A therapeutic method for the direct reprogramming of human liver cancer cells with only chemicals.

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Scientific reports

authors： Ezewudo M,Borens A,Chiner-Oms Á,Miotto P,Chindelevitch L,Starks AM,Hanna D,Liwski R,Zignol M,Gilpin C,Niemann S,Kohl TA,Warren RM,Crook D,Gagneux S,Hoffner S,Rodrigues C,Comas I,Engelthaler DM,Alland D,Rigouts L,

更新日期：2020-02-21 00:00:00

abstract：:The subjective experience of thermal pain follows the detection and encoding of noxious stimuli by primary afferent neurons called nociceptors. However, nociceptor morphology has been hard to access and the mechanisms of signal transduction remain unresolved. In order to understand how heat transducers in nociceptors ...

journal_title：Scientific reports

authors： Dezhdar T,Moshourab RA,Fründ I,Lewin GR,Schmuker M

更新日期：2015-12-07 00:00:00

abstract：:Electrolyte concentration in sweat depends on environmental context and physical condition but also on the pathophysiological status. Sweat analyzers may be therefore the future way for biological survey although how sweat electrolyte composition can reflect plasma composition remains unclear. We recruited 10 healthy ...

journal_title：Scientific reports

authors： Vairo D,Bruzzese L,Marlinge M,Fuster L,Adjriou N,Kipson N,Brunet P,Cautela J,Jammes Y,Mottola G,Burtey S,Ruf J,Guieu R,Fenouillet E

更新日期：2017-09-18 00:00:00

abstract：:Miscanthus is a rhizomatous C4 grass which is considered as potential high-yielding energy crop with the low-nutrient requirements, high water-use efficiency, and capability of C mitigation. To better understand the genetic basis, an integrative analysis of the transcriptome and proteome was performed to identify impo...

journal_title：Scientific reports

authors： Sheng J,Zheng X,Wang J,Zeng X,Zhou F,Jin S,Hu Z,Diao Y

更新日期：2017-10-23 00:00:00

abstract：:Hurricane Patricia in 2015 was the strongest Pacific hurricane to make landfall in Mexico. Although Patricia fortuitously spared major cities, it reminded us of the threat tropical cyclones (TCs) pose in the eastern North Pacific (ENP) and the importance of improving our understanding and prediction of ENP TCs. Patric...

journal_title：Scientific reports

authors： Fu D,Chang P,Patricola CM

更新日期：2017-05-10 00:00:00

abstract：:An experimental method for fabrication of a nanocomposite metamaterial based on a self-assembly of titanium dioxide microtubes with encapsulated gold nanoparticles (NPs) is proposed. The formation of microtubes is induced by laser irradiation in the presence of an external magnetic field. It is shown that the variatio...

journal_title：Scientific reports

authors： Kutrovskaya S,Kucherik A,Osipov A,Samyshkin V,Istratov A,Kavokin AV

更新日期：2019-05-07 00:00:00

abstract：:Cysteine based silver-gold nanocomposite (Cys/Ag-Au NCz) was synthesized, this was followed by its characterization using Fourier-transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), Ultraviolet-visible spectroscopy (UV-Vis), Scanning electron microscopy (SEM), Energy-dispersive X-ray spectroscopy (EDAX), ...

journal_title：Scientific reports

authors： Basik M,Mobin M,Shoeb M

更新日期：2020-01-14 00:00:00

abstract：:Eu(3+),Tb(3+) doped and undoped NiO films were deposited on TiO2 by a sol-gel spin-coating method as the photoanodes of dye sensitized solar cells (DSSCs). A comparative study with different structures including TiO2, TiO2/NiO and TiO2/NiO:Eu(3+),Tb(3+) as the photoanodes was carried out to illustrate the photovoltaic...

journal_title：Scientific reports

authors： Yao N,Huang J,Fu K,Deng X,Ding M,Zhang S,Xu X,Li L

更新日期：2016-08-10 00:00:00

abstract：:Burley tobacco (Nicotiana Tabacum) is a chlorophyll-deficiency mutant. Nitrate is one precursor of tobacco-specific nitrosamines (TSNAs) and is largely accumulated in burley tobacco. To decrease nitrate accumulation in burley tobacco, glycerol, a polyhydric alcohol compound and physiological regulating material, was s...

journal_title：Scientific reports

authors： Li Y,Chang D,Yang H,Wang J,Shi H

更新日期：2018-09-05 00:00:00

abstract：:Non-arteritic anterior ischemic optic neuropathy (NAION) causes a sudden loss of vision and lacks effective treatment. Granulocyte colony-stimulating factor (G-CSF) provides neuroprotection against the experimental optic nerve injuries but also induce leukocytosis upon typical administration. We found synergetic neuro...

journal_title：Scientific reports

authors： Liu PK,Wen YT,Lin W,Kapupara K,Tai M,Tsai RK

更新日期：2020-06-25 00:00:00

abstract：:The insect vector borne bacterium Xylella fastidiosa was first detected in olive trees in Southern Italy in 2013, and identified as the main culprit behind the 'olive quick decline syndrome'. Since then, the disease has spread rapidly through Italy's main olive oil producing region. The epidemiology of the outbreak is...

journal_title：Scientific reports

authors： Strona G,Carstens CJ,Beck PS

更新日期：2017-03-06 00:00:00

abstract：:Proton irradiation is often used as a proxy for neutron irradiation but the irradiated layer is typically <50 μm deep; this presents a problem when trying to obtain mechanical test data as a function of irradiation level. Two novel methodologies have been developed to record stress-strain curves for thin proton-irradi...

journal_title：Scientific reports

authors： Smith AD,Donoghue JM,Garner AJW,Lunt D,Harte A,Wilford K,Withers PJ,Preuss M

更新日期：2020-03-24 00:00:00

abstract：:This report describes development of spherical equivalent refraction (SER) and axial length (AL) in two population-based cohorts of white, European children. Predictive factors for myopic growth were explored. Participants were aged 6-7- (n = 390) and 12-13-years (n = 657) at baseline. SER and AL were assessed at base...

journal_title：Scientific reports

authors： McCullough S,Adamson G,Breslin KMM,McClelland JF,Doyle L,Saunders KJ

更新日期：2020-09-16 00:00:00

abstract：:A host of hormonal-metabolic alterations take place following exposure of cardiomyocytes to hypoxia and other noxious stimuli. Here, we demonstrate that exposure of cultured rat cardiomyocytes to lipopolysaccharide (LPS) resulted in upregulation (~1.5 fold) of oxidized low-density lipoprotein receptor-1 (LOX-1). There...

journal_title：Scientific reports

authors： Kore RA,Henson JC,Hamzah RN,Griffin RJ,Tackett AJ,Ding Z,Mehta JL

更新日期：2019-12-17 00:00:00

abstract：:The bacterial flagellar motor is a unique supramolecular complex which converts ion flow into rotational force. Many biological devices mainly use two types of ions, proton and sodium ion. This is probably because of the fact that life originated in seawater, which is rich in protons and sodium ions. The polar flagell...

journal_title：Scientific reports

authors： Onoue Y,Iwaki M,Shinobu A,Nishihara Y,Iwatsuki H,Terashima H,Kitao A,Kandori H,Homma M

更新日期：2019-08-02 00:00:00

abstract：:Advanced structural characterisation techniques which are rapid to use, non-destructive and structurally definitive on the nanoscale are in demand, especially for a detailed understanding of extended-defects and their influence on the properties of materials. We have applied the electron backscatter diffraction (EBSD)...

journal_title：Scientific reports

authors： Naresh-Kumar G,Vilalta-Clemente A,Jussila H,Winkelmann A,Nolze G,Vespucci S,Nagarajan S,Wilkinson AJ,Trager-Cowan C

更新日期：2017-09-07 00:00:00

abstract：:Acid-sensing ion channels (ASICs) belong to the degenerin/epithelial sodium channel protein family that form mechanosensitive ion channels. Evidence as to whether or not ASICs activity is directly modulated by mechanical force is lacking. Human ASICs (hASIC1V3, hASIC2a and hASIC3a) were heterologously expressed as hom...

journal_title：Scientific reports

authors： Barth D,Fronius M

更新日期：2019-05-01 00:00:00

abstract：:In the phytopathogenic basidiomycete Ustilago maydis, the Num1 protein has a pivotal function in hyphal morphogenesis. Num1 functions as a core component of the spliceosome-associated Prp19/CDC5 complex (NTC). The interaction of Num1 with the kinesin motor Kin1 suggests a connection between a component of the splicing...

journal_title：Scientific reports

authors： Zhou L,Obhof T,Schneider K,Feldbrügge M,Nienhaus GU,Kämper J

更新日期：2018-02-26 00:00:00

abstract：:Tuneable pressure effects associated with changing interlayer distances in two-dimensional graphene oxide (GO)/reduced GO (rGO) layers are demonstrated through monitoring the changes in the spin-crossover (SCO) temperature (T 1/2) of [Fe(Htrz)2(trz)](BF4) nanoparticles (NPs) incorporated in the interlayer spaces of th...

journal_title：Scientific reports

authors： Sekimoto Y,Ohtani R,Nakamura M,Koinuma M,Lindoy LF,Hayami S

更新日期：2017-09-22 00:00:00

abstract：:The barnase-barstar complex is one of the most stable protein-protein complexes and has a very wide range of possible applications. Here we report the use of top-down mass spectrometry for the investigation of the structure of this complex, its ionization via ESI, isolation and fragmentation. It was found that the asy...

journal_title：Scientific reports

authors： Kostyukevich Y,Shulga AA,Kononikhin A,Popov I,Nikolaev E,Deyev S

更新日期：2017-07-21 00:00:00

abstract：:The analysis of equine electrocardiographic (ECG) recordings is complicated by the absence of agreed abnormality classification criteria. We explore the applicability of several complexity analysis methods for characterization of non-linear aspects of electrocardiographic recordings. We here show that complexity estim...

journal_title：Scientific reports

authors： Alexeenko V,Fraser JA,Dolgoborodov A,Bowen M,Huang CL,Marr CM,Jeevaratnam K

更新日期：2019-02-22 00:00:00

abstract：:The anatomic and functional combinations of cusps and lophs (ridges) define the tooth shape of rodent molars, which distinguishes species. The species-specific cusp patterns result from the spatiotemporal induction of enamel knots (EKs), which require precisely controlled cellular behavior to control the epithelial in...

journal_title：Scientific reports

authors： Li L,Tang Q,Nakamura T,Suh JG,Ohshima H,Jung HS

更新日期：2016-11-28 00:00:00

abstract：:A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper. ...

journal_title：Scientific reports

authors： Caeiro C,Guo K,Mills D

更新日期：2018-07-05 00:00:00

abstract：:There is growing interest in the conservation and utilization of crop wild relatives (CWR) in international food security policy and research. Legumes play an important role in human health, sustainable food production, global food security, and the resilience of current agricultural systems. Pea belongs to the ancien...

journal_title：Scientific reports

authors： Smýkal P,Hradilová I,Trněný O,Brus J,Rathore A,Bariotakis M,Das RR,Bhattacharyya D,Richards C,Coyne CJ,Pirintsos S

更新日期：2017-12-12 00:00:00

abstract：:In a large German community sample of adults, we investigated the association of chronic anxiousness with cardiovascular disease and mortality. Self-reported anxiousness from 11,643 German adults between 40 and 80 years of age from the Gutenberg Health Study (GHS) was analyzed over 5 years. Multivariable regression mo...

journal_title：Scientific reports

authors： Reiner IC,Tibubos AN,Werner AM,Ernst M,Brähler E,Wiltink J,Michal M,Schulz A,Wild PS,Münzel T,Arnold N,Mahmoudpour SH,Lackner KJ,Pfeiffer N,Beutel ME

更新日期：2020-07-24 00:00:00

abstract：:Invasive species are characterized by their ability to colonize new habitats and establish populations away from their native range. In this sense, these plants are expected to have plastic responses to adapt to the environmental pressures during the invasion process. Hence, the role of natural selection is essential ...

journal_title：Scientific reports

authors： Dematteis B,Ferrucci MS,Coulleri JP

更新日期：2020-11-18 00:00:00

abstract：:Gaucher disease (GD) is a rare inherited metabolic disease caused by pathogenic variants in the GBA1 gene. So far, the pathomechanism of GD was investigated mainly in animal models. In order to delineate the molecular changes in GD cells we analysed gene expression profile in cultured skin fibroblasts from GD patients...

journal_title：Scientific reports

authors： Ługowska A,Hetmańczyk-Sawicka K,Iwanicka-Nowicka R,Fogtman A,Cieśla J,Purzycka-Olewiecka JK,Sitarska D,Płoski R,Filocamo M,Lualdi S,Bednarska-Makaruk M,Koblowska M

更新日期：2019-04-15 00:00:00

abstract：:Semen fertilizing potential is dependent upon the morphological, functional and molecular attributes of sperm. Sperm microRNAs (miRNAs) were recently shown to hold promise regarding their association with different fertility phenotypes. However, their role in fertility regulation remains to be determined. We postulate...

journal_title：Scientific reports

authors： Alves MBR,de Arruda RP,De Bem THC,Florez-Rodriguez SA,Sá Filho MF,Belleannée C,Meirelles FV,da Silveira JC,Perecin F,Celeghini ECC

更新日期：2019-07-17 00:00:00

abstract：:Highly selective hydrogenative carbon-carbon bond scission of biomass-derived platform oxygenates was achieved with a cerium oxide-supported ruthenium nanoparticle catalyst in water. The present catalyst enabled the selective cleavage of carbon-carbon σ bonds adjacent to carboxyl, ester, and hydroxymethyl groups, open...

journal_title：Scientific reports

authors： Mizugaki T,Togo K,Maeno Z,Mitsudome T,Jitsukawa K,Kaneda K

更新日期：2017-10-25 00:00:00

abstract：:Tunable metasurfaces have emerged as an efficient approach to manipulate the wave propagation. Different from previous work concentrating on electrically tunable mechanisms, here we demonstrate a magnetically tunable metasurface composed of ferrite rods and metallic foils. By tuning the thickness of ferrite rods, meta...

journal_title：Scientific reports

authors： Yang H,Yu T,Wang Q,Lei M

更新日期：2017-07-14 00:00:00