Abstract：
:The goal of this work was to develop a mathematical model to predict Kaplan-Meier survival curves for chemotherapy combined with radiation in Non-Small Cell Lung Cancer patients for use in clinical trial design. The Gompertz model was used to describe tumor growth, radiation effect was simulated by the linear-quadratic model with an α/β-ratio of 10, and chemotherapy effect was based on the log-cell kill model. To account for repopulation during treatment, we considered two independent methods: 1) kickoff-repopulation using exponential growth with a decreased volume doubling time, or 2) Gompertz-repopulation using the gradually accelerating growth rate with tumor shrinkage. The input parameters were independently estimated by fitting to the SEER database for untreated tumors, RTOG-8808 for radiation only, and RTOG-9410 for sequential chemo-radiation. Applying the model, the benefit from concurrent chemo-radiation comparing to sequential for stage III patients was predicted to be a 6.6% and 6.2% improvement in overall survival for 3 and 5-years respectively, comparing well to the 5.3% and 4.5% observed in RTOG-9410. In summary, a mathematical model was developed to model tumor growth over extended periods of time, and can be used for the optimization of combined chemo-radiation scheduling and sequencing.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Geng C,Paganetti H,Grassberger Cdoi
10.1038/s41598-017-13646-zsubject
Has Abstractpub_date
2017-10-19 00:00:00pages
13542issue
1issn
2045-2322pii
10.1038/s41598-017-13646-zjournal_volume
7pub_type
杂志文章abstract：:Friction stir processing (FSP) was used to achieve grain refinement on Mg-Al-Zn alloys, which also brought in significant texture modification. The different micro-texture characteristics were found to cause irregular micro-hardness distribution in FSPed region. The effects of texture and grain size were investigated ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-22344-3
更新日期：2018-03-08 00:00:00
abstract：:The ability to reprogram adult somatic cells into induced pluripotent stem cells (iPSCs) and the subsequent development of protocols for their differentiation into disease-relevant cell types have enabled in-depth molecular analyses of multiple disease states as hitherto impossible. Neurons differentiated from patient...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep28420
更新日期：2016-06-24 00:00:00
abstract：:The LiBH4/CaH2 composite are firstly studied as Concentrating Solar Power Thermal Storage Material. The LiBH4/CaH2 composite according to the stoichiometric ratio are synthesized by high-energy ball milling method. The kinetics, thermodynamics and cycling stability of LiBH4/CaH2 composite are investigated by XRD (X-ra...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep41754
更新日期：2017-01-31 00:00:00
abstract：:Despite its intrinsic advantages, translation of laser induced breakdown spectroscopy for material identification has been often impeded by the lack of robustness of developed classification models, often due to the presence of spurious correlations. While a number of classifiers exhibiting high discriminatory power h...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep13169
更新日期：2015-08-19 00:00:00
abstract：:Transgenic expression of I-E molecules prevents diabetes in NOD mice. So far, the precise role of these non-classical MHC II molecules remains elusive. Here, we showed that transgenic expression of I-E(k) alpha 16 molecule in NOD mice selectively reduced Th17 cells in the thymus and pancreatic draining lymph nodes. Th...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep12941
更新日期：2015-08-07 00:00:00
abstract：:There is no treatment for the myelin loss in multiple sclerosis, ultimately resulting in the axonal degeneration that leads to the progressive phase of the disease. We established a multi-tiered platform for the sequential screening of drugs that could be repurposed as remyelinating agents. We screened a library of 2,...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep45780
更新日期：2017-04-07 00:00:00
abstract：:Downstream analysis of genomic and transcriptomic sequence data is often executed by functional annotation that can be performed by various bioinformatics tools and biological databases. However, a full fast integrated tool is not available for such analysis. Besides, the current available software is not able to prod...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-20211-9
更新日期：2018-01-29 00:00:00
abstract：:Geographical origin determination of white rice has become the major issue of food industry. However, there is still lack of a high-throughput method for rapidly and reproducibly differentiating the geographical origins of commercial white rice. In this study, we developed a method that employed lipidomics and deep le...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-08892-0
更新日期：2017-08-17 00:00:00
abstract：:Data-independent acquisition mass spectrometry promises higher performance in terms of quantification and reproducibility compared to data-dependent acquisition mass spectrometry methods. To enable high-accuracy quantification of Staphylococcus aureus proteins, we have developed a global ion library for data-independe...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-10059-w
更新日期：2017-09-08 00:00:00
abstract：:Understanding interactions between cell-penetrating peptides and biomembrane under tension can help improve drug delivery and elucidate mechanisms underlying fundamental cellular events. As far as the effect of membrane tension on translocation, it is generally thought that tension should disorder the membrane structu...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep12808
更新日期：2015-08-03 00:00:00
abstract：:Spatiotemporal tracking of tracer particles or objects of interest can reveal localized behaviors in biological and physical systems. However, existing tracking algorithms are most effective for relatively low numbers of particles that undergo displacements smaller than their typical interparticle separation distance....
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-23488-y
更新日期：2018-04-03 00:00:00
abstract：:Accumulating evidence implies that both AKT1 and GABAA receptor (GABAAR) subunit genes are involved in schizophrenia pathogenesis. Activated Akt promotes GABAergic neuron differentiation and increases GABAAR expression on the plasma membrane. To elucidate the role of Akt1 in modulating GABAergic functions and schizoph...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep33095
更新日期：2016-09-12 00:00:00
abstract：:mRNAs lacking 5' untranslated regions (leaderless mRNAs) are molecular relics of an ancient translation initiation pathway. Nevertheless, they still represent a significant portion of transcriptome in some taxons, including a number of eukaryotic species. In bacteria and archaea, the leaderless mRNAs can bind non-diss...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep37905
更新日期：2016-11-28 00:00:00
abstract：:Despite strong evidence for NMDA receptor (NMDAR) hypofunction as an underlying factor for cognitive disorders, the precise roles of various NMDAR subtypes remains unknown. The GluN2C-containing NMDARs exhibit unique biophysical properties and expression pattern, and lower expression of GluN2C subunit has been reporte...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep38321
更新日期：2016-12-06 00:00:00
abstract：:To investigate the evolution of lung function in preterm infants with and without bronchopulmonary dysplasia (BPD) and to determine the perinatal characteristics associated with indexes of lung function in later infancy. Longitudinal lung function assessments were performed at approximately 6, 12, 18, and 24 months of...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-57359-x
更新日期：2020-01-16 00:00:00
abstract：:The spectral distribution of light emitted from a scanning tunnelling microscope junction not only bears its intrinsic plasmonic signature but is also imprinted with the characteristics of optical frequency fluc- tuations of the tunnel current. Experimental spectra from gold-gold tunnel junctions are presented that sh...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-03766-x
更新日期：2017-06-14 00:00:00
abstract：:Over 80% of perinatal mortality in Japan is due to stillbirths after 22 weeks of gestation, with one in 300 families experiencing fetal loss every year. This study aimed to assess causes and risk factors for singleton stillbirth in Japan. A retrospective cross-sectional study was conducted using the Japan Society of O...
journal_title：Scientific reports
pub_type： 临床试验,杂志文章,多中心研究
doi：10.1038/s41598-018-22546-9
更新日期：2018-03-07 00:00:00
abstract：:We introduce "sense, track and separate" approach for the removal of Hg(2+) ion from aqueous media using highly ordered and magnetic mesoporous ferrosilicate nanocages functionalised with rhodamine fluorophore derivative. These functionalised materials offer both fluorescent and magnetic properties in a single system ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep21820
更新日期：2016-02-25 00:00:00
abstract：:Cortical gyrification of the brain represents the folding characteristic of the cerebral cortex. How the brain cortical gyrification changes from childhood to old age in healthy human subjects is still unclear. Additionally, studies have shown regional gyrification alterations in patients with major psychiatric disord...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-00582-1
更新日期：2017-03-30 00:00:00
abstract：:Alterations in macronutrient intake can have profound effects on energy intake and whole-body metabolism. For example, reducing protein intake increases energy expenditure, increases insulin sensitivity and decreases body weight in rodents. Fibroblast growth factor 21 (FGF21) signaling in the brain is necessary for th...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-76593-2
更新日期：2020-11-11 00:00:00
abstract：:We present combined in situ X-ray diffraction and high-speed imaging to monitor the phase evolution upon cyclic rapid laser heating and cooling mimicking the direct energy deposition of Ti-6Al-4V in real time. Additive manufacturing of the industrially relevant alloy Ti-6Al-4V is known to create a multitude of phases ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-16760-0
更新日期：2017-11-27 00:00:00
abstract：:Respiratory syncytial virus (RSV) is an important cause of serious lower respiratory tract disease in infants. Several studies have shown evidence pointing to the genome of the host as an important factor determining susceptibility to respiratory disease caused by RSV. We sequenced the complete exomes of 54 patients i...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-15752-4
更新日期：2017-11-21 00:00:00
abstract：:Research on argillite as a possible host rock for nuclear waste disposal is still an open subject since many issues need to be clarified. In the Underground Research Laboratories constructed for this purpose, a damaged zone around the excavation has been systematically observed and characterized by the appearance of m...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep08815
更新日期：2015-03-06 00:00:00
abstract：:Species are chronically exposed to ionizing radiation, a natural phenomenon which can be enhanced by human activities. The induced toxicity mechanisms still remain unclear and seem depending on the mode of exposure, i.e. acute and chronic. To better understand these phenomena, studies need to be conducted both at the ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-29033-1
更新日期：2018-07-27 00:00:00
abstract：:Mycobacterium tuberculosis, the etiological agent of the infectious disease tuberculosis, kills approximately 1.5 million people annually, while the spread of multidrug-resistant strains is of great global concern. Thus, continuous efforts to identify new antitubercular drugs as well as novel targets are crucial. Rece...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-21614-4
更新日期：2018-02-16 00:00:00
abstract：:Quantum walks often provide telling insights about the structure of the system on which they are performed. In [Formula: see text]-symmetric and lossy dimer lattices, the topological properties of the band structure manifest themselves in the quantization of the mean displacement of such a walker. We investigate the f...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-30344-6
更新日期：2018-08-13 00:00:00
abstract：:We report an integrated system for accelerating assays with concentrators in a standard 12-well plate (ISAAC-12) and demonstrate its versatility for rapid detection of matrix metalloproteinase (MMP)-9 expression in the cell culture supernatant of breast cancer cell line MDA-MB-231 by accelerating the enzymatic reactio...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-29065-7
更新日期：2018-07-17 00:00:00
abstract：:Mutations in the Norrin (NDP) gene cause severe developmental blood vessel defects in the retina leading to congenital blindness. In the retina of Ndph-knockout mice only the superficial capillary network develops. Here, a detailed characterization of this mouse model at late stages of the disease using in vivo retina...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-24476-y
更新日期：2018-04-13 00:00:00
abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title：Scientific reports
pub_type： 已发布勘误
doi：10.1038/s41598-020-62439-4
更新日期：2020-03-24 00:00:00
abstract：:We present a detailed experimental and theoretical study of the acoustic phonon modes in rolled-up multilayers with thickness of the layers in the nanometre and diameters in the micrometre range. We compare our results to planar, unrolled multilayers grown by molecular beam epitaxy. For the planar multilayers the expe...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-05739-6
更新日期：2017-07-14 00:00:00
