Epidemiological and geospatial profile of the prescription opioid crisis in Ohio, United States.

Abstract:

:The underlying reasons behind the unprecedented increase of the mortality rates due to the opioid epidemics in the United States are still not fully uncovered. Most efforts have been focused on targeting opioids, but there is little information about vulnerable populations at high risk of opioid abuse and death. In this study, we used data from the Ohio Department of Health for deaths caused by prescription opioids from 2010-2017 to analyze the spatiotemporal dynamics of the opioid overdose epidemic. Our results showed a rapid increase in prescription opioid death rates among the white male population aged 30-39 but also a considerable increase among the black male population with an exponential growth trend. Our geospatial analysis suggests that the increasing rates of the opioid overdose epidemic in Ohio were driven by the epidemic hotspot areas. Our findings highlight the relevance of prioritizing public health measures targeting specific locations and vulnerable populations to mitigate the current opioids crisis.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Hernandez A,Branscum AJ,Li J,MacKinnon NJ,Hincapie AL,Cuadros DF

doi

10.1038/s41598-020-61281-y

subject

Has Abstract

pub_date

2020-03-09 00:00:00

pages

4341

issue

1

issn

2045-2322

pii

10.1038/s41598-020-61281-y

journal_volume

10

pub_type

杂志文章
  • Akting up in the GABA hypothesis of schizophrenia: Akt1 deficiency modulates GABAergic functions and hippocampus-dependent functions.

    abstract::Accumulating evidence implies that both AKT1 and GABAA receptor (GABAAR) subunit genes are involved in schizophrenia pathogenesis. Activated Akt promotes GABAergic neuron differentiation and increases GABAAR expression on the plasma membrane. To elucidate the role of Akt1 in modulating GABAergic functions and schizoph...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep33095

    authors: Chang CY,Chen YW,Wang TW,Lai WS

    更新日期:2016-09-12 00:00:00

  • Rat sensorimotor cortex tolerance to parallel transections induced by synchrotron-generated X-ray microbeams.

    abstract::Microbeam radiation therapy is a novel preclinical technique, which uses synchrotron-generated X-rays for the treatment of brain tumours and drug-resistant epilepsies. In order to safely translate this approach to humans, a more in-depth knowledge of the long-term radiobiology of microbeams in healthy tissues is requi...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-14757-3

    authors: Fardone E,Bravin A,Conti A,Bräuer-Krisch E,Requardt H,Bucci D,Le Duc G,Battaglia G,Romanelli P

    更新日期:2017-10-30 00:00:00

  • Th1, Th17, and Treg Responses are Differently Modulated by TNF-α Inhibitors and Methotrexate in Psoriasis Patients.

    abstract::Psoriasis is a chronic, recurrent, immune-mediated, hyperproliferative inflammatory skin disease. The role of the adaptive immune system, particularly of Th1 and Th17 lymphocytes, has been regarded as prominent in the immunopathogenesis of psoriasis, as well as decreased Tregs function. Immunobiological drugs were adm...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-43899-9

    authors: Furiati SC,Catarino JS,Silva MV,Silva RF,Estevam RB,Teodoro RB,Pereira SL,Ataide M,Rodrigues V Jr,Rodrigues DBR

    更新日期:2019-05-17 00:00:00

  • mTORC1-mediated polarization of M1 macrophages and their accumulation in the liver correlate with immunopathology in fatal ehrlichiosis.

    abstract::A polarized macrophage response into inflammatory (M1) or regenerative/anti-inflammatory (M2) phenotypes is critical in host response to multiple intracellular bacterial infections. Ehrlichia is an obligate Gram-negative intracellular bacterium that causes human monocytic ehrlichiosis (HME): a febrile illness that may...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-50320-y

    authors: Haloul M,Oliveira ERA,Kader M,Wells JZ,Tominello TR,El Andaloussi A,Yates CC,Ismail N

    更新日期:2019-10-01 00:00:00

  • Degradation of p47 by autophagy contributes to CADM1 overexpression in ATLL cells through the activation of NF-κB.

    abstract::Cell adhesion molecule 1 (CADM1), a member of the immunoglobulin superfamily, is identified as a novel cell surface marker for human T-cell leukemia virus (HTLV-1)-infected T cells. Adult T-cell leukemia/lymphoma (ATLL) is developed in HTLV-1-infected T-cells after a long infection period. To examine the mechanism of ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-39424-7

    authors: Sarkar B,Nishikata I,Nakahata S,Ichikawa T,Shiraga T,Saha HR,Fujii M,Tanaka Y,Shimoda K,Morishita K

    更新日期:2019-03-05 00:00:00

  • SOX7 co-regulates Wnt/β-catenin signaling with Axin-2: both expressed at low levels in breast cancer.

    abstract::SOX7 as a tumor suppressor belongs to the SOX F gene subfamily and is associated with a variety of human cancers, including breast cancer, but the mechanisms involved are largely unclear. In the current study, we investigated the interactions between SOX7 and AXIN2 in their co-regulation on the Wnt/β-catenin signal pa...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep26136

    authors: Liu H,Mastriani E,Yan ZQ,Yin SY,Zeng Z,Wang H,Li QH,Liu HY,Wang X,Bao HX,Zhou YJ,Kou JJ,Li D,Li T,Liu J,Liu Y,Yin L,Qiu L,Gong L,Liu SL

    更新日期:2016-05-18 00:00:00

  • Multi-component quantitative magnetic resonance imaging by phasor representation.

    abstract::Quantitative magnetic resonance imaging (qMRI) is a versatile, non-destructive and non-invasive tool in life, material, and medical sciences. When multiple components contribute to the signal in a single pixel, however, it is difficult to quantify their individual contributions and characteristic parameters. Here we i...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-00864-8

    authors: Vergeldt FJ,Prusova A,Fereidouni F,Amerongen HV,Van As H,Scheenen TWJ,Bader AN

    更新日期:2017-04-13 00:00:00

  • The screening and identification of DNA barcode sequences for Rehmannia.

    abstract::In this study, ITS, ITS2, matK, rbcL and psbA-trnH in Rehmannia were successfully amplified and sequenced, but some ITS sequences need to be proofread according to ITS2 sequences. Compared with rbcL, matK and psbA-trnH, ITS and ITS2 had higher mutation rate and more information sites, and ITS2 had higher interspecific...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-53752-8

    authors: Duan H,Wang W,Zeng Y,Guo M,Zhou Y

    更新日期:2019-11-21 00:00:00

  • Surface-modified three-dimensional graphene nanosheets as a stationary phase for chromatographic separation of chiral drugs.

    abstract::Carbon-based stationary phases for chromatographic separation have been commercially available since the 1980s. Porous graphitic carbon liquid chromatography columns are known to be highly resistant to aggressive mobile phases and extreme pH values of solvents and eluents, an important advantage compared to convention...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-33075-w

    authors: Candelaria L,Frolova LV,Kowalski BM,Artyushkova K,Serov A,Kalugin NG

    更新日期:2018-10-03 00:00:00

  • Evaluation of an antibody-PNA conjugate as a clearing agent for antibody-based PNA-mediated radionuclide pretargeting.

    abstract::Radionuclide molecular imaging of cancer-specific targets is a promising method to identify patients for targeted antibody therapy. Radiolabeled full-length antibodies however suffer from slow clearance, resulting in high background radiation. To overcome this problem, a pretargeting system based on complementary pept...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-77523-y

    authors: Myrhammar A,Vorobyeva A,Westerlund K,Yoneoka S,Orlova A,Tsukahara T,Tolmachev V,Karlström AE,Altai M

    更新日期:2020-11-27 00:00:00

  • A T7 autogene-based hybrid mRNA/DNA system for long-term shRNA expression in cytoplasm without inefficient nuclear entry.

    abstract::The transient silencing effects currently demonstrated by nonviral siRNA delivery systems limit the therapeutic utility of RNAi, but it remains a technical challenge to prolong duration of gene silencing. We have developed a T7 autogene-based hybrid mRNA/DNA system to enable long-term expression of shRNA in cytoplasm ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-39407-8

    authors: Kwak SY,Han HD,Ahn HJ

    更新日期:2019-02-28 00:00:00

  • Manganese oxide electrode with excellent electrochemical performance for sodium ion batteries by pre-intercalation of K and Na ions.

    abstract::Materials with a layered structure have attracted tremendous attention because of their unique properties. The ultrathin nanosheet structure can result in extremely rapid intercalation/de-intercalation of Na ions in the charge-discharge progress. Herein, we report a manganese oxide with pre-intercalated K and Na ions ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-02028-0

    authors: Feng M,Du Q,Su L,Zhang G,Wang G,Ma Z,Gao W,Qin X,Shao G

    更新日期:2017-05-22 00:00:00

  • Pore-scale characteristics of multiphase flow in heterogeneous porous media using the lattice Boltzmann method.

    abstract::This study provides a pore-scale investigation of two-phase flow dynamics during primary drainage in a realistic heterogeneous rock sample. Using the lattice Boltzmann (LB) method, a series of three-dimensional (3D) immiscible displacement simulations are conducted and three typical flow patterns are identified and ma...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-39741-x

    authors: Bakhshian S,Hosseini SA,Shokri N

    更新日期:2019-03-04 00:00:00

  • In vivo two-photon microscopy of the human eye.

    abstract::Two-photon (2P) microscopy is a powerful tool for imaging and exploring label-free biological tissues at high resolution. Although this type of microscopy has been demonstrated in ex vivo ocular tissues of both humans and animal models, imaging the human eye in vivo has always been challenging. This work presents a no...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-46568-z

    authors: Ávila FJ,Gambín A,Artal P,Bueno JM

    更新日期:2019-07-12 00:00:00

  • Using stable isotopes to analyse extinction risks and reintroduction opportunities of native species in invaded ecosystems.

    abstract::Invasive non-native species have pervasive impacts on native biodiversity, including population extirpations and species extinctions. Identifying reasons why a population of a native species is extirpated following an invasion often relies on literature-based results of anecdotal observations. The well-established sch...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-78328-9

    authors: Haubrock PJ,Balzani P,Britton JR,Haase P

    更新日期:2020-12-10 00:00:00

  • Genetic diversity and population structure of a mini-core subset from the world cowpea (Vigna unguiculata (L.) Walp.) germplasm collection.

    abstract::The International Institute of Tropical Agriculture maintains the world's largest collection of cowpea germplasm of over 15,000 accessions. A sub-set of 298 lines from the loosely composed mini core collection of 370 landraces were genotyped based on genotyping by sequencing (GBS). Ward's minimum variance hierarchical...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-34555-9

    authors: Fatokun C,Girma G,Abberton M,Gedil M,Unachukwu N,Oyatomi O,Yusuf M,Rabbi I,Boukar O

    更新日期:2018-10-30 00:00:00

  • Distinct roles for primate caudate dopamine D1 and D2 receptors in visual discrimination learning revealed using shRNA knockdown.

    abstract::The striatum plays important motor, associative and cognitive roles in brain functions. However, the rodent dorsolateral (the primate putamen) and dorsomedial (the primate caudate nucleus) striatum are not anatomically separated, making it difficult to distinguish their functions. By contrast, anatomical separation ex...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep35809

    authors: Takaji M,Takemoto A,Yokoyama C,Watakabe A,Mizukami H,Ozawa K,Onoe H,Nakamura K,Yamamori T

    更新日期:2016-11-02 00:00:00

  • Parasitoid envenomation alters the Galleria mellonella midgut microbiota and immunity, thereby promoting fungal infection.

    abstract::Gut bacteria influence the development of different pathologies caused by bacteria, fungi and parasitoids in insects. Wax moth larvae became more susceptible to fungal infections after envenomation by the ectoparasitoid Habrobracon hebetor. In addition, spontaneous bacterioses occurred more often in envenomated larvae...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-40301-6

    authors: Polenogova OV,Kabilov MR,Tyurin MV,Rotskaya UN,Krivopalov AV,Morozova VV,Mozhaitseva K,Kryukova NA,Alikina T,Kryukov VY,Glupov VV

    更新日期:2019-03-08 00:00:00

  • Orchid Bsister gene PeMADS28 displays conserved function in ovule integument development.

    abstract::The ovules and egg cells are well developed to be fertilized at anthesis in many flowering plants. However, ovule development is triggered by pollination in most orchids. In this study, we characterized the function of a Bsister gene, named PeMADS28, isolated from Phalaenopsis equestris, the genome-sequenced orchid. S...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-79877-9

    authors: Shen CY,Chen YY,Liu KW,Lu HC,Chang SB,Hsiao YY,Yang F,Zhu G,Zou SQ,Huang LQ,Liu ZJ,Tsai WC

    更新日期:2021-01-13 00:00:00

  • In situ estimation of optical properties of rat and monkey brains using femtosecond time-resolved measurements.

    abstract::An accurate knowledge of tissue optical properties (absorption coefficients, μa, and reduced scattering coefficients, μs') is critical for precise modeling of light propagation in biological tissue, essential for developing diagnostic and therapeutic optical techniques that utilize diffusive photons. A great number of...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-45736-5

    authors: Hoshi Y,Tanikawa Y,Okada E,Kawaguchi H,Nemoto M,Shimizu K,Kodama T,Watanabe M

    更新日期:2019-06-24 00:00:00

  • Photodynamic effect of Zirconium phosphate biocompatible nano-bilayers containing methylene blue on cancer and normal cells.

    abstract::Pharmaceutical applications of methylene blue, especially as photosensitizer, have been limited due to its rapid enzymatic reduction in the biological systems. In this study nano-platelet zirconium phosphate was synthesized and its biocompatibility was evaluated. The synthesized material was considered as drug deliver...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-51359-7

    authors: Hosseinzadeh R,Khorsandi K

    更新日期:2019-10-17 00:00:00

  • Impact of Resolution of Hyponatremia on Neurocognitive and Motor Performance in Geriatric Patients.

    abstract::This observational study investigated the impact of hyponatremia resolution on the results of a comprehensive geriatric assessment (CGA) in 150 patients with age ≥70 years and serum sodium <130 mEq/L. The test battery including Barthel index of Activities of Daily Living (ADL) and various tests of neurocognitive funct...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-49054-8

    authors: Brinkkoetter PT,Grundmann F,Ghassabeh PJ,Becker I,Johnsen M,Suaréz V,Schulz RJ,Streichert T,Burst V

    更新日期:2019-08-29 00:00:00

  • The Effect of Rotational Disorder on the Microwave Transmission of Checkerboard Metal Square Arrays.

    abstract::The effect of rotational disorder on the microwave transmission through thin metallic checkerboard arrays has been experimentally studied. Broad resonant features below the onset of diffraction, attributed to electromagnetic radiation coupling through the structure via the evanescent fields of bound surface waves, are...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep16608

    authors: Tremain B,Durrant CJ,Carter IE,Hibbins AP,Sambles JR

    更新日期:2015-11-16 00:00:00

  • Health-related quality of life analysis in differentiated thyroid carcinoma patients after thyroidectomy.

    abstract::Although differentiated thyroid carcinoma (DTC) has a good prognosis and survival rate, long-term medication and recurrence monitoring might be needed. The factors that affect postoperative health-related quality of life (HRQoL) in patients with DTC in different regions remain unclear or conflicting. The purpose of th...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-62731-3

    authors: Li J,Zhang B,Bai Y,Liu Y,Zhang B,Jin J

    更新日期:2020-04-01 00:00:00

  • Conditioned place preference reveals ongoing pain in calves 3 weeks after disbudding.

    abstract::Hot-iron disbudding, a routine procedure that prevents horn bud growth through cauterization, is painful for calves. The resulting burns remain sensitive to touch for weeks, but it is unknown whether calves experience ongoing, non-evoked pain. We evaluated conditioned place preference for analgesia in 44 calves disbud...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-60260-7

    authors: Adcock SJJ,Tucker CB

    更新日期:2020-03-02 00:00:00

  • Phase Diagram of Water Confined by Graphene.

    abstract::The behavior of water confined at the nanoscale plays a fundamental role in biological processes and technological applications, including protein folding, translocation of water across membranes, and filtration and desalination. Remarkably, nanoscale confinement drastically alters the properties of water. Using molec...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-24358-3

    authors: Gao Z,Giovambattista N,Sahin O

    更新日期:2018-04-18 00:00:00

  • Phylogenetic evidence of the intercontinental circulation of a Canine distemper virus lineage in the Americas.

    abstract::Canine distemper virus (CDV) is the cause of a multisystem disease in domestic dogs and wild animals, infecting more than 20 carnivore and non-carnivore families and even infecting human cell lines in in vitro conditions. Phylogenetic classification based on the hemagglutinin gene shows 17 lineages with a phylogeograp...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-52345-9

    authors: Duque-Valencia J,Forero-Muñoz NR,Díaz FJ,Martins E,Barato P,Ruiz-Saenz J

    更新日期:2019-10-31 00:00:00

  • Fukutin is prerequisite to ameliorate muscular dystrophic phenotype by myofiber-selective LARGE expression.

    abstract::α-Dystroglycanopathy (α-DGP) is a group of muscular dystrophy characterized by abnormal glycosylation of α-dystroglycan (α-DG), including Fukuyama congenital muscular dystrophy (FCMD), muscle-eye-brain disease, Walker-Warburg syndrome, and congenital muscular dystrophy type 1D (MDC1D), etc. LARGE, the causative gene f...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep08316

    authors: Ohtsuka Y,Kanagawa M,Yu CC,Ito C,Chiyo T,Kobayashi K,Okada T,Takeda S,Toda T

    更新日期:2015-02-09 00:00:00

  • High-throughput identification and dendritic cell-based functional validation of MHC class I-restricted Mycobacterium tuberculosis epitopes.

    abstract::Emergence of drug-resistant strains of the pathogen Mycobacterium tuberculosis (Mtb) and the ineffectiveness of BCG in curtailing Mtb infection makes vaccine development for tuberculosis an important objective. Identifying immunogenic CD8+ T cell peptide epitopes is necessary for peptide-based vaccine strategies. We p...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep04632

    authors: Nair SK,Tomaras GD,Sales AP,Boczkowski D,Chan C,Plonk K,Cai Y,Dannull J,Kepler TB,Pruitt SK,Weinhold KJ

    更新日期:2014-04-23 00:00:00

  • ABCB4 is frequently epigenetically silenced in human cancers and inhibits tumor growth.

    abstract::Epigenetic silencing through promoter hypermethylation is an important hallmark for the inactivation of tumor-related genes in carcinogenesis. Here we identified the ATP-binding cassette sub-family B member 4 (ABCB4) as a novel epigenetically silenced target gene. We investigated the epigenetic regulation of ABCB4 in ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep06899

    authors: Kiehl S,Herkt SC,Richter AM,Fuhrmann L,El-Nikhely N,Seeger W,Savai R,Dammann RH

    更新日期:2014-11-04 00:00:00