Abstract：
:We tested the hypothesis that epigenetic mechanisms in the brain and the immune system are associated with chronic pain. Genome-wide DNA methylation assessed in 9 months post nerve-injury (SNI) and Sham rats, in the prefrontal cortex (PFC) as well as in T cells revealed a vast difference in the DNA methylation landscape in the brain between the groups and a remarkable overlap (72%) between differentially methylated probes in T cells and prefrontal cortex. DNA methylation states in the PFC showed robust correlation with pain score of animals in several genes involved in pain. Finally, only 11 differentially methylated probes in T cells were sufficient to distinguish SNI or Sham individual rats. This study supports the plausibility of DNA methylation involvement in chronic pain and demonstrates the potential feasibility of DNA methylation markers in T cells as noninvasive biomarkers of chronic pain susceptibility.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Massart R,Dymov S,Millecamps M,Suderman M,Gregoire S,Koenigs K,Alvarado S,Tajerian M,Stone LS,Szyf Mdoi
10.1038/srep19615subject
Has Abstractpub_date
2016-01-28 00:00:00pages
19615issn
2045-2322pii
srep19615journal_volume
6pub_type
杂志文章abstract：:Two-dimensional (2D) cell cultures growing on plastic do not recapitulate the three dimensional (3D) architecture and complexity of human tumors. More representative models are required for drug discovery and validation. Here, 2D culture and 3D mono- and stromal co-culture models of increasing complexity have been est...
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journal_title：Scientific reports
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更新日期：2015-07-03 00:00:00
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pub_type： 杂志文章,已发布勘误
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journal_title：Scientific reports
pub_type： 杂志文章
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journal_title：Scientific reports
pub_type： 杂志文章
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journal_title：Scientific reports
pub_type： 杂志文章
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更新日期：2019-04-08 00:00:00
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pub_type： 临床试验,杂志文章,多中心研究
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pub_type： 杂志文章
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更新日期：2016-12-02 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
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journal_title：Scientific reports
pub_type： 杂志文章
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journal_title：Scientific reports
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journal_title：Scientific reports
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