Abstract:
:Spinal cord injury (SCI) leads to wide-spread neurodegeneration across the neuroaxis. We explored trajectories of surface morphology, demyelination and iron concentration within the basal ganglia-thalamic circuit over 2 years post-SCI. This allowed us to explore the predictive value of neuroimaging biomarkers and determine their suitability as surrogate markers for interventional trials. Changes in markers of surface morphology, myelin and iron concentration of the basal ganglia and thalamus were estimated from 182 MRI datasets acquired in 17 SCI patients and 21 healthy controls at baseline (1-month post injury for patients), after 3, 6, 12, and 24 months. Using regression models, we investigated group difference in linear and non-linear trajectories of these markers. Baseline quantitative MRI parameters were used to predict 24-month clinical outcome. Surface area contracted in the motor (i.e. lower extremity) and pulvinar thalamus, and striatum; and expanded in the motor thalamus and striatum in patients compared to controls over 2-years. In parallel, myelin-sensitive markers decreased in the thalamus, striatum, and globus pallidus, while iron-sensitive markers decreased within the left caudate. Baseline surface area expansions within the striatum (i.e. motor caudate) predicted better lower extremity motor score at 2-years. Extensive extrapyramidal neurodegenerative and reorganizational changes across the basal ganglia-thalamic circuitry occur early after SCI and progress over time; their magnitude being predictive of functional recovery. These results demonstrate a potential role of extrapyramidal plasticity during functional recovery after SCI.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Huber E,Patel R,Hupp M,Weiskopf N,Chakravarty MM,Freund Pdoi
10.1038/s41598-020-70805-5subject
Has Abstractpub_date
2020-08-24 00:00:00pages
14102issue
1issn
2045-2322pii
10.1038/s41598-020-70805-5journal_volume
10pub_type
杂志文章abstract::In a developing nervous system, endogenous electric field (EF) influence embryonic growth. We reported the EF-directed migration of both rat Schwann cells (SCs) and oligodendrocyte precursor cells (OPCs) and explored the molecular mechanism using RNA-sequencing assay. However, previous studies revealed the differentia...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-74085-x
更新日期:2020-10-08 00:00:00
abstract::Detailed characterization and mapping of oligonucleotide function in vivo is generally a very time consuming effort that only allows for hypothesis driven subsampling of the full sequence to be analysed. Recent advances in deep sequencing together with highly efficient parallel oligonucleotide synthesis and cloning te...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep37563
更新日期:2016-11-22 00:00:00
abstract::An accurate and efficient solution of the radiative transport equation is proposed for modeling the propagation of photons in the three-dimensional anisotropically scattering half-space medium. The exact refractive index mismatched boundary condition is considered and arbitrary rotationally invariant scattering functi...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep02018
更新日期:2013-01-01 00:00:00
abstract::Traditional risk assessment and source apportionment of sediments based on bulk polycyclic aromatic hydrocarbons (PAHs) can introduce biases due to unknown aging effects in various sediments. We used a mild solvent (hydroxypropyl-β-cyclodextrin) to extract the bioavailable fraction of PAHs (a-PAHs) from sediment sampl...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep23134
更新日期:2016-03-15 00:00:00
abstract::We have succeeded in developing hollow branching structure in vitro commonly observed in lung airway using primary lung airway epithelial cells. Cell concentration gradient is the key factor that determines production of the branching cellular structures, as optimization of this component removes the need for heteroty...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep08054
更新日期:2015-01-27 00:00:00
abstract::Both attraction and repulsion from linearly polarized light have been observed in zooplankton. A dichotomous choice experiment, consisting of plankton light traps deployed in natural waters at a depth of 30 m that projected either polarized or unpolarized light of the same intensity, was used to test the hypothesis th...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep35891
更新日期:2016-10-20 00:00:00
abstract::Specific HPV genotypes have been recognized as risk factors inducing head and neck cancers (HNC). The aim of this study was to validate a real-time PCR assay to detect accurately High Risk HPV DNA in Formalin Fixed Paraffin Embedded (FFPE) and oral cytobrush samples and compare the results with conventional PCR. Repea...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-29790-z
更新日期:2018-07-27 00:00:00
abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title:Scientific reports
pub_type: 已发布勘误
doi:10.1038/s41598-020-69600-z
更新日期:2020-07-22 00:00:00
abstract::Notch1 is regulated by E3 ubiquitin ligases, with proteasomal degradation of the Notch intracellular domain affecting the transcription of target genes. cAMP response element-binding protein (CREB) mediates the transcription of hepatitis B virus (HBV) covalently closed circular DNA (cccDNA). We assessed the relationsh...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-38139-5
更新日期:2019-02-07 00:00:00
abstract::This study demonstrated the usefulness of radiomic features based on the Hessian index of differential topology for the prediction of prognosis prior to treatment in head-and-neck (HN) cancer patients. The Hessian index, which can indicate tumor heterogeneity with convex, concave, and other points (saddle points), was...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-78338-7
更新日期:2020-12-04 00:00:00
abstract::Rett syndrome (RTT) is a neurodevelopmental disorder mainly caused by mutations in the gene encoding the transcriptional regulator Methyl-CpG-binding protein 2 (MeCP2), located on the X chromosome. Many RTT patients have breathing abnormalities, such as apnea and breathing irregularity, and respiratory infection is th...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-12293-8
更新日期:2017-09-20 00:00:00
abstract::Little is known about the effects of posterior tethers on the development of proximal junctional kyphosis (PJK). We evaluated the ability of posterior tethers to the proximal motion segment stiffness in long instrumented spinal instrumentation and fusion using a whole body human FE model. A series of finite element (F...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-59179-w
更新日期:2020-02-26 00:00:00
abstract::Aquaporins (AQPs) are a ubiquitous family of transmembrane water channel proteins. A subgroup of AQP water channels also facilitates transmembrane diffusion of small, polar solutes. A constriction within the pore, the aromatic/arginine (ar/R) selectivity filter, is thought to control solute permeability: previous stud...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-56814-z
更新日期:2019-12-30 00:00:00
abstract::The protein interface is key to understand protein function, providing a vital insight on how proteins interact with each other and with other molecules. Over the years, many computational methods to compare protein structures were developed, yet evaluating interface similarity remains a very difficult task. Here, we ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-26497-z
更新日期:2018-05-29 00:00:00
abstract::Phytoplasmas (class, Mollicutes) are insect-transmissible and plant-pathogenic bacteria that multiply intracellularly in both plants and insects through host switching. Our previous study revealed that phytoplasmal sigma factor rpoD of OY-M strain (rpoDOY) could be a key regulator of host switching, because the expres...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep11893
更新日期:2015-07-07 00:00:00
abstract::The present work presents and discusses the results of a comprehensive study on the bioactive properties of Nb-substituted silicate glass derived from 45S5 bioglass. In vitro and in vivo experiments were performed. We undertook three different types of in vitro analyses: (i) investigation of the kinetics of chemical r...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-31114-0
更新日期:2018-08-24 00:00:00
abstract::Afforestation is an important approach to mitigate global warming. Its complex interactions with the climate system, however, makes it controversial. Afforestation is expected to be effective in the tropics where biogeochemical and biogeophysical effects act in concert; however, its potential in the large semi-arid re...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-19265-6
更新日期:2018-01-17 00:00:00
abstract::Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by motor neuron loss that ultimately leads to fatal paralysis. Reducing levels or function of the tyrosine kinase, ephrin type-A receptor 4 (EphA4), has been suggested as a potential approach for slowing disease progression in ALS. Becaus...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-72723-y
更新日期:2020-09-24 00:00:00
abstract::A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has not been fixed in the paper. ...
journal_title:Scientific reports
pub_type: 已发布勘误
doi:10.1038/s41598-018-28707-0
更新日期:2018-08-07 00:00:00
abstract::Staphylococci are common causes of healthcare-associated and community-associated infections. However, limited data are available on the prevalence, phenotypes and molecular characteristics of Staphylococci in metro system around the world. 320 surface samples were collected from the Guangzhou metro system to isolate ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep16087
更新日期:2015-10-29 00:00:00
abstract::Different subtypes of bone marrow-derived stem cells are characterized by varying functionality and activity after transplantation into the infarcted heart. Improvement of stem cell therapeutics requires deep knowledge about the mechanisms that mediate the benefits of stem cell treatment. Here, we demonstrated that co...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-10122-6
更新日期:2017-08-29 00:00:00
abstract::Biomaterial injection is a novel therapy to treat ischemic heart failure (HF) that has shown to reduce remodeling and restore cardiac function in recent preclinical studies. While the effect of biomaterial injection in reducing mechanical wall stress has been recently demonstrated, the influence of biomaterials on the...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-69900-4
更新日期:2020-07-31 00:00:00
abstract::Nacre, the gold standard for biomimicry, provides an excellent example and guideline for assembling high-performance composites. Inspired by the layered structure and extraordinary strength and toughness of natural nacre, nacre-like nanolignocellulose/poly (vinyl alcohol)/TiO2 composites possessed the similar layered ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-02082-8
更新日期:2017-05-12 00:00:00
abstract::To address the limitations of titanium dioxide (TiO2) and expand the applicability of the photocatalytic activity of TiO2,WSe2 and silica, an eco-friendly, self-assembled method for combining a silica precursor with a WSe2-graphene-TiO2 composite with cetyltrimethylammonium bromide (CTAB) as surface active agents is p...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-31188-w
更新日期:2018-08-24 00:00:00
abstract::Sauropodomorpha were herbivorous saurischian dinosaurs that incorporate Sauropoda and early-diverging sauropodomorphs. The oldest sauropodomorph remains are known from Late Triassic deposits, most of them Gondwanan. The Laurasian record comprises some Triassic forms, but the bulk is Jurassic in age. Among the 14 Juras...
journal_title:Scientific reports
pub_type: 历史文章,杂志文章
doi:10.1038/s41598-020-67754-4
更新日期:2020-07-03 00:00:00
abstract::The study of factors influencing animal intake can provide a better understanding of the dynamics of the pasture ecosystem and serve as a basis for managing livestock in a more efficient way. We measured different sward surface heights of tall fescue in the process of short-term intake rate of sheep. There was a signi...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-68827-0
更新日期:2020-07-16 00:00:00
abstract::We study localized photonic excitations in a quasi-two-dimensional non-ideal binary microcavity lattice with use of the virtual crystal approximation. The effect of point defects (vacancies) on the excitation spectrum is investigated by numerical modelling. We obtain the dispersion and the energy gap of the electromag...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep06945
更新日期:2014-11-06 00:00:00
abstract::Microbial induced calcite precipitation (MICP) based on ureolysis has a high potential for many applications, e.g. restoration of construction materials. The gram-positive bacterium Sporosarcina pasteurii is the most commonly used microorganism for MICP due to its high ureolytic activity. However, Sporosarcina pasteur...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-79904-9
更新日期:2020-12-31 00:00:00
abstract::Demands for tomato local varieties are increasing worldwide, especially in organic farming mainly for their high sensory value and attractive appearance. This is the case of the "Moruno" tomato type, widely grown in the Mediterranean countries and greatly due to its highly appreciated organoleptic attributes but low y...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-41018-2
更新日期:2019-03-14 00:00:00
abstract::Activated coke (AC) has great potential in the field of low-temperature NO removal (DeNOx), especially the branch prepared by blending modification. In this study, the AC-based pyrolusite and/or titanium ore blended catalysts were prepared and applied for DeNOx. The results show blending pyrolusite and titanium ore pr...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-76592-3
更新日期:2020-11-10 00:00:00