Abstract：
:The aim of this study was to evaluate the impact of lymph node status from neck dissection pathological specimens on the survival for isolated regional nodal recurrence or persistence after primary treatment of nasopharyngeal carcinoma. Through a retrospective cohort study performed in an academic tertiary referral hospital in Hong Kong. Forty-six patients who underwent a salvage neck dissection between June 2001 and January 2013 for isolated regionally recurrent or persistent nasopharyngeal carcinoma was performed. Informed consent was waived for this retrospective study by The Joint CUHK-NTEC CREC. In the study forty-six patients had a salvage neck dissection for nodal failure with a mean age of 53 and 74% (34) were male. With a mean follow-up of 45.3 months, Overall survival, disease specific survival, loco-regional recurrence free survival, and regional recurrence free survival were 56.5%, 73.9%, 87.0%, and 91.3% respectively. For both univariate and multivariate analysis, patients with a number of positive lymph nodes more than 5 and a lymph node density more than 20% were significantly associated with poorer overall survival. Extracapsular spread and pathological cervical lymph node staging did not have an association with poorer survival. In conclusion, an absolute number of positive lymph nodes more than five and a lymph node density more than 20% were potentially useful prognostic factors affecting survival following a neck dissection for regional residual or recurrent nasopharyngeal carcinoma.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Yeung DCM,Yeung Z,Wong EWY,Vlantis AC,Chan JYKdoi
10.1038/s41598-020-62625-4subject
Has Abstractpub_date
2020-03-27 00:00:00pages
5622issue
1issn
2045-2322pii
10.1038/s41598-020-62625-4journal_volume
10pub_type
杂志文章abstract：:How diverse adult stem and progenitor populations regenerate tissue following damage to the brain is poorly understood. In highly regenerative vertebrates, such as zebrafish, radial-glia (RG) and neuro-epithelial-like (NE) stem/progenitor cells contribute to neuronal repair after injury. However, not all RG act as neu...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-40734-z
更新日期：2019-03-14 00:00:00
abstract：:Extracellular vesicles (EVs) are membrane-enclosed nanoparticles containing specific repertoires of genetic material. In mammals, EVs can mediate the horizontal transfer of various cargos and signaling molecules, notably miRNA and mRNA species. Whether this form of intercellular communication prevails in other metazoa...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep27680
更新日期：2016-06-10 00:00:00
abstract：:The behavior of diatomic molecular solids under pressure have attracted great interest and been extensively studied. Under ambient pressure, the structure of bromine is known to be a molecular phase (phase I). With increasing pressure, it transforms into an incommensurate phase (phase V) before eventually to a monoato...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep25649
更新日期：2016-05-09 00:00:00
abstract：:Aluminium nitride (AlN) is a promising semiconductor material for use as a substrate in high-power, high-frequency electronic and deep-ultraviolet optoelectronic devices. We study the feasibility of a novel AlN fabrication technique by using the Al/GaN substitution reaction method. The substitution method we propose h...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-69992-y
更新日期：2020-08-03 00:00:00
abstract：:Interspecies electron transfer is a common way to couple metabolic energy balances between different species in mixed culture consortia. Direct interspecies electron transfer (DIET) mechanism has been recently characterised with Geobacter species which couple the electron balance with other species through physical co...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep44334
更新日期：2017-03-13 00:00:00
abstract：:Betaine alleviates high-fat diet-induced fatty liver and prenatal betaine programs offspring hepatic lipid metabolism. Excessive corticosterone (CORT) exposure causes fatty liver in chickens, yet it remains unknown whether and how prenatal betaine modulates the susceptibility of CORT-induced fatty liver later in life....
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep40251
更新日期：2017-01-06 00:00:00
abstract：:Gestational diabetes mellitus (GDM) is a hyperglycaemic imbalance first recognized during pregnancy, and affects up to 22% of pregnancies worldwide, bringing negative maternal-fetal consequences in the short- and long-term. In order to better characterize GDM in pregnant women, 100 blood plasma samples (50 GDM and 50 ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-75539-y
更新日期：2020-11-06 00:00:00
abstract：:Cohesins are vital for chromosome organisation during meiosis and mitosis. In addition to the important function in sister chromatid cohesion, these complexes play key roles in meiotic recombination, DSB repair, homologous chromosome pairing and segregation. Egg-laying mammals (monotremes) feature an unusually complex...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-04560-5
更新日期：2017-06-26 00:00:00
abstract：:Allergic contact hypersensitivity (CHS) is an inflammatory skin disease mediated by allergen specific T cells. In this study, we investigated the role of transcription factor NFAT1 in the pathogenesis of contact hypersensitivity. NFAT1 knock out (KO) mice spontaneously developed CHS-like skin inflammation in old age. ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep19453
更新日期：2016-01-18 00:00:00
abstract：:This study investigated the variation characteristics of micro-topography during successive erosive stages of water erosion: splash erosion (SpE), sheet erosion (ShE), and rill erosion (RE). Micro-topography was quantified using surface elevation change, soil roughness (SR) and multifractal model. Results showed that ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-21852-6
更新日期：2018-02-22 00:00:00
abstract：:The field of genome editing was founded on the establishment of methods, such as the clustered regularly interspaced short palindromic repeat (CRISPR) and CRISPR-associated protein (CRISPR/Cas) system, used to target DNA double-strand breaks (DSBs). However, the efficiency of genome editing also largely depends on the...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-58893-9
更新日期：2020-02-13 00:00:00
abstract：:Millions of people are blind worldwide. Sensory substitution (SS) devices (e.g., vOICe) can assist the blind by encoding a video stream into a sound pattern, recruiting visual brain areas for auditory analysis via crossmodal interactions and plasticity. SS devices often require extensive training to attain limited fun...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep15628
更新日期：2015-10-22 00:00:00
abstract：:Monolayer germanene, a novel graphene-like germanium allotrope akin to silicene has been recently grown on metallic substrates. Lying directly on the metal surfaces the reconstructed atom-thin sheets are prone to lose the massless Dirac fermion character and unique associated physical properties of free standing germa...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep20714
更新日期：2016-02-10 00:00:00
abstract：:Lath martensite is the dominant microstructural feature in quenched low-carbon Fe-C alloys. Its formation mechanism is not clear, despite extensive research. The microstructure of an Fe-0.05 C (wt.%) alloy water-quenched at various austenitizing temperatures has been investigated using transmission electron microscopy...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-32679-6
更新日期：2018-09-24 00:00:00
abstract：:Topological objects of nontrivial spin or dipolar field textures, such as skyrmions, merons, and vortices, interacting with applied external fields in ferroic materials are of great scientific interest as an intriguing playground of unique physical phenomena and novel technological paradigms. The quest for new topolog...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep35199
更新日期：2016-10-07 00:00:00
abstract：:Nitrogen (N) deposition is a key factor that affects terrestrial biogeochemical cycles with a growing trend, especially in the southeast region of China, where shortage of available phosphorus (P) is particularly acute and P has become a major factor limiting plant growth and productivity. Arbuscular mycorrhizal fungi...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-69213-6
更新日期：2020-07-23 00:00:00
abstract：:In spite of extensive efforts over decades an experimentally-derived structure of full-length eukaryotic pentameric ligand-gated ion channels (pLGICs) is still lacking. These pharmaceutically highly-relevant channels contain structurally well-conserved and characterized extracellular and transmembrane domains. The int...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep23921
更新日期：2016-04-05 00:00:00
abstract：:Every day we are exposed to different ideas, or memes, competing with each other for our attention. Previous research explained popularity and persistence heterogeneity of memes by assuming them in competition for limited attention resources, distributed in a heterogeneous social network. Little has been said about wh...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep06477
更新日期：2014-09-26 00:00:00
abstract：:In this study, real-time and in-situ permittivity measurements under intense microwave electromagnetic fields are proposed as a powerful technique for the study of microwave-enhanced thermal processes in materials. In order to draw reliable conclusions about the temperatures at which transformations occur, we address ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-47296-0
更新日期：2019-07-25 00:00:00
abstract：:The fungal microbiota is an important component of the human gut microbiome and may be linked to gastrointestinal disease. In this study, the fungal microbiota of biopsy samples from adenomas and adjacent tissues was characterized by deep sequencing. Ascomycota, Glomeromycota and Basidiomycota were identified as the d...
journal_title：Scientific reports
pub_type： 临床试验,杂志文章
doi：10.1038/srep07980
更新日期：2015-01-23 00:00:00
abstract：:Brain metastasis is a significant unmet clinical problem in breast cancer treatment. It is always associated with poor prognosis and high morbidity. Recently, Slit2/Robo1 pathway has been demonstrated to be involved in the progression of breast carcinoma. However, until present, there are no convincing reports that su...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep14430
更新日期：2015-09-24 00:00:00
abstract：:Ferti-fortification of wheat with zinc, an essential micronutrient is one of the strategies for combating 'hidden hunger' in a large proportion of people all over the world. During fertilization, application of large quantities of micronutrients often results in nutrient wastage and subsequent environmental pollution....
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-25247-5
更新日期：2018-05-01 00:00:00
abstract：:Nanostructure arrays such as nanowire, nanopillar, and nanocone arrays have been proposed to be promising antireflection structures for photovoltaic applications due to their great light trapping ability. In this paper, the optical properties of Si nanopillar and nanocone arrays in visible and infrared region were stu...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep07810
更新日期：2015-01-15 00:00:00
abstract：:Herbicide resistance has been observed in Chloris truncata, an Australian native C4 grass and a summer-fallow weed, which is common in no-till agriculture situations where herbicides are involved in crop management. To investigate the role of drought and increased atmospheric carbon dioxide (CO2) in determining weed g...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-47237-x
更新日期：2019-07-24 00:00:00
abstract：:Functional Dyspepsia-Post-prandial Distress Syndrome (FD-PDS) was associated with mood-related increases in resting activity and lowered activation threshold in the somatosensory cortex (SSC), insula and perigenual anterior cingulate cortex(pgACC) in functional imaging studies. The underlying cortical neurochemical ch...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-04405-1
更新日期：2017-06-20 00:00:00
abstract：:That stalks reorient after flowering to face upwards is a common phenomenon in many flowering plants, indicating the potential importance of fruit orientation on seed dispersal. But this idea has not been subject to an empirical test. We examined this hypothesis by analysing the evolutionary correlation between fruit ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep20146
更新日期：2016-02-02 00:00:00
abstract：:Changes in the stability, hydrogen diffusion, and mechanical properties of the NbH phases from Ni-doping was studied by using first-principles methods. The calculation results reveal that the single H atom adsorption is energetically favorable at the tetrahedral interstitial site (TIS) and octahedral interstitial site...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-06658-2
更新日期：2017-07-26 00:00:00
abstract：:While previous studies separately demonstrate EEG spectral modulations during speech preparation and ERP responses to the listened speech, it is unclear whether these responses are related on a trial-by-trial basis between a speaker and listener. In order to determine whether these responses are related in real-time, ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-31038-9
更新日期：2018-08-27 00:00:00
abstract：:Interactions and coordination between conspecific individuals have produced a remarkable variety of collective behaviours. This co-operation occurs in vertebrate and invertebrate animals and is well expressed in the group flight of birds, fish shoals and highly organized activities of social insects. How individuals i...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-51012-3
更新日期：2019-10-17 00:00:00
abstract：:Diffusion tensor imaging (DTI) studies have detected white matter microstructural changes in essential tremor (ET). However, it is still unclear whether these changes are related to cognitive deficits, which have been described in ET patients. DTI-derived fractional anisotropy, mean diffusivity (MD), axial diffusivity...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-02596-1
更新日期：2017-06-07 00:00:00
