Abstract：
:Individuals perceive the wor(l)d hierarchically. Firsty, the global visual scene is processed by the right hemisphere, and later, the local features are perceived by the left hemisphere. Based on this hierarchical analysis, humans evolved unique communication ability: reading. However, for about 10% of people reading acquisition is extremely difficult, they are affected by a heritable neurodevelopmental disorder called dyslexia. Differences in perceiving the wor(l)d might be one of the causes of reading disabilities. Here we show multiple causal links between the global before local perception and learning to read. Five behavioral experiments in 353 children reveal that: (i) a local before global perception characterizes three independent groups of unselected children with dyslexia; (ii) two global before local perception trainings improve reading skills in children with dyslexia; and stringently (iii) pre-reading local before global perception longitudinally predicts future poor readers. Challenging the uni-causal and left-lateralized phonological explanation of dyslexia, our results demonstrate that learning to read depends also on an efficient right neural network for the global analysis of the visual scene. These results provide new insights in learning strategies and pave the way for early identification and possible prevention programs.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Franceschini S,Bertoni S,Gianesini T,Gori S,Facoetti Adoi
10.1038/s41598-017-17626-1subject
Has Abstractpub_date
2017-12-12 00:00:00pages
17462issue
1issn
2045-2322pii
10.1038/s41598-017-17626-1journal_volume
7pub_type
杂志文章abstract：:Three main surveillance systems (laboratory-confirmed, influenza-like illness (ILI) and nationwide Notifiable Infectious Diseases Reporting Information System (NIDRIS)) have been used for influenza surveillance in China. However, it is unclear which surveillance system is more reliable in developing influenza early wa...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-21059-9
更新日期：2018-02-12 00:00:00
abstract：:Carbonatites, usually occurring within intra-continental rift-related settings, have strong light rare earth element (LREE) enrichment; they rarely contain economic heavy REE (HREE). Here, we report the identification of Late Triassic HREE-Mo-rich carbonatites in the northernmost Qinling orogen. The rocks contain abun...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep37377
更新日期：2016-11-18 00:00:00
abstract：:An increase of nucleolar number and size has made nucleoli essential markers for cytology and tumour development. However, the underlying basis for their structural integrity and abundance remains unclear. Protein phosphatase PPM1D was found to be up-regulated in different carcinomas including breast cancers. Here, we...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep33272
更新日期：2016-09-13 00:00:00
abstract：:The NOON state, and its experimental approximation the Holland-Burnett state, have important applications in phase sensing measurement with enhanced sensitivity. However, most of the previous Holland-Burnett state interference (HBSI) experiments only investigated the area of the interference pattern in the region imme...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep36914
更新日期：2016-11-14 00:00:00
abstract：:The underlying reasons behind the unprecedented increase of the mortality rates due to the opioid epidemics in the United States are still not fully uncovered. Most efforts have been focused on targeting opioids, but there is little information about vulnerable populations at high risk of opioid abuse and death. In th...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-61281-y
更新日期：2020-03-09 00:00:00
abstract：:Cancer cells accumulate somatic mutations as result of DNA damage, inaccurate repair and other mechanisms. Different genetic instability processes result in characteristic non-random patterns of DNA mutations, also known as mutational signatures. We developed mutSignatures, an integrated R-based computational framewor...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-75062-0
更新日期：2020-10-26 00:00:00
abstract：:Recently, the first-order synchronization transition has been studied in systems of coupled phase oscillators. In this paper, we propose a framework to investigate the synchronization in the frequency-weighted Kuramoto model with all-to-all couplings. A rigorous mean-field analysis is implemented to predict the possib...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep21926
更新日期：2016-02-23 00:00:00
abstract：:Micronutrients are essential for survival and growth for all the organisms including pathogens. In this manuscript, we report that zinc (Zn) chelator N,N,N',N'-tetrakis(2-pyridinylmethyl)-1,2-ethylenediamine (TPEN) affects growth and viability of intracellular pathogen Leishmania donovani (LD) by a concentration and t...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-10041-6
更新日期：2017-09-05 00:00:00
abstract：:Tumor cell-derived exosomes (TEX) suppress functions of immune cells. Here, changes in the gene profiles of primary human T lymphocytes exposed in vitro to exosomes were evaluated. CD4(+) Tconv, CD8(+) T or CD4(+) CD39(+) Treg were isolated from normal donors' peripheral blood and co-incubated with TEX or exosomes iso...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep20254
更新日期：2016-02-04 00:00:00
abstract：:Millions of people are blind worldwide. Sensory substitution (SS) devices (e.g., vOICe) can assist the blind by encoding a video stream into a sound pattern, recruiting visual brain areas for auditory analysis via crossmodal interactions and plasticity. SS devices often require extensive training to attain limited fun...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep15628
更新日期：2015-10-22 00:00:00
abstract：:Mechanical forces are critical to modulate cell spreading, contractility, gene expression, and even stem cell differentiation. Yet, existing tools that can apply controllable subcellular forces to a large number of single cells simultaneously are still limited. Here we report a novel ultrasound tweezing cytometry util...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep02176
更新日期：2013-01-01 00:00:00
abstract：:Several mosquito species have been described as vectors for the Zika virus (ZIKV), such as those in the Aedes, Anopheles, Mansonia and Culex genera. Our previous survey studies were found the ZIKV RNA positive in both male, female and larvae of Culex quinquefasciatus Say and Aedes aegypti (L.) mosquitoes collected fro...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-41727-8
更新日期：2019-03-27 00:00:00
abstract：:Cellulose is the major component of cell wall materials. A 300 bp specific fragment from the cDNA fragment was chosen to insert into vector pFGC1008 at forward and reverse orientations to construct the recombinant RNAi vector. Knockdown of BoiCesA caused "dwarf" phenotype with smaller leaves and a loss of the content ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep41397
更新日期：2017-02-07 00:00:00
abstract：:Programmed cell death 1 (PD-1) monoclonal antibodies have been approved by regulatory agencies for the treatment of various types of cancer, and the mechanism involves the restoration of T cell functions. We report herein the X-ray crystal structure of a fully human monoclonal antibody mAb059c fragment antigen-binding...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-54231-w
更新日期：2019-11-28 00:00:00
abstract：:This corrects the article DOI: 10.1038/srep42627. ...
journal_title：Scientific reports
pub_type： 已发布勘误
doi：10.1038/srep46966
更新日期：2018-04-06 00:00:00
abstract：:We provide a proof for the necessity of quantizing fundamental interactions demonstrating that a quantum version is needed for any non trivial conservative interaction whose strength depends on the relative distance between two objects. Our proof is based on a consistency argument that in the presence of a classical f...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-47844-8
更新日期：2019-08-06 00:00:00
abstract：:Gastrointestinal (g.i.) large cell lymphoma is currently regarded as diffuse large B-cell lymphoma (DLBCL) despite a more favorable clinical outcome compared to other DLBCL. Cluster analyses on a transcriptome signature of NF-κB target genes of 30 g.i. marginal zone B-cell lymphomas (MZBL; 8 g.i. MZBL, 22 large cell M...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-05116-3
更新日期：2017-07-20 00:00:00
abstract：:Core-shell nanoparticles often exhibit improved catalytic properties due to the lattice strain created in these core-shell particles. Herein, we demonstrate the synthesis of core-shell Au@Pd nanoparticles from their core-shell Au@Ag/Pd parents. This strategy begins with the preparation of core-shell Au@Ag nanoparticle...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep11949
更新日期：2015-07-06 00:00:00
abstract：ABSTARCT:We demonstrate a novel route to control the filtering of spoof localized surface plasmons (LSPs) on the corrugated metal-insulator-metal (MIM) ring resonator. The spoof LSPs resonance modes can be effectively tuned to achieve broad passband (covering the quadrupole mode and the hexapole mode) by selecting prop...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-14708-y
更新日期：2017-10-27 00:00:00
abstract：:Excess alcohol use is known to promote development of aggressive tumors in various tissues in human patients, but the cause of alcohol promotion of tumor aggressiveness is not clearly understood. We used an animals model of fetal alcohol exposure that is known to promote tumor development and determined if alcohol pro...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-25785-y
更新日期：2018-05-16 00:00:00
abstract：:The Aspergillus niger-derived prolyl endoprotease (AN-PEP) has previously been shown to degrade gluten in healthy subjects when added to an intragastrically infused meal. The current study investigated the efficacy of AN-PEP in a physiological meal setting. In this randomized placebo-controlled crossover study, 18 glu...
journal_title：Scientific reports
pub_type： 杂志文章,随机对照试验
doi：10.1038/s41598-017-13587-7
更新日期：2017-10-12 00:00:00
abstract：:Psoriatic arthritis (PsA) patients have increased risk of both atherosclerosis and osteoporosis. Previous studies revealed that IL-33/ST2 axis may be related to both conditions; however, these associations were never evaluated in a single patients' group. Here we explored the association among plasma levels of IL-33 a...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep32116
更新日期：2016-08-24 00:00:00
abstract：:The aim of this study was to evaluate the impact of lymph node status from neck dissection pathological specimens on the survival for isolated regional nodal recurrence or persistence after primary treatment of nasopharyngeal carcinoma. Through a retrospective cohort study performed in an academic tertiary referral ho...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-62625-4
更新日期：2020-03-27 00:00:00
abstract：:Smad1, Smad5 and Smad9 (also known as Smad8) are activated by phosphorylation by bone morphogenetic protein (BMP)-bound type I receptor kinases. We examined the role of Smad1, Smad5, and Smad9 by creating constitutively active forms (Smad(DVD)). Transcriptional activity of Smad9(DVD) was lower than that of Smad1(DVD) ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep07596
更新日期：2014-12-23 00:00:00
abstract：:The present work aimed to find out the effect of different levels of hydrolysable tannin (HT) on serum hormonal profile, biochemical indices, lipid profile, apparent digestibility of nutrients and body weight gain in healthy female rats. Forty five adult healthy female rats of 8 weeks old were randomly divided into fi...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-77672-0
更新日期：2020-11-26 00:00:00
abstract：:Two objects can be distinguished if they have different measurable properties. Thus, distinguishability depends on the Physics of the objects. In considering graphs, we revisit the Ising model as a framework to define physically meaningful spectral invariants. In this context, we introduce a family of refinements of t...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep05703
更新日期：2014-07-16 00:00:00
abstract：:Understanding the factors that enable mutualisms to evolve and to subsequently remain stable over time, is essential to fully understand patterns of global biodiversity and for evidence based conservation policy. Theoretically, spatial heterogeneity of mutualists, through increased likelihood of fidelity between coope...
journal_title：Scientific reports
pub_type： 杂志文章,评审
doi：10.1038/srep14826
更新日期：2015-10-05 00:00:00
abstract：:DNA focused panel sequencing has been rapidly adopted to assess therapeutic targets in advanced/refractory cancer. Integrated Genomic Profiling (IGP) utilising DNA/RNA with tumour/normal comparisons in a Clinical Laboratory Improvement Amendments (CLIA) compliant setting enables a single assay to provide: therapeutic ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-016-0021-4
更新日期：2016-12-23 00:00:00
abstract：:Although TRAIL can directly induce cell death in some cancer cells, it appears that TRAIL resistance exists in many cancers. This study focuses on anti-cancer drugs for TRAIL-resistant head and neck cancer (HNC) to provide further progress toward effective cancer therapy. Results indicate in TRAIL-resistant HNC cells,...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-31039-8
更新日期：2018-08-21 00:00:00
abstract：:Here we present spatio-temporal localization of Kremen1, a transmembrane receptor, in the mammalian cochlea, and investigate its role in the formation of sensory organs in mammal and fish model organisms. We show that Kremen1 is expressed in prosensory cells during cochlear development and in supporting cells of the a...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep31668
更新日期：2016-08-23 00:00:00
