Abstract：
:We characterised wool traits, and skin gene expression profiles of fine wool Super Merino (SM) and coarse wool Small Tail Han (STH) sheep. SM sheep had a significantly higher total density of wool follicles, heavier fleeces, finer fibre diameter, and increased crimp frequency, staple length and wool grease (lanolin) production. We found 435 genes were expressed at significantly different levels in the skin of the two breeds (127 genes more highly in SM and 308 genes more highly in STH sheep). Classification of the genes more highly expressed in SM sheep revealed numerous lipid metabolic genes as well as genes encoding keratins, keratin-associated proteins, and wool follicle stem cell markers. In contrast, mammalian epidermal development complex genes and other genes associated with skin cornification and muscle function were more highly expressed in STH sheep. Genes identified in this study may be further evaluated for inclusion in breeding programs, or as targets for therapeutic or genetic interventions, aimed at altering wool quality or yield. Expression of the lipid metabolic genes in the skin of sheep may be used as a novel trait with the potential to alter the content or properties of lanolin or the fleece.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Zhang L,Sun F,Jin H,Dalrymple BP,Cao Y,Wei T,Vuocolo T,Zhang M,Piao Q,Ingham ABdoi
10.1038/s41598-017-14772-4subject
Has Abstractpub_date
2017-10-30 00:00:00pages
14301issue
1issn
2045-2322pii
10.1038/s41598-017-14772-4journal_volume
7pub_type
杂志文章abstract：:The network structure of biological systems provides information on the underlying processes shaping their organization and dynamics. Here we examined the structure of the network depicting protein interactions within the spliceosome, the macromolecular complex responsible for splicing in eukaryotic cells. We show the...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep14865
更新日期：2015-10-07 00:00:00
abstract：:Anammox is a cost-effective process to treat nitrogenous wastewater. In this work, excitation-emission matrix (EEM) fluorescence spectroscopy was used to characterize the intracellular and extracellular substances of anammox sludge during reactor operation of 276 days. Four main fluorophores were identified from the i...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep39289
更新日期：2017-01-16 00:00:00
abstract：:Hexane, dichloromethane and methanol extracts of the roots of Piper sarmentosum Roxb. were screened for toxicity towards Sitophilus oryzae (L.), Rhyzopertha dominica (F.), and Plodia interpunctella (Hübner) and the hexane extract exhibited the highest mortality percentage. Bioassay-guided fractionation of the hexane e...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-12898-z
更新日期：2017-10-03 00:00:00
abstract：:The FDA-approved prophylactic antimalarial drug atovaquone (ATO) recently was repurposed as an antitumor drug. Studies show that ATO exerts a profound antiproliferative effect in several cancer cells, including breast, ovarian, and glioma. Analogous to the mechanism of action proposed in parasites, ATO inhibits mitoch...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-74808-0
更新日期：2020-10-21 00:00:00
abstract：:The formation of snow-dirt sludge (SDS) via the mixing of snow and surface-deposited sediment by vehicles and pedestrians is one of the least studied sedimentation processes in urban areas. The aim of this study was to analyse the material, mineral, particle size, and chemical compositions of the SDS solid phase. The ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-53793-z
更新日期：2019-11-21 00:00:00
abstract：:Single-cell RNA-seq has been established as a reliable and accessible technique enabling new types of analyses, such as identifying cell types and studying spatial and temporal gene expression variation and change at single-cell resolution. Recently, single-cell RNA-seq has been applied to developing embryos, which of...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-61591-1
更新日期：2020-03-18 00:00:00
abstract：:Amplification and sequencing of 16S amplicons are widely used for profiling the structure of oral microbiota. However, it remains not clear whether and to what degree DNA extraction and targeted 16S rRNA hypervariable regions influence the analysis. Based on a mock community consisting of five oral bacterial species i...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-34294-x
更新日期：2018-11-05 00:00:00
abstract：:The decomposition of methane (CH4) is a catalytically important reaction in the production of syngas that is used to make a wide spectrum of hydrocarbons and alcohols, and a principal carbon deposition pathway in methane reforming. Literatures suggest that stepped Ni surface is uniquely selective toward methane decomp...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-14050-3
更新日期：2017-10-25 00:00:00
abstract：:The variation in energy bandgaps of amorphous oxide semiconducting SiZnSnO (a-SZTO) has been investigated by controlling the oxygen partial pressure (Op). The systematic change in Op during deposition has been used to control the electrical characteristics and energy bandgap of a-SZTO. As Op increased, the electrical ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-55807-2
更新日期：2019-12-17 00:00:00
abstract：:Assembly of nanowires into ordered macroscopic structures with new functionalities has been a recent focus. In this Letter, we report a new route for ordering hydrophilic Ag nanowires with high aspect ratio by flowing through a glass capillary. The present glass capillary with well-defined silver nanowire films inside...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep00987
更新日期：2012-01-01 00:00:00
abstract：:Cystatin C (CysC) is implicated in neuroprotection and repair in the nervous system in response to diverse neurotoxic conditions. In addition to being secreted from cells in a soluble form, CysC is released by cells in association with extracellular vesicles (EVs), including exosomes. We demonstrate that EVs containin...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-47524-7
更新日期：2019-07-31 00:00:00
abstract：:KIBRA has been suggested as a key regulator of the hippo pathway, regulating organ size, cell contact inhibition as well as tissue regeneration and tumorigenesis. Recently, alterations of KIBRA expression caused by promotor methylation have been reported for several types of cancer. Our current study aimed to design a...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-22600-6
更新日期：2018-03-09 00:00:00
abstract：:The nuclear factor κB (NF-κB) pathway plays a key role in innate and adaptive immunity, cell proliferation and survival, inflammation and tumors development. MiR-146a is an immune system regulator that has anti-inflammatory function in multiple cell types and conditions. Here we demonstrate activation of canonical NF-...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-41530-5
更新日期：2019-03-26 00:00:00
abstract：:The AB0 blood group has been linked to ischaemic heart disease, stroke, and periodontal disease, while the Lewis blood group has been linked to ischaemic heart disease and obesity, all of which have been associated with periodontitis. AB0 or Lewis blood group phenotype may therefore constitute common hereditary compon...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-42594-z
更新日期：2019-04-18 00:00:00
abstract：:A number of studies have shown that visible and near infrared spectroscopy (VIS-NIRS) offers a rapid on-site measurement tool for the determination of total contaminant concentration of petroleum hydrocarbons compounds (PHC), heavy metals and metalloids (HM) in soil. However none of them have yet assessed the feasibil...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-41161-w
更新日期：2019-03-14 00:00:00
abstract：:Huntington's disease (HD) is a monogenetic neurodegenerative disorder that is caused by the expansion of a polyglutamine region within the huntingtin (HTT) protein, but there is still an incomplete understanding of the molecular mechanisms that drive pathology. Expression of the mutant form of HTT is a key aspect of d...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-78790-5
更新日期：2020-12-17 00:00:00
abstract：:Although it is known that malaria parasites proliferate in the midgut of mosquito vector, their detailed behaviors, from gamete maturation to formation of next generation sporozoite, have not been fully understood at cellular or molecular level. This is mainly attributed to technical difficulties of dissection and who...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-38529-3
更新日期：2019-02-11 00:00:00
abstract：:Automatically detecting and grading cancerous regions on radical prostatectomy (RP) sections facilitates graphical and quantitative pathology reporting, potentially benefitting post-surgery prognosis, recurrence prediction, and treatment planning after RP. Promising results for detecting and grading prostate cancer on...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-66849-2
更新日期：2020-06-18 00:00:00
abstract：:CD4+Foxp3+ regulatory T cells (Tregs) are the main immune suppressors with subpopulation of inflamed-tissue related memory Tregs (mTregs) and non-related resting Treg (rTregs). Previously, Treg was proposed to be the cause of chronicity of hepatitis B virus (HBV) infection but with controversies. We then investigated ...
journal_title：Scientific reports
pub_type： 临床试验,杂志文章
doi：10.1038/s41598-017-15527-x
更新日期：2017-11-10 00:00:00
abstract：:Existing understanding of molecular composition of sputum and its role in tuberculosis patients is variously limited to its diagnostic potential. We sought to identify infection induced sputum proteome alteration in active/non tuberculosis patients (A/NTB) and their role in altered lung patho-physiology. Out of the st...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-37662-9
更新日期：2019-01-31 00:00:00
abstract：:There is a growing interest concerning the relevance of salivary cortisone levels in stress-related research. However, studies investigating morning patterns and day-to-day variability of cortisone versus cortisol levels are lacking. Cortisol and cortisone analysis by liquid chromatography-tandem mass spectroscopy (LC...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-55571-3
更新日期：2019-12-17 00:00:00
abstract：:Understanding the traits that might be linked with biological invasions represents a great challenge for preventing non-target effects on local biodiversity. In predatory insects, the ability to exploit habitats for oviposition and the physiological response to prey availability differs between species. Those species ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-03471-9
更新日期：2017-06-16 00:00:00
abstract：:Autophagy is known to be implicated in the pathogenesis of Sjögren syndrome (SS), but evidences are limited. We aimed to examine the levels of autophagy markers in tear film and conjunctival epithelial cells from SS dry eye patients, and analyze their correlations with clinical features. Patients with SS dry eye exhib...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-17128-0
更新日期：2017-12-08 00:00:00
abstract：:In order to understand the physical properties of materials it is necessary to determine the 3D positions of all atoms. There has been significant progress towards this goal using electron tomography. However, this method requires a relatively high electron dose and often extended acquisition times which precludes the...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-10654-x
更新日期：2017-09-07 00:00:00
abstract：:Disuse muscle wasting will likely affect everyone in his or her lifetime in response to pathologies such as joint immobilization, inactivity or bed rest. There are no good therapies to treat it. We previously found that allopurinol, a drug widely used to treat gout, protects muscle damage after exhaustive exercise and...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-21552-1
更新日期：2018-02-23 00:00:00
abstract：:Measurement techniques that allow the global analysis of cellular responses while retaining single-cell sensitivity are increasingly needed in order to understand complex and dynamic biological processes. In this context, compromises between sensitivity, degree of multiplexing, throughput, and invasiveness are often u...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-53428-3
更新日期：2019-11-19 00:00:00
abstract：:The positioning of electrodes in electrical impedance myography (EIM) is critical for accurately assessing disease progression and effectiveness of treatment. In human and animal trials for neuromuscular disorders, inconsistent electrode positioning adds errors to the muscle impedance. Despite its importance, how the ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep32615
更新日期：2016-09-02 00:00:00
abstract：:Using classical molecular dynamics with a more reliable reactive LCBOPII potential, we have performed a detailed study on the direct graphite-to-diamond phase transition. Our results reveal a new so-called "wave-like buckling and slipping" mechanism, which controls the transformation from hexagonal graphite to cubic d...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep05930
更新日期：2014-08-04 00:00:00
abstract：:Multisensory integration provides continuous and stable perception from separate sensory inputs. Here, we investigated the functional role of temporal binding between the visual and the tactile senses. To this end we used the paradigm of compression that induces shifts in time when probe stimuli are degraded, e.g., by...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep25843
更新日期：2016-05-16 00:00:00
abstract：:An increase in adipose tissue is caused by the increased size and number of adipocytes. Lipids accumulate in intracellular stores, known as lipid droplets (LDs). Recent studies suggest that parameters such as LD size, shape and dynamics are closely related to the development of obesity. Berberine (BBR), a natural plan...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-47060-4
更新日期：2019-07-19 00:00:00
