Abstract：
:MircoRNA's (miR) have been recognised as important modulators of gene expression and potential biomarkers. However, they have been rarely investigated in bio fluids apart from blood. We investigated the association of miR-125b and miR-155 with complications of cirrhosis. Ascites was prospectively collected from patients with cirrhosis undergoing paracentesis at our department. miR's were determined in the supernatant using qPCR and normalized by SV-40. Clinical parameters were assessed at paracentesis and during follow-up. 76 specimens from 72 patients were analysed. MiR's were not associated to age, sex or aetiology of cirrhosis. MiR-125b levels differed between patients with low and high MELD score, and miR-125b levels showed an inverse correlation to serum creatinine (r2 = -0.23; p = 0.05). MiR-155 was elevated in patients with spontaneous bacterial peritonitis (SBP) (n = 10; p = 0.04). MiR-155 levels differed between patients with and without 30-day survival (p = 0.02). No association of ascites levels of investigated miR's to size of varices, episodes of gastrointestinal bleeding or hepatorenal syndrome was observed. While miR-125b levels in ascites seem to be associated with liver and renal dysfunction, miR-155 might be implicated in local immune response in SBP.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Lutz P,M Haimid M,Pohlmann A,Lehmann J,Jansen C,Schierwagen R,Klein S,Strassburg CP,Spengler U,Trebicka Jdoi
10.1038/srep40556subject
Has Abstractpub_date
2017-01-11 00:00:00pages
40556issn
2045-2322pii
srep40556journal_volume
7pub_type
杂志文章abstract：:The CoCrMo matrix composites with nano-TiO2 particle (2 wt.%, 4 wt.% and 6 wt.%) were fabricated by using a powder metallurgy technique (P/M), and the nano-TiO2 content was optimized in matrix. The microstructures, mechanical and high-temperature tribological properties of the synthesized composites were systematicall...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-63918-4
更新日期：2020-04-22 00:00:00
abstract：:We examined the associations of age and serum magnesium, iron, lead, copper, and zinc levels with bone mineral density (BMD) in 2412 children under 3 years of age in order to find a tool to monitor BMD in children without the use of expensive imaging techniques. One-way ANOVA and chi-square tests were used to determin...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-021-81501-3
更新日期：2021-01-21 00:00:00
abstract：:Whole-slide imaging of histologic sections captures tissue microenvironments and cytologic details in expansive high-resolution images. These images can be mined to extract quantitative features that describe tissues, yielding measurements for hundreds of millions of histologic objects. A central challenge in utilizin...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-15092-3
更新日期：2017-11-06 00:00:00
abstract：:Bacterial pneumonia is a major cause of acute lung injury and acute respiratory distress syndrome, characterized by alveolar barrier disruption. NLRP3 is best known for its ability to form inflammasomes and to regulate IL-1β and IL-18 production in myeloid cells. Here we show that NLRP3 protects the integrity of the a...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep30943
更新日期：2016-08-01 00:00:00
abstract：:The distribution, characteristics of extracellular polymeric substances (EPS) of Phanerochaete chrysosporium under Pb2+ stress and the influence on Pb removal were investigated. Polysaccharides was found to be the main composition in both soluble EPS (SEPS) and bounded EPS (BEPS). More polysaccharides and protein in B...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-74983-0
更新日期：2020-10-19 00:00:00
abstract：:Therapies using mesenchymal stem cell (MSC) seeded scaffolds may be applicable to various fields of regenerative medicine, including craniomaxillofacial surgery. Plastic compression of collagen scaffolds seeded with MSC has been shown to enhance the osteogenic differentiation of MSC as it increases the collagen fibril...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep38814
更新日期：2016-12-09 00:00:00
abstract：:Theoretical model required for the evolution of regular dislocation pattern should simultaneously take into account both static distribution and dynamic evolution of dislocation pattern. In principle, there exists a stable uniformly moving dislocation with both core and far field advancing at the same constant velocit...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-04257-9
更新日期：2017-06-22 00:00:00
abstract：:We investigated the cognitive and behavioral profile of three distinct groups of epilepsies with a genetic background for intergroup differences: (1) idiopathic/genetic generalized epilepsies (IGE/GGE group); (2) idiopathic focal epilepsies (IFE group); and (3) epilepsies with proven or strongly suggested monogenic or...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-78218-0
更新日期：2020-12-09 00:00:00
abstract：:Protein degradation is an essential mechanism for maintaining proteostasis in response to internal and external perturbations. Disruption of this process is implicated in many human diseases. We present a new technique, QUAD (Quantification of Azidohomoalanine Degradation), to analyze the global degradation rates in t...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-72410-y
更新日期：2020-09-29 00:00:00
abstract：:Diapause, a programmed developmental arrest, is common in insects, enabling them to survive adverse seasons. It is well established that pupal diapause is regulated by ecdysteroids secreted by the prothoracic glands (PGs), with cessation of ecdysteroid secretion after pupal ecdysis leading to pupal diapause. A major f...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep41651
更新日期：2017-01-31 00:00:00
abstract：:Biological N2 fixation (BNF) in the rhizosphere of Podocarpaceae is currently attributed to unspecific diazotrophs with negligible impact on N acquisition. Here, we report specific and high associative BNF in dead cells of root nodules of Lepidothamnus fonkii distributed in ombrotrophic peatlands of Patagonia. BNF of ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep39072
更新日期：2016-12-15 00:00:00
abstract：:Energy plants are the main source of bioenergy which will play an increasingly important role in future energy supplies. With limited cultivated land resources in China, the development of energy plants may primarily rely on the marginal land. In this study, based on the land use data from 1990 to 2010(every 5 years i...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep05816
更新日期：2014-07-24 00:00:00
abstract：:Silicon Carbide (SiC) is a promising cladding material for accident-tolerant fuel in light water reactors due to its excellent resistance to chemical attacks at high temperatures, which can prevent severe accident-induced environmental disasters. Although it has been known for decades that radiation-induced swelling a...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-15037-w
更新日期：2017-11-07 00:00:00
abstract：:Tumor cells tend to behave differently in response to immune selective conditions. Contrary to those in therapeutic antitumor conditions, tumor cells in prophylactic antitumor conditions lose antigen expression for antitumor immune escape. Here, using a CT26/HER2 tumor model, we investigate the underlying mechanism(s)...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-39557-9
更新日期：2019-02-27 00:00:00
abstract：:Rodent species like Myodes glareolus and Microtus spp. are natural reservoirs for many zoonotic pathogens causing human diseases and are gaining increasing interest in the field of eco-immunology as candidate animal models. Despite their importance the lack of immunological reagents has hampered research in these anim...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-21143-0
更新日期：2018-02-12 00:00:00
abstract：:Although pneumococcal infection is a serious problem worldwide and has a high mortality rate, the molecular mechanisms underlying the lethality caused by pneumococcus remain elusive. Here, we show that BLT2, a G protein-coupled receptor for leukotriene B4 and 12(S)-hydroxyheptadecatrienoic acid (12-HHT), protects mice...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep34560
更新日期：2016-10-05 00:00:00
abstract：:Calcification is important for the diagnosis of papillary thyroid carcinoma (PTC). Runt-related transcription factor 2 (RUNX2), a master transcription factor associated with osteogenic differentiation, is reportedly related to PTC calcification and invasiveness. However, its regulatory role in this process is somewhat...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-43207-5
更新日期：2019-05-01 00:00:00
abstract：:Obese individuals can be categorized as "healthy obese" (MHO) and "unhealthy obese" (MUO) based on the presence or absence of metabolic abnormality. This study sets out to assess potential genetic causes behind persistence of healthy metabolic status in individuals categorized as "healthy obese". This study was conduc...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-70627-5
更新日期：2020-08-12 00:00:00
abstract：:The exact extent, by which the hydrologic cycle in the Neotropics was affected by external forcing during the last deglaciation, remains poorly understood. Here we present a new paleo-rainfall reconstruction based on high-resolution speleothem δ18O records from the core region of the South American Monsoon System (SAM...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep44267
更新日期：2017-03-10 00:00:00
abstract：:Although redox reactions are recognized to fractionate iron (Fe) isotopes, the dominant mechanisms controlling the Fe isotope fractionation and notably the role of organic matter (OM) are still debated. Here, we demonstrate how binding to organic ligands governs Fe isotope fractionation beyond that arising from redox ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-021-81494-z
更新日期：2021-01-21 00:00:00
abstract：:Previous research has shown that neighborhood-level variables such as social deprivation, social fragmentation or rurality are related to suicide risk, but most of these studies have been conducted in the U.S. or northern European countries. The aim of this study was to analyze the spatio-temporal distribution of suic...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-25268-0
更新日期：2018-04-30 00:00:00
abstract：:We show that ATM kinase inhibition using AZ31 prior to 9 or 9.25 Gy total body irradiation (TBI) reduced median time to moribund in mice to 8 days. ATR kinase inhibition using AZD6738 prior to TBI did not reduce median time to moribund. The striking finding associated with ATM inhibition prior to TBI was increased cry...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep41892
更新日期：2017-02-01 00:00:00
abstract：:To facilitate the precision of clinical electrocardiographic studies of J-to-Tpeak (JTp) and Tpeak-to-Tend (Tpe) intervals, the study investigated their differences between healthy females and males, and between subjects of African and Caucasian origin. In 523 healthy subjects (254 females; 236 subjects of African ori...
journal_title：Scientific reports
pub_type： 杂志文章,多中心研究
doi：10.1038/s41598-019-56328-8
更新日期：2019-12-27 00:00:00
abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title：Scientific reports
pub_type： 已发布勘误
doi：10.1038/s41598-019-54834-3
更新日期：2019-12-04 00:00:00
abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title：Scientific reports
pub_type： 已发布勘误
doi：10.1038/s41598-020-66682-7
更新日期：2020-06-16 00:00:00
abstract：:Varroa destructor mites express strong avoidance of the Apis cerana worker brood in the field. The molecular mechanism for this phenomenon remains unknown. We identified a Varroa toxic protein (VTP), which exhibited toxic activity toward A. cerana worker larvae, in the saliva of these mites, and expressed VTP in an Es...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-21736-9
更新日期：2018-02-21 00:00:00
abstract：:Siglec-2 undergoes constitutive endocytosis and is a drug target for autoimmune diseases and B cell-derived malignancies, including hairy cell leukaemia, marginal zone lymphoma, chronic lymphocytic leukaemia and non-Hodgkin's lymphoma (NHL). An alternative to current antibody-based therapies is the use of liposomal na...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep36012
更新日期：2016-11-03 00:00:00
abstract：:Hyaluronic acid (HA) is a glycosaminoglycan that plays many roles in health and disease and is a key biomarker of certain cancers. Therefore, its detection at an early stage, by histochemical methods, is of importance. However, intracellular HA can be masked by other HA-binding macromolecules, rendering its visualizat...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-40348-5
更新日期：2019-03-08 00:00:00
abstract：:In this study, a noninvasive quantitative measure was used to identify short and long term post-concussion syndrome (PCS) both from each other and from healthy control populations. We used Electrovestibulography (EVestG) for detecting neurophysiological PCS consequent to a mild traumatic brain injury (mTBI) in both sh...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-15487-2
更新日期：2017-11-27 00:00:00
abstract：:In this article, we experimentally and numerically investigate a planar terahertz metamaterial (MM) geometry capable of exhibiting independently tunable multi-band electromagnetically induced transparency effect (EIT). The MM structure exhibits multi-band EIT effect due to the strong near field coupling between the br...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-54414-5
更新日期：2019-12-02 00:00:00
