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Association of pre- and post-stroke glycemic status with clinical outcome in spontaneous intracerebral hemorrhage.

Abstract：

:In this study, we aimed to disclose the association of pre- and post-stroke glycemic status with clinical outcome in patients with spontaneous intracerebral hemorrhage (sICH). It was a multicenter, prospective, observational cohort study, conducted in 13 hospitals in Beijing from January 2014 to September 2016. The association of admission random blood glucose (RBG), fasting blood glucose (FBG) and hemoglobin A1c (HbA1c) with clinical outcome at 90 days after sICH onset were analyzed comprehensively. Poor outcome was defined as death or modified Rankin Scale (mRS) score >2. The results showed that elevated RBG and FBG were associated with larger hematoma volume, lower GCS, higher NIHSS (P < 0.001), and poor outcome, but HbA1c was not (P > 0.05). In stratified analysis, the association of poor outcome with elevated FBG or RBG retained statistical significance just in patients without diabetes. Kaplan-Meier curve and Cox regression showed that patients with elevated FBG or RBG had significantly higher risk of death within 90 days (P < 0.05). So we conclude that poststroke hyperglycemia was associated with larger hematoma volume, severe neurological damage and poor clinical outcome, but HbA1c was not relevant to hematoma volume or clinical outcome in patients with sICH.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Kang K,Lu J,Ju Y,Wang W,Shen Y,Wang A,Cao Z,Zhao X

doi

10.1038/s41598-019-55610-z

subject

Has Abstract

pub_date

2019-12-13 00:00:00

pages

19054

issue

1

issn

2045-2322

pii

10.1038/s41598-019-55610-z

journal_volume

9

pub_type

杂志文章,多中心研究

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