Low Expression of Slit2 and Robo1 is Associated with Poor Prognosis and Brain-specific Metastasis of Breast Cancer Patients.

abstract：:Previous studies have established that an increased Th-9 response creates a hostile environment for nematode parasites. Given that IL-23, a cytokine required for maintenance of the IL-17-secreting phenotype, has inhibitory effects on IL-9 production, we hypothesized that reducing circulating IL-23 by treatment with an...

journal_title：Scientific reports

authors： Gomez-Samblas M,Bernal D,Bolado-Ortiz A,Vilchez S,Bolás-Fernández F,Espino AM,Trelis M,Osuna A

更新日期：2018-05-17 00:00:00

abstract：:Here we proposed a novel architectural design of a ternary MnO2-based electrode - a hierarchical Co3O4@Pt@MnO2 core-shell-shell structure, where the complemental features of the three key components (a well-defined Co3O4 nanowire array on the conductive Ti substrate, an ultrathin layer of small Pt nanoparticles, and a...

journal_title：Scientific reports

authors： Xia H,Zhu D,Luo Z,Yu Y,Shi X,Yuan G,Xie J

更新日期：2013-10-17 00:00:00

abstract：:Incident myocardial infarction (MI) is a leading cause of adult mortality in the United States. However, because MI has a relatively low incidence in the young population, little information exists on the disease in younger adults. Because the retina has the unique quality that its vasculature is readily and noninvasi...

journal_title：Scientific reports

authors： Kromer R,Tigges E,Rashed N,Pein I,Klemm M,Blankenberg S

更新日期：2018-04-04 00:00:00

abstract：:Primordial germ cells (PGCs), the embryonic precursors of the sperm and egg, are used for the introduction of genetic modifications into avian genome. Introduction of small defined sequences using genome editing has not been demonstrated in bird species. Here, we compared oligonucleotide-mediated HDR using wild type S...

journal_title：Scientific reports

authors： Idoko-Akoh A,Taylor L,Sang HM,McGrew MJ

更新日期：2018-10-11 00:00:00

abstract：:We report transport studies on the 5 nm thick Bi₂Se₃ topological insulator films which are grown via molecular beam epitaxy technique. The angle-resolved photoemission spectroscopy data show that the Fermi level of the system lies in the bulk conduction band above the Dirac point, suggesting important contribution of ...

journal_title：Scientific reports

authors： Wang H,Liu H,Chang CZ,Zuo H,Zhao Y,Sun Y,Xia Z,He K,Ma X,Xie XC,Xue QK,Wang J

更新日期：2014-07-24 00:00:00

abstract：:The calcifying shell is an excellent model for studying biomineralization and evolution. However, the molecular mechanisms of shell formation are only beginning to be elucidated in Mollusca. It is known that shell matrix proteins (SMPs) play important roles in shell formation. With increasing data of shell matrix prot...

journal_title：Scientific reports

authors： Feng D,Li Q,Yu H,Kong L,Du S

更新日期：2017-04-04 00:00:00

abstract：:The molecular dissociation constant, Kd, is a well-established parameter to quantitate the affinity of protein-protein or other molecular interactions. Recently, we reported the theoretical basis and experimental procedure for Kd determination using a quantitative FRET method. Here we report a new development of Kd de...

journal_title：Scientific reports

authors： Jiang L,Xiong Z,Song Y,Lu Y,Chen Y,Schultz JS,Li J,Liao J

更新日期：2019-02-14 00:00:00

abstract：:We report here the design and multiple functions of a new hierarchical nanotheronostic platform consisting of an upconversion nanoparticle (UCNP) core: shell with an additional mesoporous silica (mSiO2) matrix load shell containing sealed, high concentration of ICG molecules. We demonstrate that this UCNP@mSiO2-ICG na...

journal_title：Scientific reports

authors： Lv R,Wang D,Xiao L,Chen G,Xia J,Prasad PN

更新日期：2017-11-16 00:00:00

abstract：:Neurotransmitters and peptide hormones are secreted into outside the cell by a vesicle fusion process. Although non-coding RNA (ncRNA) that include microRNA (miRNA) regulates gene expression inside the cell where they are transcribed, extracellular miRNA has been recently discovered outside the cells, proposing that m...

journal_title：Scientific reports

authors： Gümürdü A,Yildiz R,Eren E,Karakülah G,Ünver T,Genç Ş,Park Y

更新日期：2017-03-30 00:00:00

abstract：:The clotting factor prothrombin exists in equilibrium between closed and open conformations, but the physiological role of these forms remains unclear. As for other allosteric proteins, elucidation of the linkage between molecular transitions and function is facilitated by reagents stabilized in each of the alternativ...

journal_title：Scientific reports

authors： Chinnaraj M,Chen Z,Pelc LA,Grese Z,Bystranowska D,Di Cera E,Pozzi N

更新日期：2018-02-13 00:00:00

abstract：:The function of most long noncoding RNAs (lncRNAs) is unknown. However, recent studies reveal important roles of lncRNAs in regulating cancer-related pathways. Human antisense lncRNA-NKX2-1-AS1 partially overlaps the NKX2-1/TTF1 gene within chromosomal region 14q13.3. Amplification of this region and/or differential e...

journal_title：Scientific reports

authors： Kathuria H,Millien G,McNally L,Gower AC,Tagne JB,Cao Y,Ramirez MI

更新日期：2018-09-26 00:00:00

abstract：:We present here a combined theoretical and experimental investigation on effective excitation of microcantilever by using photoacoustic waves. The photoacoustic waves arose from a vibrating Al foil induced by an intensity-modulated laser. We demonstrate that, superior to photothermal excitation, this new configuration...

journal_title：Scientific reports

authors： Gao N,Zhao D,Jia R,Liu D

更新日期：2016-01-27 00:00:00

abstract：:Negative hemodynamic response has been widely reported in blood oxygenation level-dependent (BOLD) functional magnetic resonance imaging studies, however its origin is still controversial. Optical intrinsic signal (OIS) imaging can be used to study brain activity by simultaneously recording hemodynamic signals at diff...

journal_title：Scientific reports

authors： Ma Z,Cao P,Sun P,Zhao L,Li L,Tong S,Lu Y,Yan Y,Chen Y,Chai X

更新日期：2016-02-10 00:00:00

abstract：:Niemann-Pick type C1 (NPC1) disease is a rare autosomal recessive, neurodegenerative lysosomal storage disorder, which presents with a range of clinical phenotypes and hence diagnosis remains a challenge. In view of these difficulties, the search for a novel, NPC1-specific biomarker (or set of biomarkers) is a topic o...

journal_title：Scientific reports

authors： Probert F,Ruiz-Rodado V,Vruchte DT,Nicoli ER,Claridge TDW,Wassif CA,Farhat N,Porter FD,Platt FM,Grootveld M

更新日期：2017-07-24 00:00:00

abstract：:Working memory capacity is incredibly limited and thus it is important to use this resource wisely. Prior knowledge in long-term memory can aid in efficient encoding of information by allowing for the prioritization of novel stimuli over familiar ones. Here we used a full-report procedure in a visual working memory pa...

journal_title：Scientific reports

authors： Bruning AL,Lewis-Peacock JA

更新日期：2020-12-17 00:00:00

abstract：:During skin healing, periostin facilitates myofibroblast differentiation through a β1 integrin/FAK dependent mechanism and continued expression is associated with scarring. In contrast to skin, gingival tissue does not typically scar upon injury, but the role of periostin in gingival healing has never been investigate...

journal_title：Scientific reports

authors： Kim SS,Nikoloudaki GE,Michelsons S,Creber K,Hamilton DW

更新日期：2019-02-25 00:00:00

abstract：:Relativistic electron rings hold the possibility of very high accelerating rates, and hopefully a relatively cheap and compact accelerator/collimator for ultrahigh energy proton source. In this work, we investigate the generation of helical shaped quasi-monoenergetic relativistic electron beam and high-energy proton b...

journal_title：Scientific reports

authors： Sharma A

更新日期：2018-02-01 00:00:00

abstract：:Bio-functionalized nanoparticles with semiconducting/metallic core encapsulated in a bio- or bio-derived materials are promising for applications in biology and especially in cancer diagnostic and healing. In this report, we report a facile, single-step, first-time synthesis and in-situ functionalization strategy for ...

journal_title：Scientific reports

authors： Liao W,Yu Z,Lin Z,Lei Z,Ning Z,Regenstein JM,Yang J,Ren J

更新日期：2015-12-21 00:00:00

abstract：:Wnt/β-catenin signalling plays a prominent role in maintaining self-renewal and pluripotency of mouse embryonic stem cells (mESCs). microRNAs (miRNAs) have critical roles in maintaining pluripotency and directing reprogramming. To investigate the effect of GSK3 inhibitors on miRNA expression, we analysed the miRNA exp...

journal_title：Scientific reports

authors： Wu Y,Liu F,Liu Y,Liu X,Ai Z,Guo Z,Zhang Y

更新日期：2015-03-02 00:00:00

abstract：:In this report, a hand-held impulse-radar breast cancer detector is presented and the detectability of malignant breast tumors is demonstrated in the clinical test at Hiroshima University Hospital, Hiroshima, Japan. The core functional parts of the detector consist of 65-nm technology complementary metal-oxide-semicon...

journal_title：Scientific reports

authors： Song H,Sasada S,Kadoya T,Okada M,Arihiro K,Xiao X,Kikkawa T

更新日期：2017-11-27 00:00:00

abstract：:Insertion sequence (IS) 6110 is found at multiple sites in the Mycobacterium tuberculosis genome and displays a high degree of polymorphism with respect to copy number and insertion sites. Therefore, IS6110 is considered to be a useful molecular marker for diagnosis and strain typing of M. tuberculosis. Generally IS61...

journal_title：Scientific reports

authors： Roychowdhury T,Mandal S,Bhattacharya A

更新日期：2015-07-28 00:00:00

abstract：:Hetero-nanostructures based on magnetic contrast oxides have been prepared as highly dense nanoconsolidates. Cobalt ferrite-cobalt oxide core-shell type nanoparticles (NPs) were synthesized by seed mediated growth in polyol and subsequently consolidated by Spark Plasma Sintering (SPS) at 500 °C for a few minutes while...

journal_title：Scientific reports

authors： Flores-Martinez N,Franceschin G,Gaudisson T,Haj-Khlifa S,Derouich SG,Yaacoub N,Grenèche JM,Menguy N,Valenzuela R,Ammar S

更新日期：2019-12-19 00:00:00

abstract：:Potato (Solanum tuberosum) is an important staple crop worldwide, it has been cultivated in the Andean Altiplano under low-input farming practices at high altitudes and under harsh environment for centuries. We analyzed secondary metabolite (SM) gene diversity encoded in the potato rhizosphere microbiome during plant ...

journal_title：Scientific reports

authors： Aleti G,Nikolić B,Brader G,Pandey RV,Antonielli L,Pfeiffer S,Oswald A,Sessitsch A

更新日期：2017-05-24 00:00:00

abstract：:Cenozoic ectothermic continental tetrapods (amphibians and reptiles) have not been documented previously from Antarctica, in contrast to all other continents. Here we report a fossil ilium and an ornamented skull bone that can be attributed to the Recent, South American, anuran family Calyptocephalellidae or helmeted ...

journal_title：Scientific reports

authors： Mörs T,Reguero M,Vasilyan D

更新日期：2020-04-23 00:00:00

abstract：:Signatures of spatially varying selection have been investigated both at the genomic and transcriptomic level in several organisms. In Drosophila melanogaster, the majority of these studies have analyzed North American and Australian populations, leading to the identification of several loci and traits under selection...

journal_title：Scientific reports

authors： Mateo L,Rech GE,González J

更新日期：2018-11-01 00:00:00

abstract：:Rheumatoid arthritis (RA) is an autoimmune disease characterized by progressive immune-mediated joint deterioration. Current treatments are not antigen specific and are associated with various adverse. We have previously demonstrated that tolerogenic dendritic cells (Tol-DC) are potent antigen-specific immune regulato...

journal_title：Scientific reports

authors： Li R,Zhang Y,Zheng X,Peng S,Yuan K,Zhang X,Min W

更新日期：2017-02-23 00:00:00

abstract：:Long-term skills training is known to induce neuroplastic alterations, but it is still debated whether these changes are always modality-specific or can be supramodal components. To address this issue, we compared finger-targeted somatosensory-evoked and auditory-evoked potentials under both Go (response) and Nogo (re...

journal_title：Scientific reports

authors： Yamashiro K,Yamazaki Y,Siiya K,Ikarashi K,Baba Y,Otsuru N,Onishi H,Sato D

更新日期：2021-01-26 00:00:00

abstract：:Agriculture provides livelihood for 65% of Nepal's population contributing for 27% of its GDP. Smallholder farms constitute 60% of farming segment. Distress farming, with inadequate minimum support price, subsidies and inadequate revenue generation force 29% of the general population to be malnourished. Farming system...

journal_title：Scientific reports

authors： Ramanathan K,Sangeeviraman V,Chandrahasan P,Chaudhary BN,Ramachandra SS

更新日期：2020-06-29 00:00:00

abstract：:Ca(x)Zn(1-x)O alloys are potential candidates to achieve wide band-gap, which might significantly promote the band gap engineering and heterojunction design. We performed a crystal structure search for CaO-ZnO system under pressure, using an ab initio evolutionary algorithm implemented in the USPEX code. Four stable o...

journal_title：Scientific reports

authors： Sha X,Tian F,Li D,Duan D,Chu B,Liu Y,Liu B,Cui T

更新日期：2015-07-17 00:00:00

abstract：:Breast tissue heterogeneity is related to risk factors that lead to more aggressive tumour growth and worse prognosis, yet such heterogeneity has not been well characterized. The aim of this study is to reveal the heterogeneous signal patterns of the apparent diffusion coefficient (ADC) of a tumour and its surrounding...

journal_title：Scientific reports

authors： Fan M,He T,Zhang P,Zhang J,Li L

更新日期：2017-06-06 00:00:00