering, and wavefront modulation. However, previous metasurface-...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep07511
更新日期:2014-12-19 00:00:00
abstract::Motor symptoms are defining traits in the diagnosis of Parkinson's disease (PD). A crucial component in motor function is the integration of afferent proprioceptive sensory feedback. Previous studies have indicated abnormal movement-related cortical oscillatory activity in PD, but the role of the proprioceptive affere...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-39204-3
更新日期:2019-02-22 00:00:00
abstract::Aerogels have numerous applications due to their high surface area and low densities. However, creating aerogels from a large variety of materials has remained an outstanding challenge. Here, we report a new methodology to enable aerogel production with a wide range of materials. The method is based on the assembly of...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep00849
更新日期:2012-01-01 00:00:00
abstract::A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has not been fixed in the paper. ...
journal_title:Scientific reports
pub_type: 已发布勘误
doi:10.1038/s41598-018-23132-9
更新日期:2018-03-19 00:00:00
abstract::The basic leucine zipper (bZIP) is a widely known transcription factors family in eukaryotes. In plants, the role of bZIP proteins are crucial in various biological functions such as plant growth and development, seed maturation, response to light signal and environmental stress. To date, bZIP protein family has been ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-72390-z
更新日期:2020-09-23 00:00:00