Tropical South Atlantic influence on Northeastern Brazil precipitation and ITCZ displacement during the past 2300 years.

abstract：:The use of impedance-based label free cell analysis is increasingly popular and has many different applications. Here, we report that a real-time cell analyzer (RTCA) can be used to study the stimulation of Natural Killer (NK) cells. Engagement of NK cells via plate-bound antibodies directed against different activati...

journal_title：Scientific reports

authors： Fasbender F,Watzl C

更新日期：2018-03-21 00:00:00

abstract：:Bats have been shown as important mammal resevoirs to carry a variety of zoonotic pathogens. To analyze pathogenic species in bats from southeast coastal regions of China, we performed metagenomic sequencing technology for high throughput sequencing of six sentinels from southeast coastal area of China. We obtained 5,...

journal_title：Scientific reports

authors： Hu D,Zhu C,Wang Y,Ai L,Yang L,Ye F,Ding C,Chen J,He B,Zhu J,Qian H,Xu W,Feng Y,Tan W,Wang C

更新日期：2017-09-07 00:00:00

abstract：:Brønsted-Lewis acidic ionic liquids (ILs) were applied to catalyze cellobiose to prepare levulinic acid (LA) in one pot under hydrothermal conditions. Under the optimum conditions, the highest LA yield of 67.51% was obtained when low [HO3S-(CH2)3-mim]Cl-FeCl3 (molar fraction of FeCl3 x = 0.60) was used. This indicated...

journal_title：Scientific reports

authors： Liu S,Wang K,Yu H,Li B,Yu S

更新日期：2019-02-12 00:00:00

abstract：:Inosine-5'-monophosphate dehydrogenase (IMPDH) is an essential enzyme for nucleotide metabolism and cell proliferation. Despite IMPDH is the target of drugs with antiviral, immunosuppressive and antitumor activities, its physiological mechanisms of regulation remain largely unknown. Using the enzyme from the industria...

journal_title：Scientific reports

authors： Buey RM,Fernández-Justel D,Marcos-Alcalde Í,Winter G,Gómez-Puertas P,de Pereda JM,Luis Revuelta J

更新日期：2017-06-01 00:00:00

abstract：:The animal gut microbiota evolves quickly towards a complex community and plays crucial roles in its host's health and development. Factors such as host genetics and environmental changes are regarded as important for controlling the dynamics of animal gut microbiota. Migratory animals are an important group for study...

journal_title：Scientific reports

authors： Le MH,Wang D

更新日期：2020-05-05 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Scientific reports

authors： Boonma K,Kumar A,Garcia-Castellanos D,Jiménez-Munt I,Fernández M

更新日期：2020-01-15 00:00:00

abstract：:Growth cones of extending axons navigate to correct targets by sensing a guidance cue gradient via membrane protein receptors. Although most signaling mechanisms have been clarified using an in vitro approach, it is still difficult to investigate the growth cone behavior in complicated extracellular environment of liv...

journal_title：Scientific reports

authors： Endo M,Hattori M,Toriyabe H,Ohno H,Kamiguchi H,Iino Y,Ozawa T

更新日期：2016-04-07 00:00:00

abstract：:Clobetasol propionate (CLO) is a potent glucocorticoid used to treat inflammation-based skin, scalp, and hair disorders. In such conditions, hair follicles (HF) are not only the target site but can also act as drug reservoirs when certain formulations are topically applied. Recently, we have demonstrated nanostructure...

journal_title：Scientific reports

authors： Angelo T,El-Sayed N,Jurisic M,Koenneke A,Gelfuso GM,Cunha-Filho M,Taveira SF,Lemor R,Schneider M,Gratieri T

更新日期：2020-01-13 00:00:00

abstract：:RNA virus-based episomal vector (REVec) is an emerging viral vector system that mediates long-term stable gene expression in variety of cell types in vitro. However, little is known about its tissue tropism and persistence of gene expression in vivo. Here, to evaluate the feasibility of REVec for in vivo gene delivery...

journal_title：Scientific reports

authors： Komatsu Y,Tanaka C,Komorizono R,Tomonaga K

更新日期：2020-04-03 00:00:00

abstract：:Coupling between dynamical heterogeneity of ionic liquids and their structural periodicity on different length-scales can be directly probed by quasielastic neutron scattering with polarization analysis. The technique provides the tools to investigate single-particle and cooperative ion motions separately and, thus, d...

journal_title：Scientific reports

authors： Burankova T,Mora Cardozo JF,Rauber D,Wildes A,Embs JP

更新日期：2018-11-06 00:00:00

abstract：:FMS-like tyrosine kinase 3 (FLT3) is a key driver of acute myeloid leukemia (AML). Several tyrosine kinase inhibitors (TKIs) targeting FLT3 have been evaluated clinically, but their effects are limited when used in monotherapy due to the emergence of drug-resistance. Thus, a better understanding of drug-resistance pat...

journal_title：Scientific reports

authors： Morales ML,Arenas A,Ortiz-Ruiz A,Leivas A,Rapado I,Rodríguez-García A,Castro N,Zagorac I,Quintela-Fandino M,Gómez-López G,Gallardo M,Ayala R,Linares M,Martínez-López J

更新日期：2019-12-09 00:00:00

abstract：:Psoriasis is a chronic inflammatory skin disease characterized by abnormal keratinocyte proliferation and terminal differentiation. Interleukin-22 (IL-22) and the transcription factor Stat3 play pivotal roles in the pathogenesis of psoriasis. CD147 is a transmembrane glycosylation protein that belongs to the immunoglo...

journal_title：Scientific reports

authors： Peng C,Zhang S,Lei L,Zhang X,Jia X,Luo Z,Huang X,Kuang Y,Zeng W,Su J,Chen X

更新日期：2017-03-08 00:00:00

abstract：:We investigate the Lorentz-covariant deformed algebra for Dirac oscillator problem, which is a generalization of Kempf deformed algebra in 3 + 1 dimension of space-time, where Lorentz symmetry are preserved. The energy spectrum of the system is analyzed by taking advantage of the corresponding wave functions with expl...

journal_title：Scientific reports

authors： Betrouche M,Maamache M,Choi JR

更新日期：2013-11-14 00:00:00

abstract：:Routers, switches, and repeaters are essential components of modern information-processing systems. Similar devices will be needed in future superconducting quantum computers. In this work we investigate experimentally the time evolution of Autler-Townes splitting in a superconducting phase qubit under the application...

journal_title：Scientific reports

authors： Li J,Paraoanu GS,Cicak K,Altomare F,Park JI,Simmonds RW,Sillanpää MA,Hakonen PJ

更新日期：2012-01-01 00:00:00

abstract：:In southeastern China (SEC), the precipitation amount produced by the East Asian summer monsoon (EASM) is almost equivalent to that during the non-summer monsoon (NSM) period, both of them significantly affecting agriculture and socioeconomy. Here, we present a seasonally-resolved stalagmite δ18O record (δ18Os) for th...

journal_title：Scientific reports

authors： Zhang H,Cheng H,Spötl C,Cai Y,Sinha A,Tan L,Yi L,Yan H,Kathayat G,Ning Y,Li X,Zhang F,Zhao J,Edwards RL

更新日期：2018-08-17 00:00:00

abstract：:For translocated animals, behavioral competence may be key to post-release survival. However, monitoring behavior is typically limited to tracking movements or inferring behavior at a gross scale via collar-mounted sensors. Animal-bourne acoustic monitoring may provide a unique opportunity to monitor behavior at a fin...

journal_title：Scientific reports

authors： Yan X,Zhang H,Li D,Wu D,Zhou S,Sun M,Hu H,Liu X,Mou S,He S,Owen MA,Huang Y

更新日期：2019-03-26 00:00:00

abstract：:Mutations in the CACNA1C gene are associated with ventricular tachycardia (VT). Although the CACNA1C mutations were well identified in patients with cardiac arrhythmias, mechanisms by which cardiac arrhythmias are generated in such genetic mutation conditions remain unclear. In this study, we identified a novel mechan...

journal_title：Scientific reports

authors： Bai J,Wang K,Li Q,Yuan Y,Zhang H

更新日期：2016-08-09 00:00:00

abstract：:We have developed a plasma cell treatment device called Plasma-on-Chip that enables the real-time monitoring of a single cell culture during plasma treatment. The device consists of three parts: 1) microwells for cell culture, 2) a microplasma device for generating reactive oxygen and nitrogen species (RONS) for use i...

journal_title：Scientific reports

authors： Oh JS,Kojima S,Sasaki M,Hatta A,Kumagai S

更新日期：2017-02-08 00:00:00

abstract：:Previous results regarding the associations between esophageal squamous-cell carcinoma (ESCC) risk and smoking/alcohol drinking in high-risk areas are inconsistent. We performed a large population-based case-control study from 2010 to 2013 in a high-incidence area of China, and enrolled 1353 ESCC cases and 1961 contro...

journal_title：Scientific reports

authors： Yang X,Chen X,Zhuang M,Yuan Z,Nie S,Lu M,Jin L,Ye W

更新日期：2017-12-08 00:00:00

abstract：:Staphylococcus aureus colonizes the skin of atopic dermatitis (AD) individuals, but the impact of its enterotoxins on the chronic activation of CD4+ T cells demands further analysis. We aimed to analyze the CD4+ T cell anergy profile and their phenotypic and functional features through differential expression of cellu...

journal_title：Scientific reports

authors： Orfali RL,Yoshikawa FSY,Oliveira LMDS,Pereira NZ,de Lima JF,Ramos YÁL,Duarte AJDS,Sato MN,Aoki V

更新日期：2019-09-11 00:00:00

abstract：:Adaptive responses to hypoxia regulate hepatic lipid metabolism, but their consequences in nonalcoholic fatty liver disease (NAFLD) are largely unknown. Here, we show that hypoxia inducible factor-1 (HIF-1), a key determinant of hypoxic adaptations, prevents excessive hepatic lipid accumulation in the progression of N...

journal_title：Scientific reports

authors： Arai T,Tanaka M,Goda N

更新日期：2018-09-21 00:00:00

abstract：:Bemisia tabaci is a cryptic whitefly-species complex that includes some of the most damaging pests and plant-virus vectors of a diverse range of food and fibre crops worldwide. We combine experimental evidence of: (i) differences in reproductive compatibility, (ii) hybrid verification using a specific nuclear DNA mark...

journal_title：Scientific reports

authors： Vyskočilová S,Tay WT,van Brunschot S,Seal S,Colvin J

更新日期：2018-07-18 00:00:00

abstract：:Insecticides are the main method of controlling lepidopteran pests of eucalyptus plantations and those selective to natural enemies, such as the endoparasitoid Palmistichus elaeisis Delvare et LaSalle (Hymenoptera: Eulophidae), are preferable. The objective of this study was to evaluate the selectivity and effects on ...

journal_title：Scientific reports

authors： Pereira Costa ES,Soares MA,Caldeira ZV,Von Dos Santos Veloso R,da Silva LA,da Silva DJH,de Lima Santos IC,de Castro E Castro BM,Zanuncio JC,Legaspi JC

更新日期：2020-07-24 00:00:00

abstract：:Increased biosynthesis of abscisic acid (ABA) occurs in plants in response to water deficit, which is mediated by changes in the levels of reactive oxygen species such as H2O2. Water deficit and ABA induce expression of some RD22-like proteins. This study aimed to evaluate the effect of water deficit and exogenous ABA...

journal_title：Scientific reports

authors： Phillips K,Ludidi N

更新日期：2017-08-18 00:00:00

abstract：:Metastasis causes approximately 90% of breast cancer-related deaths in women. Previously, we have demonstrated that 2-dodecyl-6-methoxycyclohexa-2,5-diene- 1,4-dione (DMDD) remarkably inhibited the growth of human breast cancer cells with little toxicity. In this study, we investigated the toxicity and efficacy of DMD...

journal_title：Scientific reports

authors： Chen C,Nong Z,Xie Q,He J,Cai W,Tang X,Chen X,Huang R,Gao Y

更新日期：2017-07-27 00:00:00

abstract：:Vaccines have become fundamental in the control and elimination of Glässer Disease, a systemic disease of pigs caused by Haemophilus parasuis. The classic vaccines available for prevention of this infection were developed without a robust knowledge about host immunological mechanisms. In this study, we demonstrated th...

journal_title：Scientific reports

authors： Barasuol BM,Guizzo JA,Fegan JE,Martínez-Martínez S,Rodríguez-Ferri EF,Gutiérrez-Martín CB,Kreutz LC,Schryvers AB,Frandoloso R

更新日期：2017-09-04 00:00:00

abstract：:Ruminococcus albus 8 is a specialist plant cell wall degrading ruminal bacterium capable of utilizing hemicellulose and cellulose. Cellulose degradation requires a suite of enzymes including endoglucanases, exoglucanases, and β-glucosidases. The enzymes employed by R. albus 8 in degrading cellulose are yet to be compl...

journal_title：Scientific reports

authors： Iakiviak M,Devendran S,Skorupski A,Moon YH,Mackie RI,Cann I

更新日期：2016-07-21 00:00:00

abstract：:Ambient seismic noise is characterized by randomness incurred by the random position and strength of the noise sources as well as the heterogeneous properties of the medium through which it propagates. Here we use ambient noise data recorded prior to the 1996 Gjálp eruption in Iceland in order to show that a reduction...

journal_title：Scientific reports

authors： Glynn CC,Konstantinou KI

更新日期：2016-11-24 00:00:00

abstract：:Novelty seeking (NS) is a personality trait reflecting excitement in response to novel stimuli. High NS is usually a predictor of risky behaviour such as drug abuse. However, the relationships between NS and risk-related cognitive processes, including individual risk preference and the brain activation associated with...

journal_title：Scientific reports

authors： Wang Y,Liu Y,Yang L,Gu F,Li X,Zha R,Wei Z,Pei Y,Zhang P,Zhou Y,Zhang X

更新日期：2015-06-11 00:00:00

abstract：:Deleterious mutations in patchd1 domain containing 1 (PTCHD1) gene have been identified in patients with intellectual disability and/or autism spectrum disorder (ASD). To clarify the causal relationship between Ptchd1 deficiency and behavioral defects relevant to neurodevelopmental disorders, we generated global Ptchd...

journal_title：Scientific reports

authors： Murakami Y,Imamura Y,Saito K,Sakai D,Motoyama J

更新日期：2019-09-12 00:00:00