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Assessment of the pulmonary adaptive immune response to Cladosporium cladosporioides infection using an experimental mouse model.

Abstract：

:Cladosporium cladosporioides causes asthma and superficial and deep infections, mostly in immunodeficient individuals and animals. This study aimed to investigate whether C. cladosporioides spores can enter the lungs through pulmonary circulation and influence pulmonary immune response. We intravenously injected mice with C. cladosporioides spore suspension and conducted several assays on the lungs. Pulmonary hemorrhage symptoms and congestion were most severe on days 1, 2, and 3 post-inoculation (PI). Extensive inflammatory cell infiltration occurred throughout the period of infection. More spores and hyphae colonizing the lungs were detected on days 1, 2, and 3 PI, and fewer spores and hyphae were observed within 21 d of infection. Numerous macrophages, dendritic cells, and neutrophils were observed on day 5 PI, along with upregulation of CD54, an intercellular adhesion molecule. Th1 and Th2 cells increased after infection; specifically, Th2 cells increased considerably on day 5 PI. These results suggest that days 2 and 5 PI represent the inflammatory peak in the lungs and that the Th2 and Th1 signaling pathways are potentially involved in pulmonary immune responses. In conclusion, the further adaptive immune responses played important roles in establishing effective pulmonary immunity against C. cladosporioides systemic infections based on innate immune responses.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Ma X,Hu J,Yu Y,Wang C,Gu Y,Cao S,Huang X,Wen Y,Zhao Q,Wu R,Zuo Z,Deng J,Ren Z,Yu S,Shen L,Zhong Z,Peng G

doi

10.1038/s41598-020-79642-y

subject

Has Abstract

pub_date

2021-01-13 00:00:00

pages

909

issue

1

issn

2045-2322

pii

10.1038/s41598-020-79642-y

journal_volume

11

pub_type

杂志文章

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