Abstract：
:Spores of pathogenic fungi are virtually ubiquitous and cause human disease and severe losses in crops. The endophytic fungi Alternaria species produce host-selective phytotoxins. Alt a 1 is a strongly allergenic protein found in A. alternata that causes severe asthma. Despite the well-established pathogenicity of Alt a 1, the molecular mechanisms underlying its action and physiological function remain largely unknown. To gain insight into the role played by this protein in the pathogenicity of the fungus, we studied production of Alt a 1 and its activity in spores. We found that Alt a 1 accumulates inside spores and that its release with a ligand is pH-dependent, with optimum production in the 5.0-6.5 interval. The Alt a 1 ligand was identified as a methylated flavonoid that inhibits plant root growth and detoxifies reactive oxygen species. We also found that Alt a 1 changes its oligomerization state depending on the pH of the surrounding medium and that these changes facilitate the release of the ligand. Based on these results, we propose that release of Alt a 1 should be a pathogenic target in approaches used to block plant defenses and consequently to favor fungal entry into the plant.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Garrido-Arandia M,Silva-Navas J,Ramírez-Castillejo C,Cubells-Baeza N,Gómez-Casado C,Barber D,Pozo JC,Melendi PG,Pacios LF,Díaz-Perales Adoi
10.1038/srep33468subject
Has Abstractpub_date
2016-09-16 00:00:00pages
33468issn
2045-2322pii
srep33468journal_volume
6pub_type
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