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Four translation initiation pathways employed by the leaderless mRNA in eukaryotes.

Abstract：

:mRNAs lacking 5' untranslated regions (leaderless mRNAs) are molecular relics of an ancient translation initiation pathway. Nevertheless, they still represent a significant portion of transcriptome in some taxons, including a number of eukaryotic species. In bacteria and archaea, the leaderless mRNAs can bind non-dissociated 70 S ribosomes and initiate translation without protein initiation factors involved. Here we use the Fleeting mRNA Transfection technique (FLERT) to show that translation of a leaderless reporter mRNA is resistant to conditions when eIF2 and eIF4F, two key eukaryotic translation initiation factors, are inactivated in mammalian cells. We report an unconventional translation initiation pathway utilized by the leaderless mRNA in vitro, in addition to the previously described 80S-, eIF2-, or eIF2D-mediated modes. This mechanism is a bacterial-like eIF5B/IF2-assisted initiation that has only been reported for hepatitis C virus-like internal ribosome entry sites (IRESs). Therefore, the leaderless mRNA is able to take any of four different translation initiation pathways in eukaryotes.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Akulich KA,Andreev DE,Terenin IM,Smirnova VV,Anisimova AS,Makeeva DS,Arkhipova VI,Stolboushkina EA,Garber MB,Prokofjeva MM,Spirin PV,Prassolov VS,Shatsky IN,Dmitriev SE

doi

10.1038/srep37905

subject

Has Abstract

pub_date

2016-11-28 00:00:00

pages

37905

issn

2045-2322

pii

srep37905

journal_volume

6

pub_type

杂志文章

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