Abstract：
:To investigate the evolution of lung function in preterm infants with and without bronchopulmonary dysplasia (BPD) and to determine the perinatal characteristics associated with indexes of lung function in later infancy. Longitudinal lung function assessments were performed at approximately 6, 12, 18, and 24 months of corrected age in preterm infants. Perinatal characteristics were further analyzed to ascertain the determinants of lung function indexes. Although all preterm infants (n = 121; 61 without BPD and 60 with BPD) exhibited decreased lung function in early infancy (6 months of age), after body length was adjusted for, only infants with BPD exhibited poor performance. Furthermore, the lung function of infants with mild to moderate BPD caught up gradually, but the generally poor lung function performance of infants with severe BPD, especially in forced expiratory flow, persisted until later age (24 months). Regarding perinatal characteristics, the z-score of body length at the time of examination and total number of days on positive-pressure ventilation are the major determinants of lung function in later infancy.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Lai SH,Chiang MC,Chu SM,Hsu JF,Yao TC,Tsai MH,Hua MC,Chiu CY,Yeh KW,Huang JL,Liao SLdoi
10.1038/s41598-019-57359-xsubject
Has Abstractpub_date
2020-01-16 00:00:00pages
490issue
1issn
2045-2322pii
10.1038/s41598-019-57359-xjournal_volume
10pub_type
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