Abstract:
:Cortical gyrification of the brain represents the folding characteristic of the cerebral cortex. How the brain cortical gyrification changes from childhood to old age in healthy human subjects is still unclear. Additionally, studies have shown regional gyrification alterations in patients with major psychiatric disorders, such as major depressive disorder (MDD), bipolar disorder (BD), and schizophrenia (SCZ). However, whether the lifespan trajectory of gyrification over the brain is altered in patients diagnosed with major psychiatric disorders is still unknown. In this study, we investigated the trajectories of gyrification in three independent cohorts based on structural brain images of 881 subjects from age 4 to 83. We discovered that the trajectory of gyrification during normal development and aging was not linear and could be modeled with a logarithmic function. We also found that the gyrification trajectories of patients with MDD, BD and SCZ were deviated from the healthy one during adulthood, indicating altered aging in the brain of these patients.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Cao B,Mwangi B,Passos IC,Wu MJ,Keser Z,Zunta-Soares GB,Xu D,Hasan KM,Soares JCdoi
10.1038/s41598-017-00582-1subject
Has Abstractpub_date
2017-03-30 00:00:00pages
511issue
1issn
2045-2322pii
10.1038/s41598-017-00582-1journal_volume
7pub_type
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