Abstract：
:Excess alcohol use is known to promote development of aggressive tumors in various tissues in human patients, but the cause of alcohol promotion of tumor aggressiveness is not clearly understood. We used an animals model of fetal alcohol exposure that is known to promote tumor development and determined if alcohol programs the pituitary to acquire aggressive prolactin-secreting tumors. Our results show that pituitaries of fetal alcohol-exposed rats produced increased levels of intra-pituitary aromatase protein and plasma estrogen, enhanced pituitary tissue growth, and upon estrogen challenge developed prolactin-secreting tumors (prolactinomas) that were hemorrhagic and often penetrated into the surrounding tissue. Pituitary tumors of fetal alcohol-exposed rats produced higher levels of hemorrhage-associated genes and proteins and multipotency genes and proteins. Cells of pituitary tumor of fetal alcohol exposed rat grew into tumor spheres in ultra-low attachment plate, expressed multipotency genes, formed an increased number of colonies, showed enhanced cell migration, and induced solid tumors following inoculation in immunodeficient mice. These data suggest that fetal alcohol exposure programs the pituitary to develop aggressive prolactinoma after estrogen treatment possibly due to increase in stem cell niche within the tumor microenvironment.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Jabbar S,Reuhl K,Sarkar DKdoi
10.1038/s41598-018-25785-ysubject
Has Abstractpub_date
2018-05-16 00:00:00pages
7720issue
1issn
2045-2322pii
10.1038/s41598-018-25785-yjournal_volume
8pub_type
杂志文章abstract：:This paper presents the correlative imaging of collagen denaturation by nonlinear optical microscopy (NLO) and nanoscale infrared (IR) spectroscopy to obtain morphological and chemical information at different length scales. Such multiscale correlated measurements are applied to the investigation of ancient parchments...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep26344
更新日期：2016-05-19 00:00:00
abstract：:Riboflavin (Rf) is a vitamin and endogenous photosensitizer capable to generate reactive oxygen species (ROS) under UV-blue irradiation and kill cancer cells, which are characterized by the enhanced uptake of Rf. We confirmed its phototoxicity on human breast adenocarcinoma cells SK-BR-3 preincubated with 30-μM Rf and...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep35103
更新日期：2016-10-12 00:00:00
abstract：:Parkinson's disease (PD) is a degenerative disorder that affects the central nervous system. PD-related alterations in structural and functional neuroimaging have not been fully explored. This study explored multi-modal PD neuroimaging and its application for predicting clinical scores on the Movement Disorder Society...
journal_title：Scientific reports
pub_type： 杂志文章,随机对照试验
doi：10.1038/srep38070
更新日期：2016-11-30 00:00:00
abstract：:Neoadjuvant systemic treatment is increasingly being integrated in the standard treatment of pancreatic ductal adenocarcinoma (PDAC) patients to improve oncological outcomes. Current available imaging techniques remain unreliable in assessing response to therapies, as they cannot distinguish between (vital) tumor tiss...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-73242-6
更新日期：2020-10-01 00:00:00
abstract：:Transcranial focused ultrasound (US) has been demonstrated to stimulate neurons in animals and humans, but the mechanism of this effect is unknown. It has been hypothesized that US, a mechanical stimulus, may mediate cellular discharge by activating mechanosensitive ion channels embedded within cellular membranes. To ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep24170
更新日期：2016-04-26 00:00:00
abstract：:Although the Guangxi region accounts for 10% of all HIV-1 cases new reported in 2011 in China, the sources of the transmitted HIV-1 strains are virtually unknown. To determine the extent to which recent HIV infections were derived from already circulating local strains as opposed to recently introduced strains, we per...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-29201-3
更新日期：2018-08-27 00:00:00
abstract：:Regional brain sizes of very-preterm infants at term-equivalent age differ from those of term-born peers, which have been linked with later cognitive impairments. However, dependence of regional brain volume loss on gestational age has not been studied in detail. To investigate the spatial pattern of brain growth in n...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep33995
更新日期：2016-09-23 00:00:00
abstract：:Phosphoinositides play important roles in numerous intracellular membrane pathways. Little is known about the regulation or function of these lipids in rod photoreceptor cells, which have highly active membrane dynamics. Using new assays with femtomole sensitivity, we determined that whereas levels of phosphatidylinos...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep26978
更新日期：2016-06-01 00:00:00
abstract：:Biliverdin (BV) possesses antioxidant and anti-inflammatory properties, with previous reports identifying protection against oxidant and inflammatory injury in animal models. Recent reports indicate that intra-duodenal administration of BV results in the formation of an uncharacterised metabolite, which is potently ab...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-39548-w
更新日期：2019-02-27 00:00:00
abstract：:The success of mesenchymal stem cell transplantation is highly dependent on their survival and controlled fate regulation. This study demonstrates that dual-delivery of connective tissue growth factor (CTGF) and fibroblast growth factor 2 (FGF-2) from a core-shell fiber of Silk Fibroin/poly(L-lactic acid-co-ε-caprolac...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-08226-0
更新日期：2017-08-17 00:00:00
abstract：:Secondary bacterial infections increase morbidity and mortality of influenza A virus (IAV) infections. Bacteria are able to invade due to virus-induced depletion of alveolar macrophages (AMs), but this is not the only contributing factor. By analyzing a kinetic model, we uncovered a nonlinear initial dose threshold th...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep38703
更新日期：2016-12-15 00:00:00
abstract：:Transcriptional enhancers are non-coding segments of DNA that play a central role in the spatiotemporal regulation of gene expression programs. However, systematically and precisely predicting enhancers remain a major challenge. Although existing methods have achieved some success in enhancer prediction, they still su...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep28517
更新日期：2016-06-22 00:00:00
abstract：:Transplanted neural stem cells (NSC) interact with the host brain microenvironment. A neovascularization is commonly observed in the vicinity of the cell deposit, which is correlated with behavioral improvements. To elucidate the signaling mechanisms between human NSCs and endothelial cells (ECs), these were coculture...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep29029
更新日期：2016-07-04 00:00:00
abstract：:A novel III-Nitride digital alloy (DA) with ultra-broadband optical gain is proposed. Numerical analysis shows a 50-period InN/GaN DA yields minibands that are densely quantized by numerous confined states. Interband transitions between the conduction and valence minibands create ultra-broadband optical gain spectra w...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-21434-6
更新日期：2018-02-15 00:00:00
abstract：:The black rhinoceros is again on the verge of extinction due to unsustainable poaching in its native range. Despite a wide historic distribution, the black rhinoceros was traditionally thought of as depauperate in genetic variation, and with very little known about its evolutionary history. This knowledge gap has hamp...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep41417
更新日期：2017-02-08 00:00:00
abstract：:Accurate intraocular lens (IOL) power calculation is always a challenge in ophthalmology, and unoptimized process may lead to inaccurate refractive outcomes. Quality control circle (QCC) has shown its success in many fields as a process management tool. However, its efficacy in ophthalmology remains unclear. Here we u...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-14171-9
更新日期：2017-11-01 00:00:00
abstract：:Malaria remains a major public health problem in the Peruvian Amazon where the persistence of high-risk transmission areas (hotspots) challenges the current malaria control strategies. This study aimed at identifying significant space-time clusters of malaria incidence in Loreto region 2002-2013 and to determine signi...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep40350
更新日期：2017-01-16 00:00:00
abstract：:Plate subduction continuously transports crustal materials with high-δ(18)O values down to the mantle wedge, where mantle peridotites are expected to achieve the high-δ(18)O features. Elevated δ(18)O values relative to the upper mantle value have been reported for magmas from some subduction zones. However, peridotite...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep04232
更新日期：2014-02-28 00:00:00
abstract：:The accumulation of repetitive DNA sequences on the sex-limited W or Y chromosomes is a well-known process that is likely triggered by the suppression of recombination between the sex chromosomes, which leads to major differences in their sizes and genetic content. Here, we report an analysis conducted on the satellit...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-42383-8
更新日期：2019-04-10 00:00:00
abstract：:Microbial detoxification has been proposed as a new alternative for removing toxins and pollutants. In this study, the biodetoxification activities of yeasts against aflatoxin B1 and zinc were evaluated by HPLC and voltammetric techniques. The strains with the best activity were also subjected to complementary assays,...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-68154-4
更新日期：2020-07-09 00:00:00
abstract：:Prediction of infection trends, estimating the efficacy of contact tracing, testing or impact of influx of infected are of vital importance for administration during an ongoing epidemic. Most effective methods currently are empirical in nature and their relation to parameters of interest to administrators are not evid...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-73308-5
更新日期：2020-10-06 00:00:00
abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title：Scientific reports
pub_type： 已发布勘误
doi：10.1038/s41598-020-62381-5
更新日期：2020-04-06 00:00:00
abstract：:Lassa virus (LASV) is the causative agent of Lassa fever (LF), an often-fatal hemorrhagic disease. LF is endemic in Nigeria, Sierra Leone and other West African countries. Diagnosis of LASV infection is challenged by the genetic diversity of the virus, which is greatest in Nigeria. The ReLASV Pan-Lassa Antigen Rapid T...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-65736-0
更新日期：2020-05-26 00:00:00
abstract：:The performance and emission affected by piston catalytic coating have been analyzed in this study. The main contributing factors for improving performance such as load, fuel and speed have been preferred to reduce the emission and improve the performance of an IC engine. These specific standard parameters have been m...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-57129-9
更新日期：2020-02-07 00:00:00
abstract：:Deep eutectic solvents have been recently reported as an interesting alternative to improve the therapeutic efficacy of conventional drugs, hence called therapeutic deep eutectic solvents (THEDES). The main objective of this work was to evaluate the potential of limonene (LIM) based THEDES as new possible systems for ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-51472-7
更新日期：2019-10-17 00:00:00
abstract：:Environmental stimuli have the ability to generate specific representations of the rewards they predict and in so doing alter the selection and performance of reward-seeking actions. The basolateral amygdala participates in this process, but precisely how is unknown. To rectify this, we monitored, in near-real time, b...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep12511
更新日期：2015-07-27 00:00:00
abstract：:Infestation by the biotrophic pathogen Gymnosporangium asiaticum can be devastating for plant of the family Rosaceae. However, the phytopathology of this process has not been thoroughly elucidated. Using a metabolomics approach, we discovered the intrinsic activities that induce disease symptoms after fungal invasion ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep37434
更新日期：2016-11-28 00:00:00
abstract：:Sterile liver inflammation and fibrosis are associated with many liver disorders of different etiologies. Both type 1 and type 2 inflammatory responses have been reported to contribute to liver pathology. However, the mechanisms controlling the balance between these responses are largely unknown. Natural killer T (NKT...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-78688-2
更新日期：2020-12-11 00:00:00
abstract：:In chickens, the sensory organs for taste are the taste buds in the oral cavity, of which there are ~240-360 in total number as estimated by scanning electron microscopy (SEM). There is not an easy way to visualize all taste buds in chickens. Here, we report a highly efficient method for labeling chicken taste buds in...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep37247
更新日期：2016-11-17 00:00:00
abstract：:Capable of generating plasmonic and other effects, gold nanostructures can offer a variety of diagnostic and therapy functionalities for biomedical applications, but conventional chemically-synthesized Au nanomaterials cannot always match stringent requirements for toxicity levels and surface conditioning. Laser-synth...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-48748-3
更新日期：2019-09-09 00:00:00
