Abstract：
:Exendin-4 is a long acting glucagon-like peptide 1 (GLP-1) analogue that is an agonist for the GLP-1 receptor, a G-protein coupled receptor (GPCR). Exendin-4 is used to clinically improve glucose tolerance in diabetic patients due to its ability to enhance insulin secretion. In rodents, and possibly in humans, exendin-4 can stimulate β-cell proliferation. The exact mechanism of action to induce β-cell proliferation is not well understood. Here, using a β-cell specific epidermal growth factor receptor (EGFR) null mouse, we show that exendin-4 induced an increase in proliferation and β-cell mass through EGFR. Thus, our study sheds light on the role of EGFR signaling in the effects of exendin-4 on the control of blood glucose metabolism and β-cell mass.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Fusco J,Xiao X,Prasadan K,Sheng Q,Chen C,Ming YC,Gittes Gdoi
10.1038/s41598-017-09898-4subject
Has Abstractpub_date
2017-08-22 00:00:00pages
9100issue
1issn
2045-2322pii
10.1038/s41598-017-09898-4journal_volume
7pub_type
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