Bitter Taste Receptor Agonists Mitigate Features of Allergic Asthma in Mice.

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Scientific reports

authors： Gómez-Brandón M,Probst M,Siles JA,Peintner U,Bardelli T,Egli M,Insam H,Ascher-Jenull J

更新日期：2020-06-16 00:00:00

abstract：:Because histologic types are subjective and difficult to reproduce between pathologists, tissue morphology often takes a back seat to molecular testing for the selection of breast cancer treatments. This work explores whether a deep-learning algorithm can learn objective histologic H&E features that predict the clinic...

journal_title：Scientific reports

authors： Rawat RR,Ortega I,Roy P,Sha F,Shibata D,Ruderman D,Agus DB

更新日期：2020-04-29 00:00:00

abstract：:The observation and analysis of dendritic spines morphological changes poses a major challenge in neuroscience studies. The alterations of their density and/or morphology are indicators of the cellular processes involved in neural plasticity underlying learning and memory, and are symptomatic in neuropsychiatric disor...

journal_title：Scientific reports

authors： Basu S,Saha PK,Roszkowska M,Magnowska M,Baczynska E,Das N,Plewczynski D,Wlodarczyk J

更新日期：2018-02-23 00:00:00

abstract：:We present a proposal to realize the quantum Zeno effect (QZE) and quantum Zeno-like effect (QZLE) in a proximal (13)C nuclear spin by controlling a proximal electron spin of a nitrogen vacancy (NV) center. The measurement is performed by applying a microwave pulse to induce the transition between different electronic...

journal_title：Scientific reports

authors： Qiu J,Wang YY,Yin ZQ,Zhang M,Ai Q,Deng FG

更新日期：2015-12-01 00:00:00

abstract：:Porphyry systems supply most copper and significant gold to our economy. Recent studies indicate that they are frequently associated with high Sr/Y magmatic rocks, but the meaning of this association remains elusive. Understanding the association between high Sr/Y magmatic rocks and porphyry-type deposits is essential...

journal_title：Scientific reports

authors： Chiaradia M,Ulianov A,Kouzmanov K,Beate B

更新日期：2012-01-01 00:00:00

abstract：:F-box and WD40 domain protein 7 (FBXW7) is a component of the SKP1-CUL1-F-box protein (SCF) complex that mediates the ubiquitination of diverse oncogenic target proteins. The exploration of FBXW7 mutations in human primary cancer has revealed three mutation hotspots at conserved arginine residues (Arg465, Arg479, and ...

journal_title：Scientific reports

authors： Ikenoue T,Terakado Y,Zhu C,Liu X,Ohsugi T,Matsubara D,Fujii T,Kakuta S,Kubo S,Shibata T,Yamaguchi K,Iwakura Y,Furukawa Y

更新日期：2018-01-31 00:00:00

abstract：:Silver has long been employed as an electrically conductive component, and morphology-dependent properties have been actively investigated. Here we present a novel scalable synthesis method of flower-shaped silver nanoparticles (silver nanoflowers, Ag NFs). The preferential affinity of citrate molecules on (111) surfa...

journal_title：Scientific reports

authors： C MA,K P F,Singh S,Baik S

更新日期：2016-10-07 00:00:00

abstract：:RNA interference has had major advances as a developing tool for pest management. In laboratory experiments, double-stranded RNA (dsRNA) is often administered to the insect by genetic modification of the crop, or synthesized in vitro and topically applied to the crop. Here, we engineered genetically modified yeast tha...

journal_title：Scientific reports

authors： Murphy KA,Tabuloc CA,Cervantes KR,Chiu JC

更新日期：2016-03-02 00:00:00

abstract：:We evaluate the track segment yield G' of typical water radiolysis products (eaq-, ·OH and H2O2) under heavy ions (He, C and Fe ions) using a Monte Carlo simulation code in the Geant4-DNA. Furthermore, we reproduce experimental results of ·OH of He and C ions around the Bragg peak energies (< 6 MeV/u). In the relative...

journal_title：Scientific reports

authors： Baba K,Kusumoto T,Okada S,Ogawara R,Kodaira S,Raffy Q,Barillon R,Ludwig N,Galindo C,Peaupardin P,Ishikawa M

更新日期：2021-01-15 00:00:00

abstract：:Mapping the location of bound cellulase enzymes provides information on the micro-scale distribution of amenable and recalcitrant sites in pretreated woody biomass for biofuel applications. The interaction of a fluorescently labelled cellulase enzyme cocktail with steam-exploded pine (SEW) was quantified using confoca...

journal_title：Scientific reports

authors： Donaldson L,Vaidya A

更新日期：2017-03-10 00:00:00

abstract：:Jasmonates (JAs) are plant-specific key signaling molecules that respond to various stimuli and are involved in the synthesis of secondary metabolites. However, little is known about the JA signal pathway, especially in economically significant medicinal plants. To determine the functions of novel genes that participa...

journal_title：Scientific reports

authors： Ge Q,Zhang Y,Hua WP,Wu YC,Jin XX,Song SH,Wang ZZ

更新日期：2015-09-21 00:00:00

abstract：:After prolonged stay in an intensive care unit (ICU) patients often complain about cognitive impairments that affect health-related quality of life after discharge. The aim of this proof-of-concept study was to test the feasibility and effects of controlled visual and acoustic stimulation in a virtual reality (VR) set...

journal_title：Scientific reports

authors： Gerber SM,Jeitziner MM,Wyss P,Chesham A,Urwyler P,Müri RM,Jakob SM,Nef T

更新日期：2017-10-16 00:00:00

abstract：:One of the health hazards of PM2.5 exposure is to induce pulmonary inflammatory responses. In our previous study, we demonstrated that exposing both the immortalized and primary human bronchial epithelial cells to PM2.5 results in a significant upregulation of VEGF production, a typical signaling event to trigger chro...

journal_title：Scientific reports

authors： Xu H,Xu X,Wang H,Qimuge A,Liu S,Chen Y,Zhang C,Hu M,Song L

更新日期：2019-11-12 00:00:00

abstract：:The foregut endoderm gives rise to several organs including liver, pancreas, lung and thyroid with important roles in human physiology. Understanding which genes and signalling pathways regulate their development is crucial for understanding developmental disorders as well as diseases in adulthood. We exploited unique...

journal_title：Scientific reports

authors： Trubiroha A,Gillotay P,Giusti N,Gacquer D,Libert F,Lefort A,Haerlingen B,De Deken X,Opitz R,Costagliola S

更新日期：2018-04-04 00:00:00

abstract：:The herbal medicine berberine (BBR) has been recently shown to be an AMP-activated protein kinase (AMPK) productive activator with various properties that induce anti-inflammatory responses. We investigated the effects of BBR on the mechanisms of mucosal CD4+T cell activation in vitro and on the inflammatory responses...

journal_title：Scientific reports

authors： Takahara M,Takaki A,Hiraoka S,Adachi T,Shimomura Y,Matsushita H,Nguyen TTT,Koike K,Ikeda A,Takashima S,Yamasaki Y,Inokuchi T,Kinugasa H,Sugihara Y,Harada K,Eikawa S,Morita H,Udono H,Okada H

更新日期：2019-08-15 00:00:00

abstract：:Bone scan abnormalities, especially rib lesions, are often confusing for physicians due to a high number of false-positive lesions. This study investigated risk factors that are associated with bone metastasis in 613 breast cancer patients with bone scan abnormalities. Significantly increased rates of bone metastasis ...

journal_title：Scientific reports

authors： Li Q,Chen Z,Zhao Y,Li X,Pan H,Xia T,Chen L,Xu Z,Zhou W,Liu X

更新日期：2015-05-05 00:00:00

abstract：:Secondary thrombocytosis (ST) is frequently observed in children with a variety of clinical conditions. The leading cause of ST is respiratory tract infection (RTI) in children. Nasopharyngeal aspirate samples were collected and assessed for common respiratory viruses. The relationships between virus infections and se...

journal_title：Scientific reports

authors： Zheng SY,Xiao QY,Xie XH,Deng Y,Ren L,Tian DY,Luo ZX,Luo J,Fu Z,Huang AL,Liu EM

更新日期：2016-03-11 00:00:00

abstract：:We collected Solidago altissima clones to explore their leaf damage resistance, and as a result identified five accessions that exhibited variable defense abilities against the generalist herbivore Spodoptera litura. In order to characterize molecules involved in such natural variation, we focused on ethylene response...

journal_title：Scientific reports

authors： Takafuji K,Rim H,Kawauchi K,Mujiono K,Shimokawa S,Ando Y,Shiojiri K,Galis I,Arimura GI

更新日期：2020-03-24 00:00:00

abstract：:Rust fungi are plant pathogens that secrete an arsenal of effector proteins interfering with plant functions and promoting parasitic infection. Effectors are often species-specific, evolve rapidly, and display low sequence similarities with known proteins. How rust fungal effectors function in host cells remains elusi...

journal_title：Scientific reports

authors： de Guillen K,Lorrain C,Tsan P,Barthe P,Petre B,Saveleva N,Rouhier N,Duplessis S,Padilla A,Hecker A

更新日期：2019-12-02 00:00:00

abstract：:There is a growing desire to integrate the food requirements of predators living in marine ecosystems impacted by humans into sustainable fisheries management. We used non-invasive video-recording, photography and focal observations to build time-energy budget models and to directly estimate the fish mass delivered to...

journal_title：Scientific reports

authors： Gaglio D,Sherley RB,Ryan PG,Cook TR

更新日期：2018-05-29 00:00:00

abstract：:Reproductive investment generally involves a trade-off between somatic growth and energy allocation for reproduction. Previous studies have inferred that jumbo squid Dosidicus gigas support growth during maturation through continuous feeding (an "income" source). However, our recent work suggests possible remobilizati...

journal_title：Scientific reports

authors： Chen X,Han F,Zhu K,Punt AE,Lin D

更新日期：2020-06-15 00:00:00

abstract：:Imaging the fields of magnetic materials provides crucial insight into the physical and chemical processes surrounding magnetism, and has been a key ingredient in the spectacular development of magnetic data storage. Existing approaches using the magneto-optic Kerr effect, x-ray and electron microscopy have limitation...

journal_title：Scientific reports

authors： Simpson DA,Tetienne JP,McCoey JM,Ganesan K,Hall LT,Petrou S,Scholten RE,Hollenberg LC

更新日期：2016-03-14 00:00:00

abstract：:Visceral adiposity is a risk factor for cardiovascular disorders, type 2 diabetes mellitus (T2D) and associated metabolic diseases. Sub-cutaneous fat is believed to be intrinsically different from visceral fat. To understand molecular mechanisms involved in metabolic advantages of fat transplantation, we studied a rat...

journal_title：Scientific reports

authors： Satoor SN,Puranik AS,Kumar S,Williams MD,Ghale M,Rahalkar A,Karandikar MS,Shouche Y,Patole M,Bhonde R,Yajnik CS,Hardikar AA

更新日期：2011-01-01 00:00:00

abstract：:The effects of ocean acidification (OA) on the early recruitment of pteropods in the Scotia Sea, was investigated considering the process of spawning, quality of the spawned eggs and their capacity to develop. Maternal OA stress was induced on female pteropods (Limacina helicina antarctica) through exposure to present...

journal_title：Scientific reports

authors： Manno C,Peck VL,Tarling GA

更新日期：2016-05-16 00:00:00

abstract：:The effect of a 2-aminoanthraquinone-graphene oxide (AQ-GO) composite on the anaerobic dechlorination and degradation of chloroanilines by an enriched bacterial consortium was investigated. The results showed that the maximal degradation efficiency of 20 mg/L 2-chloroaniline (2-CA) reached 91.4% at a dose of 20 mg/L A...

journal_title：Scientific reports

authors： Lu H,Zhang T,Zhou Y,Zhou J,Wang J,Wang X

更新日期：2019-08-26 00:00:00

abstract：:The mechanical behavior of a single phase (fcc) Al0.3CoCrFeNi high-entropy alloy (HEA) was studied in the low and high strain-rate regimes. The combination of multiple strengthening mechanisms such as solid solution hardening, forest dislocation hardening, as well as mechanical twinning leads to a high work hardening ...

journal_title：Scientific reports

authors： Li Z,Zhao S,Diao H,Liaw PK,Meyers MA

更新日期：2017-02-17 00:00:00

abstract：:The fungal communities of different soil compartments in mangrove ecosystem are poorly studied. We sequenced the internal transcribed spacer (ITS) regions to characterize the fungal communities in Avicennia marina root-associated soils (rhizosphere and pneumatophore) and bulk soil compartments. The rhizosphere but not...

journal_title：Scientific reports

authors： Sanka Loganathachetti D,Poosakkannu A,Muthuraman S

更新日期：2017-08-17 00:00:00

abstract：:Hepatitis C virus (HCV) infection of hepatocytes promotes liver fibrosis by activation of hepatic stellate cells (HSCs) and excessive deposition of extracellular matrix in liver tissue. Whether or not host factors released from the HCV-infected hepatocytes play role in HSCs activation is unclear. In this study, HSCs w...

journal_title：Scientific reports

authors： Cheng JC,Tseng CP,Liao MH,Peng CY,Yu JS,Chuang PH,Huang JT,Chen JJW

更新日期：2017-06-30 00:00:00

abstract：:A large amount of energy, perhaps twice the total amount of all other hydrocarbon reserves combined, is trapped within gas hydrate deposits. Despite emerging as a potential energy source for the world over the next several hundred years and one of the key factors in causing future climate change, gas hydrate is poorly...

journal_title：Scientific reports

authors： Palodkar AV,Jana AK

更新日期：2017-07-25 00:00:00

abstract：:Energy plants are the main source of bioenergy which will play an increasingly important role in future energy supplies. With limited cultivated land resources in China, the development of energy plants may primarily rely on the marginal land. In this study, based on the land use data from 1990 to 2010(every 5 years i...

journal_title：Scientific reports

authors： Jiang D,Hao M,Fu J,Zhuang D,Huang Y

更新日期：2014-07-24 00:00:00