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HIV-1 Transmissions Among Recently Infected Individuals in Southwest China are Predominantly Derived from Circulating Local Strains.

Abstract：

:Although the Guangxi region accounts for 10% of all HIV-1 cases new reported in 2011 in China, the sources of the transmitted HIV-1 strains are virtually unknown. To determine the extent to which recent HIV infections were derived from already circulating local strains as opposed to recently introduced strains, we performed a cross-sectional molecular epidemiological investigation of recent infections across Guangxi during 2012-2013. HIV-1 nucleotide sequences were amplified and sequenced. Phylogenetic analyses of pol gene regions were used to determine HIV-1 transmission source strains. Based on 229 sequences generated, the subtype/CRF distribution was as follows: CRF01_AE (61.1%), CRF07_BC (18.8%), CRF08_BC (16.6%), CRF55_01B (3.1%), and subtype B' (0.4%). In total, 213 of 229 (93.0%) sequenced transmission strains were derived from already-circulating local strains. Multivariate logistic regression analysis showed that only an age of 18-25 years was significantly associated with transmission from outside Guangxi (compared to >25 years, AOR: 5.15, 95% CI: 1.18-22.48, p < 0.01). This is the first study to use a Bayesian discrete phylogeographic approach to analyze transmission source strains in China. Our results provide useful data for designing evidence-based prevention strategies and methods for combating the rapid spread of sexually transmitted HIV in Guangxi.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Li J,Feng Y,Shen Z,Li Y,Tang Z,Xiong R,Zhang H,Wei J,Zhou X,Deng Y,Fang N,Lan G,Liang S,Zhu Q,Xing H,Ruan Y,Shao Y

doi

10.1038/s41598-018-29201-3

subject

Has Abstract

pub_date

2018-08-27 00:00:00

pages

12831

issue

1

issn

2045-2322

pii

10.1038/s41598-018-29201-3

journal_volume

8

pub_type

杂志文章

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