Abstract：
:It has been reported that in patients with operable stage I non-small cell lung cancer (NSCLC), overall survival (OS) is better in those who undergo hypofractionated stereotactic radiation therapy (HSRT) than in those who undergo surgery. However, the reason that HSRT has a better OS has not been fully explored. Here, we analyzed reconstitution kinetics in immune cells in the peripheral blood of NSCLC patients after HSRT. We found that HSRT increased the frequency of total T cells, especially the proportion of CD8+ T cells, but decreased the frequency of inhibitory Tregs. Intracellular staining showed that after HSRT, peripheral CD8+ T cells were transformed into activated T cells, which express high levels of TNF-α, IFN-γ, granzyme B and IL-2. HSRT also increased the production of IL-2, TNF-α, and IFN-γ but down-regulated the production of TGF-β in CD4+ T cells. The frequencies of naïve B cells and double-negative B cells were lower, while the proportions of MZ-like B cells, transitional B cells and plasmablast cells were higher after HSRT. Collectively, our results demonstrate that HSRT activates the peripheral immune response and indicate the dynamic variation in peripheral lymphocytes after HSRT, which is very important for optimizing combination treatments in clinical practice.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Zhang T,Yu H,Ni C,Zhang T,Liu L,Lv Q,Zhang Z,Wang Z,Wu D,Wu P,Chen G,Wang L,Wei Q,Huang J,Wang Xdoi
10.1038/s41598-017-04978-xsubject
Has Abstractpub_date
2017-07-07 00:00:00pages
4866issue
1issn
2045-2322pii
10.1038/s41598-017-04978-xjournal_volume
7pub_type
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