Abstract：
:Gut microbiota mediated low-grade inflammation is involved in the onset of type 2 diabetes (T2DM). In this study, we used a high fat sucrose (HFS) diet-induced pre-insulin resistance and a low dose-STZ HFS rat models to study the effect and mechanism of Lactobacillus casei Zhang in protecting against T2DM onset. Hyperglycemia was favorably suppressed by L. casei Zhang treatment. Moreover, the hyperglycemia was connected with type 1 immune response, high plasma bile acids and urine chloride ion loss. This chloride ion loss was significantly prevented by L. casei via upregulating of chloride ion-dependent genes (ClC1-7, GlyRα1, SLC26A3, SLC26A6, GABAAα1, Bestrophin-3 and CFTR). A shift in the caecal microflora, particularly the reduction of bile acid 7α-dehydroxylating bacteria, and fecal bile acid profiles also occurred. These change coincided with organ chloride influx. Thus, we postulate that the prevention of T2DM onset by L. casei Zhang may be via a microbiota-based bile acid-chloride exchange mechanism.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Zhang Y,Guo X,Guo J,He Q,Li H,Song Y,Zhang Hdoi
10.1038/srep05654subject
Has Abstractpub_date
2014-07-18 00:00:00pages
5654issn
2045-2322pii
srep05654journal_volume
4pub_type
杂志文章abstract：:A weakening of the gut mucous barrier permits an increase in the access of intestinal luminal contents to the epithelial cells, which will trigger the inflammatory response. In inflammatory bowel diseases, there is an inappropriate and ongoing activation of the immune system, possibly because the intestinal mucus is l...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep09577
更新日期：2015-05-14 00:00:00
abstract：:Recent reports have demonstrated the role of phyto-constituents in modulating inflammatory responses. Mangiferin isolated from Mangifera indica is known to induce potent anti-oxidative, anti-diabetic and anti-inflammatory activity. However, the molecular mechanism of its anti-inflammatory activity is not properly unde...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep42683
更新日期：2017-02-20 00:00:00
abstract：:Angiogenesis is a key restorative process following stroke but has also been linked to increased vascular permeability and blood brain barrier (BBB) disruption. Previous pre-clinical approaches primarily focused on the administration of vascular endothelial growth factor (VEGF) to promote vascular repair after stroke....
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-56634-1
更新日期：2019-12-27 00:00:00
abstract：:A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper. ...
journal_title：Scientific reports
pub_type： 已发布勘误
doi：10.1038/s41598-018-31524-0
更新日期：2018-09-03 00:00:00
abstract：:This study presents, attenuated total reflection Fourier transforms infrared spectroscopy of dried serum samples in an effort to assess biochemical changes induced by non-Hodgkin's lymphoma and subcutaneous melanoma. An EL4 mouse model of non-Hodgkin lymphoma and a B16 mouse model of subcutaneous melanoma are used to ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-17027-4
更新日期：2017-12-05 00:00:00
abstract：:While previous studies separately demonstrate EEG spectral modulations during speech preparation and ERP responses to the listened speech, it is unclear whether these responses are related on a trial-by-trial basis between a speaker and listener. In order to determine whether these responses are related in real-time, ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-31038-9
更新日期：2018-08-27 00:00:00
abstract：:Success of immunotherapeutic approaches using genetically engineered antibodies and T cells modified with chimeric antigen receptors (CARs) depends, among other things, on the selection of antigen binding domains with desirable expression and binding characteristics. We developed a luciferase-based assay, termed Malib...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-59099-9
更新日期：2020-02-11 00:00:00
abstract：:Algicidal microbes could effectively remove the harmful algae from the waters. In this study, we were concerned with the ecological influence of an algicide extracted from Streptomyces alboflavus RPS, which could completely lyse the Phaeocystis globosa cells within two days. In microcosms, 4 μg/mL of the microbial alg...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep20081
更新日期：2016-02-05 00:00:00
abstract：:Plasmodiophora brassicae causes clubroot disease in cruciferous. In this report, lipid droplets were observed in the resting spores of P. brassicae. 295 lipid droplet-associated proteins were identified and categorized into nine groups. Transcriptome analysis of these proteins during three different zoosporic stages r...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep36965
更新日期：2016-11-22 00:00:00
abstract：:Weathered granite of ion-adsorption rare earth elements (REEs) ore collected at Jiangxi Province, China was investigated to identify the minerals abundant in REEs. The analyses of scanning electron microscopy (SEM)-energy dispersive spectrometry (EDS) and laser ablation inductively coupled plasma mass spectrometry (LA...
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pub_type： 杂志文章
doi：10.1038/s41598-020-76981-8
更新日期：2020-11-19 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep06542
更新日期：2014-10-13 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep39360
更新日期：2016-12-20 00:00:00
abstract：:Intrahepatic cholangiocarcinoma (IHCC) is a highly aggressive malignancy with a poor prognosis. It is thought to originate from cholangiocytes, which are the component cells of intrahepatic bile ducts. However, as patients with viral hepatitis often develop IHCC, it has been suggested that transformed hepatocytes may ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-21121-6
更新日期：2018-02-12 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-27463-5
更新日期：2018-06-18 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep32196
更新日期：2016-08-24 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-24967-y
更新日期：2018-04-27 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep25854
更新日期：2016-05-12 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-08831-z
更新日期：2017-08-22 00:00:00
abstract：:Skin allergy is a chronic condition that affects about 20% of the population of the western world. This disease is caused by small reactive compounds, haptens, able to penetrate into the epidermis and modify endogenous proteins, thereby triggering an immunogenic reaction. Phenyl isothiocyanate (PITC) and ethyl isothio...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep21203
更新日期：2016-02-17 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-15391-9
更新日期：2017-11-09 00:00:00
abstract：:We have designed a fully automated optical microscope running at high-speed and achieving a very high spatial resolution. In order to overcome the resolution limit of optical microscopes, it exploits the localized surface plasmon resonance phenomenon. The customized setup using a polarization analyzer, based on liquid...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-75883-z
更新日期：2020-11-02 00:00:00
abstract：:In order to make full use of the impact of internal and external factors on the performance of title catalyst for ethyl benzene oxidation, the key internal influencing factors on the catalytic performance were modulated by coordinating and grafting manganese porphyrin to mesoporous and macroporous chitosan, and the im...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-70210-y
更新日期：2020-08-24 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-13961-5
更新日期：2017-10-20 00:00:00
abstract：:Steering magnetism by electric fields upon interfacing ferromagnetic (FM) and ferroelectric (FE) materials to achieve an emergent multiferroic response bears a great potential for nano-scale devices with novel functionalities. FM/FE heterostructures allow, for instance, the electrical manipulation of magnetic anisotro...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep11111
更新日期：2015-06-09 00:00:00
abstract：:Routers, switches, and repeaters are essential components of modern information-processing systems. Similar devices will be needed in future superconducting quantum computers. In this work we investigate experimentally the time evolution of Autler-Townes splitting in a superconducting phase qubit under the application...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep00645
更新日期：2012-01-01 00:00:00
abstract：:A new electrically small antenna with size ka = 0.415 is presented, fabricated and measured in this work. This is intrinsically matched to 50 Ω, has omni-directional and linear-polarized radiation pattern in the horizontal plane with maximum directivity of 1.75 dBi and simulated radiation efficiency of 93%. The antenn...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-33388-w
更新日期：2018-10-09 00:00:00
abstract：:Accurately predicting the response of a cancer patient to a therapeutic agent is a core goal of precision medicine. Existing approaches were mainly relied primarily on genomic alterations in cancer cells that have been treated with different drugs. Here we focus on predicting drug response based on integration of the ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep32679
更新日期：2016-09-20 00:00:00
abstract：:Ovarian cancer is the second most common gynaecologic malignancy and the main cause of death from gynaecologic cancer, due to late diagnosis and chemoresistance. Studies have reported the role of cysteine in cancer, by contributing for hydrogen sulphide (H2S) generation and as a precursor of glutathione (GSH). However...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-27753-y
更新日期：2018-06-22 00:00:00
abstract：:Sensitive High-Resolution Ion Microprobe (SHRIMP) U-Pb analyses of zircons from Paleoarchean (~3.4 Ga) tonalite-gneiss called the Older Metamorphic Tonalitic Gneiss (OMTG) from the Champua area of the Singhbhum Craton, India, reveal 4.24-4.03 Ga xenocrystic zircons, suggesting that the OMTG records the hitherto unknow...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-25494-6
更新日期：2018-05-04 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-14847-2
更新日期：2017-11-07 00:00:00
