A Rapid CRISPR/Cas-based Mutagenesis Assay in Zebrafish for Identification of Genes Involved in Thyroid Morphogenesis and Function.

abstract：:The expanding distribution of African swine fever (ASF) is threatening the pig industry worldwide. Most outbreaks occur in backyard and small-scale herds, where poor farmers often attempt to limit the disease's economic consequences by the emergency sale of their pigs. The risk of African swine fever virus (ASFV) rele...

journal_title：Scientific reports

authors： Costard S,Zagmutt FJ,Porphyre T,Pfeiffer DU

更新日期：2015-11-27 00:00:00

abstract：:Systemic lupus erythematosus (SLE) patients are vulnerable to infections. We aim to explore the approach to differentiate active infection from disease activity in pediatric SLE patients. Fifty pediatric SLE patients presenting with 185 clinical visits were collected. The associations between both clinical and laborat...

journal_title：Scientific reports

authors： Luo KL,Yang YH,Lin YT,Hu YC,Yu HH,Wang LC,Chiang BL,Lee JH

更新日期：2020-11-16 00:00:00

abstract：:Hundreds of cellular host factors are required to support dengue virus infection, but their identity and roles are incompletely characterized. Here, we identify human host dependency factors required for efficient dengue virus-2 (DENV2) infection of human cells. We focused on two, TTC35 and TMEM111, which we previousl...

journal_title：Scientific reports

authors： Barrows NJ,Anglero-Rodriguez Y,Kim B,Jamison SF,Le Sommer C,McGee CE,Pearson JL,Dimopoulos G,Ascano M,Bradrick SS,Garcia-Blanco MA

更新日期：2019-07-04 00:00:00

abstract：:The Pax3/7 transcription factor family is integral to developmental gene networks contributing to important innovations in vertebrate evolution, including the neural crest. The basal chordate lineage of amphioxus is ideally placed to understand the dynamics of the gene regulatory network evolution that produced these ...

journal_title：Scientific reports

authors： Barton-Owen TB,Ferrier DEK,Somorjai IML

更新日期：2018-06-20 00:00:00

abstract：:Smad1, Smad5 and Smad9 (also known as Smad8) are activated by phosphorylation by bone morphogenetic protein (BMP)-bound type I receptor kinases. We examined the role of Smad1, Smad5, and Smad9 by creating constitutively active forms (Smad(DVD)). Transcriptional activity of Smad9(DVD) was lower than that of Smad1(DVD) ...

journal_title：Scientific reports

authors： Tsukamoto S,Mizuta T,Fujimoto M,Ohte S,Osawa K,Miyamoto A,Yoneyama K,Murata E,Machiya A,Jimi E,Kokabu S,Katagiri T

更新日期：2014-12-23 00:00:00

abstract：:Temporal baselines are needed for biodiversity, in order for the change in biodiversity to be measured over time, the targets for biodiversity conservation to be defined and conservation progress to be evaluated. Limited biodiversity information is widely recognized as a major barrier for identifying temporal baseline...

journal_title：Scientific reports

authors： Mihoub JB,Henle K,Titeux N,Brotons L,Brummitt NA,Schmeller DS

更新日期：2017-01-30 00:00:00

abstract：:Rhizomorphic lycopsids are the land plant group that includes the first giant trees to grow on Earth and extant species in the genus Isoetes. Two mutually exclusive hypotheses account for the evolution of terminal rooting axes called rootlets among the rhizomorphic lycopsids. One hypothesis states that rootlets are tr...

journal_title：Scientific reports

authors： Hetherington AJ,Emms DM,Kelly S,Dolan L

更新日期：2020-12-09 00:00:00

abstract：:Translational motion of neurotransmitter receptors is key for determining receptor number at the synapse and hence, synaptic efficacy. We combine live-cell STORM superresolution microscopy of nicotinic acetylcholine receptor (nAChR) with single-particle tracking, mean-squared displacement (MSD), turning angle, ergodic...

journal_title：Scientific reports

authors： Mosqueira A,Camino PA,Barrantes FJ

更新日期：2018-08-10 00:00:00

abstract：:Risk stratification is crucial in prevention. Circulating microRNAs have been proposed as biomarkers in cardiovascular disease. Here a miR panel consisting of miRs related to different cardiovascular pathophysiologies, was evaluated to predict outcome in the context of prevention. MiR-34a, miR-223, miR-378, miR-499 an...

journal_title：Scientific reports

authors： Keller T,Boeckel JN,Groß S,Klotsche J,Palapies L,Leistner D,Pieper L,Stalla GK,Lehnert H,Silber S,Pittrow D,Maerz W,Dörr M,Wittchen HU,Baumeister SE,Völker U,Felix SB,Dimmeler S,Zeiher AM

更新日期：2017-07-03 00:00:00

abstract：:In this study, an interval optimization model is developed to maximize the benefits of a water rights transfer system that comprises industry and agriculture sectors in the Ningxia Hui Autonomous Region in China. The model is subjected to a number of constraints including water saving potential from agriculture and ec...

journal_title：Scientific reports

authors： Sun L,Li C,Cai Y,Wang X

更新日期：2017-06-14 00:00:00

abstract：:A series of nanocomposites of cobalt embedded in N-doped nanoporous carbons, carbon nanotubes or hollow carbon onions have been synthesized by a one-step carbonization of metal-organic-framework ZIF-67. The effect of the carbonization temperature on the structural evolution of the resulting nanocomposites has been inv...

journal_title：Scientific reports

authors： Chen B,Ma G,Zhu Y,Xia Y

更新日期：2017-07-13 00:00:00

abstract：:Genome editing has emerged as a technology with a potential to revolutionize plant breeding. In this study, we report on generating, in less than ten months, Tomelo, a non-transgenic tomato variety resistant to the powdery mildew fungal pathogen using the CRISPR/Cas9 technology. We used whole-genome sequencing to show...

journal_title：Scientific reports

authors： Nekrasov V,Wang C,Win J,Lanz C,Weigel D,Kamoun S

更新日期：2017-03-28 00:00:00

abstract：:Three-dimensional integrated circuits (3D ICs) are an attractive replacement for conventional 2D ICs as high-performance, low-power-consumption, and small-footprint microelectronic devices. However, one of the major remaining challenges is the manufacture of high-aspect-ratio through-silicon vias (TSVs), which is a cr...

journal_title：Scientific reports

authors： He F,Yu J,Tan Y,Chu W,Zhou C,Cheng Y,Sugioka K

更新日期：2017-01-18 00:00:00

abstract：:Cinnabar is a natural mercury sulfide (HgS) mineral of volcanic or hydrothermal origin that is found worldwide. It has been mined prehistorically and historically in China, Japan, Europe, and the Americas to extract metallic mercury (Hg(0)) for use in metallurgy, as a medicinal, a preservative, and as a red pigment fo...

journal_title：Scientific reports

authors： Emslie SD,Brasso R,Patterson WP,Carlos Valera A,McKenzie A,Maria Silva A,Gleason JD,Blum JD

更新日期：2015-10-01 00:00:00

abstract：:Tremendous efforts have been made to explore biomarkers for classification and grading on gliomas. The goal of this study was to identify more molecular features that are associated with clinical outcomes by comparing the genomic profiles of primary and recurrent gliomas and determine potential recurrence leading fact...

journal_title：Scientific reports

authors： Zhang L,Liu Z,Li J,Huang T,Wang Y,Chang L,Zheng W,Ma Y,Chen F,Gong X,Yuan Q,Teaw S,Fang X,Song T,Huo L,Li X,Xia X,Liu Z,Wu J

更新日期：2019-11-05 00:00:00

abstract：:In everyday life, people must often determine how much time and effort to allocate to cooperative activities. In the current study, we tested the hypothesis that the perception of others' effort investment in a cooperative activity may elicit a sense of commitment, leading people to allocate more time and effort to th...

journal_title：Scientific reports

authors： Chennells M,Michael J

更新日期：2018-10-24 00:00:00

abstract：:Abnormal expression of microRNAs (miRNAs) contributes to glioma initiation. However, the expression of miRNAs in tumour tissue or blood of spinal cord glioma (SCG) patients, particularly in high-grade spinal gliomas (Grade IV) known as glioblastoma (GBM), remains largely unknown. In this study we aimed to determine di...

journal_title：Scientific reports

authors： An T,Fan T,Zhang XQ,Liu YF,Huang J,Liang C,Lv BH,Wang YQ,Zhao XG,Liu JX,Fu YH,Jiang GJ

更新日期：2019-06-24 00:00:00

abstract：:Density functional theory predictions have been combined with the microwave-plasma chemical vapor deposition technique to explore metastable synthesis of boron-rich boron-carbide materials. A thin film synthesis of high-hardness (up to 37 GPa) B50C2 via chemical vapor deposition was achieved. Characterization of the e...

journal_title：Scientific reports

authors： Baker PA,Chen WC,Chen CC,Catledge SA,Vohra YK

更新日期：2020-03-10 00:00:00

abstract：:Alternative polyadenylation has been recognized as a key contributor of gene expression regulation by generating different transcript isoforms with altered 3' ends. Although polyadenylation is well known for marking the end of a 3' UTR, an increasing number of studies have reported previously less-addressed polyadenyl...

journal_title：Scientific reports

authors： Guo C,Spinelli M,Liu M,Li QQ,Liang C

更新日期：2016-06-15 00:00:00

abstract：:This is a systematical report on the potential health risk of heavy metals from the leather industries in Pakistan based on multiple biological matrices of the exposed workers and indoor dust samples. The adverse impacts of heavy metals on the oxidative enzyme and their risks to workers' health were also explored. Our...

journal_title：Scientific reports

authors： Junaid M,Hashmi MZ,Tang YM,Malik RN,Pei DS

更新日期：2017-08-18 00:00:00

abstract：:Leucine-rich repeat kinase 2 (LRRK2) is a promising therapeutic target for the treatment of Parkinson's disease (PD) and LRRK2 kinase inhibitors are currently being tested in early phase clinical trials. In order to ensure the highest chance of success, a biomarker-guided entry into clinical trials is key. LRRK2 phosp...

journal_title：Scientific reports

authors： Gonzalez-Hunt CP,Thacker EA,Toste CM,Boularand S,Deprets S,Dubois L,Sanders LH

更新日期：2020-10-14 00:00:00

abstract：:The vertebrate gut is host to large communities of bacteria, and one of the beneficial contributions of this commensal gut microbiota is the increased nutritional gain from feed components that the host cannot degrade on its own. Fish larvae of similar age and under the same rearing conditions often diverge with regar...

journal_title：Scientific reports

authors： Forberg T,Sjulstad EB,Bakke I,Olsen Y,Hagiwara A,Sakakura Y,Vadstein O

更新日期：2016-02-15 00:00:00

abstract：:Cell penetrating peptides (CPPs) are peptides that can be translocated into cells and used as a carrier platform for the intracellular uptake of cargo molecules. Subject to the source of CPP sequences and their positively charged nature, the cytotoxicity and immunogenicity of conventional CPPs needs to be optimized to...

journal_title：Scientific reports

authors： Young Kim H,Young Yum S,Jang G,Ahn DR

更新日期：2015-06-26 00:00:00

abstract：:This study compares the effects of temperature (constant at 15, 20, 25, 30 and 35 °C) on adult longevity, oviposition, and nymph development of the brown planthopper, Nilaparvata lugens, on susceptible and resistant rice varieties. The resistant variety contained the BPH32 gene. In our experiments, nymphs failed to de...

journal_title：Scientific reports

authors： Horgan FG,Arida A,Ardestani G,Almazan MLP

更新日期：2021-01-08 00:00:00

abstract：:The anatomic and functional combinations of cusps and lophs (ridges) define the tooth shape of rodent molars, which distinguishes species. The species-specific cusp patterns result from the spatiotemporal induction of enamel knots (EKs), which require precisely controlled cellular behavior to control the epithelial in...

journal_title：Scientific reports

authors： Li L,Tang Q,Nakamura T,Suh JG,Ohshima H,Jung HS

更新日期：2016-11-28 00:00:00

abstract：:The advent of flexible optoelectronic devices has accelerated the development of semiconducting polymeric materials. We seek to replace conventional expensive semiconducting photodetector materials with our cost-effective composite system. We demonstrate in this work the successful fabrication of a photoconductive com...

journal_title：Scientific reports

authors： Tong Y,Zhao X,Tan MC,Zhao R

更新日期：2015-11-16 00:00:00

abstract：:Structural cardiac remodeling, accompanying cytoskeletal reorganization of cardiac cells, is a major clinical outcome of diastolic heart failure. A highly local Ca2+ influx across the plasma membrane has been suggested to code signals to induce Rho GTPase-mediated fibrosis, but it is obscure how the heart specifically...

journal_title：Scientific reports

authors： Numaga-Tomita T,Kitajima N,Kuroda T,Nishimura A,Miyano K,Yasuda S,Kuwahara K,Sato Y,Ide T,Birnbaumer L,Sumimoto H,Mori Y,Nishida M

更新日期：2016-12-19 00:00:00

abstract：:We propose a novel class of mixed fluctuations with different orientations and fractal scaling features as a model for anisotropic two-dimensional (2D) trajectories hypothesized to appear in complex systems. Furthermore, we develop the oriented fractal scaling component analysis (OFSCA) to decompose such mixed fluctua...

journal_title：Scientific reports

authors： Seleznov I,Popov A,Kikuchi K,Kolosova E,Kolomiiets B,Nakata A,Kaneko M,Kiyono K

更新日期：2020-12-14 00:00:00

abstract：:YidC, a bacterial member of the YidC/Alb3/Oxa1 insertase family, mediates membrane protein assembly and insertion. Cytoplasmic loops are known to have functional significance in membrane proteins such as YidC. Employing microsecond-level molecular dynamics (MD) simulations, we show that the crystallographically unreso...

journal_title：Scientific reports

authors： Harkey T,Govind Kumar V,Hettige J,Tabari SH,Immadisetty K,Moradi M

更新日期：2019-10-08 00:00:00

abstract：:We delineate the four principal surface plasmon polariton coupling and interaction mechanisms in subwavelength gratings, and demonstrate their significant roles in shaping the optical response of plasmonic gratings. Within the framework of width-graded metal-insulator-metal nano-gratings, electromagnetic field confine...

journal_title：Scientific reports

authors： Shayegannia M,Montazeri AO,Dixon K,Prinja R,Kazemi-Zanjani N,Kherani NP

更新日期：2021-01-12 00:00:00