Permeability-driven selection in a semi-empirical protocell model: the roots of prebiotic systems evolution.

abstract：:The values of physiological indices and the enzymes activities involved in the overwintering stage were studied in D. armandi larvae in each month from October 2014 to March 2015. The sorbitol, trehalose and glycerol values initially tended to increase as the ambient temperature decreased, before declining until the e...

journal_title：Scientific reports

authors： Wang J,Zhang RR,Gao GQ,Ma MY,Chen H

更新日期：2016-10-05 00:00:00

abstract：:Gastric cancer is one of the most aggressive cancers and is the second leading cause of cancer death worldwide. Approximately 40% of global gastric cancer cases occur in China, with peritoneal metastasis being the prevalent form of recurrence and metastasis in advanced disease. Currently, there are limited clinical ap...

journal_title：Scientific reports

authors： Zhang J,Huang JY,Chen YN,Yuan F,Zhang H,Yan FH,Wang MJ,Wang G,Su M,Lu G,Huang Y,Dai H,Ji J,Zhang J,Zhang JN,Jiang YN,Chen SJ,Zhu ZG,Yu YY

更新日期：2015-09-02 00:00:00

abstract：:We compared the gut microbial populations in 100 women, from rural Ghana and urban US [50% lean (BMI < 25 kg/m2) and 50% obese (BMI ≥ 30 kg/m2)] to examine the ecological co-occurrence network topology of the gut microbiota as well as the relationship of short chain fatty acids (SCFAs) with obesity. Ghanaians consumed...

journal_title：Scientific reports

authors： Dugas LR,Bernabé BP,Priyadarshini M,Fei N,Park SJ,Brown L,Plange-Rhule J,Nelson D,Toh EC,Gao X,Dong Q,Sun J,Kliethermes S,Gottel N,Luke A,Gilbert JA,Layden BT

更新日期：2018-11-20 00:00:00

abstract：:Methylated non-CpGs (mCpH; H means A, C, and T) have emerged as key epigenetic marks in mammalian embryonic stem cells (ESCs) and neurons, regulating cell type-specific functions. In these two cell types, mCpHs show distinct motifs and correlations to transcription that could be a key in understanding the cell type-sp...

journal_title：Scientific reports

authors： Lee JH,Park SJ,Nakai K

更新日期：2017-09-12 00:00:00

abstract：:Recent advances in RNA-seq methodologies from limiting amounts of mRNA have facilitated the characterization of rare cell-types in various biological systems. So far, however, technical variations in these methods have not been adequately characterized, vis-à-vis sensitivity, starting with reduced levels of mRNA. Here...

journal_title：Scientific reports

authors： Bhargava V,Head SR,Ordoukhanian P,Mercola M,Subramaniam S

更新日期：2014-01-14 00:00:00

abstract：:Congenital ptosis may be associated with abnormalities of visual development and function, including amblyopia, strabismus and refractive errors. However, the prevalence estimates of these abnormalities vary widely. We performed a systematic review and meta-analysis to estimate the prevalence of amblyopia, strabismus ...

journal_title：Scientific reports

authors： Wang Y,Xu Y,Liu X,Lou L,Ye J

更新日期：2018-05-29 00:00:00

abstract：:Despite numerous advances in genomics and bioinformatics, technological hurdles remain to examine host-microbe transcriptomics. Sometimes the transcriptome of either or both can be ascertained merely by generating more sequencing reads. However, many cases exist where bacterial mRNA needs to be enriched further to ena...

journal_title：Scientific reports

authors： Kumar N,Lin M,Zhao X,Ott S,Santana-Cruz I,Daugherty S,Rikihisa Y,Sadzewicz L,Tallon LJ,Fraser CM,Dunning Hotopp JC

更新日期：2016-10-07 00:00:00

abstract：:Histone deacetylase inhibition (HDACi) has been suggested as a promising approach to bolster TLR-mediated induction of antimicrobial peptides such as human β-defensin 2 (hBD2). In inflammatory bowel disease (IBD), Crohn's disease (CD) patients display an attenuated expression of hBD2 as compared to ulcerative colitis ...

journal_title：Scientific reports

authors： Stebe-Frick S,Ostaff MJ,Stange EF,Malek NP,Wehkamp J

更新日期：2018-08-27 00:00:00

abstract：:Angiogenesis, the formation of new blood vessels, is a vital process for tissue growth and development. The Notch cell-cell signalling pathway plays an important role in endothelial cell specification during angiogenesis. Dll4 - Notch1 signalling directs endothelial cells into migrating tip or proliferating stalk cell...

journal_title：Scientific reports

authors： Tiemeijer LA,Frimat JP,Stassen OMJA,Bouten CVC,Sahlgren CM

更新日期：2018-04-23 00:00:00

abstract：:Observational studies examining the relationship between hypertension and breast cancer risk have reported conflicting findings. We conducted this systematic review and meta-analysis to summarize the evidence regarding the association between hypertension and risk of breast cancer. Eligible studies were identified thr...

journal_title：Scientific reports

authors： Han H,Guo W,Shi W,Yu Y,Zhang Y,Ye X,He J

更新日期：2017-03-20 00:00:00

abstract：:Mammalian Eag1 (Kv10.1) potassium (K+) channels are widely expressed in the brain. Several mutations in the gene encoding human Eag1 K+ channel have been associated with congenital neurodevelopmental anomalies. Currently very little is known about the molecules mediating protein synthesis and degradation of Eag1 chann...

journal_title：Scientific reports

authors： Hsu PH,Ma YT,Fang YC,Huang JJ,Gan YL,Chang PT,Jow GM,Tang CY,Jeng CJ

更新日期：2017-01-18 00:00:00

abstract：:An increase in mechanical load in the heart causes cardiac hypertrophy, either physiologically (heart development, exercise and pregnancy) or pathologically (high blood pressure and heart-valve regurgitation). Understanding cardiac hypertrophy is critical to comprehending the mechanisms of heart development and treatm...

journal_title：Scientific reports

authors： Yang H,Schmidt LP,Wang Z,Yang X,Shao Y,Borg TK,Markwald R,Runyan R,Gao BZ

更新日期：2016-02-10 00:00:00

abstract：:Glioma is the most common primary intracranial tumor and is associated with very low survival rates. The development of reliable biomarkers can help to elucidate the molecular mechanisms involved in glioma development. Here the expression of ABCC8 mRNA, clinical characteristics, and survival information based on 1893 ...

journal_title：Scientific reports

authors： Zhou K,Liu Y,Zhao Z,Wang Y,Huang L,Chai R,Li G,Jiang T

更新日期：2020-07-29 00:00:00

abstract：:We tested the hypothesis that epigenetic mechanisms in the brain and the immune system are associated with chronic pain. Genome-wide DNA methylation assessed in 9 months post nerve-injury (SNI) and Sham rats, in the prefrontal cortex (PFC) as well as in T cells revealed a vast difference in the DNA methylation landsca...

journal_title：Scientific reports

authors： Massart R,Dymov S,Millecamps M,Suderman M,Gregoire S,Koenigs K,Alvarado S,Tajerian M,Stone LS,Szyf M

更新日期：2016-01-28 00:00:00

abstract：:As antibody-based diagnosis and therapy grow at an increased pace, there is a need for methods which rapidly and accurately determine antibody-antigen interactions. Here, we report a method for the multiplex determination of antibody epitopes using bacterial cell-surface display. A protein-fragment library with 10(7) ...

journal_title：Scientific reports

authors： Hudson EP,Uhlen M,Rockberg J

更新日期：2012-01-01 00:00:00

abstract：:It has been reported that in patients with operable stage I non-small cell lung cancer (NSCLC), overall survival (OS) is better in those who undergo hypofractionated stereotactic radiation therapy (HSRT) than in those who undergo surgery. However, the reason that HSRT has a better OS has not been fully explored. Here,...

journal_title：Scientific reports

authors： Zhang T,Yu H,Ni C,Zhang T,Liu L,Lv Q,Zhang Z,Wang Z,Wu D,Wu P,Chen G,Wang L,Wei Q,Huang J,Wang X

更新日期：2017-07-07 00:00:00

abstract：:Lambdoid craniosynostosis (LC) is a rare non-syndromic craniosynostosis characterised by fusion of the lambdoid sutures at the back of the head. Surgical correction including the spring assisted cranioplasty is the only option to correct the asymmetry at the skull in LC. However, the aesthetic outcome from spring assi...

journal_title：Scientific reports

authors： Bozkurt S,Borghi A,van de Lande LS,Jeelani NUO,Dunaway DJ,Schievano S

更新日期：2020-10-29 00:00:00

abstract：:The recent discovery that human noroviruses (huNoVs) recognize sialic acids (SAs) in addition to histo-blood group antigens (HBGAs) pointed to a new direction in studying virus-host interactions during calicivirus infection. HuNoVs remain difficult to study due to the lack of an effective cell culture model. In this s...

journal_title：Scientific reports

authors： Tan M,Wei C,Huang P,Fan Q,Quigley C,Xia M,Fang H,Zhang X,Zhong W,Klassen JS,Jiang X

更新日期：2015-07-06 00:00:00

abstract：:This paper proposes a novel "micro-gun" structure for laser pulse propulsion. The "micro-bullets" (glass microspheres) are irradiated by a laser pulse with a 10 ns duration in a dynamic process. Experimental parameters such as the microsphere diameter and the laser pulse energy are varied to investigate their influenc...

journal_title：Scientific reports

authors： Yu H,Li H,Cui L,Liu S,Yang J

更新日期：2017-11-24 00:00:00

abstract：:To what extent deep-time dispersal limitation shapes present-day biodiversity at broad spatial scales remains elusive. Here, we compiled a continental dataset on the distributions of African lizard species in the reptile subfamily Agaminae (a relatively young, Neogene radiation of agamid lizards which ancestors coloni...

journal_title：Scientific reports

authors： Kissling WD,Blach-Overgaard A,Zwaan RE,Wagner P

更新日期：2016-09-27 00:00:00

abstract：:Cyanobacteria are attractive microbial hosts for production of chemicals using light and CO2. However, their low productivity of chemicals is a major challenge for commercial applications. This is mostly due to their relatively slow growth rate and carbon partitioning toward biomass rather than products. Many cyanobac...

journal_title：Scientific reports

authors： Lin PC,Zhang F,Pakrasi HB

更新日期：2020-01-15 00:00:00

abstract：:Electroceutical wound dressings, especially those involving current flow with silver based electrodes, show promise for treating biofilm infections. However, their mechanism of action is poorly understood. We have developed an in vitro agar based model using a bioluminescent strain of Pseudomonas aeruginosa to measure...

journal_title：Scientific reports

authors： Dusane DH,Lochab V,Jones T,Peters CW,Sindeldecker D,Das A,Roy S,Sen CK,Subramaniam VV,Wozniak DJ,Prakash S,Stoodley P

更新日期：2019-02-14 00:00:00

abstract：:Molecular characterization of the coral host and the microbial assemblages associated with it (referred to as the coral holobiont) is currently undertaken via marker gene sequencing. This requires bulky instruments and controlled laboratory conditions which are impractical for environmental experiments in remote areas...

journal_title：Scientific reports

authors： Carradec Q,Poulain J,Boissin E,Hume BCC,Voolstra CR,Ziegler M,Engelen S,Cruaud C,Planes S,Wincker P

更新日期：2020-09-28 00:00:00

abstract：:Photonic qubits lie at the heart of quantum information technology, often encoding information in their polarization state. So far, only low-frequency optical and infrared photons have been employed as flying qubits, as the resources that are at present easiest to control. With their essentially different way of inter...

journal_title：Scientific reports

authors： Gunst J,Keitel CH,Pálffy A

更新日期：2016-04-27 00:00:00

abstract：:We investigate the timescales of the horizontal mass flux decay of wind remobilised volcanic particles in Argentina, associated with the tephra-fallout deposit produced by the 2011-2012 Cordón Caulle (Chile) eruption. Particle removal processes are controlled by complex interactions of meteorological conditions, surfa...

journal_title：Scientific reports

authors： Dominguez L,Rossi E,Mingari L,Bonadonna C,Forte P,Panebianco JE,Bran D

更新日期：2020-09-02 00:00:00

abstract：:Despite recent advances, the myocardial microstructure remains imperfectly understood. In particular, bundles of cardiomyocytes have been observed but their three-dimensional organisation remains debated and the associated mechanical consequences unknown. One of the major challenges remains to perform multiscale obser...

journal_title：Scientific reports

authors： Tueni N,Vizet J,Genet M,Pierangelo A,Allain JM

更新日期：2020-11-25 00:00:00

abstract：:Lateral organ boundaries domain (LBD) proteins are plant-specific transcription factors that play a crucial role in growth and development, as well as metabolic processes. However, knowledge of the function of LBD proteins in Camellia sinensis is limited, and no systematic investigations of the LBD family have been re...

journal_title：Scientific reports

authors： Zhang X,He Y,He W,Su H,Wang Y,Hong G,Xu P

更新日期：2019-10-30 00:00:00

abstract：:This study aimed to examine hemodynamic responses and the necessity of breaks under long working hours. Thirty-eight healthy males conducted PC-based work from 9:10 to 22:00. Nine 10-minute short breaks and two long breaks (a 1-hour break and a 50-minute break) were provided, and hemodynamic responses were measured re...

journal_title：Scientific reports

authors： Liu X,Ikeda H,Oyama F,Wakisaka K,Takahashi M

更新日期：2018-09-28 00:00:00

abstract：:Within year individual variation in the timing of seasonal reproduction within wild bird populations in highly seasonal environments can be pronounced, but the molecular and physiological mechanisms responsible for this variation are unclear. We investigated the relationship between Clock gene poly-Q length, activatio...

journal_title：Scientific reports

authors： Zhang S,Xu X,Wang W,Yang W,Liang W

更新日期：2017-11-03 00:00:00

abstract：:Free-ocean CO2 enrichment (FOCE) experiments have been deployed in marine ecosystems to manipulate carbonate system conditions to those predicted in future oceans. We investigated whether the pH/carbonate chemistry of extremely cold polar waters can be manipulated in an ecologically relevant way, to represent conditio...

journal_title：Scientific reports

authors： Stark JS,Roden NP,Johnstone GJ,Milnes M,Black JG,Whiteside S,Kirkwood W,Newbery K,Stark S,van Ooijen E,Tilbrook B,Peltzer ET,Berry K,Roberts D

更新日期：2018-02-12 00:00:00