Abstract:
:Exposure to light at night (LAN) is associated with insomnia in humans. Light provides the main input to the master clock in the hypothalamic suprachiasmatic nucleus (SCN) that coordinates the sleep-wake cycle. We aimed to develop a rodent model for the effects of LAN on sleep. Therefore, we exposed male Wistar rats to either a 12 h light (150-200lux):12 h dark (LD) schedule or a 12 h light (150-200 lux):12 h dim white light (5 lux) (LDim) schedule. LDim acutely decreased the amplitude of daily rhythms of REM and NREM sleep, with a further decrease over the following days. LDim diminished the rhythms of 1) the circadian 16-19 Hz frequency domain within the NREM sleep EEG, and 2) SCN clock gene expression. LDim also induced internal desynchronization in locomotor activity by introducing a free running rhythm with a period of ~25 h next to the entrained 24 h rhythm. LDim did not affect body weight or glucose tolerance. In conclusion, we introduce the first rodent model for disturbed circadian control of sleep due to LAN. We show that internal desynchronization is possible in a 24 h L:D cycle which suggests that a similar desynchronization may explain the association between LAN and human insomnia.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Stenvers DJ,van Dorp R,Foppen E,Mendoza J,Opperhuizen AL,Fliers E,Bisschop PH,Meijer JH,Kalsbeek A,Deboer Tdoi
10.1038/srep35662subject
Has Abstractpub_date
2016-10-20 00:00:00pages
35662issn
2045-2322pii
srep35662journal_volume
6pub_type
杂志文章abstract::Zika virus (ZIKV) is an emerging mosquito-borne pathogen representing a global health concern. It has been linked to fetal microcephaly and other birth defects and neurological disorders in adults. Sanofi Pasteur has engaged in the development of an inactivated ZIKV vaccine, as well as a live chimeric vaccine candidat...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-31375-9
更新日期:2018-09-04 00:00:00
abstract::Hydrocarbons fuel our economy. Furthermore, intermediate goods and consumer products are often hydrocarbon-based. Beside all the progress they made possible, hydrogen-containing substances can have severe detrimental effects on materials exposed to them. Hydrogen-assisted failure of iron alloys has been recognised mor...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-60370-2
更新日期:2020-02-27 00:00:00
abstract::A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper. ...
journal_title:Scientific reports
pub_type: 已发布勘误
doi:10.1038/s41598-019-39693-2
更新日期:2019-04-17 00:00:00
abstract::Growth in salmon aquaculture over the past two decades has raised concerns regarding the potential impacts of the industry on neighboring ecosystems and wild fish productivity. Despite limited evidence, sea lice have been identified as a major cause for the decline in some wild Pacific salmon populations on the west c...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-22458-8
更新日期:2018-03-05 00:00:00
abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title:Scientific reports
pub_type: 已发布勘误
doi:10.1038/s41598-020-59761-2
更新日期:2020-02-11 00:00:00
abstract::E. coli expressed recombinant basic fibroblast growth factor (bFGF) with histidine-tag (bFGF-His) was immobilized onto the surface of a glass plate modified with a Ni(II)-chelated alkanethiol monolayer. The immobilization is expected to take place through the coordination between Ni(II) and His-tag. The bFGF-immobiliz...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-65572-2
更新日期:2020-05-29 00:00:00
abstract::We characterised wool traits, and skin gene expression profiles of fine wool Super Merino (SM) and coarse wool Small Tail Han (STH) sheep. SM sheep had a significantly higher total density of wool follicles, heavier fleeces, finer fibre diameter, and increased crimp frequency, staple length and wool grease (lanolin) p...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-14772-4
更新日期:2017-10-30 00:00:00
abstract::Materials with a layered structure have attracted tremendous attention because of their unique properties. The ultrathin nanosheet structure can result in extremely rapid intercalation/de-intercalation of Na ions in the charge-discharge progress. Herein, we report a manganese oxide with pre-intercalated K and Na ions ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-02028-0
更新日期:2017-05-22 00:00:00
abstract::Although intestinal trefoil factor (ITF) can alleviate the burn-induced intestinal mucosa injury, the underlying mechanisms remains elusive. In this study, we investigated if ITF alters glutamine transport on the brush border membrane vesicles (BBMVs) of the intestines in Sprague-Dawley rats inflicted with 30% TBSA an...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-21282-4
更新日期:2018-02-16 00:00:00
abstract::N-myc downstream regulated gene 1 (NDRG1) is a responsible gene for a hereditary motor and sensory neuropathy-Lom (Charcot-Marie-Tooth disease type 4D). This is the first study aiming to assess the contribution of NDRG1 to differentiation of macrophage lineage cells, which has important implications for bone remodelin...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep19470
更新日期:2016-01-18 00:00:00
abstract::Whether age has any impact on the risk of lymph node (LN) metastasis in patients with early-stage non-small cell lung cancer (NSCLC) remains controversial. Therefore, we aimed to objectively compare the risk of LN metastasis between elderly and young patients so as to justify for age-different extent of surgical resec...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-66509-5
更新日期:2020-06-12 00:00:00
abstract::The poor bonding strength between biopolymer and bioceramic has remained an unsolved issue. In this study, graphene oxide (GO) was introduced as an interface phase to improve the interfacial bonding between polyetheretherketone (PEEK) and hydroxyapatite (HAP) for tissue engineering scaffolds. On the one hand, the conj...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep46604
更新日期:2017-04-20 00:00:00
abstract::Electrochemical capacitors (EC) have received tremendous interest due to their high potential to satisfy the urgent demand in many advanced applications. The development of new electrode materials is considered to be the most promising approach to enhance the EC performance substantially. Herein, we present a high-cap...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep06083
更新日期:2014-08-15 00:00:00
abstract::The kynurenine pathway (KP) is dysregulated in neuroinflammatory diseases including Alzheimer's disease (AD), however has not been investigated in preclinical AD characterized by high neocortical amyloid-β load (NAL), prior to cognitive impairment. Serum KP metabolites were measured in the cognitively normal KARVIAH c...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-25968-7
更新日期:2018-05-22 00:00:00
abstract::Locusts have excellent jumping and kicking abilities to survive in nature, which are achieved through the energy storage and release processes occurring in cuticles, especially in the semi-lunar processes (SLP) at the femorotibial joints. As yet, however, the strain energy-storage mechanisms of the SLP cuticles remain...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep35219
更新日期:2016-10-17 00:00:00
abstract::Efficient inactivation of Escherichia coli (E. coli) under visible (532 nm) pulsed light irradiation was achieved by fusion of a visible light-absorbing dye with E. coli. Inactivation experiments showed that 3-log inactivation of E. coli was obtained within 20 min under a 50 kJ/cm2 dose. This treatment time and dose m...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-74714-5
更新日期:2020-10-20 00:00:00
abstract::While a large body of research has focused on the study of functional brain "connectivity", few investigators have focused on directionality of brain-brain interactions which, in spite of the mostly bidirectional anatomical substrates, cannot be assumed to be symmetrical. We employ a multivariate Granger Causality-bas...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-23996-x
更新日期:2018-04-03 00:00:00
abstract::Non-homologous end joining (NHEJ) is a major DNA double-strand break (DSB) repair mechanism. We characterized here a series of plasmid-based DSB templates that were repaired in Xenopus egg extracts via the canonical, Ku-dependent NHEJ pathway. We showed that the template with compatible ends was efficiently repaired w...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep27797
更新日期:2016-06-21 00:00:00
abstract::Previous studies demonstrated independent contributions of plasma free amino acids (PFAAs) and high uric acid (UA) concentrations to increased risks of lifestyle-related diseases (LSRDs), but the important associations between these factors and LSRDs remain unknown. We quantified PFAAs and UA amongst Japanese subjects...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-17710-6
更新日期:2017-12-15 00:00:00
abstract::The leaf venation architecture is an ideal, highly structured and efficient irrigation system in plant leaves. Leaf vein density (LVD) and vein thickness are the two major properties of this system. Leaf laminae carry out photosynthesis to harvest the maximum biological yield. It is still unknown whether the LVD and/o...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep36894
更新日期:2016-11-16 00:00:00
abstract::Pyocyanin is a blue green phenazine pigment produced in large quantities by active cultures of Pseudomonas aeruginosa, with advantageous applications in medicine, agriculture and for the environment. Hence, in the present study, a potent bacterium was isolated from agricultural soil and was identified morphologically ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-58335-6
更新日期:2020-01-31 00:00:00
abstract::The Y chromosome has high genetic variability with low rates of parallel and back mutations, which make up the most informative haplotyping system. To examine whether Y chromosome haplogroups (Y-hgs) could modify the effects of autosomal variants on non-obstructive azoospermia (NOA), based on our previous genome-wide ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep33363
更新日期:2016-09-15 00:00:00
abstract::Haematopoietic cells arise from endothelial cells within the dorsal aorta of the embryo via a process called the endothelial-haematopoietic transition (EHT). This process crucially depends on the transcription factor RUNX1 which rapidly activates the expression of genes essential for haematopoietic development. Using ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-28506-7
更新日期:2018-07-10 00:00:00
abstract::Honeybee pupae morphology can be affected by a number of stressor, but in vivo investigation is difficult. A computed tomography (CT) technique was applied to visualize a comb's inner structure without damaging the brood. The CT scan was performed on a brood comb containing pupae developed from eggs laid by the queen ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-46474-4
更新日期:2019-07-23 00:00:00
abstract::The aim was to analyze the effect of fractional flow reserve (FFR), intravascular ultrasound (IVUS) and optical coherence tomography (OCT) on fluoroscopy time (FT), radiation dose (RD) and contrast volume (CV) in patients undergoing coronary angiography. This case-control study included consecutive patients above the ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-63791-1
更新日期:2020-04-24 00:00:00
abstract::Observations and modeling studies have shown that during CO2 injection into underground carbonate reservoirs, the dissolution of CO2 into formation water forms acidic brine, leading to fluid-rock interactions that can significantly impact the hydraulic properties of the host formation. However, the impacts of these in...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-60247-4
更新日期:2020-02-27 00:00:00
abstract::Spatial organization of G-protein coupled receptors (GPCRs) into dimers and higher order oligomers has been demonstrated in vitro and in vivo. The pharmacological readout was shown to depend on the specific interfaces, but why particular regions of the GPCR structure are involved, and how ligand-determined states chan...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep02909
更新日期:2013-10-09 00:00:00
abstract::The influence of meteorological determinants on tuberculosis (TB) incidence remains severely under-discussed, especially through the perspective of time series analysis. In the current study, we used a distributed lag nonlinear model (DLNM) to analyze a 10-year series of consecutive surveillance data. We found that, a...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-28426-6
更新日期:2018-07-03 00:00:00
abstract::The mosquito, Aedes baisasi, which inhabits brackish mangrove swamps, is known to feed on fish. However, its host assemblage has not been investigated at the species level. We amplified and sequenced the cytochrome oxidase subunit I barcoding regions as well as some other regions from blood-fed females to identify hos...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-40509-6
更新日期:2019-03-08 00:00:00
abstract::Graphene has been identified as an emerging horizon for a nanoscale photonic platform because the Fermi level of intrinsic graphene can be engineered to support surface plasmons (SPs). The current solid back electrical gating and chemical doping methods cannot facilitate the demonstration of graphene SPs at the near-i...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep06559
更新日期:2014-10-09 00:00:00