Clock gene is associated with individual variation in the activation of reproductive endocrine and behavior of Asian short toed lark.

Abstract:

:Within year individual variation in the timing of seasonal reproduction within wild bird populations in highly seasonal environments can be pronounced, but the molecular and physiological mechanisms responsible for this variation are unclear. We investigated the relationship between Clock gene poly-Q length, activation of the HPG endocrine axis, and the timing of breeding behavior, in a wild population of the Asian short-toed lark (Calandrella cheleensis) in Inner Mongolia, China. Six variants of Clock gene poly-Q alleles were identified in this population. Clock poly-Q mean allele length was positively correlated with the mean peak date deviation of individual birds. The shorter an individual's Clock poly-Q mean allele length, the earlier its plasma LH, T and E2 values peaked. Mean Clock poly-Q allele length of nestlings in the same nest were positively correlated with the standardized laying date of the first egg in that nest. These results suggest that the Clock gene influences the reproductive timing of birds through its effect on the HPG endocrine axis, and that individual variation in the timing of reproduction may have a genetic basis.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Zhang S,Xu X,Wang W,Yang W,Liang W

doi

10.1038/s41598-017-15064-7

subject

Has Abstract

pub_date

2017-11-03 00:00:00

pages

15002

issue

1

issn

2045-2322

pii

10.1038/s41598-017-15064-7

journal_volume

7

pub_type

杂志文章
  • Ligand induced dissociation of the AR homodimer precedes AR monomer translocation to the nucleus.

    abstract::The androgen receptor (AR) regulates male sexual development. We have now investigated AR homodimerization, hormone-dependent monomerization and nuclear translocation in PC-3 and COS-1 cells, by utilizing mutations associated with the androgen insensitivity syndrome: Pro767Ala, Phe765Leu, Met743Val and Trp742Arg. AR w...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-53139-9

    authors: Shizu R,Yokobori K,Perera L,Pedersen L,Negishi M

    更新日期:2019-11-13 00:00:00

  • Effect of drug metabolizing enzymes and transporters in Thai colorectal cancer patients treated with irinotecan-based chemotherapy.

    abstract::Genetic polymorphisms in drug metabolizing enzymes and drug transporters may affect irinotecan toxicity. Although genetic polymorphisms have been shown to influence the irinotecan toxicity, data are limited in Thai population. Thus, the aim of this study was to assess the allele and genotype frequencies and the relati...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-70351-0

    authors: Atasilp C,Chansriwong P,Sirachainan E,Reungwetwattana T,Sirilerttrakul S,Chamnanphon M,Puangpetch A,Sukasem C

    更新日期:2020-08-10 00:00:00

  • Maternal Smoking in Pregnancy and Offspring Depression: a cross cohort and negative control study.

    abstract::Previous reports suggest that offspring of mothers who smoke during pregnancy have greater risk of developing depression. However, it is unclear whether this is due to intrauterine effects. Using data from the Avon Longitudinal Study of Parents and Children (ALSPAC) from the UK (N = 2,869), the Nord-Trøndelag health s...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-11836-3

    authors: Taylor AE,Carslake D,de Mola CL,Rydell M,Nilsen TIL,Bjørngaard JH,Horta BL,Pearson R,Rai D,Galanti MR,Barros FC,Romundstad PR,Davey Smith G,Munafò MR

    更新日期:2017-10-03 00:00:00

  • Continuous leaky-wave scanning using periodically modulated spoof plasmonic waveguide.

    abstract::The plasmonic waveguide made of uniform corrugated metallic strip can support and guide spoof surface plasmon polaritons (SSPPs) with high confinements. Here, we propose periodically-modulated plasmonic waveguide composed of non-uniform corrugated metallic strip to convert SSPPs to radiating waves, in which the main b...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep29600

    authors: Kong GS,Ma HF,Cai BG,Cui TJ

    更新日期:2016-07-12 00:00:00

  • NemaLife chip: a micropillar-based microfluidic culture device optimized for aging studies in crawling C. elegans.

    abstract::In this study, we report a microfluidic device for the whole-life culture of the nematode Caenorhabditis elegans that allows the scoring of animal survival and health measures. This device referred to as the NemaLife chip features: (1) an optimized micropillar arena in which animals can crawl, (2) sieve channels that ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-73002-6

    authors: Rahman M,Edwards H,Birze N,Gabrilska R,Rumbaugh KP,Blawzdziewicz J,Szewczyk NJ,Driscoll M,Vanapalli SA

    更新日期:2020-10-01 00:00:00

  • Author Correction: Impact of hormone receptor status and distant recurrence-free interval on survival benefits from trastuzumab in HER2-positive metastatic breast cancer.

    abstract::A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has not been fixed in the paper. ...

    journal_title:Scientific reports

    pub_type: 已发布勘误

    doi:10.1038/s41598-018-32881-6

    authors: Yang HY,Ma D,Liu YR,Hu X,Zhang J,Wang ZH,Di GH,Hu XC,Shao ZM

    更新日期:2018-10-12 00:00:00

  • Association between systemic oxidative stress and visual field damage in open-angle glaucoma.

    abstract::Local and systemic oxidative stress in intraocular pressure (IOP) elevation and optic nerve damage may be involved in the pathogenesis of glaucoma. We reported previously that a lower level of systemic antioxidative capacity is associated with IOP elevation in open-angle glaucoma (OAG). We assessed the correlation bet...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep25792

    authors: Tanito M,Kaidzu S,Takai Y,Ohira A

    更新日期:2016-05-11 00:00:00

  • Analysis of alternative splicing events for cancer diagnosis using a multiplexing nanophotonic biosensor.

    abstract::Personalized medicine is a promising tool not only for prevention, screening and development of more efficient treatment strategies, but also for diminishing the side effects caused by current therapies. Deciphering gene regulation pathways provides a reliable prognostic analysis to elucidate the origin of grave disea...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep41368

    authors: Huertas CS,Domínguez-Zotes S,Lechuga LM

    更新日期:2017-01-25 00:00:00

  • Oscillations of ultra-weak photon emission from cancer and non-cancer cells stressed by culture medium change and TNF-α.

    abstract::Cells spontaneously emit photons in the UV to visible/near-infrared range (ultra-weak photon emission, UPE). Perturbations of the cells' state cause changes in UPE (evoked UPE). The aim of the present study was to analyze the evoked UPE dynamics of cells caused by two types of cell perturbations (stressors): (i) a cel...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-10949-z

    authors: Madl P,Verwanger T,Geppert M,Scholkmann F

    更新日期:2017-09-12 00:00:00

  • Network reconstruction of platelet metabolism identifies metabolic signature for aspirin resistance.

    abstract::Recently there has not been a systematic, objective assessment of the metabolic capabilities of the human platelet. A manually curated, functionally tested, and validated biochemical reaction network of platelet metabolism, iAT-PLT-636, was reconstructed using 33 proteomic datasets and 354 literature references. The n...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep03925

    authors: Thomas A,Rahmanian S,Bordbar A,Palsson BØ,Jamshidi N

    更新日期:2014-01-29 00:00:00

  • The impact of inhibitory mechanisms in the inner retina on spatial tuning of RGCs.

    abstract::Spatial tuning properties of retinal ganglion cells (RGCs) are sharpened by lateral inhibition originating at both the outer and inner plexiform layers. Lateral inhibition in the retina contributes to local contrast enhancement and sharpens edges. In this study, we used dynamic clamp recordings to examine the contribu...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep21966

    authors: Huang JY,Protti DA

    更新日期:2016-02-24 00:00:00

  • Cardioprotective medication adherence in Western Australians in the first year after myocardial infarction: restricted cubic spline analysis of adherence-outcome relationships.

    abstract::Adherence to cardioprotective medications following myocardial infarction (MI) is commonly assessed using a binary threshold of 80%. We investigated the relationship between medication adherence as a continuous measure and outcomes in MI survivors using restricted cubic splines (RCS). We identified all patients aged ≥...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-60799-5

    authors: Greenland M,Knuiman MW,Hung J,Nedkoff L,Arnet I,Rankin JM,Kilkenny MF,Sanfilippo FM

    更新日期:2020-03-09 00:00:00

  • RhoA phosphorylation mediated by Rho/RhoA-associated kinase pathway improves the anti-freezing potentiality of murine hatched and diapaused blastocysts.

    abstract::Embryonic cryopreservation has a relatively low survival rate because of cytoskeletal damage. However, molecular anti-freezing mechanisms have been largely unexplored. This study investigated the significance of RhoA, involved in embryonic development, and the Rho/RhoA-associated kinase (ROCK) signalling pathway in cr...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-07066-2

    authors: Gu M,Ni H,Sheng X,Pauciullo A,Liu Y,Guo Y

    更新日期:2017-07-27 00:00:00

  • Acute LPS sensitization and continuous infusion exacerbates hypoxic brain injury in a piglet model of neonatal encephalopathy.

    abstract::Co-existing infection/inflammation and birth asphyxia potentiate the risk of developing neonatal encephalopathy (NE) and adverse outcome. In a newborn piglet model we assessed the effect of E. coli lipopolysaccharide (LPS) infusion started 4 h prior to and continued for 48 h after hypoxia on brain cell death and syste...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-46488-y

    authors: Martinello KA,Meehan C,Avdic-Belltheus A,Lingam I,Ragab S,Hristova M,Tann CJ,Peebles D,Hagberg H,Wolfs TGAM,Klein N,Tachtsidis I,Golay X,Kramer BW,Fleiss B,Gressens P,Robertson NJ

    更新日期:2019-07-15 00:00:00

  • Differentially expressed microRNAs between cattleyak and yak testis.

    abstract::Cattleyak are interspecific hybrids between cattle and yak, exhibiting the same prominent adaptability as yak and much higher performances than yak. However, male infertility of cattleyak resulted from spermatogenic arrest has greatly restricted their effective utilization in yak breeding. In past decades, much work h...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-18607-0

    authors: Xu C,Wu S,Zhao W,Mipam T,Liu J,Liu W,Yi C,Shah MA,Yu S,Cai X

    更新日期:2018-01-12 00:00:00

  • Human Endometrial Stromal Cells Are Highly Permissive To Productive Infection by Zika Virus.

    abstract::Zika virus (ZIKV) is a recently re-emerged flavivirus transmitted to humans by mosquito bites but also from mother to fetus and by sexual intercourse. We here show that primary human endometrial stromal cells (HESC) are highly permissive to ZIKV infection and support its in vitro replication. ZIKV envelope expression ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep44286

    authors: Pagani I,Ghezzi S,Ulisse A,Rubio A,Turrini F,Garavaglia E,Candiani M,Castilletti C,Ippolito G,Poli G,Broccoli V,Panina-Bordignon P,Vicenzi E

    更新日期:2017-03-10 00:00:00

  • Musical pitch classes have rainbow hues in pitch class-color synesthesia.

    abstract::Synesthesia, an anomalous blending of senses in which stimulation of one sensory modality produces sensation in a different modality, provides a unique opportunity to study how multimodal information is represented in the human brain. We investigated how pitch classes (do, re, mi, etc.) are associated with the three d...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-18150-y

    authors: Itoh K,Sakata H,Kwee IL,Nakada T

    更新日期:2017-12-19 00:00:00

  • The metabolic flux regulation of Klebsiella pneumoniae based on quorum sensing system.

    abstract::Quorum-sensing (QS) systems exist universally in bacteria to regulate multiple biological functions. Klebsiella pneumoniae, an industrially important bacterium that produces bio-based chemicals such as 2,3-butanediol and acetoin, can secrete a furanosyl borate diester (AI-2) as the signalling molecule mediating a QS s...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep38725

    authors: Sun S,Zhang H,Lu S,Lai C,Liu H,Zhu H

    更新日期:2016-12-07 00:00:00

  • Bursty properties revealed in large-scale brain networks with a point-based method for dynamic functional connectivity.

    abstract::The brain is organized into large scale spatial networks that can be detected during periods of rest using fMRI. The brain is also a dynamic organ with activity that changes over time. We developed a method and investigated properties where the connections as a function of time are derived and quantified. The point ba...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep39156

    authors: Thompson WH,Fransson P

    更新日期:2016-12-19 00:00:00

  • Proposed mechanism for the length dependence of the force developed in maximally activated muscles.

    abstract::The molecular bases of the Frank-Starling law of the heart and of its cellular counterpart, the length dependent activation (LDA), are largely unknown. However, the recent discovery of the thick filament activation, a second pathway beside the well-known calcium mediated thin filament activation, is promising for eluc...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-36706-4

    authors: Marcucci L,Washio T,Yanagida T

    更新日期:2019-02-04 00:00:00

  • Bitter Taste Receptor Agonists Mitigate Features of Allergic Asthma in Mice.

    abstract::Asthma is characterized by airway inflammation, mucus secretion, remodeling and hyperresponsiveness (AHR). Recent research has established the bronchodilatory effect of bitter taste receptor (TAS2R) agonists in various models. Comprehensive pre-clinical studies aimed at establishing effectiveness of TAS2R agonists in ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep46166

    authors: Sharma P,Yi R,Nayak AP,Wang N,Tang F,Knight MJ,Pan S,Oliver B,Deshpande DA

    更新日期:2017-04-11 00:00:00

  • VirB8-like protein TraH is crucial for DNA transfer in Enterococcus faecalis.

    abstract::Untreatable bacterial infections caused by a perpetual increase of antibiotic resistant strains represent a serious threat to human healthcare in the 21(st) century. Conjugative DNA transfer is the most important mechanism for antibiotic resistance and virulence gene dissemination among bacteria and is mediated by a p...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep24643

    authors: Fercher C,Probst I,Kohler V,Goessweiner-Mohr N,Arends K,Grohmann E,Zangger K,Meyer NH,Keller W

    更新日期:2016-04-22 00:00:00

  • Differential responses of heterotrophic and autotrophic respiration to nitrogen addition and precipitation changes in a Tibetan alpine steppe.

    abstract::Soil respiration (Rs) is an important source of atmospheric CO2 flux and is sensitive to changes in soil nutrient and water contents. Despite extensive studies on the effects of enhanced atmospheric nitrogen (N) deposition and changes in precipitation (P) on Rs, few studies have taken into account the effects of inter...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-34969-5

    authors: Li C,Peng Y,Nie X,Yang Y,Yang L,Li F,Fang K,Xiao Y,Zhou G

    更新日期:2018-11-08 00:00:00

  • Osteogenic impact of pro-apoptotic caspase inhibitors in MC3T3-E1 cells.

    abstract::Caspases are proteases traditionally associated with inflammation and cell death. Recently, they have also been shown to modulate cell proliferation and differentiation. The aim of the current research was to search for osteogenic molecules affected by caspase inhibition and to specify the individual caspases critical...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-64294-9

    authors: Kratochvílová A,Veselá B,Ledvina V,Švandová E,Klepárník K,Dadáková K,Beneš P,Matalová E

    更新日期:2020-05-04 00:00:00

  • Targeted and Untargeted Metabolic Profiling of Wild Grassland Plants identifies Antibiotic and Anthelmintic Compounds Targeting Pathogen Physiology, Metabolism and Reproduction.

    abstract::Plants traditionally used by farmers to manage livestock ailments could reduce reliance on synthetic antibiotics and anthelmintics but in many cases their chemical composition is unknown. As a case study, we analyzed the metabolite profiles of 17 plant species and 45 biomass samples from agricultural grasslands in Eng...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-20091-z

    authors: French KE,Harvey J,McCullagh JSO

    更新日期:2018-01-26 00:00:00

  • Relevance of control diet choice in metabolic studies: impact in glucose homeostasis and vascular function.

    abstract::The experimental approach for the study of cardiometabolic disorders requires the use of animal models fed with commercial diets whose composition differs notably, even between diets used for control groups. While chow diets are usually made of agricultural by-products, purified low-fat diets (LF) contain a higher per...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-59674-0

    authors: González-Blázquez R,Alcalá M,Fernández-Alfonso MS,Villa-Valverde P,Viana M,Gil-Ortega M,Somoza B

    更新日期:2020-02-19 00:00:00

  • Transcription factor NFAT1 controls allergic contact hypersensitivity through regulation of activation induced cell death program.

    abstract::Allergic contact hypersensitivity (CHS) is an inflammatory skin disease mediated by allergen specific T cells. In this study, we investigated the role of transcription factor NFAT1 in the pathogenesis of contact hypersensitivity. NFAT1 knock out (KO) mice spontaneously developed CHS-like skin inflammation in old age. ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep19453

    authors: Kwon HK,Kim GC,Hwang JS,Kim Y,Chae CS,Nam JH,Jun CD,Rudra D,Surh CD,Im SH

    更新日期:2016-01-18 00:00:00

  • Capability of tip-growing plant cells to penetrate into extremely narrow gaps.

    abstract::Plant cells are covered with rigid cell walls, yet tip-growing cells can elongate by providing new cell wall material to their apical regions. Studies of the mechanical properties of tip-growing plant cells typically involve measurement of the turgor pressure and stiffness of the cells' apical regions. These experimen...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-01610-w

    authors: Yanagisawa N,Sugimoto N,Arata H,Higashiyama T,Sato Y

    更新日期:2017-05-03 00:00:00

  • Cerebrospinal fluid neurogranin and TREM2 in Huntington's disease.

    abstract::Biomarkers of Huntington's disease (HD) in cerebrospinal fluid (CSF) could be of value in elucidating the biology of this genetic neurodegenerative disease, as well as in the development of novel therapeutics. Deranged synaptic and immune function have been reported in HD, and concentrations of the synaptic protein ne...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-21788-x

    authors: Byrne LM,Rodrigues FB,Johnson EB,De Vita E,Blennow K,Scahill R,Zetterberg H,Heslegrave A,Wild EJ

    更新日期:2018-03-09 00:00:00

  • Metabolomics Analysis of Skeletal Muscles from FKRP-Deficient Mice Indicates Improvement After Gene Replacement Therapy.

    abstract::Muscular dystrophy-dystroglycanopathies comprise a heterogeneous and complex group of disorders caused by loss-of-function mutations in a multitude of genes that disrupt the glycobiology of α-dystroglycan, thereby affecting its ability to function as a receptor for extracellular matrix proteins. Of the various genes i...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-46431-1

    authors: Vannoy CH,Leroy V,Broniowska K,Lu QL

    更新日期:2019-07-11 00:00:00