Abstract:
:Statins are well known to have muscle toxicity problem. Herba Cistanches (HC) is a Chinese herb traditionally used for pain in the loins and knees. Our previous in vitro study suggested that it could protect against statin-induced muscle toxicity. However, its in vivo protective effect has never been investigated. The objective of this study was to determine if the aqueous extract of HC (HCE) could prevent simvastatin-induced muscle toxicity in rats, and whether HCE could also exert beneficial effects on reducing high-fat diet-induced hypercholesterolemia and elevated liver cholesterol, thereby reducing the dose of simvastatin when used in combined therapy. From our results, HCE significantly restored simvastatin-induced reduction in muscle weights and reduced elevated plasma creatine kinase in rats. HCE also improved simvastatin-induced reduction in muscle glutathione levels, muscle mitochondrial membrane potential, and reduced simvastatin-induced muscle inflammation. Furthermore, HCE could exert reduction on liver weight, total liver lipid levels and plasma lipid levels in high-fat-fed mice. In conclusion, our study provided in vivo evidence that HCE has potential protective effect on simvastatin-induced toxicity in muscles, and also beneficial effects on diet-induced non-alcoholic fatty liver and hyperlipidemia when being used alone or in combination with simvastatin at a reduced dose.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Wat E,Ng CF,Koon CM,Zhang C,Gao S,Tomlinson B,Lau CBSdoi
10.1038/s41598-017-10008-7subject
Has Abstractpub_date
2017-08-24 00:00:00pages
9391issue
1issn
2045-2322pii
10.1038/s41598-017-10008-7journal_volume
7pub_type
杂志文章abstract::Purpose Global sagittal imbalance with lumbar hypo-lordosis leads to various problems in elderly populations and is often treated with long-segment fusion and osteotomy. These highly invasive procedures result in a wide range of rigid spines with a high rate of complications. Although some reports have mentioned the p...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-63648-7
更新日期:2020-04-21 00:00:00
abstract::Anoectochilus roxburghii and Anoectochilus formasanus are the major species of genus Anoectochilus used in traditional Chinese medicine for their abundant content of flavonoids and some other medicinal constituents. In recent years, their wild resources are gradually exhausted due to over-collection and ecological det...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-56821-0
更新日期:2019-12-27 00:00:00
abstract::Dorso-ventral (DV) countershading is a highly-conserved pigmentary adaptation in vertebrates. In mammals, spatially regulated expression of agouti-signaling protein (ASIP) generates the difference in shading by driving a switch between the production of chemically-distinct melanins in melanocytes in dorsal and ventral...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-40251-z
更新日期:2019-03-05 00:00:00
abstract::Lung cancer is the deadliest cancer worldwide. The mutational frequency of EGFR and KRAS genes in lung adenocarcinoma varies worldwide per ethnicity and smoking. The impact of EGFR and KRAS mutations in Brazilian lung cancer remains poorly explored. Thus, we investigated the frequency of EGFR and KRAS mutations in a l...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-39965-x
更新日期:2019-03-01 00:00:00
abstract::Inhalation exposure to airborne respirable crystalline silica (RCS) poses major health risks in many industrial environments. There is a need for new sensitive instruments and methods for in-field or near real-time measurement of crystalline silica aerosol. The objective of this study was to develop an approach, using...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-14363-3
更新日期:2017-10-24 00:00:00
abstract::Neuroscience findings have recently received critique on the lack of replications. To examine the reproducibility of brain indices of speech sound discrimination and their role in dyslexia, a specific reading difficulty, brain event-related potentials using EEG were measured using the same cross-linguistic passive odd...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-41992-7
更新日期:2019-06-11 00:00:00
abstract::Marek's disease virus (MDV) is a highly cell-associated alphaherpesvirus that causes deadly lymphomas in chickens. While vaccination protects against clinical symptoms, MDV field strains can still circulate in vaccinated flocks and continuously evolve towards greater virulence. MDV vaccines do not provide sterilizing ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-67951-1
更新日期:2020-07-02 00:00:00
abstract::Twenty-six imprinted genes were quantified in bovine in vivo produced oocytes and embryos using RNA-seq. Eighteen were detectable and their transcriptional patterns were: largely decreased (MEST and PLAGL1); first decreased and then increased (CDKN1C and IGF2R); peaked at a specific stage (PHLDA2, SGCE, PEG10, PEG3, G...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep17898
更新日期:2015-12-07 00:00:00
abstract::The overall goal of this work was to measure the efficacy of fMRI for predicting whether a dog would be a successful service dog. The training and imaging were performed in 49 dogs entering service training at 17-21 months of age. 33 dogs completed service training and were matched with a person, while 10 were release...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep43704
更新日期:2017-03-07 00:00:00
abstract::Bisphenol A (BPA) is one of the commonest Endocrine Disruptor Compounds worldwide. It interferes with vertebrate reproduction, possibly by inducing deregulation of epigenetic mechanisms. To determine its effects on female reproductive physiology and investigate whether changes in the expression levels of genes related...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep21982
更新日期:2016-02-25 00:00:00
abstract::Both genetic and environmental factors are suggested to influence overweight and obesity risks. Although individual loci and genes have been frequently shown to be associated with body mass index (BMI), the overall interaction of these genes and their role in BMI remains underexplored. Data were collected in 90 health...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-43881-5
更新日期:2019-05-15 00:00:00
abstract::Insect glutathione S-transferases (GSTs) play important roles in insecticide/drug resistance and stress response. Medically, GSTs of house dust mites (Dermatophagoides pteronyssinus and Blomia tropicalis) and German cockroach (Blattella germanica) are human allergens. In this study, classes, isoforms and B-cell and al...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-18759-z
更新日期:2018-01-11 00:00:00
abstract::Osteoporosis is associated with reduced density and quality of bone leading to weakened skeleton thereby increasing the risk of fractures responsible for increased morbidity and mortality. Due to preference for western food style the consumption of salt intake in our diets has increased many folds. High dietary salt i...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-20896-y
更新日期:2018-02-06 00:00:00
abstract::Mechanical interlocking is widely applied in industry and general lives of human beings. In this work, we realized the control of locking or sliding states of cotton fibers on the metal surfaces with slightly different textures through traditional machining. Three types of sliding states, i.e., locking, one-way slidin...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep25403
更新日期:2016-05-09 00:00:00
abstract::In order to ensure successful development, cells of the early mammalian embryo must differentiate to either trophectoderm (TE) or inner cell mass (ICM), followed by epiblast (EPI) or primitive endoderm (PE) specification within the ICM. Here, we deciphered the mechanism that assures the correct order of these sequenti...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-15427-0
更新日期:2017-11-09 00:00:00
abstract::The pentameric serum IgMs are critical to immune defense and surveillance through cytotoxicity against microbes and nascent cancer cells. Ficolins, a group of oligomeric lectins with an overall structure similar to C1q and mannose-binding lectin (MBL) participate in microbe infection and apoptotic cell clearance by ac...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep07824
更新日期:2015-01-16 00:00:00
abstract::X-ray phase-contrast imaging (XPCI) can dramatically improve soft tissue contrast in X-ray medical imaging. Despite worldwide efforts to develop novel XPCI systems, a numerical framework to rigorously predict the performance of a clinical XPCI system at a human scale is not yet available. We have developed such a tool...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep12011
更新日期:2015-07-14 00:00:00
abstract::Inflammation is considered as a major contributor to brain injury following cerebral ischemia. The therapeutic potential of both MLC601/MLC901, which are herbal extract preparations derived from Chinese Medicine, has been reported both in advanced stroke clinical trials and also in animal and cellular models. The aim ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-36138-0
更新日期:2018-12-24 00:00:00
abstract::We demonstrate a designed interaction between two isolated cell populations of Euglena gracilis and Chlamydomonas reinhardtii, separately confined in two 25-square micro-aquariums of lab-on-chip size. The interaction was realized by interlinking two identical optical feedback systems, which measured the cell distribut...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep24602
更新日期:2016-04-21 00:00:00
abstract::Late endothelial progenitor cells (LEPCs) are derived from mononuclear cells (MNCs) and are thought to directly incorporate into blood vessels and differentiate into mature endothelial cells (ECs). Using transcriptome and proteome analysis, we identified distinctive LEPC profiles and found that Hedgehog-interacting pr...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-12571-5
更新日期:2017-09-29 00:00:00
abstract::Previous studies have consistently reported an association between circulating levels of branched-chain amino acids (BCAAs) or adipokines and insulin resistance; however, the association between BCAA and adipokine levels remains to be clarified. In this cross-sectional study involving 678 participants (435 men) withou...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-19388-w
更新日期:2018-01-18 00:00:00
abstract::Tyrosine kinase activity of the asymmetric EGFR homodimer is negatively regulated via ERK-mediated phosphorylation of Thr-669 in the juxtamembrane domain. In the present study, we investigated in human breast cancer cells whether a similar mechanism plays a role in the feedback regulation of the ErbB2/ErbB3 heterodime...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep31502
更新日期:2016-08-17 00:00:00
abstract::Phenotypic plasticity describes the ability of a given genotype to produce distinct phenotypes in different environments. We use the temperature sensitivity of abdominal pigmentation in Drosophila melanogaster females as a model to analyse the effect of the environment on development. We reported previously that therm...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep43370
更新日期:2017-02-23 00:00:00
abstract::The spontaneous emission coefficient, Arad, a global molecular property, is one of the most important quantities related to the luminescence of complexes of lanthanide ions. In this work, by suitable algebraic transformations of the matrices involved, we introduce a partition that allows us to compute, for the first t...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep21204
更新日期:2016-02-19 00:00:00
abstract::In this paper, we propose an angle- and polarization-insensitive metamaterial absorber. We design a metamaterial unit cell that is based on a split ring cross resonator (SRCR). We observe that the absorption frequency and absorption ratio are insensitive to incident angles when a via array surrounds the SRR. We demons...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep39686
更新日期:2016-12-21 00:00:00
abstract::We evaluated the performance of three PGx panels to estimate biogeographical ancestry: the DMET panel, and the VIP and Preemptive PGx panels described in the literature. Our analysis indicate that the three panels capture quite well the individual variation in admixture proportions observed in recently admixed populat...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-80389-9
更新日期:2021-01-13 00:00:00
abstract::Acute lymphoblastic leukaemia (ALL) is the most common childhood cancer and has a high survival rate when properly managed. Prognosis is correlated with many factors such as age, gender, white blood cell (WBC) count, CD10, French-American-British (FAB) classification, and many others. Many of these factors are include...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-63528-0
更新日期:2020-04-21 00:00:00
abstract::Tremendous efforts have been made to explore biomarkers for classification and grading on gliomas. The goal of this study was to identify more molecular features that are associated with clinical outcomes by comparing the genomic profiles of primary and recurrent gliomas and determine potential recurrence leading fact...
journal_title:Scientific reports
pub_type: 临床试验,杂志文章
doi:10.1038/s41598-019-52515-9
更新日期:2019-11-05 00:00:00
abstract::Anti-EGFR antibodies are effective in therapies for late-stage colorectal cancer (CRC); however, many tumours are unresponsive or develop resistance. We performed genomic analysis of intrinsic and acquired resistance to anti-EGFR therapy in prospectively collected tumour samples from 25 CRC patients receiving cetuxima...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-51981-5
更新日期:2019-10-25 00:00:00
abstract::Sufficient tissue oxygenation is required for regular brain function; thus oxygen supply must be tightly regulated to avoid hypoxia and irreversible cell damage. If hypoxia occurs the transcription factor complex hypoxia-inducible factor (HIF) will accumulate and coordinate adaptation of cells to hypoxia. However, eve...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-75838-4
更新日期:2020-11-05 00:00:00