Enhanced homologous recombination by the modulation of targeting vector ends.

abstract：:Cyanobacteria are ubiquitous organisms with a relevant contribution to primary production in all range of habitats. Cyanobacteria are well known for their part in worldwide occurrence of aquatic blooms while producing a myriad of natural compounds, some with toxic potential, but others of high economical impact, as ge...

journal_title：Scientific reports

authors： Churro C,Semedo-Aguiar AP,Silva AD,Pereira-Leal JB,Leite RB

更新日期：2020-05-26 00:00:00

abstract：:The dissolution of ferrihydrite induced by low molar mass (LMM) organics is an important process that provides bioavailable iron for organisms. Here, ATR-FTIR analysis was combined with characterization of ferrihydrite nanoparticles and kinetic modeling to investigate the roles of different oxalate surface complex spe...

journal_title：Scientific reports

authors： Li F,Koopal L,Tan W

更新日期：2018-02-01 00:00:00

abstract：:Single epitaxially-grown semiconductor quantum dots have great potential as single photon sources for photonic quantum technologies, though in practice devices often exhibit nonideal behavior. Here, we demonstrate that amplitude modulation can improve the performance of quantum-dot-based sources. Starting with a brigh...

journal_title：Scientific reports

authors： Ates S,Agha I,Gulinatti A,Rech I,Badolato A,Srinivasan K

更新日期：2013-01-01 00:00:00

abstract：:One quarter of individuals with Preserved Ratio Impaired Spirometry (PRISm) will develop airflow obstruction, but there are no established methods to identify these individuals. We examined the utility of FVC/TLC in identifying features of obstructive lung disease. The ratio of post-bronchodilator FVC and TLCCT from c...

journal_title：Scientific reports

authors： Fortis S,Comellas A,Kim V,Casaburi R,Hokanson JE,Crapo JD,Silverman EK,Wan ES

更新日期：2020-03-20 00:00:00

abstract：:Plant derived biogenic synthesis of nanoparticles (NP) has been the recent trend in material science as featured sustainable catalysts. A great deal of the current nanocatalytic research has been oriented on the bio-inspired green catalysts based on their wide applicability. In this context, CuO NPs are synthesized fo...

journal_title：Scientific reports

authors： Veisi H,Karmakar B,Tamoradi T,Hemmati S,Hekmati M,Hamelian M

更新日期：2021-01-21 00:00:00

abstract：:Plant extracts, or phytonutrients, are used in traditional medicine practices as supplements to enhance the immune system and gain resistance to various infectious diseases and are used in animal production as health promoting feed additives. To date, there are no studies that have assessed their mechanism of action a...

journal_title：Scientific reports

authors： Wlodarska M,Willing BP,Bravo DM,Finlay BB

更新日期：2015-03-19 00:00:00

abstract：:We present a new class of TiBw/Ti6Al4V composites with a network reinforcement architecture that exhibits a significant creep resistance compared to monolithic Ti6Al4V alloys. Creep tests performed at temperatures between 773 K and 923 K and stress range of 100 MPa-300 MPa indicate both a significant improvement of th...

journal_title：Scientific reports

authors： Wang S,Huang LJ,Geng L,Scarpa F,Jiao Y,Peng HX

更新日期：2017-01-17 00:00:00

abstract：:Fluid strategy is the key to the successful management of patients with sepsis. However, previous studies failed to consider individualized treatment strategy, and clinical trials typically included patients with sepsis as a homogeneous study population. We aimed to develop sequential decision rules for managing fluid...

journal_title：Scientific reports

authors： Zhang Z,Zheng B,Liu N

更新日期：2020-10-21 00:00:00

abstract：:Angiotensin II (AngII) promotes hypertension, atherogenesis, vascular aneurysm and impairs post-ischemic cardiac remodeling through concerted roles on vascular cells, monocytes and T lymphocytes. However, the role of AngII in B lymphocyte responses is largely unexplored. Here, we show that chronic B cell depletion (Ba...

journal_title：Scientific reports

authors： Ponnuswamy P,Joffre J,Herbin O,Esposito B,Laurans L,Binder CJ,Tedder TF,Zeboudj L,Loyer X,Giraud A,Zhang Y,Tedgui A,Mallat Z,Ait-Oufella H

更新日期：2017-06-23 00:00:00

abstract：:Study of knockout (KO) mice has helped understand the link between many genes/proteins and human diseases. Identification of infertile KO mice provides valuable tools to characterize the molecular mechanisms underlying gamete formation. The KIAA0319L gene has been described to have a putative association with dyslexia...

journal_title：Scientific reports

authors： Guidi LG,Holloway ZG,Arnoult C,Ray PF,Monaco AP,Molnár Z,Velayos-Baeza A

更新日期：2018-07-10 00:00:00

abstract：:Monitoring of disease/therapeutic conditions is an important application of circulating tumor DNA (ctDNA). We devised numerical indices, based on ctDNA dynamics, for therapeutic response and disease progression. 52 lung cancer patients subjected to the EGFR-TKI treatment were prospectively collected, and ctDNA levels ...

journal_title：Scientific reports

authors： Kato K,Uchida J,Kukita Y,Kumagai T,Nishino K,Inoue T,Kimura M,Oba S,Imamura F

更新日期：2016-07-06 00:00:00

abstract：:The spatial distributions of diverse facilities are often understood in terms of the optimization of the commute distance or the economic profit. Incorporating more general objective functions into such optimization framework may be useful, helping the policy decisions to meet various social and economic demands. As a...

journal_title：Scientific reports

authors： Lee MJ,Kim K,Son J,Lee DS

更新日期：2020-05-25 00:00:00

abstract：:Although guidelines recommend BRCA testing for all women with non-mucinous epithelial ovarian cancer, there is significant variability in access to testing across the UK. A germline BRCA mutation (BRCAm) in ovarian cancer patients provides prognostic and predictive information and influences clinical management, such ...

journal_title：Scientific reports

authors： Rumford M,Lythgoe M,McNeish I,Gabra H,Tookman L,Rahman N,George A,Krell J

更新日期：2020-02-25 00:00:00

abstract：:Cholestasis impairs liver regeneration following partial liver resection (PHx). Bile acid receptor farnesoid X-receptor (FXR) is a key mediator of liver regeneration. The effects of FXR agonist obeticholic acid (OCA) on liver (re)growth were therefore studied in cholestatic rats. Animals underwent sham surgery or reve...

journal_title：Scientific reports

authors： van Golen RF,Olthof PB,Lionarons DA,Reiniers MJ,Alles LK,Uz Z,de Haan L,Ergin B,de Waart DR,Maas A,Verheij J,Jansen PL,Damink SWO,Schaap FG,van Gulik TM,Heger M

更新日期：2018-11-08 00:00:00

abstract：:We aimed to evaluate the etiologies of constipation in patients with anorectal malformations having a good prognosis for bowel control but a high risk of constipation. We included twenty-five patients from the Odense university hospital in Denmark. Patients were subjected to colon transit time examination and high res...

journal_title：Scientific reports

authors： Bjørsum-Meyer T,Christensen P,Baatrup G,Jakobsen MS,Asmussen J,Qvist N

更新日期：2020-11-12 00:00:00

abstract：:A novel NaAgMoO4 material with spinel-like structure was synthesized by using the solid state reaction method and the ceramic sample was well densified at an extreme low sintering temperature about 400°C. Rietveld refinement of the crystal structure was performed using FULLPROF program and the cell parameters are a = ...

journal_title：Scientific reports

authors： Di Z,Li-Xia P,Ze-Ming Q,Biao-Bing J,Xi Y

更新日期：2014-08-07 00:00:00

abstract：:The study of factors influencing animal intake can provide a better understanding of the dynamics of the pasture ecosystem and serve as a basis for managing livestock in a more efficient way. We measured different sward surface heights of tall fescue in the process of short-term intake rate of sheep. There was a signi...

journal_title：Scientific reports

authors： Szymczak LS,de Moraes A,Sulc RM,Monteiro ALG,Lang CR,Moraes RF,da Silva DFF,Bremm C,de Faccio Carvalho PC

更新日期：2020-07-16 00:00:00

abstract：:Exhaled nitric oxide (eNO) is a useful biomarker of various physiological conditions, including asthma and other pulmonary diseases. Herein a fast and sensitive analytical method has been developed for the quantitative detection of eNO based on extractive electrospray ionization mass spectrometry (EESI-MS). Exhaled NO...

journal_title：Scientific reports

authors： Pan S,Tian Y,Li M,Zhao J,Zhu L,Zhang W,Gu H,Wang H,Shi J,Fang X,Li P,Chen H

更新日期：2015-03-04 00:00:00

abstract：:Amine quantification is an important strategy in patient stratification and personalised medicine. This is because amines, including amino acids and methylarginines impact on many homeostatic processes. One important pathway regulated by amine levels is nitric oxide synthase (NOS). NOS is regulated by levels of (i) th...

journal_title：Scientific reports

authors： Ahmetaj-Shala B,Olanipekun M,Tesfai A,MacCallum N,Kirkby NS,Quinlan GJ,Shih CC,Kawai R,Mumby S,Paul-Clark M,Want EJ,Mitchell JA

更新日期：2018-09-18 00:00:00

abstract：:Protein phosphorylation is an important type of post-translational modification that is involved in a variety of biological activities. Most phosphorylation events occur on serine, threonine and tyrosine residues in eukaryotes. In recent years, many phosphorylation sites have been identified as a result of advances in...

journal_title：Scientific reports

authors： Xiao Q,Miao B,Bi J,Wang Z,Li Y

更新日期：2016-04-19 00:00:00

abstract：:N-myc downstream regulated gene 1 (NDRG1) is a responsible gene for a hereditary motor and sensory neuropathy-Lom (Charcot-Marie-Tooth disease type 4D). This is the first study aiming to assess the contribution of NDRG1 to differentiation of macrophage lineage cells, which has important implications for bone remodelin...

journal_title：Scientific reports

authors： Watari K,Shibata T,Nabeshima H,Shinoda A,Fukunaga Y,Kawahara A,Karasuyama K,Fukushi J,Iwamoto Y,Kuwano M,Ono M

更新日期：2016-01-18 00:00:00

abstract：:We have experimentally demonstrated a strong correlation between the electrical properties of Zn1-xTex Ovonic threshold switching (OTS) selector device and the material properties analysed by X-ray diffraction (XRD), spectroscopic ellipsometry, and X-ray photoelectron spectroscopy (XPS). The correlation and the key ma...

journal_title：Scientific reports

authors： Koo Y,Hwang H

更新日期：2018-08-07 00:00:00

abstract：:Aldehyde dehydrogenase (ALDH) is a key enzyme for the catalytic oxidation of acetaldehyde to acetic acid. Genetic polymorphisms of ALDH2 have been associated with a wide range of diseases and cancers. However, little information is found about the association between ALDH2 polymorphisms and lumbar disc herniation (LDH...

journal_title：Scientific reports

authors： Dong Q,Ren G,Zhang K,Liu D,Dou Q,Hao D

更新日期：2018-08-30 00:00:00

abstract：:A previous study identified 3 nonsynonymous and 6 synonymous mutations in the entire mosquito sodium channel of Culex quinquefasciatus, the prevalence of which were strongly correlated with levels of resistance and increased dramatically following insecticide selection. However, it is unclear whether this is unique to...

journal_title：Scientific reports

authors： Li T,Zhang L,Reid WR,Xu Q,Dong K,Liu N

更新日期：2012-01-01 00:00:00

abstract：:To explore soil organic carbon (SOC) accumulation mechanisms, the dynamics of C functional groups and macroaggregation were studied synchronously through aggregate fractionation and (13)C NMR spectroscopy in sandy loam soil following an 18-year application of compost and fertilizer in China. Compared with no fertilize...

journal_title：Scientific reports

authors： Yu H,Ding W,Chen Z,Zhang H,Luo J,Bolan N

更新日期：2015-09-11 00:00:00

abstract：:Differences in the pathogenesis of radiation-induced lung injury among murine strains offer a unique opportunity to elucidate the molecular mechanisms driving the divergence in tissue response from repair and recovery to organ failure. Here, we utilized two well-characterized murine models of radiation pneumonitis/fib...

journal_title：Scientific reports

authors： Jackson IL,Zhang Y,Bentzen SM,Hu J,Zhang A,Vujaskovic Z

更新日期：2016-11-15 00:00:00

abstract：:8-band k · p Hamiltonian together with envelope function approximation and planewave expansion method are applied to calculate the electronic band structure and material gain for Ge1-wSnw/SiyGe1-x-ySnx/Ge1-wSnw quantum wells (QWs) grown on virtual Ge1-zSnz substrates integrated with Si platform. It is clearly shown ho...

journal_title：Scientific reports

authors： Mączko HS,Kudrawiec R,Gladysiewicz M

更新日期：2019-03-01 00:00:00

abstract：:Recent whole-exome sequencing (WES) studies demonstrated that TRAIP is associated with primordial dwarfism. Although TRAIP was partially studied in mitosis, its function in oocyte meiosis remained unknown. In this study, we investigated the roles of TRAIP during mouse oocyte meiosis. TRAIP was stably expressed during ...

journal_title：Scientific reports

authors： Yuan YF,Ren YX,Yuan P,Yan LY,Qiao J

更新日期：2016-07-11 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Scientific reports

authors： Heo S,Lee J,Lee GH,Heo CJ,Kim SH,Yun DJ,Park JB,Kim K,Kim Y,Lee D,Park GS,Cho HY,Shin T,Yun SY,Kim S,Jin YW,Park KB

更新日期：2020-02-13 00:00:00

abstract：:Mammals typically keep their body temperature (Tb) within a narrow limit with changing environmental conditions. There are indications that some wild ungulates can exhibit certain forms of energy saving mechanisms when ambient temperatures are low and/or food is scarce. Therefore, the aim of the study was to determine...

journal_title：Scientific reports

authors： Riek A,Brinkmann L,Gauly M,Perica J,Ruf T,Arnold W,Hambly C,Speakman JR,Gerken M

更新日期：2017-08-08 00:00:00