Transient desialylation in combination with a novel antithrombin deficiency causing a severe and recurrent thrombosis despite anticoagulation therapy.

abstract：:Thrombosis has proven to be extremely difficult to predict. Measuring the generation of thrombin is a very sensitive method to detect changes in the hemostatic system. We developed a method based on the generation of thrombin to further fingerprint hemostasis, which we have named thrombin dynamics. Via this method we ...

journal_title：Scientific reports

authors： de Laat-Kremers RMW,Yan Q,Ninivaggi M,de Maat M,de Laat B

更新日期：2020-07-27 00:00:00

abstract：:Papillary thyroid carcinoma (PTC) displays strong but so far largely uncharacterized heritability. Here we studied genetic predisposition in a family with six affected individuals. We genotyped all available family members and conducted whole exome sequencing of blood DNA from two affected individuals. Haplotype analy...

journal_title：Scientific reports

authors： Tomsic J,He H,Akagi K,Liyanarachchi S,Pan Q,Bertani B,Nagy R,Symer DE,Blencowe BJ,de la Chapelle A

更新日期：2015-07-02 00:00:00

abstract：:Recent advances in the field of Tissue Engineering allowed to control the three-dimensional organization of engineered constructs. Cell pattern imaging and in vivo follow-up remain a major hurdle in in situ bioprinting onto deep tissues. Magnetic Resonance Imaging (MRI) associated with Micron-sized superParamagnetic I...

journal_title：Scientific reports

authors： Kérourédan O,Ribot EJ,Fricain JC,Devillard R,Miraux S

更新日期：2018-10-25 00:00:00

abstract：:Traumatic brain injury (TBI) is a leading cause of injury-related death worldwide, yet there are no approved neuroprotective therapies that improve neurological outcome post-injury. Transient opening of the blood-brain barrier following injury provides an opportunity for passive accumulation of intravenously administe...

journal_title：Scientific reports

authors： Miller HA,Magsam AW,Tarudji AW,Romanova S,Weber L,Gee CC,Madsen GL,Bronich TK,Kievit FM

更新日期：2019-11-06 00:00:00

abstract：:Nucleic acid amplification tests have become a common method for diagnosis of STIs due to their improved sensitivity over immunoassays and traditional culture-based methods. Isothermal nucleic acid amplification methods offer significant advantages over polymerase chain reaction (PCR) because they do not require sophi...

journal_title：Scientific reports

authors： Eboigbodin KE,Hoser MJ

更新日期：2016-02-03 00:00:00

abstract：:Hypertension is the most common and lethal risk factor for cardiovascular disease (CVD). Numerous variants have been associated with hypertension, however, most of which failed to get replication due to ethnic differences. In this study, we analyzed associations of 10 newly reported single nucleotide polymorphisms (SN...

journal_title：Scientific reports

authors： Yu Q,Sun HP,Chen WQ,Chen XQ,Xu Y,He YH,Kong QP

更新日期：2015-10-21 00:00:00

abstract：:In a large German community sample of adults, we investigated the association of chronic anxiousness with cardiovascular disease and mortality. Self-reported anxiousness from 11,643 German adults between 40 and 80 years of age from the Gutenberg Health Study (GHS) was analyzed over 5 years. Multivariable regression mo...

journal_title：Scientific reports

authors： Reiner IC,Tibubos AN,Werner AM,Ernst M,Brähler E,Wiltink J,Michal M,Schulz A,Wild PS,Münzel T,Arnold N,Mahmoudpour SH,Lackner KJ,Pfeiffer N,Beutel ME

更新日期：2020-07-24 00:00:00

abstract：:Human-induced forest fragmentation poses one of the largest threats to global diversity yet its impact on rattans (climbing palms) has remained virtually unexplored. Rattan is arguably the world's most valuable non-timber forest product though current levels of harvesting and land-use change place wild populations at ...

journal_title：Scientific reports

authors： Campbell MJ,Edwards W,Magrach A,Laurance SG,Alamgir M,Porolak G,Laurance WF

更新日期：2017-07-20 00:00:00

abstract：:The neural bases of the inter-trial validity/invalidity sequential effects in a visuo-auditory modified version of the Central Cue Posner's Paradigm (CCPP) are analyzed by means of Early Directing Attention Negativity (EDAN), Contingent Negative Variation (CNV) and Lateralized Readiness Potential (LRP). ERPs results i...

journal_title：Scientific reports

authors： Arjona A,Escudero M,Gómez CM

更新日期：2014-03-31 00:00:00

abstract：:Both chronic calorie restriction (CCR) and intermittent calorie restriction (ICR) have shown anticancer effects. However, the direct evidence comparing ICR to CCR with respect to cancer prevention is controversial and inconclusive. PubMed and Web of Science were searched on November 25, 2015. The relative risk (RR) [9...

journal_title：Scientific reports

authors： Chen Y,Ling L,Su G,Han M,Fan X,Xun P,Xu G

更新日期：2016-09-22 00:00:00

abstract：:Severe sepsis or septic shock is one of the rising causes for mortality worldwide representing nearly 10% of intensive care unit admissions. Susceptibility to sepsis is identified to be mediated by innate pattern recognition receptors and responsive signaling pathways of the host. The c-Jun N-terminal Kinase (JNK)-med...

journal_title：Scientific reports

authors： Prasad KD,Trinath J,Biswas A,Sekar K,Balaji KN,Guru Row TN

更新日期：2014-11-27 00:00:00

abstract：:The dynamics of networks of neuronal cultures has been recently shown to be strongly dependent on the network geometry and in particular on their dimensionality. However, this phenomenon has been so far mostly unexplored from the theoretical point of view. Here we reveal the rich interplay between network geometry and...

journal_title：Scientific reports

authors： Millán AP,Torres JJ,Bianconi G

更新日期：2018-07-02 00:00:00

abstract：:Some neural network can be trained by transfer learning, which uses a pre-trained neural network as the source task, for a small target task's dataset. The performance of the transfer learning depends on the knowledge (i.e., layers) selected from the pre-trained network. At present, this knowledge is usually chosen by...

journal_title：Scientific reports

authors： Imai S,Kawai S,Nobuhara H

更新日期：2020-05-18 00:00:00

abstract：:Emotional expressions of others are salient biological stimuli that automatically capture attention and prepare us for action. We investigated the early cortical dynamics of automatic visual discrimination of fearful body expressions by monitoring cortical activity using magnetoencephalography. We show that right pari...

journal_title：Scientific reports

authors： Meeren HK,Hadjikhani N,Ahlfors SP,Hämäläinen MS,de Gelder B

更新日期：2016-04-20 00:00:00

abstract：:Hepatocarcinoma (HCC) is one of the deadliest cancers in the world and represents a significant disease burden. Better biomarkers are needed for early detection of HCC. Metabolomics was applied to urine samples obtained from HCC patients to discover noninvasive and reliable biomarkers for rapid diagnosis of HCC. Metab...

journal_title：Scientific reports

authors： Liang Q,Liu H,Wang C,Li B

更新日期：2016-01-25 00:00:00

abstract：:Diffuse large B-cell lymphoma (DLBCL) is a heterogeneous disease with diverse clinical presentation and outcome. Bio-clinical prognostic models including oncogene expression and cell-of-origin phenotyping has been developed, however, approximately 30% of all patients still die from their disease, illustrating the need...

journal_title：Scientific reports

authors： Jespersen DS,Schönherz AA,Due H,Bøgsted M,Sondergaard TE,Dybkær K

更新日期：2019-01-23 00:00:00

abstract：:In higher plants, L-galactono-1,4-lactone dehydrogenase (GLDH) plays important roles in ascorbic acid (AsA) biosynthesis and assembly of respiration complex I. Here we report three homoeologous genes (TaGLDH-A1, -B1 and -D1) encoding common wheat GLDH isozymes and a unique allelic variant (TaGLDH-A1b) associated with ...

journal_title：Scientific reports

authors： Zhang J,Li B,Yang Y,Mu P,Qian W,Dong L,Zhang K,Liu X,Qin H,Ling H,Wang D

更新日期：2016-07-22 00:00:00

abstract：:Lung adenosquamous cell carcinomas (ASCs) is a rare variant of NSCLC with a poorer prognosis and fewer treatment option than the more common variants. PD-L1 expression is reported to be the predictor of clinical response in trials of NSCLC. In our study, PD-L1 expression was evaluated via immunohistochemistry using a ...

journal_title：Scientific reports

authors： Shi X,Wu S,Sun J,Liu Y,Zeng X,Liang Z

更新日期：2017-04-07 00:00:00

abstract：:The β5 subunit of the proteasome has been shown in worms and in human cell lines to be regulatory. In these models, β5 overexpression results in upregulation of the entire proteasome complex which is sufficient to increase proteotoxic stress resistance, improve metabolic parameters, and increase longevity. However, fu...

journal_title：Scientific reports

authors： Nguyen NN,Rana A,Goldman C,Moore R,Tai J,Hong Y,Shen J,Walker DW,Hur JH

更新日期：2019-02-28 00:00:00

abstract：:The prognosis of pancreatic cancer remains dismal, with little advance in chemotherapy because of its high frequency of chemoresistance. Metformin is widely used to treat type II diabetes, and was shown recently to inhibit pancreatic cancer stem cell proliferation. In the present study, we investigated the role of met...

journal_title：Scientific reports

authors： Chai X,Chu H,Yang X,Meng Y,Shi P,Gou S

更新日期：2015-09-22 00:00:00

abstract：:Intestinal injury and immune dysfunction are commonly encountered after irradiation therapy. While the curative abilities of ginseng root have been reported in prior studies, there is little known regarding its role in immunoregulation of intestinal repairability in cancer patients treated with irradiation. Our curren...

journal_title：Scientific reports

authors： He LX,Zhang ZF,Zhao J,Li L,Xu T,Bin Sun,Ren JW,Liu R,Chen QH,Wang JB,Salem MM,Pettinato G,Zhou JR,Li Y

更新日期：2018-09-17 00:00:00

abstract：:The valosin-containing protein (VCP) participates in signaling pathways essential for cell homeostasis in multiple tissues, however, its function in the heart in vivo remains unknown. Here we offer the first description of the expression, function and mechanism of action of VCP in the mammalian heart in vivo in both n...

journal_title：Scientific reports

authors： Lizano P,Rashed E,Stoll S,Zhou N,Wen H,Hays TT,Qin G,Xie LH,Depre C,Qiu H

更新日期：2017-04-20 00:00:00

abstract：:Increased connectivity with the mainland has led to the arrival of many invasive species to the Galápagos Islands, including novel pathogens, threatening the archipelago's unique fauna. Here we consider the potential role of the mosquito Aedes taeniorhynchus in maintaining the flavivirus West Nile virus [WNV] should i...

journal_title：Scientific reports

authors： Eastwood G,Goodman SJ,Cunningham AA,Kramer LD

更新日期：2013-01-01 00:00:00

abstract：:This prospective randomized double-masked study investigated the effects of 20 mg lutein supplementation with two different capsules (beeswax or glycerol fatty acid esters) for 6 months on the fellow eyes of 39 Japanese patients with unilateral age-related macular degeneration, and assessed the factors associated with...

journal_title：Scientific reports

authors： Sawa M,Shunto T,Nishiyama I,Yokoyama A,Shigeta R,Miura S,Kawasaki R

更新日期：2020-04-06 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Scientific reports

authors： Jacquemond I,Muggeo A,Lamblin G,Tristan A,Gillet Y,Bolze PA,Bes M,Gustave CA,Rasigade JP,Golfier F,Ferry T,Dubost A,Abrouk D,Barreto S,Prigent-Combaret C,Thioulouse J,Lina G,Muller D

更新日期：2020-01-30 00:00:00

abstract：:Periodontal (gum) disease is a highly prevalent infection and inflammation accounting for the majority of tooth loss in adult population worldwide. Porphyromonas gingivalis is a keystone periodontal pathogen and its lipopolysaccharide (PgLPS) acts as a major virulence attribute to the disease. Herein, we deciphered th...

journal_title：Scientific reports

authors： Herath TDK,Darveau RP,Seneviratne CJ,Wang CY,Wang Y,Jin L

更新日期：2016-08-19 00:00:00

abstract：:Human parainfluenza type-3 virus (hPIV-3) is one of the principal aetiological agents of acute respiratory illness in infants worldwide and also shows high disease severity in the elderly and immunocompromised, but neither therapies nor vaccines are available to treat or prevent infection, respectively. Using a multid...

journal_title：Scientific reports

authors： Bailly B,Dirr L,El-Deeb IM,Altmeyer R,Guillon P,von Itzstein M

更新日期：2016-04-07 00:00:00

abstract：:Human immunodeficiency virus type 1 (HIV-1) infection promotes a generalized activation of host responses that involves not only CD4 T cells, but also cells of the microenvironment, which are not directly infected, such as endothelial cells. The mechanisms triggering HIV-1-associated vascular alterations remain poorly...

journal_title：Scientific reports

authors： Balducci E,Leroyer AS,Lacroix R,Robert S,Todorova D,Simoncini S,Lyonnet L,Chareyre C,Zaegel-Faucher O,Micallef J,Poizot-Martin I,Roll P,Dignat-George F

更新日期：2019-07-16 00:00:00

abstract：:Inhomogeneity in the ground state is an intriguing, emergent phenomenon in magnetism. Recently, it has been observed in the magnetostructural channel of the geometrically frustrated α-NaMnO2, for the first time in the absence of active charge degrees of freedom. Here we report an in-depth numerical and local-probe exp...

journal_title：Scientific reports

authors： Zorko A,Kokalj J,Komelj M,Adamopoulos O,Luetkens H,Arčon D,Lappas A

更新日期：2015-03-19 00:00:00

abstract：:The production of male and female offspring is often determined by the presence of specific sex chromosomes which control sex-specific expression, and sex chromosomes evolve through reduced recombination and specialized gene content. Here we present the genomes of Chrysomya rufifacies, a monogenic blow fly (females pr...

journal_title：Scientific reports

authors： Andere AA,Pimsler ML,Tarone AM,Picard CJ

更新日期：2020-09-25 00:00:00