Effect of Intermittent versus Chronic Calorie Restriction on Tumor Incidence: A Systematic Review and Meta-Analysis of Animal Studies.

abstract：:A growing proportion of head and neck cancers (HNC) result from HPV infection. Between HNC aetiological groups (HPV positive and HPV negative) clinical evidence demonstrates significantly better treatment response among HPV positive cancers. Cancer stem cells (CSCs) are identified in HNC tumour populations as agents o...

journal_title：Scientific reports

authors： Reid P,Staudacher AH,Marcu LG,Olver I,Moghaddasi L,Brown MP,Bezak E

更新日期：2020-02-17 00:00:00

abstract：:Cholesterol 25-hydroxylase (CH25H) encodes the enzyme that converts cholesterol to 25-hydroxycholesterol (25-HC). 25-HC has been demonstrated to be involved in the pathogenesis of inflammatory bowel disease. However, the role of CH25H in experimental colitis remains unknown. Dextran sulfate sodium (DSS)-induced coliti...

journal_title：Scientific reports

authors： Sheng N,Ma Z,Zhou Y,Xu J,Gao Y,Fu XY

更新日期：2020-08-28 00:00:00

abstract：:Grading of essential hypertension according to blood pressure (BP) level may not adequately reflect clinical heterogeneity of hypertensive patients. This study was carried out to explore clinical phenotypes in essential hypertensive patients using cluster analysis. This study recruited 513 hypertensive patients and ev...

journal_title：Scientific reports

authors： Guo Q,Lu X,Gao Y,Zhang J,Yan B,Su D,Song A,Zhao X,Wang G

更新日期：2017-03-07 00:00:00

abstract：:Loss of stromal Caveolin-1 (CAV1) expression is associated with poor prognosis in various cancers. We evaluated the prognostic value of CAV1 expression of both cancer cells and stromal cells in colorectal liver metastases (CRLM) in patients undergoing hepatectomy. In this retrospective study, 109 patients were enrolle...

journal_title：Scientific reports

authors： Neofytou K,Pikoulis E,Petrou A,Agrogiannis G,Petrides C,Papakonstandinou I,Papalambros A,Aggelou A,Kavatzas N,Liakakos T,Felekouras E

更新日期：2017-05-17 00:00:00

abstract：:Newly synthesized mitochondrial precursor proteins have to become unfolded to cross the mitochondrial membranes. This unfolding is achieved primarily by mitochondrial Hsp70 (mtHsp70) for presequence-containing precursor proteins. However, the membrane potential across the inner membrane (ΔΨ) could also contribute to u...

journal_title：Scientific reports

authors： Sato TK,Kawano S,Endo T

更新日期：2019-05-21 00:00:00

abstract：:Usher Syndrome (USH) is a rare disease with hearing loss, retinitis pigmentosa and, sometimes, vestibular dysfunction. A phenotype heterogeneity is reported. Recent evidence indicates that USH is likely to belong to an emerging class of sensory ciliopathies. Olfaction has recently been implicated in ciliopathies, but ...

journal_title：Scientific reports

authors： Ribeiro JC,Oliveiros B,Pereira P,António N,Hummel T,Paiva A,Silva ED

更新日期：2016-06-22 00:00:00

abstract：:We investigated the metabolic outcome of different coping strategies in 129S6/SvEvTac (129Sv) and C57BL/6Ntac (Bl6) strains. Two different batches of male 129Sv and Bl6 mice were used. One batch was not subjected to any behavioral manipulations (home cage control; HCC), whereas the other batch was treated with saline ...

journal_title：Scientific reports

authors： Narvik J,Vanaveski T,Innos J,Philips MA,Ottas A,Haring L,Zilmer M,Vasar E

更新日期：2018-02-21 00:00:00

abstract：:Owing to the diversity of pulse-wave morphology, pulse-based diagnosis is difficult, especially pulse-wave-pattern classification (PWPC). A powerful method for PWPC is a convolutional neural network (CNN). It outperforms conventional methods in pattern classification due to extracting informative abstraction and featu...

journal_title：Scientific reports

authors： Li G,Watanabe K,Anzai H,Song X,Qiao A,Ohta M

更新日期：2019-10-17 00:00:00

abstract：:The causes of Cenozoic uplift of the Colorado Plateau, southwestern USA, are strongly debated, though most hypotheses acknowledge the importance of northwest-directed subduction of the Farallon oceanic plate beneath North America since c. 100 Ma. Existing thermomechanical models suggest that the Farallon slab underthr...

journal_title：Scientific reports

authors： Hernández-Uribe D,Palin RM

更新日期：2019-05-31 00:00:00

abstract：:Natural infection with measles virus (MV) establishes lifelong immunity. Persistent infection with MV is likely involved in this phenomenon, as non-replicating protein antigens never induce such long-term immunity. Although MV establishes stable persistent infection in vitro and possibly in vivo, the mechanism by whic...

journal_title：Scientific reports

authors： Doi T,Kwon HJ,Honda T,Sato H,Yoneda M,Kai C

更新日期：2016-11-24 00:00:00

abstract：:Hepatitis C virus (HCV) uses components of the very-low-density lipoprotein (VLDL) pathway for assembly/release. We previously reported that hepatocyte nuclear factor 4α (HNF4α) participates in HCV assembly/release through downstream factors those participate in VLDL assembly/secretion. Cell-death-inducing DFFA-like e...

journal_title：Scientific reports

authors： Cai H,Yao W,Li L,Li X,Hu L,Mai R,Peng T

更新日期：2016-06-10 00:00:00

abstract：:Traditional strengthening ways, such as strain, precipitation, and solid-solution, come into effect by pinning the motion of dislocation. Here, through first-principles calculations we report on an extra-electron induced covalent strengthening mechanism, which alters chemical bonding upon the introduction of extra-val...

journal_title：Scientific reports

authors： Niu H,Chen XQ,Liu P,Xing W,Cheng X,Li D,Li Y

更新日期：2012-01-01 00:00:00

abstract：:Vascular leakage is a life-threatening complication of dengue virus (DENV) infection. Previously, association between "paracellular" endothelial hyperpermeability and plasma leakage had been extensively investigated. However, whether "transcellular" endothelial leakage is involved in dengue hemorrhagic fever (DHF) and...

journal_title：Scientific reports

authors： Chanthick C,Kanlaya R,Kiatbumrung R,Pattanakitsakul SN,Thongboonkerd V

更新日期：2016-08-22 00:00:00

abstract：:Neurotransmitter release is mediated by the SNARE complex, but the role of its phosphorylation has scarcely been elucidated. Although PKC activators are known to facilitate synaptic transmission, there has been a heated debate on whether PKC mediates facilitation of neurotransmitter release through phosphorylation. On...

journal_title：Scientific reports

authors： Katayama N,Yamamori S,Fukaya M,Kobayashi S,Watanabe M,Takahashi M,Manabe T

更新日期：2017-08-11 00:00:00

abstract：:The balance between ovarian folliculogenesis and follicular atresia is critical for female fertility and is strictly regulated by a complex network of neuroendocrine and intra-ovarian signals. Despite the numerous functions executed by granulosa cells (GCs) in ovarian physiology, the role of multifunctional proteins a...

journal_title：Scientific reports

authors： Arcos A,de Paola M,Gianetti D,Acuña D,Velásquez ZD,Miró MP,Toro G,Hinrichsen B,Muñoz RI,Lin Y,Mardones GA,Ehrenfeld P,Rivera FJ,Michaut MA,Batiz LF

更新日期：2017-09-18 00:00:00

abstract：:Sodium glucose cotransporter 2 (SGLT2) inhibitors, an antidiabetic drug, promotes urinary excretion of glucose by blocking its reabsorption in the renal proximal tubules. It is unclear whether SGLT2 inhibition could attenuate nonalcoholic steatohepatitis (NASH) and NASH-associated hepatocellular carcinoma. We examined...

journal_title：Scientific reports

authors： Shiba K,Tsuchiya K,Komiya C,Miyachi Y,Mori K,Shimazu N,Yamaguchi S,Ogasawara N,Katoh M,Itoh M,Suganami T,Ogawa Y

更新日期：2018-02-05 00:00:00

abstract：:A major goal of biology is to develop a quantitative ligand-binding assay that does not involve the use of radioactivity. Existing fluorescence-based assays have a serious drawback due to fluorescence quenching that accompanies the binding of fluorescently-labeled ligands to their receptors. This limitation of existin...

journal_title：Scientific reports

authors： Breen CJ,Raverdeau M,Voorheis HP

更新日期：2016-05-10 00:00:00

abstract：:Most tropical evergreen rain forests are characterised by varying degrees of precipitation seasonality that influence plant phenology and litterfall dynamics. Soil microbes are sensitive to soil water:air ratio and to nutrient availability. We studied if within-year seasonality in precipitation and litterfall-derived ...

journal_title：Scientific reports

authors： Buscardo E,Geml J,Schmidt SK,Freitas H,da Cunha HB,Nagy L

更新日期：2018-03-12 00:00:00

abstract：:The obesity-associated inflammation of white adipose tissue (WAT) is one of the factors leading to the development of related diseases such as insulin resistance and liver steatosis. Recently, microRNAs (miRNAs) were identified as important regulators of WAT functions. Herein, we cultured human Simpson-Golabi-Behmel s...

journal_title：Scientific reports

authors： Roos J,Enlund E,Funcke JB,Tews D,Holzmann K,Debatin KM,Wabitsch M,Fischer-Posovszky P

更新日期：2016-12-06 00:00:00

abstract：:Transition metal dichalcogenides (TMDCs) are promising materials for sensing applications, due to their exceptional high performance in nano-electronics. Inherentely, the chemical and thermal responses of TMDCs are highly stable, hence, they pave way for real time sensor applications. This article proposes inceptively...

journal_title：Scientific reports

authors： Awais M,Khan MU,Hassan A,Bae J,Chattha TE

更新日期：2020-03-26 00:00:00

abstract：:In a single glass of champagne about a million bubbles nucleate on the wall and rise towards the surface. When these bubbles reach the surface and rupture, they project a multitude of tiny droplets in the form of a particular aerosol holding a concentrate of wine aromas. Based on the model experiment of a single bubbl...

journal_title：Scientific reports

authors： Ghabache E,Liger-Belair G,Antkowiak A,Séon T

更新日期：2016-04-29 00:00:00

abstract：:Metal nitrides have been proposed to replace noble metals in plasmonics for some specific applications. In particular, while titanium nitride (TiN) and zirconium nitride (ZrN) possess localized plasmon resonances very similar to gold in magnitude and wavelength, they benefit from a much higher sustainability to temper...

journal_title：Scientific reports

authors： Lalisse A,Tessier G,Plain J,Baffou G

更新日期：2016-12-09 00:00:00

abstract：:Impedance, or oscillometry, measurements of the respiratory system can generate information about the function of the respiratory system not possible with traditional spirometry. There are currently several instruments on the market using different perturbations. We have compared a new respiratory oscillometry instrum...

journal_title：Scientific reports

authors： Lundblad LKA,Miletic R,Piitulainen E,Wollmer P

更新日期：2019-08-12 00:00:00

abstract：:Chronic atrophic gastritis (CAG) is a common gastrointestinal disease which has been considered as precancerous lesions of gastric carcinoma. Previously, electro-acupuncture stimulation has been shown to be effective in ameliorating symptoms of CAG. However the underlying mechanism of this beneficial treatment is yet ...

journal_title：Scientific reports

authors： Xu J,Zheng X,Cheng KK,Chang X,Shen G,Liu M,Wang Y,Shen J,Zhang Y,He Q,Dong J,Yang Z

更新日期：2017-03-30 00:00:00

abstract：:Angiopoietin-1 (Ang1) and Angiopoietin-2 (Ang2) are ligands for Tie2, an endothelial-specific receptor tyrosine kinase that is an essential regulator of angiogenesis. Here we report the identification, via expression cloning, of thrombomodulin (TM) as another receptor for Ang1 and Ang2. Thrombomodulin is an endothelia...

journal_title：Scientific reports

authors： Daly C,Qian X,Castanaro C,Pasnikowski E,Jiang X,Thomson BR,Quaggin SE,Papadopoulos N,Wei Y,Rudge JS,Thurston G,Yancopoulos GD,Davis S

更新日期：2018-01-11 00:00:00

abstract：:Bats are an important reservoir for zoonotic viruses. To date, only three RVA strains have been reported in bats in Kenya and China. In the current study we investigated the genetic diversity of RVAs in fecal samples from 87 straw-colored fruit bats living in close contact with humans in Cameroon using viral metagenom...

journal_title：Scientific reports

authors： Yinda CK,Zeller M,Conceição-Neto N,Maes P,Deboutte W,Beller L,Heylen E,Ghogomu SM,Van Ranst M,Matthijnssens J

更新日期：2016-09-26 00:00:00

abstract：:Autophagy is a major regulator of pancreatic beta cell homeostasis. Altered autophagic activity has been implicated in the beta cells of patients with type 2 diabetes, and in the beta cells of obese diabetic rodents. Here, we show that autophagy was induced in beta cells by either a high-fat diet or a combined high-fa...

journal_title：Scientific reports

authors： Sheng Q,Xiao X,Prasadan K,Chen C,Ming Y,Fusco J,Gangopadhyay NN,Ricks D,Gittes GK

更新日期：2017-11-27 00:00:00

abstract：:Bone scan abnormalities, especially rib lesions, are often confusing for physicians due to a high number of false-positive lesions. This study investigated risk factors that are associated with bone metastasis in 613 breast cancer patients with bone scan abnormalities. Significantly increased rates of bone metastasis ...

journal_title：Scientific reports

authors： Li Q,Chen Z,Zhao Y,Li X,Pan H,Xia T,Chen L,Xu Z,Zhou W,Liu X

更新日期：2015-05-05 00:00:00

abstract：:Enzymatic gold nanoparticles (B-GNPs) have been synthesized using a natural anticancer agent bromelain (a cysteine protease) and these nanoparticles were used to bioconjugate Cisplatin (highly effective against osteosarcoma and lung cancer). Cisplatin bioconjugated bromelain encapsulated gold nanoparticles (B-C-GNPs) ...

journal_title：Scientific reports

authors： Iram S,Zahera M,Wahid I,Baker A,Raish M,Khan A,Ali N,Ahmad S,Khan MS

更新日期：2019-09-25 00:00:00

abstract：:Lipofectamine reagents are widely accepted as "gold-standard" for the safe delivery of exogenous DNA or RNA into cells. Despite this, a satisfactory mechanism-based explanation of their superior efficacy has remained mostly elusive thus far. Here we apply a straightforward combination of live cell imaging, single-part...

journal_title：Scientific reports

authors： Cardarelli F,Digiacomo L,Marchini C,Amici A,Salomone F,Fiume G,Rossetta A,Gratton E,Pozzi D,Caracciolo G

更新日期：2016-05-11 00:00:00